5O7E
Crystal structure of the peptidase domain of collagenase H from Clostridium histolyticum in complex with N-aryl mercaptoacetamide-based inhibitor
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 801 |
| Chain | Residue |
| A | HIS455 |
| A | HIS459 |
| A | GLU487 |
| A | 9NB803 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 802 |
| Chain | Residue |
| A | HOH930 |
| A | GLU430 |
| A | GLY463 |
| A | VAL467 |
| A | GLY469 |
| A | HOH924 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | binding site for residue 9NB A 803 |
| Chain | Residue |
| A | MET427 |
| A | TYR428 |
| A | GLU430 |
| A | HIS455 |
| A | GLU456 |
| A | HIS459 |
| A | TRP471 |
| A | GLU486 |
| A | GLU487 |
| A | ZN801 |
| A | HOH974 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. LFRHEYTHYL |
| Chain | Residue | Details |
| A | LEU452-LEU461 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000305|PubMed:9452493 |
| Chain | Residue | Details |
| A | GLU456 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23703618, ECO:0007744|PDB:4AR1 |
| Chain | Residue | Details |
| A | ASP421 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23703618, ECO:0000269|PubMed:28820255, ECO:0007744|PDB:4AR1, ECO:0007744|PDB:4ARF, ECO:0007744|PDB:5O7E |
| Chain | Residue | Details |
| A | GLY463 | |
| A | VAL467 | |
| A | GLY469 | |
| A | GLU430 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:23703618, ECO:0000269|PubMed:28820255, ECO:0000305|PubMed:10217773, ECO:0007744|PDB:4AR1, ECO:0007744|PDB:4ARF, ECO:0007744|PDB:5O7E |
| Chain | Residue | Details |
| A | HIS455 | |
| A | HIS459 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23703618, ECO:0000269|PubMed:28820255, ECO:0000305|PubMed:10217773, ECO:0007744|PDB:4AR1, ECO:0007744|PDB:4ARF, ECO:0007744|PDB:5O7E |
| Chain | Residue | Details |
| A | GLU487 |
