5O5K
X-ray structure of a bacterial adenylyl cyclase soluble domain
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0009190 | biological_process | cyclic nucleotide biosynthetic process |
A | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
A | 0035556 | biological_process | intracellular signal transduction |
B | 0009190 | biological_process | cyclic nucleotide biosynthetic process |
B | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
B | 0035556 | biological_process | intracellular signal transduction |
C | 0009190 | biological_process | cyclic nucleotide biosynthetic process |
C | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
C | 0035556 | biological_process | intracellular signal transduction |
D | 0009190 | biological_process | cyclic nucleotide biosynthetic process |
D | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
D | 0035556 | biological_process | intracellular signal transduction |
E | 0009190 | biological_process | cyclic nucleotide biosynthetic process |
E | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
E | 0035556 | biological_process | intracellular signal transduction |
F | 0009190 | biological_process | cyclic nucleotide biosynthetic process |
F | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
F | 0035556 | biological_process | intracellular signal transduction |
G | 0009190 | biological_process | cyclic nucleotide biosynthetic process |
G | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
G | 0035556 | biological_process | intracellular signal transduction |
H | 0009190 | biological_process | cyclic nucleotide biosynthetic process |
H | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
H | 0035556 | biological_process | intracellular signal transduction |
I | 0009190 | biological_process | cyclic nucleotide biosynthetic process |
I | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
I | 0035556 | biological_process | intracellular signal transduction |
J | 0009190 | biological_process | cyclic nucleotide biosynthetic process |
J | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
J | 0035556 | biological_process | intracellular signal transduction |
K | 0009190 | biological_process | cyclic nucleotide biosynthetic process |
K | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
K | 0035556 | biological_process | intracellular signal transduction |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 19 |
Details | binding site for residue ONM A 501 |
Chain | Residue |
A | ASP256 |
A | ARG344 |
A | MN502 |
A | MN503 |
B | MET303 |
B | ASP365 |
B | VAL366 |
B | TRP367 |
B | ASN372 |
B | ARG376 |
B | LYS411 |
A | ILE257 |
A | VAL258 |
A | GLY259 |
A | PHE260 |
A | THR261 |
A | SER298 |
A | GLY299 |
A | ASP300 |
site_id | AC2 |
Number of Residues | 4 |
Details | binding site for residue MN A 502 |
Chain | Residue |
A | ASP256 |
A | ILE257 |
A | ASP300 |
A | ONM501 |
site_id | AC3 |
Number of Residues | 3 |
Details | binding site for residue MN A 503 |
Chain | Residue |
A | ASP256 |
A | ASP300 |
A | ONM501 |
site_id | AC4 |
Number of Residues | 6 |
Details | binding site for residue SO4 A 504 |
Chain | Residue |
A | ALA224 |
A | LEU227 |
A | PRO228 |
A | GLY229 |
B | ARG360 |
B | ARG361 |
site_id | AC5 |
Number of Residues | 3 |
Details | binding site for residue SO4 A 505 |
Chain | Residue |
A | SER241 |
A | VAL242 |
B | ARG274 |
site_id | AC6 |
Number of Residues | 21 |
Details | binding site for residue ONM B 501 |
