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5O66

Asymmetric AcrABZ-TolC

Replaces:  5V78
Functional Information from GO Data
ChainGOidnamespacecontents
A0015562molecular_functionefflux transmembrane transporter activity
A0019867cellular_componentouter membrane
A0055085biological_processtransmembrane transport
B0015562molecular_functionefflux transmembrane transporter activity
B0019867cellular_componentouter membrane
B0055085biological_processtransmembrane transport
C0015562molecular_functionefflux transmembrane transporter activity
C0019867cellular_componentouter membrane
C0055085biological_processtransmembrane transport
D0005886cellular_componentplasma membrane
D0015721biological_processbile acid and bile salt transport
D0016020cellular_componentmembrane
D0022857molecular_functiontransmembrane transporter activity
D0046677biological_processresponse to antibiotic
D0055085biological_processtransmembrane transport
D0140330biological_processxenobiotic detoxification by transmembrane export across the cell outer membrane
E0005886cellular_componentplasma membrane
E0015721biological_processbile acid and bile salt transport
E0016020cellular_componentmembrane
E0022857molecular_functiontransmembrane transporter activity
E0046677biological_processresponse to antibiotic
E0055085biological_processtransmembrane transport
E0140330biological_processxenobiotic detoxification by transmembrane export across the cell outer membrane
F0005886cellular_componentplasma membrane
F0015721biological_processbile acid and bile salt transport
F0016020cellular_componentmembrane
F0022857molecular_functiontransmembrane transporter activity
F0046677biological_processresponse to antibiotic
F0055085biological_processtransmembrane transport
F0140330biological_processxenobiotic detoxification by transmembrane export across the cell outer membrane
G0005886cellular_componentplasma membrane
G0015721biological_processbile acid and bile salt transport
G0016020cellular_componentmembrane
G0022857molecular_functiontransmembrane transporter activity
G0046677biological_processresponse to antibiotic
G0055085biological_processtransmembrane transport
G0140330biological_processxenobiotic detoxification by transmembrane export across the cell outer membrane
H0005886cellular_componentplasma membrane
H0015721biological_processbile acid and bile salt transport
H0016020cellular_componentmembrane
H0022857molecular_functiontransmembrane transporter activity
H0046677biological_processresponse to antibiotic
H0055085biological_processtransmembrane transport
H0140330biological_processxenobiotic detoxification by transmembrane export across the cell outer membrane
I0005886cellular_componentplasma membrane
I0015721biological_processbile acid and bile salt transport
I0016020cellular_componentmembrane
I0022857molecular_functiontransmembrane transporter activity
I0046677biological_processresponse to antibiotic
I0055085biological_processtransmembrane transport
I0140330biological_processxenobiotic detoxification by transmembrane export across the cell outer membrane
J0005515molecular_functionprotein binding
J0005886cellular_componentplasma membrane
J0009410biological_processresponse to xenobiotic stimulus
J0009636biological_processresponse to toxic substance
J0015125molecular_functionbile acid transmembrane transporter activity
J0015562molecular_functionefflux transmembrane transporter activity
J0015567molecular_functionalkane transmembrane transporter activity
J0015721biological_processbile acid and bile salt transport
J0015895biological_processalkane transport
J0015908biological_processfatty acid transport
J0016020cellular_componentmembrane
J0022857molecular_functiontransmembrane transporter activity
J0042802molecular_functionidentical protein binding
J0042908biological_processxenobiotic transport
J0042910molecular_functionxenobiotic transmembrane transporter activity
J0042930biological_processenterobactin transport
J0042931molecular_functionenterobactin transmembrane transporter activity
J0046677biological_processresponse to antibiotic
J0055085biological_processtransmembrane transport
J0098567cellular_componentperiplasmic side of plasma membrane
J0140330biological_processxenobiotic detoxification by transmembrane export across the cell outer membrane
J1990281cellular_componentefflux pump complex
K0005515molecular_functionprotein binding
K0005886cellular_componentplasma membrane
K0009410biological_processresponse to xenobiotic stimulus
K0009636biological_processresponse to toxic substance
K0015125molecular_functionbile acid transmembrane transporter activity
K0015562molecular_functionefflux transmembrane transporter activity
K0015567molecular_functionalkane transmembrane transporter activity
K0015721biological_processbile acid and bile salt transport
K0015895biological_processalkane transport
K0015908biological_processfatty acid transport
K0016020cellular_componentmembrane
K0022857molecular_functiontransmembrane transporter activity
K0042802molecular_functionidentical protein binding
K0042908biological_processxenobiotic transport
K0042910molecular_functionxenobiotic transmembrane transporter activity
K0042930biological_processenterobactin transport
K0042931molecular_functionenterobactin transmembrane transporter activity
K0046677biological_processresponse to antibiotic
K0055085biological_processtransmembrane transport
K0098567cellular_componentperiplasmic side of plasma membrane
K0140330biological_processxenobiotic detoxification by transmembrane export across the cell outer membrane
K1990281cellular_componentefflux pump complex
L0005515molecular_functionprotein binding
L0005886cellular_componentplasma membrane
L0009410biological_processresponse to xenobiotic stimulus
L0009636biological_processresponse to toxic substance
L0015125molecular_functionbile acid transmembrane transporter activity
L0015562molecular_functionefflux transmembrane transporter activity
L0015567molecular_functionalkane transmembrane transporter activity
L0015721biological_processbile acid and bile salt transport
L0015895biological_processalkane transport
L0015908biological_processfatty acid transport
L0016020cellular_componentmembrane
L0022857molecular_functiontransmembrane transporter activity
L0042802molecular_functionidentical protein binding
L0042908biological_processxenobiotic transport
L0042910molecular_functionxenobiotic transmembrane transporter activity
L0042930biological_processenterobactin transport
L0042931molecular_functionenterobactin transmembrane transporter activity
L0046677biological_processresponse to antibiotic
L0055085biological_processtransmembrane transport
L0098567cellular_componentperiplasmic side of plasma membrane
L0140330biological_processxenobiotic detoxification by transmembrane export across the cell outer membrane
L1990281cellular_componentefflux pump complex
M0005886cellular_componentplasma membrane
M0042910molecular_functionxenobiotic transmembrane transporter activity
M0046677biological_processresponse to antibiotic
M1990961biological_processxenobiotic detoxification by transmembrane export across the plasma membrane
N0005886cellular_componentplasma membrane
N0042910molecular_functionxenobiotic transmembrane transporter activity
N0046677biological_processresponse to antibiotic
N1990961biological_processxenobiotic detoxification by transmembrane export across the plasma membrane
O0005886cellular_componentplasma membrane
O0042910molecular_functionxenobiotic transmembrane transporter activity
O0046677biological_processresponse to antibiotic
O1990961biological_processxenobiotic detoxification by transmembrane export across the plasma membrane
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues630
DetailsTopological domain: {"description":"Periplasmic"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues33
DetailsTransmembrane: {"description":"Beta stranded; Name=S1"}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues81
DetailsTopological domain: {"description":"Extracellular"}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues39
DetailsTransmembrane: {"description":"Beta stranded; Name=S2"}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues30
DetailsTransmembrane: {"description":"Beta stranded; Name=S4"}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues30
DetailsTransmembrane: {"description":"Beta stranded; Name=S5"}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues621
DetailsRepeat: {"description":"1"}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues645
DetailsRepeat: {"description":"2"}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues84
DetailsRegion: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues45
DetailsCompositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues444
DetailsCoiled coil: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues372
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"15919996","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI13
Number of Residues54
DetailsTransmembrane: {"description":"Helical; Name=1"}
ChainResidueDetails

