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5O66

Asymmetric AcrABZ-TolC

Replaces:  5V78
Functional Information from GO Data
ChainGOidnamespacecontents
A0015562molecular_functionefflux transmembrane transporter activity
A0019867cellular_componentouter membrane
A0055085biological_processtransmembrane transport
B0015562molecular_functionefflux transmembrane transporter activity
B0019867cellular_componentouter membrane
B0055085biological_processtransmembrane transport
C0015562molecular_functionefflux transmembrane transporter activity
C0019867cellular_componentouter membrane
C0055085biological_processtransmembrane transport
D0005886cellular_componentplasma membrane
D0009636biological_processresponse to toxic substance
D0016020cellular_componentmembrane
D0022857molecular_functiontransmembrane transporter activity
D0046677biological_processresponse to antibiotic
D0055085biological_processtransmembrane transport
E0005886cellular_componentplasma membrane
E0009636biological_processresponse to toxic substance
E0016020cellular_componentmembrane
E0022857molecular_functiontransmembrane transporter activity
E0046677biological_processresponse to antibiotic
E0055085biological_processtransmembrane transport
F0005886cellular_componentplasma membrane
F0009636biological_processresponse to toxic substance
F0016020cellular_componentmembrane
F0022857molecular_functiontransmembrane transporter activity
F0046677biological_processresponse to antibiotic
F0055085biological_processtransmembrane transport
G0005886cellular_componentplasma membrane
G0009636biological_processresponse to toxic substance
G0016020cellular_componentmembrane
G0022857molecular_functiontransmembrane transporter activity
G0046677biological_processresponse to antibiotic
G0055085biological_processtransmembrane transport
H0005886cellular_componentplasma membrane
H0009636biological_processresponse to toxic substance
H0016020cellular_componentmembrane
H0022857molecular_functiontransmembrane transporter activity
H0046677biological_processresponse to antibiotic
H0055085biological_processtransmembrane transport
I0005886cellular_componentplasma membrane
I0009636biological_processresponse to toxic substance
I0016020cellular_componentmembrane
I0022857molecular_functiontransmembrane transporter activity
I0046677biological_processresponse to antibiotic
I0055085biological_processtransmembrane transport
J0005515molecular_functionprotein binding
J0005886cellular_componentplasma membrane
J0009410biological_processresponse to xenobiotic stimulus
J0009636biological_processresponse to toxic substance
J0015125molecular_functionbile acid transmembrane transporter activity
J0015562molecular_functionefflux transmembrane transporter activity
J0015567molecular_functionalkane transmembrane transporter activity
J0015721biological_processbile acid and bile salt transport
J0015895biological_processalkane transport
J0015908biological_processfatty acid transport
J0016020cellular_componentmembrane
J0022857molecular_functiontransmembrane transporter activity
J0042802molecular_functionidentical protein binding
J0042908biological_processxenobiotic transport
J0042910molecular_functionxenobiotic transmembrane transporter activity
J0042930biological_processenterobactin transport
J0042931molecular_functionenterobactin transmembrane transporter activity
J0046677biological_processresponse to antibiotic
J0055085biological_processtransmembrane transport
J0098567cellular_componentperiplasmic side of plasma membrane
J0140330biological_processxenobiotic detoxification by transmembrane export across the cell outer membrane
J1990281cellular_componentefflux pump complex
K0005515molecular_functionprotein binding
K0005886cellular_componentplasma membrane
K0009410biological_processresponse to xenobiotic stimulus
K0009636biological_processresponse to toxic substance
K0015125molecular_functionbile acid transmembrane transporter activity
K0015562molecular_functionefflux transmembrane transporter activity
K0015567molecular_functionalkane transmembrane transporter activity
K0015721biological_processbile acid and bile salt transport
K0015895biological_processalkane transport
K0015908biological_processfatty acid transport
K0016020cellular_componentmembrane
K0022857molecular_functiontransmembrane transporter activity
K0042802molecular_functionidentical protein binding
K0042908biological_processxenobiotic transport
K0042910molecular_functionxenobiotic transmembrane transporter activity
K0042930biological_processenterobactin transport
K0042931molecular_functionenterobactin transmembrane transporter activity
K0046677biological_processresponse to antibiotic
K0055085biological_processtransmembrane transport
K0098567cellular_componentperiplasmic side of plasma membrane
K0140330biological_processxenobiotic detoxification by transmembrane export across the cell outer membrane
K1990281cellular_componentefflux pump complex
L0005515molecular_functionprotein binding
L0005886cellular_componentplasma membrane
L0009410biological_processresponse to xenobiotic stimulus
L0009636biological_processresponse to toxic substance
L0015125molecular_functionbile acid transmembrane transporter activity
L0015562molecular_functionefflux transmembrane transporter activity
L0015567molecular_functionalkane transmembrane transporter activity
L0015721biological_processbile acid and bile salt transport
L0015895biological_processalkane transport
L0015908biological_processfatty acid transport
L0016020cellular_componentmembrane
L0022857molecular_functiontransmembrane transporter activity
L0042802molecular_functionidentical protein binding
L0042908biological_processxenobiotic transport
L0042910molecular_functionxenobiotic transmembrane transporter activity
L0042930biological_processenterobactin transport
L0042931molecular_functionenterobactin transmembrane transporter activity
L0046677biological_processresponse to antibiotic
L0055085biological_processtransmembrane transport
L0098567cellular_componentperiplasmic side of plasma membrane
L0140330biological_processxenobiotic detoxification by transmembrane export across the cell outer membrane
L1990281cellular_componentefflux pump complex
M0005886cellular_componentplasma membrane
M0042910molecular_functionxenobiotic transmembrane transporter activity
M0046677biological_processresponse to antibiotic
M1990961biological_processxenobiotic detoxification by transmembrane export across the plasma membrane
N0005886cellular_componentplasma membrane
N0042910molecular_functionxenobiotic transmembrane transporter activity
N0046677biological_processresponse to antibiotic
N1990961biological_processxenobiotic detoxification by transmembrane export across the plasma membrane
O0005886cellular_componentplasma membrane
O0042910molecular_functionxenobiotic transmembrane transporter activity
O0046677biological_processresponse to antibiotic
O1990961biological_processxenobiotic detoxification by transmembrane export across the plasma membrane
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues18
DetailsTOPO_DOM: Periplasmic => ECO:0000250
ChainResidueDetails
MMET1-SER7
KGLU414-ILE438
KALA491-THR538
KALA889-PRO898
KLEU944-LEU972
KILE1019-HIS1049
LMET1-PRO9
LLEU357-THR365
LGLU414-ILE438
LALA491-THR538
LALA889-PRO898
NMET1-SER7
LLEU944-LEU972
LILE1019-HIS1049
OMET1-SER7
JALA491-THR538
JALA889-PRO898
JLEU944-LEU972
JILE1019-HIS1049
KMET1-PRO9
KLEU357-THR365

