5O5L
X-ray structure of a bacterial adenylyl cyclase soluble domain, solved at cryogenic temperature
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0009190 | biological_process | cyclic nucleotide biosynthetic process |
| A | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
| A | 0035556 | biological_process | intracellular signal transduction |
| B | 0009190 | biological_process | cyclic nucleotide biosynthetic process |
| B | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
| B | 0035556 | biological_process | intracellular signal transduction |
| C | 0009190 | biological_process | cyclic nucleotide biosynthetic process |
| C | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
| C | 0035556 | biological_process | intracellular signal transduction |
| D | 0009190 | biological_process | cyclic nucleotide biosynthetic process |
| D | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
| D | 0035556 | biological_process | intracellular signal transduction |
| E | 0009190 | biological_process | cyclic nucleotide biosynthetic process |
| E | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
| E | 0035556 | biological_process | intracellular signal transduction |
| F | 0009190 | biological_process | cyclic nucleotide biosynthetic process |
| F | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
| F | 0035556 | biological_process | intracellular signal transduction |
| G | 0009190 | biological_process | cyclic nucleotide biosynthetic process |
| G | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
| G | 0035556 | biological_process | intracellular signal transduction |
| H | 0009190 | biological_process | cyclic nucleotide biosynthetic process |
| H | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
| H | 0035556 | biological_process | intracellular signal transduction |
| I | 0009190 | biological_process | cyclic nucleotide biosynthetic process |
| I | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
| I | 0035556 | biological_process | intracellular signal transduction |
| J | 0009190 | biological_process | cyclic nucleotide biosynthetic process |
| J | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
| J | 0035556 | biological_process | intracellular signal transduction |
| K | 0009190 | biological_process | cyclic nucleotide biosynthetic process |
| K | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
| K | 0035556 | biological_process | intracellular signal transduction |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | binding site for residue ONM A 501 |
| Chain | Residue |
| A | ASP256 |
| A | ARG344 |
| A | MN502 |
| A | MN503 |
| A | HOH624 |
| B | LYS296 |
| B | ASP365 |
| B | VAL366 |
| B | TRP367 |
| B | GLY368 |
| B | ASP369 |
| A | ILE257 |
| B | ASN372 |
| B | ARG376 |
| B | LYS411 |
| A | GLY259 |
| A | PHE260 |
| A | THR261 |
| A | PRO269 |
| A | SER298 |
| A | GLY299 |
| A | ASP300 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MN A 502 |
| Chain | Residue |
| A | ASP256 |
| A | ILE257 |
| A | ASP300 |
| A | ARG344 |
| A | ONM501 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue MN A 503 |
| Chain | Residue |
| A | ASP256 |
| A | ASP300 |
| A | ONM501 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 504 |
| Chain | Residue |
| A | ALA224 |
| A | LEU227 |
| A | PRO228 |
| A | GLY229 |
| B | ARG360 |
| B | ARG361 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 501 |
| Chain | Residue |
| A | ARG274 |
| B | SER241 |
| B | VAL242 |
| B | HOH618 |
| C | LYS246 |
| site_id | AC6 |
| Number of Residues | 20 |
| Details | binding site for residue ONM B 502 |
| Chain | Residue |
| A | PHE254 |
| A | LYS296 |
| A | VAL366 |
| A | TRP367 |
| A | GLY368 |
| A | VAL371 |
| A | ASN372 |
| B | ASP256 |
| B | ILE257 |
| B | VAL258 |
| B | GLY259 |
| B | PHE260 |
| B | THR261 |
