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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5O9H

Crystal structure of thermostabilised human C5a anaphylatoxin chemotactic receptor 1 (C5aR) in complex with NDT9513727

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004875	molecular_function	complement receptor activity
A	0004930	molecular_function	G protein-coupled receptor activity
A	0006935	biological_process	chemotaxis
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0016020	cellular_component	membrane
B	0004875	molecular_function	complement receptor activity
B	0004930	molecular_function	G protein-coupled receptor activity
B	0006935	biological_process	chemotaxis
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue 9P2 A 401

Chain	Residue
A	ILE124
A	PRO214
A	THR217
A	OLA406
B	ALA158
B	GLY162
A	LEU125
A	ALA128
A	THR129
A	LEU156
A	VAL159
A	LEU163
A	LEU209
A	TRP213

site_id	AC2
Number of Residues	9
Details	binding site for residue TLA A 402

Chain	Residue
A	THR69
A	ILE70
A	ASN71
A	ARG148
A	GLU325
A	GLU326
A	SER327
A	VAL328
A	ARG330

site_id	AC3
Number of Residues	6
Details	binding site for residue TLA A 403

Chain	Residue
A	THR229
A	ALA232
A	ARG233
A	THR235
A	SER237
A	HOH509

site_id	AC4
Number of Residues	2
Details	binding site for residue OLA A 404

Chain	Residue
A	ALA132
A	TRP143

site_id	AC5
Number of Residues	4
Details	binding site for residue OLA A 405

Chain	Residue
A	PHE135
A	LYS140
A	OLA406
B	ILE155

site_id	AC6
Number of Residues	4
Details	binding site for residue OLA A 406

Chain	Residue
A	LEU218
A	9P2401
A	OLA405
B	OLA405

site_id	AC7
Number of Residues	1
Details	binding site for residue OLA A 407

Chain	Residue
A	ALA63

site_id	AC8
Number of Residues	2
Details	binding site for residue OLA A 408

Chain	Residue
A	THR94
A	GLN98

site_id	AC9
Number of Residues	1
Details	binding site for residue OLA A 409

Chain	Residue
A	VAL42

site_id	AD1
Number of Residues	7
Details	binding site for residue OLA A 411

Chain	Residue
A	LEU216
A	ILE220
A	THR223
A	PHE224
A	LEU227
A	ARG228
A	SER231

site_id	AD2
Number of Residues	4
Details	binding site for residue OLA A 412

Chain	Residue
A	THR223
A	LEU226
A	TRP230
A	OLA417

site_id	AD3
Number of Residues	3
Details	binding site for residue OLA A 413

Chain	Residue
A	LYS242
A	ILE253
A	ILE295

site_id	AD4
Number of Residues	4
Details	binding site for residue OLA A 416

Chain	Residue
A	ALA158
A	GLY162
B	9P2401
B	OLA406

site_id	AD5
Number of Residues	3
Details	binding site for residue OLA A 417

Chain	Residue
A	VAL245
A	PHE252
A	OLA412

site_id	AD6
Number of Residues	12
Details	binding site for residue 9P2 B 401

Chain	Residue
A	ILE155
A	OLA416
B	LEU125
B	ALA128
B	THR129
B	LEU156
B	LEU163
B	LEU209
B	TRP213
B	PRO214
B	THR217
B	OLA404

