Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5O5K

X-ray structure of a bacterial adenylyl cyclase soluble domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0009190	biological_process	cyclic nucleotide biosynthetic process
A	0016849	molecular_function	phosphorus-oxygen lyase activity
A	0035556	biological_process	intracellular signal transduction
B	0009190	biological_process	cyclic nucleotide biosynthetic process
B	0016849	molecular_function	phosphorus-oxygen lyase activity
B	0035556	biological_process	intracellular signal transduction
C	0009190	biological_process	cyclic nucleotide biosynthetic process
C	0016849	molecular_function	phosphorus-oxygen lyase activity
C	0035556	biological_process	intracellular signal transduction
D	0009190	biological_process	cyclic nucleotide biosynthetic process
D	0016849	molecular_function	phosphorus-oxygen lyase activity
D	0035556	biological_process	intracellular signal transduction
E	0009190	biological_process	cyclic nucleotide biosynthetic process
E	0016849	molecular_function	phosphorus-oxygen lyase activity
E	0035556	biological_process	intracellular signal transduction
F	0009190	biological_process	cyclic nucleotide biosynthetic process
F	0016849	molecular_function	phosphorus-oxygen lyase activity
F	0035556	biological_process	intracellular signal transduction
G	0009190	biological_process	cyclic nucleotide biosynthetic process
G	0016849	molecular_function	phosphorus-oxygen lyase activity
G	0035556	biological_process	intracellular signal transduction
H	0009190	biological_process	cyclic nucleotide biosynthetic process
H	0016849	molecular_function	phosphorus-oxygen lyase activity
H	0035556	biological_process	intracellular signal transduction
I	0009190	biological_process	cyclic nucleotide biosynthetic process
I	0016849	molecular_function	phosphorus-oxygen lyase activity
I	0035556	biological_process	intracellular signal transduction
J	0009190	biological_process	cyclic nucleotide biosynthetic process
J	0016849	molecular_function	phosphorus-oxygen lyase activity
J	0035556	biological_process	intracellular signal transduction
K	0009190	biological_process	cyclic nucleotide biosynthetic process
K	0016849	molecular_function	phosphorus-oxygen lyase activity
K	0035556	biological_process	intracellular signal transduction

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	binding site for residue ONM A 501

Chain	Residue
A	ASP256
A	ARG344
A	MN502
A	MN503
B	MET303
B	ASP365
B	VAL366
B	TRP367
B	ASN372
B	ARG376
B	LYS411
A	ILE257
A	VAL258
A	GLY259
A	PHE260
A	THR261
A	SER298
A	GLY299
A	ASP300

site_id	AC2
Number of Residues	4
Details	binding site for residue MN A 502

Chain	Residue
A	ASP256
A	ILE257
A	ASP300
A	ONM501

site_id	AC3
Number of Residues	3
Details	binding site for residue MN A 503

Chain	Residue
A	ASP256
A	ASP300
A	ONM501

site_id	AC4
Number of Residues	6
Details	binding site for residue SO4 A 504

Chain	Residue
A	ALA224
A	LEU227
A	PRO228
A	GLY229
B	ARG360
B	ARG361

site_id	AC5
Number of Residues	3
Details	binding site for residue SO4 A 505

Chain	Residue
A	SER241
A	VAL242
B	ARG274

site_id	AC6
Number of Residues	21
Details	binding site for residue ONM B 501

Chain	Residue
A	PHE254
A	LYS296
A	MET303
A	VAL366
A	TRP367
A	GLY368
A	ASP369
A	VAL371
A	ASN372
A	SER375
B	ASP256
B	ILE257
B	GLY259
B	PHE260
B	THR261
B	PRO269
B	GLY299
B	ASP300
B	ARG344
B	MN503
B	MN504

site_id	AC7
Number of Residues	4
Details	binding site for residue SO4 B 502

Chain	Residue
A	ARG274
B	SER241
B	VAL242
D	ARG274

site_id	AC8
Number of Residues	4
Details	binding site for residue MN B 503

Chain	Residue
B	ASP256
B	ILE257
B	ASP300
B	ONM501

site_id	AC9
Number of Residues	3
Details	binding site for residue MN B 504

Chain	Residue
B	ASP256
B	ASP300
B	ONM501

site_id	AD1
Number of Residues	24
Details	binding site for residue ONM D 501

Chain	Residue
C	MET303
C	ASP365
C	VAL366
C	TRP367
C	GLY368
C	ASP369
C	VAL371
C	ASN372
C	ARG376
C	LYS411
D	ASP256
D	ILE257
D	VAL258
D	GLY259
D	PHE260
D	THR261
D	PRO269
D	LEU272
D	SER298
D	GLY299
D	ASP300
D	ARG344
D	MN502
D	MN503

