5O9S

HsNMT1 in complex with CoA and Myristoylated-GKSNSKLK octapeptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004379	molecular_function	glycylpeptide N-tetradecanoyltransferase activity
A	0006499	biological_process	N-terminal protein myristoylation
B	0004379	molecular_function	glycylpeptide N-tetradecanoyltransferase activity
B	0006499	biological_process	N-terminal protein myristoylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue GOL A 501

Chain	Residue
A	LYS289
A	VAL291
A	TYR477
A	LEU478
A	TRP481
A	CYS483

---

site_id	AC2
Number of Residues	4
Details	binding site for residue CL A 502

Chain	Residue
A	SER485
A	VAL132
A	LYS289
A	PRO484

---

site_id	AC3
Number of Residues	7
Details	binding site for residue GOL A 503

Chain	Residue
A	GLU244
A	PRO364
A	MET366
A	TRP374
A	TYR423
A	VAL494
A	GLN496

---

site_id	AC4
Number of Residues	7
Details	binding site for residue GOL B 501

Chain	Residue
B	LYS289
B	PRO290
B	VAL291
B	LEU478
B	TRP481
B	LYS482
B	CYS483

---

site_id	AC5
Number of Residues	4
Details	binding site for residue CL B 502

Chain	Residue
B	VAL131
B	VAL132
B	LYS289
B	SER485

---

site_id	AC6
Number of Residues	5
Details	binding site for residue CL B 503

Chain	Residue
B	LEU161
B	LEU163
B	ARG202
B	TRP206
B	HIS211

---

site_id	AC7
Number of Residues	8
Details	binding site for residue GOL B 504

Chain	Residue
B	GLU244
B	PRO364
B	MET366
B	TRP374
B	TYR423
B	LEU493
B	VAL494
B	GLN496

---

site_id	AC8
Number of Residues	12
Details	binding site for Di-peptide MYR C 101 and GLY C 2

Chain	Residue
A	TRP120
A	TYR180
A	ASN246
A	PHE247
A	LEU248
A	THR268
A	GLN278
A	ALA279
A	TYR281
A	THR282
A	ALA283
C	LYS3

---

site_id	AC9
Number of Residues	13
Details	binding site for Di-peptide MYR D 101 and GLY D 2

Chain	Residue
B	TYR180
B	ILE245
B	PHE247
B	LEU248
B	THR268
B	PHE277
B	GLN278
B	ALA279
B	TYR281
B	THR282
B	ALA283
B	TYR479
D	LYS3

---

Functional Information from PROSITE/UniProt

site_id	PS00975
Number of Residues	9
Details	NMT_1 Myristoyl-CoA:protein N-myristoyltransferase signature 1. EINFLCvHK

Chain	Residue	Details
A	GLU244-LYS252

---

site_id	PS00976
Number of Residues	7
Details	NMT_2 Myristoyl-CoA:protein N-myristoyltransferase signature 2. KFGiGDG

Chain	Residue	Details
A	LYS466-GLY472

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25255805","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32111831","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90055.","authoringGroup":["Structural genomics consortium (SGC)"]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25255805","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32103017","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32111831","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90055.","authoringGroup":["Structural genomics consortium (SGC)"]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32103017","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25255805","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90055.","authoringGroup":["Structural genomics consortium (SGC)"]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Lipidation: {"description":"N-myristoyl glycine","evidences":[{"source":"PubMed","id":"25255805","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---