site_idSWS_FT_FI2
Number of Residues60
DetailsTRANSMEM: Helical => ECO:0000255|HAMAP-Rule:MF_01484
ChainResidueDetails
MLEU8-GLY28
NLEU8-GLY28
OLEU8-GLY28

site_idSWS_FT_FI3
Number of Residues60
DetailsTOPO_DOM: Cytoplasmic => ECO:0000250
ChainResidueDetails
MLEU29-HIS49
KPHE556-ASN871
KARG919-ASP924
KTHR993-GLY998
LLYS29-SER336
LPHE386-ASN391
LPHE458-ALA465
LPHE556-ASN871
LARG919-ASP924
LTHR993-GLY998
NLEU29-HIS49
OLEU29-HIS49
JPHE556-ASN871
JARG919-ASP924
JTHR993-GLY998
KLYS29-SER336
KPHE386-ASN391
KPHE458-ALA465

site_idSWS_FT_FI4
Number of Residues57
DetailsTRANSMEM: Helical; Name=2
ChainResidueDetails
JILE337-TYR356
KILE337-TYR356
LILE337-TYR356

site_idSWS_FT_FI5
Number of Residues57
DetailsTRANSMEM: Helical; Name=3
ChainResidueDetails
JLEU366-ALA385
KLEU366-ALA385
LLEU366-ALA385

site_idSWS_FT_FI6
Number of Residues63
DetailsTRANSMEM: Helical; Name=4
ChainResidueDetails
JTHR392-VAL413
KTHR392-VAL413
LTHR392-VAL413

site_idSWS_FT_FI7
Number of Residues54
DetailsTRANSMEM: Helical; Name=5
ChainResidueDetails
JGLN439-ALA457
KGLN439-ALA457
LGLN439-ALA457

site_idSWS_FT_FI8
Number of Residues72
DetailsTRANSMEM: Helical; Name=6
ChainResidueDetails
JILE466-PRO490
KILE466-PRO490
LILE466-PRO490

site_idSWS_FT_FI9
Number of Residues48
DetailsTRANSMEM: Helical; Name=7
ChainResidueDetails
JGLY539-LEU555
KGLY539-LEU555
LGLY539-LEU555

site_idSWS_FT_FI10
Number of Residues48
DetailsTRANSMEM: Helical; Name=8
ChainResidueDetails
JGLN872-LEU888
KGLN872-LEU888
LGLN872-LEU888

site_idSWS_FT_FI11
Number of Residues57
DetailsTRANSMEM: Helical; Name=9
ChainResidueDetails
JPHE899-PHE918
KPHE899-PHE918
LPHE899-PHE918

site_idSWS_FT_FI12
Number of Residues54
DetailsTRANSMEM: Helical; Name=10
ChainResidueDetails
JVAL925-ILE943
KVAL925-ILE943
LVAL925-ILE943

site_idSWS_FT_FI13
Number of Residues57
DetailsTRANSMEM: Helical; Name=11
ChainResidueDetails
JARG973-SER992
KARG973-SER992
LARG973-SER992

site_idSWS_FT_FI14
Number of Residues57
DetailsTRANSMEM: Helical; Name=12
ChainResidueDetails
JALA999-ALA1018
KALA999-ALA1018
LALA999-ALA1018

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PDB entries from 2024-07-24

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