5OE7

Structure of OTULIN bound to the Met1-linked diubiquitin activity probe

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004843	molecular_function	cysteine-type deubiquitinase activity
A	1990108	biological_process	protein linear deubiquitination

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
B	LYS27-ASP52
B	LYS103-ASP128

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	Region: {"description":"Linear diubiquitin binding","evidences":[{"source":"PubMed","id":"23708998","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23746843","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ZNZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KSL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	10
Details	Region: {"description":"Linear diubiquitin binding","evidences":[{"source":"PubMed","id":"23708998","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23746843","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ZNZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KSL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PubMed","id":"23708998","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23746843","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ZNZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KSL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"23708998","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23746843","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24726327","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ZNZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KSL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Site: {"description":"Linear diubiquitin binding","evidences":[{"source":"PubMed","id":"23708998","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23746843","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ZNZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KSL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	75
Details	Domain: {"description":"Ubiquitin-like 8","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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