5O7X

CRYSTAL STRUCTURE OF S. CEREVISIAE CORE FACTOR AT 3.2A RESOLUTION

Replaces:  5N5X

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001163	molecular_function	RNA polymerase I transcription regulatory region sequence-specific DNA binding
A	0001179	molecular_function	RNA polymerase I general transcription initiation factor binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0006361	biological_process	transcription initiation at RNA polymerase I promoter
A	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
A	0070860	cellular_component	RNA polymerase I core factor complex
B	0000120	cellular_component	RNA polymerase I transcription regulator complex
B	0001164	molecular_function	RNA polymerase I core promoter sequence-specific DNA binding
B	0001188	biological_process	RNA polymerase I preinitiation complex assembly
B	0003677	molecular_function	DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005730	cellular_component	nucleolus
B	0006360	biological_process	transcription by RNA polymerase I
B	0008270	molecular_function	zinc ion binding
B	0017025	molecular_function	TBP-class protein binding
B	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
B	0046872	molecular_function	metal ion binding
B	0070860	cellular_component	RNA polymerase I core factor complex
C	0001164	molecular_function	RNA polymerase I core promoter sequence-specific DNA binding
C	0001181	molecular_function	RNA polymerase I general transcription initiation factor activity
C	0001188	biological_process	RNA polymerase I preinitiation complex assembly
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005730	cellular_component	nucleolus
C	0006361	biological_process	transcription initiation at RNA polymerase I promoter
C	0017025	molecular_function	TBP-class protein binding
C	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
C	0070860	cellular_component	RNA polymerase I core factor complex
D	0001163	molecular_function	RNA polymerase I transcription regulatory region sequence-specific DNA binding
D	0001179	molecular_function	RNA polymerase I general transcription initiation factor binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005730	cellular_component	nucleolus
D	0005737	cellular_component	cytoplasm
D	0006361	biological_process	transcription initiation at RNA polymerase I promoter
D	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
D	0070860	cellular_component	RNA polymerase I core factor complex
E	0000120	cellular_component	RNA polymerase I transcription regulator complex
E	0001164	molecular_function	RNA polymerase I core promoter sequence-specific DNA binding
E	0001188	biological_process	RNA polymerase I preinitiation complex assembly
E	0003677	molecular_function	DNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005730	cellular_component	nucleolus
E	0006360	biological_process	transcription by RNA polymerase I
E	0008270	molecular_function	zinc ion binding
E	0017025	molecular_function	TBP-class protein binding
E	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
E	0046872	molecular_function	metal ion binding
E	0070860	cellular_component	RNA polymerase I core factor complex
F	0001164	molecular_function	RNA polymerase I core promoter sequence-specific DNA binding
F	0001181	molecular_function	RNA polymerase I general transcription initiation factor activity
F	0001188	biological_process	RNA polymerase I preinitiation complex assembly
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005730	cellular_component	nucleolus
F	0006361	biological_process	transcription initiation at RNA polymerase I promoter
F	0017025	molecular_function	TBP-class protein binding
F	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
F	0070860	cellular_component	RNA polymerase I core factor complex
G	0001163	molecular_function	RNA polymerase I transcription regulatory region sequence-specific DNA binding
G	0001179	molecular_function	RNA polymerase I general transcription initiation factor binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005730	cellular_component	nucleolus
G	0005737	cellular_component	cytoplasm
G	0006361	biological_process	transcription initiation at RNA polymerase I promoter
G	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
G	0070860	cellular_component	RNA polymerase I core factor complex
H	0000120	cellular_component	RNA polymerase I transcription regulator complex
H	0001164	molecular_function	RNA polymerase I core promoter sequence-specific DNA binding
H	0001188	biological_process	RNA polymerase I preinitiation complex assembly
H	0003677	molecular_function	DNA binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005730	cellular_component	nucleolus
H	0006360	biological_process	transcription by RNA polymerase I
H	0008270	molecular_function	zinc ion binding
H	0017025	molecular_function	TBP-class protein binding
H	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
H	0046872	molecular_function	metal ion binding
H	0070860	cellular_component	RNA polymerase I core factor complex
I	0001164	molecular_function	RNA polymerase I core promoter sequence-specific DNA binding
I	0001181	molecular_function	RNA polymerase I general transcription initiation factor activity
I	0001188	biological_process	RNA polymerase I preinitiation complex assembly
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005730	cellular_component	nucleolus
I	0006361	biological_process	transcription initiation at RNA polymerase I promoter
I	0017025	molecular_function	TBP-class protein binding
I	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
I	0070860	cellular_component	RNA polymerase I core factor complex
