Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0009820 | biological_process | alkaloid metabolic process |
| A | 0030782 | molecular_function | (S)-tetrahydroprotoberberine N-methyltransferase activity |
| A | 0032259 | biological_process | methylation |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051213 | molecular_function | dioxygenase activity |
| A | 0097295 | biological_process | morphine biosynthetic process |
| A | 0102802 | molecular_function | thebaine 6-O-demethylase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue NI A 401 |
| Chain | Residue |
| A | HIS238 |
| A | ASP240 |
| A | HIS295 |
| A | SIN402 |
| A | EDO403 |
| A | EDO418 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue SIN A 402 |
| Chain | Residue |
| A | LEU247 |
| A | HIS295 |
| A | ARG305 |
| A | SER307 |
| A | NI401 |
| A | EDO403 |
| A | EDO418 |
| A | HOH588 |
| A | TYR223 |
| A | LEU235 |
| A | HIS238 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 403 |
| Chain | Residue |
| A | HIS238 |
| A | ASP240 |
| A | PHE311 |
| A | NI401 |
| A | SIN402 |
| A | EDO418 |
| A | PEG421 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 404 |
| Chain | Residue |
| A | PRO56 |
| A | VAL57 |
| A | ARG77 |
| A | HOH614 |
| A | HOH694 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 405 |
| Chain | Residue |
| A | LYS72 |
| A | LEU75 |
| A | ASP76 |
| A | HIS79 |
| A | ALA196 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 406 |
| Chain | Residue |
| A | GLU117 |
| A | LYS118 |
| A | THR119 |
| A | LYS120 |
| A | TYR121 |
| A | HOH517 |
| A | HOH641 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 407 |
| Chain | Residue |
| A | ILE284 |
| A | ILE320 |
| A | LYS336 |
| A | SER337 |
| A | GLY338 |
| A | SER339 |
| A | MET362 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 408 |
| Chain | Residue |
| A | GLY321 |
| A | SER337 |
| A | EDO416 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 409 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 410 |
| Chain | Residue |
| A | LYS120 |
| A | SER165 |
| A | LYS166 |
| A | LEU167 |
| A | HIS291 |
| A | EDO419 |
| A | HOH654 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 411 |
| Chain | Residue |
| A | HIS93 |
| A | GLU181 |
| A | EDO417 |
| A | HOH501 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 412 |
| Chain | Residue |
| A | LEU73 |
| A | PHE80 |
| A | HOH552 |
| A | HOH555 |
| A | HOH630 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 413 |
| Chain | Residue |
| A | GLN123 |
| A | GLY132 |
| A | GLN133 |
| A | GLY134 |
| A | PHE135 |
| A | HOH534 |
| A | HOH667 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 414 |
| Chain | Residue |
| A | ASN11 |
| A | GLY12 |
| A | ASP59 |
| A | VAL91 |
| A | HOH540 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 415 |
| Chain | Residue |
| A | LYS5 |
| A | GLU28 |
| A | ILE69 |
| A | GLN228 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 416 |
| Chain | Residue |
| A | LYS205 |
| A | VAL319 |
| A | ILE320 |
| A | GLY321 |
| A | EDO408 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 417 |
| Chain | Residue |
| A | GLY94 |
| A | EDO411 |
| A | HOH582 |
| site_id | AD9 |
| Number of Residues | 10 |
| Details | binding site for residue EDO A 418 |
| Chain | Residue |
| A | SIN402 |
| A | EDO403 |
| A | HOH547 |
| A | PHE87 |
| A | ASP240 |
| A | THR245 |
| A | LEU247 |
| A | ASN277 |
| A | HIS295 |
| A | NI401 |
| site_id | AE1 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 419 |
| Chain | Residue |
| A | LYS83 |
| A | GLU84 |
| A | VAL169 |
| A | HIS291 |
| A | EDO410 |
| A | HOH504 |
| A | HOH541 |
| site_id | AE2 |
| Number of Residues | 6 |
| Details | binding site for residue PEG A 420 |
| Chain | Residue |
| A | GLU317 |
| A | SER324 |
| A | SER325 |
| A | ILE327 |
| A | HOH507 |
| A | HOH549 |
| site_id | AE3 |
| Number of Residues | 11 |
| Details | binding site for residue PEG A 421 |
| Chain | Residue |
| A | SER239 |
| A | ASP240 |
| A | PHE241 |
| A | GLY242 |
| A | LEU244 |
| A | THR245 |
| A | PHE311 |
| A | HIS312 |
| A | ASP313 |
| A | EDO403 |
| A | HOH551 |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | TYR223 | |
| A | SER307 | |
| Chain | Residue | Details |
| A | HIS238 | |
| A | ASP240 | |
| A | HIS295 | |
| Chain | Residue | Details |
| A | ARG305 | |