| B | PRO269 |
| B | LEU272 |
| B | GLY299 |
| B | ASP300 |
| B | ARG344 |
| B | MN504 |
| B | MN505 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 503 |
| Chain | Residue |
| A | LYS246 |
| B | ALA270 |
| B | ARG274 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue MN B 504 |
| Chain | Residue |
| B | ASP256 |
| B | ILE257 |
| B | ASP300 |
| B | ONM502 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue MN B 505 |
| Chain | Residue |
| B | ASP256 |
| B | ASP300 |
| B | ONM502 |
| B | HOH632 |
| site_id | AD1 |
| Number of Residues | 21 |
| Details | binding site for residue ONM C 501 |
| Chain | Residue |
| C | ASP256 |
| C | ILE257 |
| C | VAL258 |
| C | GLY259 |
| C | PHE260 |
| C | THR261 |
| C | PRO269 |
| C | LEU272 |
| C | GLY299 |
| C | ASP300 |
| C | ARG344 |
| C | MN503 |
| C | MN504 |
| D | PHE254 |
| D | LYS296 |
| D | VAL366 |
| D | TRP367 |
| D | GLY368 |
| D | VAL371 |
| D | ASN372 |
| D | SER375 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 C 502 |
| Chain | Residue |
| B | LYS246 |
| C | SER241 |
| C | VAL242 |
| C | HOH611 |
| D | ARG274 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue MN C 503 |
| Chain | Residue |
| C | ILE257 |
| C | ASP300 |
| C | ONM501 |
| C | ASP256 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue MN C 504 |
| Chain | Residue |
| C | ASP256 |
| C | ASP300 |
| C | ONM501 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 D 501 |
| Chain | Residue |
| C | ARG360 |
| C | ARG361 |
| D | ALA224 |
| D | LEU227 |
| D | PRO228 |
| D | GLY229 |
| site_id | AD6 |
| Number of Residues | 23 |
| Details | binding site for residue ONM D 502 |
| Chain | Residue |
| C | ASP365 |
| C | VAL366 |
| C | TRP367 |
| C | GLY368 |
| C | ASP369 |
| C | ASN372 |
| C | ARG376 |
| C | LYS411 |
| D | ASP256 |
| D | ILE257 |
| D | GLY259 |
| D | PHE260 |
| D | THR261 |
| D | GLU262 |
| D | PRO269 |
| D | SER298 |
| D | GLY299 |
| D | ASP300 |
| D | ARG344 |
| D | MN503 |
| D | MN504 |
| D | HOH606 |
| D | HOH607 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue MN D 503 |
| Chain | Residue |
| D | ASP256 |
| D | ILE257 |
| D | ASP300 |
| D | ONM502 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue MN D 504 |
| Chain | Residue |
| D | ASP256 |
| D | ASP300 |
| D | ONM502 |
| site_id | AD9 |
| Number of Residues | 19 |
| Details | binding site for residue ONM E 501 |
| Chain | Residue |
| E | ASP256 |
| E | ILE257 |
| E | PHE260 |
| E | THR261 |
| E | PRO269 |
| E | ASP300 |
| E | ARG344 |
| E | MN503 |
| E | MN504 |
| F | LYS296 |
| F | MET303 |
| F | ASP365 |
| F | VAL366 |
| F | TRP367 |
| F | GLY368 |
| F | ASP369 |
| F | VAL371 |
| F | ASN372 |
| F | ARG376 |
| site_id | AE1 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 E 502 |
| Chain | Residue |
| C | ALA270 |
| C | ARG274 |
| D | LYS246 |
| E | SER241 |
| E | VAL242 |
| F | ARG274 |
| site_id | AE2 |
| Number of Residues | 4 |
| Details | binding site for residue MN E 503 |
| Chain | Residue |
| E | ASP256 |
| E | ILE257 |
| E | ASP300 |
| E | ONM501 |
| site_id | AE3 |
| Number of Residues | 3 |
| Details | binding site for residue MN E 504 |
| Chain | Residue |
| E | ASP256 |
| E | ASP300 |
| E | ONM501 |
| site_id | AE4 |
| Number of Residues | 19 |
| Details | binding site for residue ONM F 501 |
| Chain | Residue |
| E | PHE254 |
| E | LYS296 |
| E | VAL366 |
| E | TRP367 |
| E | GLY368 |
| E | VAL371 |
| E | ASN372 |
| E | SER375 |
| F | ASP256 |
| F | ILE257 |
| F | GLY259 |
| F | PHE260 |
| F | THR261 |
| F | PRO269 |
| F | GLY299 |
| F | ASP300 |
| F | ARG344 |
| F | MN502 |
| F | MN503 |
| site_id | AE5 |
| Number of Residues | 2 |
| Details | binding site for residue MN F 502 |
| Chain | Residue |
| F | ASP256 |
| F | ONM501 |
| site_id | AE6 |
| Number of Residues | 4 |
| Details | binding site for residue MN F 503 |