J	0001163	molecular_function	RNA polymerase I transcription regulatory region sequence-specific DNA binding
J	0001179	molecular_function	RNA polymerase I general transcription initiation factor binding
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005730	cellular_component	nucleolus
J	0005737	cellular_component	cytoplasm
J	0006361	biological_process	transcription initiation at RNA polymerase I promoter
J	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
J	0070860	cellular_component	RNA polymerase I core factor complex
K	0000120	cellular_component	RNA polymerase I transcription regulator complex
K	0001164	molecular_function	RNA polymerase I core promoter sequence-specific DNA binding
K	0001188	biological_process	RNA polymerase I preinitiation complex assembly
K	0003677	molecular_function	DNA binding
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005730	cellular_component	nucleolus
K	0006360	biological_process	transcription by RNA polymerase I
K	0008270	molecular_function	zinc ion binding
K	0017025	molecular_function	TBP-class protein binding
K	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
K	0046872	molecular_function	metal ion binding
K	0070860	cellular_component	RNA polymerase I core factor complex
L	0001164	molecular_function	RNA polymerase I core promoter sequence-specific DNA binding
L	0001181	molecular_function	RNA polymerase I general transcription initiation factor activity
L	0001188	biological_process	RNA polymerase I preinitiation complex assembly
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005730	cellular_component	nucleolus
L	0006361	biological_process	transcription initiation at RNA polymerase I promoter
L	0017025	molecular_function	TBP-class protein binding
L	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
L	0070860	cellular_component	RNA polymerase I core factor complex
M	0001163	molecular_function	RNA polymerase I transcription regulatory region sequence-specific DNA binding
M	0001179	molecular_function	RNA polymerase I general transcription initiation factor binding
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005730	cellular_component	nucleolus
M	0005737	cellular_component	cytoplasm
M	0006361	biological_process	transcription initiation at RNA polymerase I promoter
M	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
M	0070860	cellular_component	RNA polymerase I core factor complex
N	0000120	cellular_component	RNA polymerase I transcription regulator complex
N	0001164	molecular_function	RNA polymerase I core promoter sequence-specific DNA binding
N	0001188	biological_process	RNA polymerase I preinitiation complex assembly
N	0003677	molecular_function	DNA binding
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005730	cellular_component	nucleolus
N	0006360	biological_process	transcription by RNA polymerase I
N	0008270	molecular_function	zinc ion binding
N	0017025	molecular_function	TBP-class protein binding
N	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
N	0046872	molecular_function	metal ion binding
N	0070860	cellular_component	RNA polymerase I core factor complex
O	0001164	molecular_function	RNA polymerase I core promoter sequence-specific DNA binding
O	0001181	molecular_function	RNA polymerase I general transcription initiation factor activity
O	0001188	biological_process	RNA polymerase I preinitiation complex assembly
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005730	cellular_component	nucleolus
O	0006361	biological_process	transcription initiation at RNA polymerase I promoter
O	0017025	molecular_function	TBP-class protein binding
O	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
O	0070860	cellular_component	RNA polymerase I core factor complex
P	0001163	molecular_function	RNA polymerase I transcription regulatory region sequence-specific DNA binding
P	0001179	molecular_function	RNA polymerase I general transcription initiation factor binding
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005730	cellular_component	nucleolus
P	0005737	cellular_component	cytoplasm
P	0006361	biological_process	transcription initiation at RNA polymerase I promoter
P	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
P	0070860	cellular_component	RNA polymerase I core factor complex
Q	0000120	cellular_component	RNA polymerase I transcription regulator complex
Q	0001164	molecular_function	RNA polymerase I core promoter sequence-specific DNA binding
Q	0001188	biological_process	RNA polymerase I preinitiation complex assembly
Q	0003677	molecular_function	DNA binding
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005730	cellular_component	nucleolus
Q	0006360	biological_process	transcription by RNA polymerase I
Q	0008270	molecular_function	zinc ion binding
Q	0017025	molecular_function	TBP-class protein binding
Q	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
Q	0046872	molecular_function	metal ion binding
Q	0070860	cellular_component	RNA polymerase I core factor complex
R	0001164	molecular_function	RNA polymerase I core promoter sequence-specific DNA binding
R	0001181	molecular_function	RNA polymerase I general transcription initiation factor activity
R	0001188	biological_process	RNA polymerase I preinitiation complex assembly
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005730	cellular_component	nucleolus
R	0006361	biological_process	transcription initiation at RNA polymerase I promoter
R	0017025	molecular_function	TBP-class protein binding
R	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
R	0070860	cellular_component	RNA polymerase I core factor complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue SO4 A 1001