site_id	AD2
Number of Residues	4
Details	binding site for residue MN D 502

Chain	Residue
D	ASP256
D	ILE257
D	ASP300
D	ONM501

site_id	AD3
Number of Residues	3
Details	binding site for residue MN D 503

Chain	Residue
D	ASP256
D	ASP300
D	ONM501

site_id	AD4
Number of Residues	6
Details	binding site for residue SO4 D 504

Chain	Residue
D	SER241
D	VAL242
E	LYS246
F	ALA270
F	ARG274
C	ARG274

site_id	AD5
Number of Residues	21
Details	binding site for residue ONM C 501

Chain	Residue
C	ASP256
C	ILE257
C	GLY259
C	PHE260
C	THR261
C	LEU272
C	GLY299
C	ASP300
C	ARG344
C	MN504
C	MN505
D	PHE254
D	LYS296
D	MET303
D	VAL366
D	TRP367
D	GLY368
D	ASP369
D	VAL371
D	ASN372
D	SER375

site_id	AD6
Number of Residues	5
Details	binding site for residue SO4 C 502

Chain	Residue
A	ARG274
B	LYS246
C	SER241
C	VAL242
D	ARG274

site_id	AD7
Number of Residues	5
Details	binding site for residue SO4 C 503

Chain	Residue
C	ARG360
C	ARG361
D	ALA224
D	LEU227
D	GLY229

site_id	AD8
Number of Residues	4
Details	binding site for residue MN C 504

Chain	Residue
C	ASP256
C	ILE257
C	ASP300
C	ONM501

site_id	AD9
Number of Residues	2
Details	binding site for residue MN C 505

Chain	Residue
C	ASP256
C	ONM501

site_id	AE1
Number of Residues	21
Details	binding site for residue ONM E 501

Chain	Residue
E	ASP256
E	ILE257
E	GLY259
E	PHE260
E	THR261
E	PRO269
E	LEU272
E	VAL273
E	GLY299
E	ASP300
E	ARG344
E	MN502
E	MN503
F	MET303
F	ASP365
F	VAL366
F	TRP367
F	GLY368
F	ASN372
F	ARG376
F	LYS411

site_id	AE2
Number of Residues	5
Details	binding site for residue MN E 502

Chain	Residue
E	ASP256
E	ILE257
E	ASP300
E	ONM501
E	MN503

site_id	AE3
Number of Residues	4
Details	binding site for residue MN E 503

Chain	Residue
E	ASP256
E	ASP300
E	ONM501
E	MN502

site_id	AE4
Number of Residues	2
Details	binding site for residue SO4 E 504

Chain	Residue
E	ARG274
F	VAL242

site_id	AE5
Number of Residues	6
Details	binding site for residue SO4 E 505

Chain	Residue
C	ALA270
C	ARG274
D	LYS246
E	SER241
E	VAL242
F	ARG274

site_id	AE6
Number of Residues	19
Details	binding site for residue ONM F 501

Chain	Residue
E	LYS296
E	VAL366
E	TRP367
E	GLY368
E	VAL371
E	ASN372
F	ASP256
F	ILE257
F	VAL258
F	GLY259
F	PHE260
F	THR261
F	PRO269
F	LEU272
F	GLY299
F	ASP300
F	ARG344
F	MN503
F	MN504

site_id	AE7
Number of Residues	3
Details	binding site for residue SO4 F 502

Chain	Residue
E	LEU227
E	GLU293
F	ARG361

site_id	AE8
Number of Residues	5
Details	binding site for residue MN F 503

Chain	Residue
F	ASP256
F	ILE257
F	ASP300
F	ONM501
F	MN504

site_id	AE9
Number of Residues	3
Details	binding site for residue MN F 504

Chain	Residue
F	ASP256
F	ONM501
F	MN503

site_id	AF1
Number of Residues	5
Details	binding site for residue MN I 501

Chain	Residue
I	ASP256
I	ILE257
I	ASP300
I	MN502
I	ONM504

site_id	AF2
Number of Residues	4
Details	binding site for residue MN I 502

Chain	Residue
I	ASP256
I	ASP300
I	MN501
I	ONM504

site_id	AF3
Number of Residues	6
Details	binding site for residue SO4 I 503

Chain	Residue
I	ALA224
I	LEU227
I	PRO228
I	GLY229
J	ARG360
J	ARG361

site_id	AF4
Number of Residues	25
Details	binding site for residue ONM I 504

Chain	Residue
I	ASP256
I	ILE257
I	VAL258
I	GLY259
I	PHE260
I	THR261
I	PRO269
I	LEU272
I	SER298
I	GLY299
I	ASP300
I	ARG344
I	MN501
I	MN502
J	PHE254
J	MET303
J	ASP365
J	VAL366
J	GLY368
J	ASP369
J	VAL371
J	ASN372
J	SER375
J	ARG376
J	LYS411