| Chain | Residue |
| F | ASP256 |
| F | ILE257 |
| F | ASP300 |
| F | ONM501 |
| site_id | AE7 |
| Number of Residues | 4 |
| Details | binding site for residue MN G 501 |
| Chain | Residue |
| G | ASP256 |
| G | ASP300 |
| G | MN502 |
| G | ONM503 |
| site_id | AE8 |
| Number of Residues | 5 |
| Details | binding site for residue MN G 502 |
| Chain | Residue |
| G | ASP256 |
| G | ILE257 |
| G | ASP300 |
| G | MN501 |
| G | ONM503 |
| site_id | AE9 |
| Number of Residues | 19 |
| Details | binding site for residue ONM G 503 |
| Chain | Residue |
| G | ASP256 |
| G | ILE257 |
| G | GLY259 |
| G | PHE260 |
| G | THR261 |
| G | PRO269 |
| G | LEU272 |
| G | GLY299 |
| G | ASP300 |
| G | ARG344 |
| G | MN501 |
| G | MN502 |
| H | LYS296 |
| H | VAL366 |
| H | TRP367 |
| H | GLY368 |
| H | ASP369 |
| H | VAL371 |
| H | ASN372 |
| site_id | AF1 |
| Number of Residues | 17 |
| Details | binding site for residue ONM H 501 |
| Chain | Residue |
| G | LYS296 |
| G | ASP365 |
| G | VAL366 |
| G | VAL371 |
| G | ASN372 |
| G | ARG376 |
| G | LYS411 |
| H | ASP256 |
| H | PHE260 |
| H | THR261 |
| H | GLU262 |
| H | SER298 |
| H | GLY299 |
| H | ASP300 |
| H | ARG344 |
| H | MN502 |
| H | MN503 |
| site_id | AF2 |
| Number of Residues | 4 |
| Details | binding site for residue MN H 502 |
| Chain | Residue |
| H | ASP256 |
| H | ILE257 |
| H | ASP300 |
| H | ONM501 |
| site_id | AF3 |
| Number of Residues | 3 |
| Details | binding site for residue MN H 503 |
| Chain | Residue |
| H | ASP256 |
| H | ASP300 |
| H | ONM501 |
| site_id | AF4 |
| Number of Residues | 16 |
| Details | binding site for residue ONM J 501 |
| Chain | Residue |
| I | ASP365 |
| I | VAL366 |
| I | GLY368 |
| I | VAL371 |
| I | ASN372 |
| I | ARG376 |
| I | LYS411 |
| J | ILE257 |
| J | PHE260 |
| J | THR261 |
| J | PRO269 |
| J | LEU272 |
| J | ASP300 |
| J | ARG344 |
| J | MN502 |
| J | MN503 |
| site_id | AF5 |
| Number of Residues | 4 |
| Details | binding site for residue MN I 501 |
| Chain | Residue |
| I | ASP256 |
| I | ILE257 |
| I | ASP300 |
| I | ONM503 |
| site_id | AF6 |
| Number of Residues | 3 |
| Details | binding site for residue MN I 502 |
| Chain | Residue |
| I | ASP256 |
| I | SER298 |
| I | ONM503 |
| site_id | AF7 |
| Number of Residues | 18 |
| Details | binding site for residue ONM I 503 |
| Chain | Residue |
| I | ASP256 |
| I | ILE257 |
| I | PHE260 |
| I | THR261 |
| I | PRO269 |
| I | ASP300 |
| I | ARG344 |
| I | MN501 |
| I | MN502 |
| J | PHE254 |
| J | LYS296 |
| J | VAL366 |
| J | TRP367 |
| J | GLY368 |
| J | ASP369 |
| J | VAL371 |
| J | ASN372 |
| J | SER375 |
| site_id | AF8 |
| Number of Residues | 4 |
| Details | binding site for residue MN J 502 |
| Chain | Residue |
| J | ONM501 |
| J | ASP256 |
| J | SER298 |
| J | ASP300 |
| site_id | AF9 |
| Number of Residues | 4 |
| Details | binding site for residue MN J 503 |
| Chain | Residue |
| J | ONM501 |
| J | ASP256 |
| J | ILE257 |
| J | ASP300 |
| site_id | AG1 |
| Number of Residues | 12 |
| Details | binding site for residue ONM K 501 |
| Chain | Residue |
| K | ASP256 |
| K | ILE257 |
| K | PHE260 |
| K | THR261 |
| K | GLU262 |
| K | PRO269 |
| K | SER298 |
| K | GLY299 |
| K | ASP300 |
| K | ARG344 |
| K | MN502 |
| K | MN503 |
| site_id | AG2 |
| Number of Residues | 3 |
| Details | binding site for residue MN K 502 |
| Chain | Residue |
| K | ASP256 |
| K | ARG344 |
| K | ONM501 |
| site_id | AG3 |
| Number of Residues | 4 |
| Details | binding site for residue MN K 503 |
| Chain | Residue |
| K | SER298 |
| K | ASP300 |
| K | SER301 |
| K | ONM501 |
Functional Information from PROSITE/UniProt
| site_id | PS00452 |
| Number of Residues | 24 |
| Details | GUANYLATE_CYCLASE_1 Guanylate cyclase signature. GVV.GsrrffYdVWGDAVNvasrmE |
| Chain | Residue | Details |
| A | GLY355-GLU378 |