Chain	Residue
A	ARG472
A	ARG475
B	LYS360
C	MET1

---

site_id	AC2
Number of Residues	2
Details	binding site for residue SO4 A 1002

Chain	Residue
A	ARG603
B	LYS271

---

site_id	AC3
Number of Residues	3
Details	binding site for residue SO4 A 1003

Chain	Residue
A	HIS701
A	HIS705
B	MET123

---

site_id	AC4
Number of Residues	4
Details	binding site for residue SO4 A 1004

Chain	Residue
A	ARG472
B	LYS360
C	LYS199
C	SER203

---

site_id	AC5
Number of Residues	4
Details	binding site for residue SO4 A 1005

Chain	Residue
A	GLU706
A	LYS717
B	ILE439
B	GLU440

---

site_id	AC6
Number of Residues	2
Details	binding site for residue MG A 1006

Chain	Residue
A	GLU392
A	ALA396

---

site_id	AC7
Number of Residues	4
Details	binding site for residue SO4 D 1001

Chain	Residue
D	ARG472
D	ARG475
E	LYS360
F	MET1

---

site_id	AC8
Number of Residues	2
Details	binding site for residue SO4 D 1002

Chain	Residue
D	ARG603
E	LYS271

---

site_id	AC9
Number of Residues	3
Details	binding site for residue SO4 D 1003

Chain	Residue
D	HIS701
D	HIS705
E	MET123

---

site_id	AD1
Number of Residues	4
Details	binding site for residue SO4 D 1004

Chain	Residue
D	GLU706
D	LYS717
E	ILE439
E	GLU440

---

site_id	AD2
Number of Residues	2
Details	binding site for residue MG D 1005

Chain	Residue
D	GLU392
D	ALA396

---

site_id	AD3
Number of Residues	3
Details	binding site for residue SO4 F 601

Chain	Residue
D	ARG472
F	LYS199
F	SER203

---

site_id	AD4
Number of Residues	2
Details	binding site for residue SO4 G 901

Chain	Residue
G	ARG603
H	LYS271

---

site_id	AD5
Number of Residues	3
Details	binding site for residue SO4 G 902

Chain	Residue
G	HIS701
G	HIS705
H	MET123

---

site_id	AD6
Number of Residues	4
Details	binding site for residue SO4 G 903

Chain	Residue
G	GLU706
G	LYS717
H	ILE439
H	GLU440

---

site_id	AD7
Number of Residues	2
Details	binding site for residue MG G 904

Chain	Residue
G	GLU392
G	ALA396

---

site_id	AD8
Number of Residues	5
Details	binding site for residue SO4 H 1001

Chain	Residue
G	ARG472
G	HIS473
G	ARG475
H	LYS360
I	MET1

---

site_id	AD9
Number of Residues	4
Details	binding site for residue SO4 I 601

Chain	Residue
G	ARG472
H	LYS360
I	LYS199
I	SER203

---

site_id	AE1
Number of Residues	4
Details	binding site for residue SO4 J 1001

Chain	Residue
J	ARG472
J	ARG475
K	LYS360
L	MET1

---

site_id	AE2
Number of Residues	3
Details	binding site for residue SO4 J 1002

Chain	Residue
J	HIS701
J	HIS705
K	MET123

---

site_id	AE3
Number of Residues	4
