5OEY
Crystal structure of Leishmania major fructose-1,6-bisphosphatase in holo form.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006094 | biological_process | gluconeogenesis |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016791 | molecular_function | phosphatase activity |
| A | 0020015 | cellular_component | glycosome |
| A | 0042132 | molecular_function | fructose 1,6-bisphosphate 1-phosphatase activity |
| A | 0042578 | molecular_function | phosphoric ester hydrolase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006094 | biological_process | gluconeogenesis |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016791 | molecular_function | phosphatase activity |
| B | 0020015 | cellular_component | glycosome |
| B | 0042132 | molecular_function | fructose 1,6-bisphosphate 1-phosphatase activity |
| B | 0042578 | molecular_function | phosphoric ester hydrolase activity |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0006094 | biological_process | gluconeogenesis |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0016791 | molecular_function | phosphatase activity |
| C | 0020015 | cellular_component | glycosome |
| C | 0042132 | molecular_function | fructose 1,6-bisphosphate 1-phosphatase activity |
| C | 0042578 | molecular_function | phosphoric ester hydrolase activity |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0005975 | biological_process | carbohydrate metabolic process |
| D | 0006094 | biological_process | gluconeogenesis |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0016791 | molecular_function | phosphatase activity |
| D | 0020015 | cellular_component | glycosome |
| D | 0042132 | molecular_function | fructose 1,6-bisphosphate 1-phosphatase activity |
| D | 0042578 | molecular_function | phosphoric ester hydrolase activity |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue PO4 A 701 |
| Chain | Residue |
| A | ASP68 |
| A | MN702 |
| A | MN703 |
| A | K704 |
| A | GLU97 |
| A | ASP118 |
| A | LEU120 |
| A | ASP121 |
| A | GLY122 |
| A | SER123 |
| A | ARG280 |
| A | GLU284 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue MN A 702 |
| Chain | Residue |
| A | ASP74 |
| A | GLU97 |
| A | GLU98 |
| A | ASP118 |
| A | LEU120 |
| A | PO4701 |
| A | K704 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue MN A 703 |
| Chain | Residue |
| A | ASP118 |
| A | ASP121 |
| A | GLU284 |
| A | PO4701 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue K A 704 |
| Chain | Residue |
| A | ASP68 |
| A | GLU97 |
| A | PO4701 |
| A | MN702 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | binding site for residue PO4 B 701 |
| Chain | Residue |
| B | GLU97 |
| B | ASP118 |
| B | ASP121 |
| B | GLY122 |
| B | SER123 |
| B | GLU284 |
| B | MN702 |
| B | MN703 |
| B | K704 |
| D | LYS210 |
| D | HOH801 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | binding site for residue MN B 702 |
| Chain | Residue |
| B | GLU97 |
| B | GLU98 |
| B | ASP118 |
| B | LEU120 |
| B | PO4701 |
| B | MN703 |
| B | HOH801 |
| D | LYS210 |
| D | HOH801 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue MN B 703 |
| Chain | Residue |
| B | GLU97 |
| B | ASP118 |
| B | ASP121 |
| B | GLU284 |
| B | PO4701 |
| B | MN702 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue K B 704 |
| Chain | Residue |
| B | PO4701 |
| D | GLN326 |
| site_id | AC9 |
| Number of Residues | 12 |
| Details | binding site for residue PO4 C 701 |
| Chain | Residue |
| C | ASP68 |
| C | GLU97 |
| C | ASP118 |
| C | LEU120 |
| C | ASP121 |
| C | GLY122 |
| C | SER123 |
| C | ARG280 |
| C | GLU284 |
| C | MN702 |
| C | MN703 |
| C | K704 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue MN C 702 |
| Chain | Residue |
| C | GLU97 |
| C | ASP118 |
| C | LEU120 |
| C | PO4701 |
| C | MN703 |
| C | K704 |
| C | HOH801 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue MN C 703 |
| Chain | Residue |
| C | ASP118 |
| C | ASP121 |
| C | GLU284 |
| C | PO4701 |
| C | MN702 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue K C 704 |
| Chain | Residue |
| C | ASP68 |
| C | GLU97 |
| C | PO4701 |
| C | MN702 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue CIT C 705 |
| Chain | Residue |
| A | LYS52 |
| C | ARG48 |
| C | LYS52 |
| site_id | AD5 |
| Number of Residues | 10 |
| Details | binding site for residue PO4 D 701 |
| Chain | Residue |
| D | ASP74 |
| D | GLU97 |
| D | ASP118 |
| D | LEU120 |
| D | ASP121 |
| D | SER123 |
| D | MN702 |
| D | MN703 |
| D | K704 |
| D | HOH803 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue MN D 702 |
| Chain | Residue |
| D | K704 |
| D | ASP74 |
| D | GLU98 |
| D | PO4701 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue MN D 703 |
| Chain | Residue |
| D | GLU97 |
| D | ASP118 |
| D | ASP121 |
| D | GLU284 |
| D | PO4701 |
| site_id | AD8 |
| Number of Residues | 7 |
| Details | binding site for residue K D 704 |
| Chain | Residue |
| D | ASP74 |
| D | GLU97 |
| D | GLU98 |
| D | ASP118 |
| D | LEU120 |
| D | PO4701 |
| D | MN702 |
| site_id | AD9 |
| Number of Residues | 3 |
| Details | binding site for residue CIT D 705 |
| Chain | Residue |
| B | LYS52 |
| D | LYS44 |
| D | LYS52 |
Functional Information from PROSITE/UniProt
| site_id | PS00124 |
| Number of Residues | 13 |
| Details | FBPASE Fructose-1-6-bisphosphatase active site. GKLrlLYEaaPMA |
| Chain | Residue | Details |
| A | GLY277-ALA289 |