site_idSWS_FT_FI14
Number of Residues1932
DetailsTopological domain: {"description":"Periplasmic","evidences":[{"source":"PubMed","id":"15919996","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI15
Number of Residues57
DetailsTransmembrane: {"description":"Helical; Name=2"}
ChainResidueDetails

site_idSWS_FT_FI16
Number of Residues57
DetailsTransmembrane: {"description":"Helical; Name=3"}
ChainResidueDetails

site_idSWS_FT_FI17
Number of Residues63
DetailsTransmembrane: {"description":"Helical; Name=4"}
ChainResidueDetails

site_idSWS_FT_FI18
Number of Residues54
DetailsTransmembrane: {"description":"Helical; Name=5"}
ChainResidueDetails

site_idSWS_FT_FI19
Number of Residues72
DetailsTransmembrane: {"description":"Helical; Name=6"}
ChainResidueDetails

site_idSWS_FT_FI20
Number of Residues48
DetailsTransmembrane: {"description":"Helical; Name=7"}
ChainResidueDetails

site_idSWS_FT_FI21
Number of Residues48
DetailsTransmembrane: {"description":"Helical; Name=8"}
ChainResidueDetails

site_idSWS_FT_FI22
Number of Residues57
DetailsTransmembrane: {"description":"Helical; Name=9"}
ChainResidueDetails

site_idSWS_FT_FI23
Number of Residues54
DetailsTransmembrane: {"description":"Helical; Name=10"}
ChainResidueDetails

site_idSWS_FT_FI24
Number of Residues57
DetailsTransmembrane: {"description":"Helical; Name=11"}
ChainResidueDetails

site_idSWS_FT_FI25
Number of Residues57
DetailsTransmembrane: {"description":"Helical; Name=12"}
ChainResidueDetails

site_idSWS_FT_FI26
Number of Residues18
DetailsTopological domain: {"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI27
Number of Residues60
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"HAMAP-Rule","id":"MF_01484","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

247947

PDB entries from 2026-01-21

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