5OD3

Crystal structure of R. ruber ADH-A, mutant Y54G, L119Y

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008270	molecular_function	zinc ion binding
A	0016491	molecular_function	oxidoreductase activity
B	0008270	molecular_function	zinc ion binding
B	0016491	molecular_function	oxidoreductase activity
C	0008270	molecular_function	zinc ion binding
C	0016491	molecular_function	oxidoreductase activity
D	0008270	molecular_function	zinc ion binding
D	0016491	molecular_function	oxidoreductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 501

Chain	Residue
A	CYS92
A	CYS95
A	CYS98
A	CYS106

---

site_id	AC2
Number of Residues	5
Details	binding site for residue ZN A 502

Chain	Residue
A	CYS38
A	SER40
A	HIS62
A	ASP153
A	NAD503

---

site_id	AC3
Number of Residues	35
Details	binding site for residue NAD A 503

Chain	Residue
A	CYS38
A	HIS39
A	SER40
A	ASP153
A	THR157
A	VAL180
A	GLY181
A	GLY182
A	LEU183
A	ASP203
A	LEU204
A	ARG208
A	SER223
A	PHE246
A	VAL247
A	THR252
A	VAL269
A	GLY270
A	ILE271
A	PRO293
A	TYR294
A	TRP295
A	LEU332
A	ARG340
A	ZN502
A	HOH656
A	HOH658
A	HOH693
A	HOH706
A	HOH718
A	HOH727
A	HOH739
A	HOH793
A	HOH809
D	PHE281

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN B 501

Chain	Residue
B	CYS92
B	CYS95
B	CYS98
B	CYS106

---

site_id	AC5
Number of Residues	6
Details	binding site for residue ZN B 502

Chain	Residue
B	CYS38
B	SER40
B	HIS62
B	ASP153
B	NAD503
B	HOH791

---

site_id	AC6
Number of Residues	34
Details	binding site for residue NAD B 503

Chain	Residue
B	HIS39
B	SER40
B	ASP153
B	THR157
B	VAL180
B	GLY181
B	GLY182
B	LEU183
B	ASP203
B	LEU204
B	ARG208
B	SER223
B	PHE246
B	VAL247
B	THR252
B	VAL269
B	GLY270
B	ILE271
B	PRO293
B	TYR294
B	TRP295
B	ARG340
B	ZN502
B	HOH618
B	HOH632
B	HOH633
B	HOH692
B	HOH721
B	HOH722
B	HOH726
B	HOH750
B	HOH791
B	HOH800
C	PHE281

---

site_id	AC7
Number of Residues	4
Details	binding site for residue ZN C 501

Chain	Residue
C	CYS92
C	CYS95
C	CYS98
C	CYS106

---

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN C 502

Chain	Residue
C	CYS38
C	HIS62
C	ASP153
C	NAD503

---

site_id	AC9
Number of Residues	37
Details	binding site for residue NAD C 503

Chain	Residue
C	ASP153
C	THR157
C	VAL180
C	GLY181
C	GLY182
C	LEU183
C	ASP203
C	LEU204
C	ARG208
C	SER223
C	PHE246
C	VAL247
C	THR252
C	VAL269
C	GLY270
C	ILE271
C	PRO293
C	TYR294
C	TRP295
C	LEU332
C	ARG340
C	ZN502
C	HOH608
C	HOH622
C	HOH649
C	HOH652
C	HOH667
C	HOH675
C	HOH679
C	HOH722
C	HOH739
C	HOH741
C	HOH768
C	HOH782
C	CYS38
C	HIS39
C	SER40

---

site_id	AD1
Number of Residues	4
Details	binding site for residue ZN D 501

Chain	Residue
D	CYS92
D	CYS95
D	CYS98
D	CYS106

---

site_id	AD2
Number of Residues	5
Details	binding site for residue ZN D 502

Chain	Residue
D	CYS38
D	HIS62
D	ASP153
D	NAD503
D	HOH744

---

site_id	AD3
Number of Residues	34
Details	binding site for residue NAD D 503

Chain	Residue
A	PHE281
D	HIS39
D	SER40
D	ASP153
D	THR157
D	GLY179
D	VAL180
D	GLY181
D	GLY182
D	LEU183
D	ASP203
D	LEU204
D	ARG208
D	SER223
D	PHE246
D	VAL247
D	THR252
D	VAL269
D	GLY270
D	ILE271
D	PRO293
D	TYR294
D	TRP295
D	LEU332
D	ARG340
D	ZN502
D	HOH629
D	HOH631
D	HOH648
D	HOH684
D	HOH712
D	HOH727
D	HOH743
D	HOH761

---

Functional Information from PROSITE/UniProt

site_id	PS00059
Number of Residues	15
Details	ADH_ZINC Zinc-containing alcohol dehydrogenases signature. GHEgVGTvaelGegV

Chain	Residue	Details
A	GLY61-VAL75

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