5O8H

Crystal structure of R. ruber ADH-A, mutant Y294F, W295A, F43H, H39Y

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008270	molecular_function	zinc ion binding
A	0016491	molecular_function	oxidoreductase activity
B	0008270	molecular_function	zinc ion binding
B	0016491	molecular_function	oxidoreductase activity
C	0008270	molecular_function	zinc ion binding
C	0016491	molecular_function	oxidoreductase activity
D	0008270	molecular_function	zinc ion binding
D	0016491	molecular_function	oxidoreductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 501

Chain	Residue
A	CYS92
A	CYS95
A	CYS98
A	CYS106

---

site_id	AC2
Number of Residues	6
Details	binding site for residue ZN A 502

Chain	Residue
A	HOH846
A	CYS38
A	SER40
A	HIS62
A	ASP153
A	NAD503

---

site_id	AC3
Number of Residues	34
Details	binding site for residue NAD A 503

Chain	Residue
A	TYR39
A	SER40
A	HIS43
A	ASP153
A	THR157
A	VAL180
A	GLY181
A	GLY182
A	LEU183
A	ASP203
A	LEU204
A	ARG208
A	SER223
A	PHE246
A	VAL247
A	THR252
A	VAL269
A	GLY270
A	ILE271
A	PRO293
A	PHE294
A	ALA295
A	ARG340
A	ZN502
A	HOH624
A	HOH655
A	HOH658
A	HOH665
A	HOH693
A	HOH695
A	HOH697
A	HOH709
A	HOH736
C	PHE281

---

site_id	AC4
Number of Residues	5
Details	binding site for residue K A 504

Chain	Residue
A	ARG192
A	SER195
A	HOH619
B	ALA193
B	HOH620

---

site_id	AC5
Number of Residues	4
Details	binding site for residue GOL A 505

Chain	Residue
A	ASP314
A	ILE315
A	HIS316
A	THR317

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN B 501

Chain	Residue
B	CYS92
B	CYS95
B	CYS98
B	CYS106

---

site_id	AC7
Number of Residues	6
Details	binding site for residue ZN B 502

Chain	Residue
B	CYS38
B	SER40
B	HIS62
B	ASP153
B	NAD503
B	HOH849

---

site_id	AC8
Number of Residues	35
Details	binding site for residue NAD B 503

Chain	Residue
B	TYR39
B	SER40
B	HIS43
B	ASP153
B	THR157
B	VAL180
B	GLY181
B	GLY182
B	LEU183
B	ASP203
B	LEU204
B	ARG208
B	SER223
B	PHE246
B	VAL247
B	THR252
B	VAL269
B	GLY270
B	ILE271
B	PRO293
B	PHE294
B	ALA295
B	ARG340
B	ZN502
B	HOH632
B	HOH638
B	HOH653
B	HOH656
B	HOH665
B	HOH666
B	HOH673
B	HOH685
B	HOH702
B	HOH786
B	HOH815

---

site_id	AC9
Number of Residues	4
Details	binding site for residue ZN C 501

Chain	Residue
C	CYS95
C	CYS98
C	CYS106
C	CYS92

---

site_id	AD1
Number of Residues	6
Details	binding site for residue ZN C 502

Chain	Residue
C	CYS38
C	SER40
C	HIS62
C	ASP153
C	NAD503
C	HOH813

---

site_id	AD2
Number of Residues	35
Details	binding site for residue NAD C 503

Chain	Residue
A	PHE281
C	CYS38
C	TYR39
C	SER40
C	HIS43
C	ASP153
C	THR157
C	VAL180
C	GLY181
C	GLY182
C	LEU183
C	ASP203
C	LEU204
C	ARG208
C	SER223
C	PHE246
C	VAL247
C	THR252
C	VAL269
C	ILE271
C	PRO293
C	PHE294
C	ALA295
C	ARG340
C	ZN502
C	HOH607
C	HOH612
C	HOH627
C	HOH656
C	HOH658
C	HOH682
C	HOH707
C	HOH722
C	HOH723
C	HOH770

---

site_id	AD3
Number of Residues	5
Details	binding site for residue K C 504

Chain	Residue
C	ARG192
C	SER195
D	ARG192
D	ALA193
D	HOH610

---

site_id	AD4
Number of Residues	4
Details	binding site for residue ZN D 501

Chain	Residue
D	CYS92
D	CYS95
D	CYS98
D	CYS106

---

site_id	AD5
Number of Residues	5
Details	binding site for residue ZN D 502

Chain	Residue
D	CYS38
D	SER40
D	ASP153
D	NAD503
D	HOH776

---

site_id	AD6
Number of Residues	35
Details	binding site for residue NAD D 503

Chain	Residue
D	CYS38
D	TYR39
D	SER40
D	HIS43
D	ASP153
D	THR157
D	VAL180
D	GLY181
D	GLY182
D	LEU183
D	ASP203
D	LEU204
D	ARG208
D	SER223
D	PHE246
D	VAL247
D	THR252
D	VAL269
D	GLY270
D	ILE271
D	PRO293
D	PHE294
D	ALA295
D	ARG340
D	ZN502
D	HOH606
D	HOH624
D	HOH640
D	HOH659
D	HOH673
D	HOH677
D	HOH716
D	HOH722
D	HOH750
D	HOH756

---

Functional Information from PROSITE/UniProt

site_id	PS00059
Number of Residues	15
Details	ADH_ZINC Zinc-containing alcohol dehydrogenases signature. GHEgVGTvaelGegV

Chain	Residue	Details
A	GLY61-VAL75

---