5OHY
A GH31 family sulfoquinovosidase in complex with aza-sugar inhibitor IFGSQ
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0030246 | molecular_function | carbohydrate binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| B | 0030246 | molecular_function | carbohydrate binding |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| C | 0030246 | molecular_function | carbohydrate binding |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| D | 0005975 | biological_process | carbohydrate metabolic process |
| D | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| D | 0030246 | molecular_function | carbohydrate binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue K A 701 |
| Chain | Residue |
| A | GLY137 |
| A | ASP455 |
| A | ASP464 |
| A | HOH816 |
| A | HOH1164 |
| A | HOH1227 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 702 |
| Chain | Residue |
| A | TYR491 |
| A | 9VH704 |
| A | GLU135 |
| A | ARG438 |
| A | ASP455 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue SCN A 703 |
| Chain | Residue |
| A | PHE251 |
| A | TYR295 |
| A | PRO296 |
| A | HIS297 |
| A | LEU298 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | binding site for residue 9VH A 704 |
| Chain | Residue |
| A | GLU270 |
| A | ARG283 |
| A | LEU284 |
| A | TRP286 |
| A | MET386 |
| A | ASP388 |
| A | ARG438 |
| A | ASP455 |
| A | TYR491 |
| A | HIS520 |
| A | EDO702 |
| A | HOH814 |
| A | HOH841 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 A 705 |
| Chain | Residue |
| A | ARG462 |
| A | VAL467 |
| A | GLN587 |
| A | ASP588 |
| A | TRP602 |
| A | HOH1027 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue K B 701 |
| Chain | Residue |
| B | GLY137 |
| B | ASP455 |
| B | ASP464 |
| B | HOH947 |
| B | HOH1146 |
| B | HOH1220 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 702 |
| Chain | Residue |
| B | GLU135 |
| B | PHE389 |
| B | ARG438 |
| B | ASP455 |
| B | TYR491 |
| B | EDO704 |
| B | 9VH707 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 703 |
| Chain | Residue |
| B | ARG276 |
| B | VAL322 |
| B | ASP323 |
| B | PHE352 |
| B | ASP353 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 704 |
| Chain | Residue |
| B | GLU135 |
| B | PHE280 |
| B | ARG283 |
| B | EDO702 |
| B | HOH892 |
| B | HOH1075 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue SCN B 705 |
| Chain | Residue |
| B | TYR295 |
| B | PRO296 |
| B | HIS297 |
| B | LEU298 |
| B | LYS301 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue SCN B 706 |
| Chain | Residue |
| B | GLY281 |
| B | ALA282 |
| B | ARG524 |
| B | PRO525 |
| B | ARG526 |
| B | HOH1158 |
| site_id | AD3 |
| Number of Residues | 14 |
| Details | binding site for residue 9VH B 707 |
| Chain | Residue |
| B | GLU270 |
| B | ARG283 |
| B | LEU284 |
| B | TRP286 |
| B | TYR315 |
| B | MET386 |
| B | ASP388 |
| B | ARG438 |
| B | ASP455 |
| B | TYR491 |
| B | HIS520 |
| B | EDO702 |
| B | HOH834 |
| B | HOH888 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 B 708 |
| Chain | Residue |
| B | ASP25 |
| B | PRO27 |
| B | PHE30 |
| B | ARG58 |
| B | ARG103 |
| B | HOH820 |
| B | HOH1105 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue K C 701 |
| Chain | Residue |
| C | GLY137 |
| C | ASP455 |
| C | ASP464 |
| C | HOH921 |
| C | HOH1119 |
| C | HOH1155 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue EDO C 702 |
| Chain | Residue |
| C | PHE349 |
| C | EDO703 |
| C | HOH813 |
| C | HOH1059 |
| C | GLU135 |
| C | PHE280 |
| site_id | AD7 |
| Number of Residues | 7 |
| Details | binding site for residue EDO C 703 |