Details	binding site for residue SO4 J 1003

Chain	Residue
J	GLU706
J	LYS717
K	ILE439
K	GLU440

---

site_id	AE4
Number of Residues	2
Details	binding site for residue MG J 1004

Chain	Residue
J	GLU392
J	ALA396

---

site_id	AE5
Number of Residues	2
Details	binding site for residue SO4 K 601

Chain	Residue
J	ARG603
K	LYS271

---

site_id	AE6
Number of Residues	4
Details	binding site for residue SO4 L 601

Chain	Residue
J	ARG472
K	LYS360
L	LYS199
L	SER203

---

site_id	AE7
Number of Residues	4
Details	binding site for residue SO4 M 1001

Chain	Residue
M	ARG472
M	ARG475
N	LYS360
O	MET1

---

site_id	AE8
Number of Residues	2
Details	binding site for residue SO4 M 1002

Chain	Residue
M	ARG603
N	LYS271

---

site_id	AE9
Number of Residues	3
Details	binding site for residue SO4 M 1003

Chain	Residue
M	HIS701
M	HIS705
N	MET123

---

site_id	AF1
Number of Residues	4
Details	binding site for residue SO4 M 1004

Chain	Residue
M	GLU706
M	LYS717
N	ILE439
N	GLU440

---

site_id	AF2
Number of Residues	2
Details	binding site for residue MG M 1005

Chain	Residue
M	GLU392
M	ALA396

---

site_id	AF3
Number of Residues	4
Details	binding site for residue SO4 O 601

Chain	Residue
M	ARG472
N	LYS360
O	LYS199
O	SER203

---

site_id	AF4
Number of Residues	4
Details	binding site for residue SO4 P 1001

Chain	Residue
P	ARG472
P	ARG475
Q	LYS360
R	MET1

---

site_id	AF5
Number of Residues	2
Details	binding site for residue SO4 P 1002

Chain	Residue
P	ARG603
Q	LYS271

---

site_id	AF6
Number of Residues	3
Details	binding site for residue SO4 P 1003

Chain	Residue
P	HIS701
P	HIS705
Q	MET123

---

site_id	AF7
Number of Residues	4
Details	binding site for residue SO4 P 1004

Chain	Residue
P	ARG472
Q	LYS360
R	LYS199
R	SER203

---

site_id	AF8
Number of Residues	4
Details	binding site for residue SO4 P 1005

Chain	Residue
P	GLU706
P	LYS717
Q	ILE439
Q	GLU440

---

site_id	AF9
Number of Residues	2
Details	binding site for residue MG P 1006

Chain	Residue
P	GLU392
P	ALA396

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	198
Details	ZN_FING: RRN7-type

Chain	Residue	Details
B	THR3-GLU36
E	THR3-GLU36
H	THR3-GLU36
K	THR3-GLU36
N	THR3-GLU36
Q	THR3-GLU36

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	BINDING: BINDING => ECO:0000305

Chain	Residue	Details
B	CYS10
H	CYS15
H	CYS29
H	HIS33
K	CYS10
K	CYS15
K	CYS29
K	HIS33
N	CYS10
N	CYS15
N	CYS29
B	CYS15
N	HIS33
Q	CYS10
Q	CYS15
Q	CYS29
Q	HIS33
B	CYS29
B	HIS33
E	CYS10
E	CYS15
E	CYS29
E	HIS33
H	CYS10

---