site_id	AD7
Number of Residues	7
Details	binding site for residue TLA B 402

Chain	Residue
B	ARG68
B	THR69
B	ILE70
B	ARG148
B	GLU326
B	SER327
B	VAL328

site_id	AD8
Number of Residues	2
Details	binding site for residue OLA B 403

Chain	Residue
B	TRP143
B	OLA404

site_id	AD9
Number of Residues	4
Details	binding site for residue OLA B 404

Chain	Residue
B	TRP213
B	9P2401
B	OLA403
B	OLA406

site_id	AE1
Number of Residues	3
Details	binding site for residue OLA B 405

Chain	Residue
A	OLA406
B	GLY151
B	ILE155

site_id	AE2
Number of Residues	4
Details	binding site for residue OLA B 406

Chain	Residue
A	OLA416
B	LEU209
B	TRP213
B	OLA404

site_id	AE3
Number of Residues	4
Details	binding site for residue OLA B 407

Chain	Residue
B	OLA408
B	TRP74
B	ALA132
B	LEU156

site_id	AE4
Number of Residues	6
Details	binding site for residue OLA B 408

Chain	Residue
A	TRP143
A	PHE147
B	LEU136
B	TRP143
B	ARG148
B	OLA407

site_id	AE5
Number of Residues	1
Details	binding site for residue OLA B 409

Chain	Residue
B	ALA172

site_id	AE6
Number of Residues	3
Details	binding site for residue OLA B 410

Chain	Residue
B	TRP154
B	TRP161
B	OLA417

site_id	AE7
Number of Residues	5
Details	binding site for residue OLA B 412

Chain	Residue
B	LEU216
B	THR219
B	PHE224
B	LEU227
B	OLA414

site_id	AE8
Number of Residues	1
Details	binding site for residue OLA B 413

Chain	Residue
B	TRP230

site_id	AE9
Number of Residues	3
Details	binding site for residue OLA B 414

Chain	Residue
B	LEU215
B	ILE263
B	OLA412

site_id	AF1
Number of Residues	3
Details	binding site for residue OLA B 415

Chain	Residue
B	VAL245
B	ALA246
B	OLA416

site_id	AF2
Number of Residues	4
Details	binding site for residue OLA B 416

Chain	Residue
B	LYS242
B	VAL302
B	ALA303
B	OLA415

site_id	AF3
Number of Residues	1
Details	binding site for residue OLA B 417

Chain	Residue
B	OLA410

site_id	AF4
Number of Residues	6
Details	binding site for residue OLA B 419

Chain	Residue
A	LEU166
A	LEU167
B	LEU166
B	PRO170
B	TYR174
B	TYR192

site_id	AF5
Number of Residues	1
Details	binding site for residue CIT B 420

Chain	Residue
B	TYR181

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIlLLATISADRFLlV

Chain	Residue	Details
A	ALA122-VAL138

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	52
Details	TRANSMEM: Helical; Name=1 => ECO:0000269\|PubMed:29300009

Chain	Residue	Details
A	ILE38-PHE64
B	ILE38-PHE64

site_id	SWS_FT_FI2
Number of Residues	78
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:29300009

Chain	Residue	Details
A	GLU65-THR69
A	ASP133-ALA153
A	LEU227-LYS242
B	GLU65-THR69
B	ASP133-ALA153
B	LEU227-LYS242

site_id	SWS_FT_FI3
Number of Residues	46
Details	TRANSMEM: Helical; Name=2 => ECO:0000269\|PubMed:29300009

Chain	Residue	Details
A	ILE70-PHE93
B	ILE70-PHE93

site_id	SWS_FT_FI4
Number of Residues	114
Details	TOPO_DOM: Extracellular => ECO:0000269\|PubMed:29300009

Chain	Residue	Details
A	THR94-SER110
A	ARG175-ARG200
A	SER266-ASP282
B	THR94-SER110
B	ARG175-ARG200
B	SER266-ASP282

site_id	SWS_FT_FI5
Number of Residues	42
Details	TRANSMEM: Helical; Name=3 => ECO:0000269\|PubMed:29300009

Chain	Residue	Details
A	ILE111-ALA132
B	ILE111-ALA132

site_id	SWS_FT_FI6
Number of Residues	40
Details	TRANSMEM: Helical; Name=4 => ECO:0000269\|PubMed:29300009

Chain	Residue	Details
A	TRP154-TYR174
B	TRP154-TYR174

site_id	SWS_FT_FI7
Number of Residues	50
Details	TRANSMEM: Helical; Name=5 => ECO:0000269\|PubMed:29300009

Chain	Residue	Details
A	ALA201-LEU226
B	ALA201-LEU226

site_id	SWS_FT_FI8
Number of Residues	44
Details	TRANSMEM: Helical; Name=6 => ECO:0000269\|PubMed:29300009

Chain	Residue	Details
A	VAL243-MET265
B	VAL243-MET265

site_id	SWS_FT_FI9
Number of Residues	40
Details	TRANSMEM: Helical; Name=7 => ECO:0000269\|PubMed:29300009

Chain	Residue	Details
A	SER283-ALA303
B	SER283-ALA303

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000305\|PubMed:7642584

Chain	Residue	Details
A	SER314
B	SER314

site_id	SWS_FT_FI11
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0000269\|PubMed:10636859, ECO:0000269\|PubMed:7642584

Chain	Residue	Details
A	GLU317
A	SER327
A	SER332
B	GLU317
B	SER327
B	SER332

221371

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