site_id	AF5
Number of Residues	22
Details	binding site for residue ONM J 501

Chain	Residue
I	PHE254
I	LYS296
I	MET303
I	VAL366
I	TRP367
I	GLY368
I	ASP369
I	VAL371
I	ASN372
I	SER375
J	ASP256
J	ILE257
J	VAL258
J	GLY259
J	PHE260
J	THR261
J	ALA264
J	GLY299
J	ASP300
J	ARG344
J	MN503
J	MN504

site_id	AF6
Number of Residues	2
Details	binding site for residue SO4 J 502

Chain	Residue
J	SER241
J	VAL242

site_id	AF7
Number of Residues	7
Details	binding site for residue MN J 503

Chain	Residue
J	ASP256
J	ILE257
J	VAL258
J	GLY259
J	ASP300
J	ARG344
J	ONM501

site_id	AF8
Number of Residues	3
Details	binding site for residue MN J 504

Chain	Residue
J	ASP256
J	ASP300
J	ONM501

site_id	AF9
Number of Residues	5
Details	binding site for residue SO4 J 505

Chain	Residue
G	ARG274
H	SER241
H	VAL242
J	ALA270
J	ARG274

site_id	AG1
Number of Residues	4
Details	binding site for residue SO4 H 501

Chain	Residue
G	ALA224
G	GLU293
H	ARG360
H	ARG361

site_id	AG2
Number of Residues	4
Details	binding site for residue MN H 502

Chain	Residue
H	ASP256
H	ILE257
H	ASP300
H	ONM504

site_id	AG3
Number of Residues	2
Details	binding site for residue MN H 503

Chain	Residue
H	ASP256
H	ONM504

site_id	AG4
Number of Residues	20
Details	binding site for residue ONM H 504

Chain	Residue
G	PHE254
G	LYS296
G	TRP367
G	GLY368
G	ASP369
G	VAL371
G	ASN372
G	SER375
H	ASP256
H	ILE257
H	VAL258
H	GLY259
H	PHE260
H	THR261
H	GLU262
H	PRO269
H	ASP300
H	ARG344
H	MN502
H	MN503

site_id	AG5
Number of Residues	19
Details	binding site for residue ONM G 501

Chain	Residue
G	ASP256
G	ILE257
G	PHE260
G	THR261
G	PRO269
G	LEU272
G	GLY299
G	ASP300
G	ARG344
G	MN502
G	MN503
H	PHE254
H	LYS296
H	MET303
H	ASP365
H	TRP367
H	ASN372
H	ARG376
H	LYS411

site_id	AG6
Number of Residues	4
Details	binding site for residue MN G 502

Chain	Residue
G	ASP256
G	ILE257
G	ASP300
G	ONM501

site_id	AG7
Number of Residues	3
Details	binding site for residue MN G 503

Chain	Residue
G	ASP256
G	ASP300
G	ONM501

site_id	AG8
Number of Residues	14
Details	binding site for residue ONM K 501

Chain	Residue
K	ASP256
K	ILE257
K	GLY259
K	PHE260
K	THR261
K	GLU262
K	PRO269
K	LEU272
K	SER298
K	GLY299
K	ASP300
K	ARG344
K	MN502
K	MN503

site_id	AG9
Number of Residues	5
Details	binding site for residue MN K 502

Chain	Residue
K	ASP256
K	ILE257
K	ASP300
K	ONM501
K	MN503

site_id	AH1
Number of Residues	3
Details	binding site for residue MN K 503

Chain	Residue
K	ASP256
K	ONM501
K	MN502

Functional Information from PROSITE/UniProt

site_id	PS00452
Number of Residues	24
Details	GUANYLATE_CYCLASE_1 Guanylate cyclase signature. GVV.GsrrffYdVWGDAVNvasrmE

Chain	Residue	Details
A	GLY355-GLU378

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)