5O9W

Thebaine 6-O-demethylase (T6ODM) from Papaver somniferum in complex with 2-oxoglutarate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008168	molecular_function	methyltransferase activity
A	0009820	biological_process	alkaloid metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016706	molecular_function	2-oxoglutarate-dependent dioxygenase activity
A	0016740	molecular_function	transferase activity
A	0032259	biological_process	methylation
A	0046872	molecular_function	metal ion binding
A	0051213	molecular_function	dioxygenase activity
A	0097295	biological_process	morphine biosynthetic process
A	0102802	molecular_function	thebaine 6-O-demethylase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue NI A 401

Chain	Residue
A	HIS238
A	ASP240
A	HIS295
A	AKG402
A	HOH526

---

site_id	AC2
Number of Residues	16
Details	binding site for residue AKG A 402

Chain	Residue
A	HIS238
A	ASP240
A	LEU247
A	LEU256
A	HIS295
A	ARG305
A	SER307
A	ALA309
A	PHE311
A	NI401
A	HOH526
A	HOH702
A	ARG219
A	ASN221
A	TYR223
A	LEU235

---

site_id	AC3
Number of Residues	4
Details	binding site for residue EDO A 403

Chain	Residue
A	LYS72
A	LEU75
A	ASP76
A	HIS79

---

site_id	AC4
Number of Residues	5
Details	binding site for residue EDO A 404

Chain	Residue
A	PRO56
A	VAL57
A	ARG77
A	HOH618
A	HOH660

---

site_id	AC5
Number of Residues	8
Details	binding site for residue EDO A 405

Chain	Residue
A	ILE284
A	ILE320
A	GLY321
A	LYS336
A	SER337
A	GLY338
A	SER339
A	MET362

---

site_id	AC6
Number of Residues	1
Details	binding site for residue EDO A 406

Chain	Residue
A	HOH715

---

site_id	AC7
Number of Residues	5
Details	binding site for residue EDO A 407

Chain	Residue
A	ASP76
A	ARG77
A	HOH513
A	HOH609
A	HOH697

---

site_id	AC8
Number of Residues	8
Details	binding site for residue EDO A 408

Chain	Residue
A	GLN123
A	GLY132
A	GLN133
A	GLY134
A	PHE135
A	HOH598
A	HOH612
A	HOH717

---

site_id	AC9
Number of Residues	2
Details	binding site for residue EDO A 409

Chain	Residue
A	GLY94
A	HOH633

---

site_id	AD1
Number of Residues	7
Details	binding site for residue EDO A 410

Chain	Residue
A	GLU117
A	LYS118
A	LYS120
A	TYR121
A	LYS166
A	HOH617
A	HOH647

---

site_id	AD2
Number of Residues	7
Details	binding site for residue EDO A 411

Chain	Residue
A	LYS205
A	GLY206
A	VAL210
A	VAL319
A	ILE320
A	GLY321
A	ILE323

---

site_id	AD3
Number of Residues	4
Details	binding site for residue EDO A 412

Chain	Residue
A	HIS93
A	GLU181
A	LYS184
A	HOH540

---

site_id	AD4
Number of Residues	5
Details	binding site for residue EDO A 413

Chain	Residue
A	ASN11
A	ASP59
A	VAL91
A	HOH541
A	HOH692

---

site_id	AD5
Number of Residues	1
Details	binding site for residue EDO A 414

Chain	Residue
A	ILE69

---

site_id	AD6
Number of Residues	3
Details	binding site for residue EDO A 415

Chain	Residue
A	ALA22
A	LYS23
A	HOH587

---

site_id	AD7
Number of Residues	4
Details	binding site for residue UNX A 416

Chain	Residue
A	SER-2
A	ASN-1
A	ALA0
A	UNX417

---

site_id	AD8
Number of Residues	3
Details	binding site for residue UNX A 417

Chain	Residue
A	LYS3
A	UNX416
A	UNX418

---

site_id	AD9
Number of Residues	2
Details	binding site for residue UNX A 418

Chain	Residue
A	LYS3
A	UNX417

---

site_id	AE1
Number of Residues	3
Details	binding site for residue UNX A 419

Chain	Residue
A	LYS336
A	SER337
A	SER339

---

site_id	AE2
Number of Residues	5
Details	binding site for residue UNX A 420

Chain	Residue
A	LYS336
A	GLU347
A	MET362
A	UNX421
A	HOH747

---

site_id	AE3
Number of Residues	4
Details	binding site for residue UNX A 421

Chain	Residue
A	SER339
A	GLU347
A	UNX420
A	LYS336

---

site_id	AE4
Number of Residues	5
Details	binding site for residue PEG A 422

Chain	Residue
A	VAL128
A	MET150
A	HOH508
A	HOH539
A	HOH636

---

site_id	AE5
Number of Residues	6
Details	binding site for residue NA A 423

Chain	Residue
A	SER324
A	ILE327
A	HOH603
A	HOH802
A	HOH813
A	HOH818

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	100
Details	Domain: {"description":"Fe2OG dioxygenase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00805","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29408320","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5O9W","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00805","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00805","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"29408320","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5O9W","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---