| Chain | Residue |
| C | GLU135 |
| C | PHE389 |
| C | ARG438 |
| C | ASP455 |
| C | TYR491 |
| C | EDO702 |
| C | 9VH707 |
| site_id | AD8 |
| Number of Residues | 6 |
| Details | binding site for residue EDO C 704 |
| Chain | Residue |
| C | ARG276 |
| C | VAL322 |
| C | ASP323 |
| C | PHE352 |
| C | ASP353 |
| C | HOH860 |
| site_id | AD9 |
| Number of Residues | 3 |
| Details | binding site for residue SCN C 705 |
| Chain | Residue |
| C | TYR295 |
| C | HIS297 |
| C | LEU298 |
| site_id | AE1 |
| Number of Residues | 6 |
| Details | binding site for residue SCN C 706 |
| Chain | Residue |
| C | GLN277 |
| C | GLY281 |
| C | ALA282 |
| C | ARG524 |
| C | PRO525 |
| C | ARG526 |
| site_id | AE2 |
| Number of Residues | 13 |
| Details | binding site for residue 9VH C 707 |
| Chain | Residue |
| C | GLU270 |
| C | ARG283 |
| C | LEU284 |
| C | TRP286 |
| C | MET386 |
| C | ASP388 |
| C | ARG438 |
| C | ASP455 |
| C | TYR491 |
| C | HIS520 |
| C | EDO703 |
| C | HOH819 |
| C | HOH897 |
| site_id | AE3 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 C 708 |
| Chain | Residue |
| C | ARG462 |
| C | VAL467 |
| C | GLN587 |
| C | ASP588 |
| C | TRP602 |
| C | HOH963 |
| site_id | AE4 |
| Number of Residues | 6 |
| Details | binding site for residue K D 701 |
| Chain | Residue |
| D | GLY137 |
| D | ASP455 |
| D | ASP464 |
| D | HOH907 |
| D | HOH1090 |
| D | HOH1119 |
| site_id | AE5 |
| Number of Residues | 7 |
| Details | binding site for residue EDO D 702 |
| Chain | Residue |
| D | GLU135 |
| D | PHE389 |
| D | ARG438 |
| D | ASP455 |
| D | TYR491 |
| D | EDO703 |
| D | 9VH705 |
| site_id | AE6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO D 703 |
| Chain | Residue |
| D | PHE280 |
| D | EDO702 |
| D | HOH937 |
| D | HOH955 |
| D | HOH1099 |
| site_id | AE7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO D 704 |
| Chain | Residue |
| D | VAL322 |
| D | ASP323 |
| D | PHE352 |
| D | ASP353 |
| site_id | AE8 |
| Number of Residues | 13 |
| Details | binding site for residue 9VH D 705 |
| Chain | Residue |
| D | GLU270 |
| D | ARG283 |
| D | LEU284 |
| D | TRP286 |
| D | MET386 |
| D | ASP388 |
| D | ARG438 |
| D | ASP455 |
| D | TYR491 |
| D | HIS520 |
| D | EDO702 |
| D | HOH828 |
| D | HOH862 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Nucleophile => ECO:0000250|UniProtKB:P32138 |
| Chain | Residue | Details |
| A | ASP388 | |
| B | ASP388 | |
| C | ASP388 | |
| D | ASP388 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:P31434 |
| Chain | Residue | Details |
| A | GLU391 | |
| B | GLU391 | |
| C | GLU391 | |
| D | GLU391 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton donor => ECO:0000250|UniProtKB:P32138 |
| Chain | Residue | Details |
| A | ASP455 | |
| B | ASP455 | |
| C | ASP455 | |
| D | ASP455 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:35074914, ECO:0007744|PDB:7OFX |
| Chain | Residue | Details |
| A | GLU135 | |
| A | ARG438 | |
| B | GLU135 | |
| B | ARG438 | |
| C | GLU135 | |
| C | ARG438 | |
| D | GLU135 | |
| D | ARG438 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:35074914, ECO:0000305|PubMed:30276262, ECO:0007744|PDB:5OHS, ECO:0007744|PDB:7OFX |
| Chain | Residue | Details |
| A | GLU270 | |
| B | HIS520 | |
| C | GLU270 | |
| C | ARG283 | |
| C | LEU284 | |
| C | TRP286 | |
| C | HIS520 | |
| D | GLU270 | |
| D | ARG283 | |
| D | LEU284 | |
| D | TRP286 | |
| A | ARG283 | |
| D | HIS520 | |
| A | LEU284 | |
| A | TRP286 | |
| A | HIS520 | |
| B | GLU270 | |
| B | ARG283 | |
| B | LEU284 | |
| B | TRP286 |