Chain | Residue |
A | PHE254 |
A | LYS296 |
A | MET303 |
A | VAL366 |
A | TRP367 |
A | GLY368 |
A | ASP369 |
A | VAL371 |
A | ASN372 |
A | SER375 |
B | ASP256 |
B | ILE257 |
B | GLY259 |
B | PHE260 |
B | THR261 |
B | PRO269 |
B | GLY299 |
B | ASP300 |
B | ARG344 |
B | MN503 |
B | MN504 |
site_id | AC7 |
Number of Residues | 4 |
Details | binding site for residue SO4 B 502 |
Chain | Residue |
A | ARG274 |
B | SER241 |
B | VAL242 |
D | ARG274 |
site_id | AC8 |
Number of Residues | 4 |
Details | binding site for residue MN B 503 |
Chain | Residue |
B | ASP256 |
B | ILE257 |
B | ASP300 |
B | ONM501 |
site_id | AC9 |
Number of Residues | 3 |
Details | binding site for residue MN B 504 |
Chain | Residue |
B | ASP256 |
B | ASP300 |
B | ONM501 |
site_id | AD1 |
Number of Residues | 24 |
Details | binding site for residue ONM D 501 |
Chain | Residue |
C | MET303 |
C | ASP365 |
C | VAL366 |
C | TRP367 |
C | GLY368 |
C | ASP369 |
C | VAL371 |
C | ASN372 |
C | ARG376 |
C | LYS411 |
D | ASP256 |
D | ILE257 |
D | VAL258 |
D | GLY259 |
D | PHE260 |
D | THR261 |
D | PRO269 |
D | LEU272 |
D | SER298 |
D | GLY299 |
D | ASP300 |
D | ARG344 |
D | MN502 |
D | MN503 |
site_id | AD2 |
Number of Residues | 4 |
Details | binding site for residue MN D 502 |
Chain | Residue |
D | ASP256 |
D | ILE257 |
D | ASP300 |
D | ONM501 |
site_id | AD3 |
Number of Residues | 3 |
Details | binding site for residue MN D 503 |
Chain | Residue |
D | ASP256 |
D | ASP300 |
D | ONM501 |
site_id | AD4 |
Number of Residues | 6 |
Details | binding site for residue SO4 D 504 |
Chain | Residue |
D | SER241 |
D | VAL242 |
E | LYS246 |
F | ALA270 |
F | ARG274 |
C | ARG274 |
site_id | AD5 |
Number of Residues | 21 |
Details | binding site for residue ONM C 501 |
Chain | Residue |
C | ASP256 |
C | ILE257 |
C | GLY259 |
C | PHE260 |
C | THR261 |
C | LEU272 |
C | GLY299 |
C | ASP300 |
C | ARG344 |
C | MN504 |
C | MN505 |
D | PHE254 |
D | LYS296 |
D | MET303 |
D | VAL366 |
D | TRP367 |
D | GLY368 |
D | ASP369 |
D | VAL371 |
D | ASN372 |
D | SER375 |
site_id | AD6 |
Number of Residues | 5 |
Details | binding site for residue SO4 C 502 |
Chain | Residue |
A | ARG274 |
B | LYS246 |
C | SER241 |
C | VAL242 |
D | ARG274 |
site_id | AD7 |
Number of Residues | 5 |
Details | binding site for residue SO4 C 503 |
Chain | Residue |
C | ARG360 |
C | ARG361 |
D | ALA224 |
D | LEU227 |
D | GLY229 |
site_id | AD8 |
Number of Residues | 4 |
Details | binding site for residue MN C 504 |
Chain | Residue |
C | ASP256 |
C | ILE257 |
C | ASP300 |
C | ONM501 |
site_id | AD9 |
Number of Residues | 2 |
Details | binding site for residue MN C 505 |
Chain | Residue |
C | ASP256 |
C | ONM501 |
site_id | AE1 |
Number of Residues | 21 |
Details | binding site for residue ONM E 501 |
Chain | Residue |
E | ASP256 |
E | ILE257 |
E | GLY259 |
E | PHE260 |
E | THR261 |
E | PRO269 |
E | LEU272 |
E | VAL273 |
E | GLY299 |
E | ASP300 |
E | ARG344 |
E | MN502 |
E | MN503 |
F | MET303 |
F | ASP365 |
F | VAL366 |
F | TRP367 |
F | GLY368 |
F | ASN372 |
F | ARG376 |
F | LYS411 |
site_id | AE2 |
Number of Residues | 5 |
Details | binding site for residue MN E 502 |
Chain | Residue |
E | ASP256 |
E | ILE257 |
E | ASP300 |
E | ONM501 |
E | MN503 |
site_id | AE3 |
Number of Residues | 4 |
Details | binding site for residue MN E 503 |
Chain | Residue |
E | ASP256 |
E | ASP300 |
E | ONM501 |
E | MN502 |
site_id | AE4 |
Number of Residues | 2 |
Details | binding site for residue SO4 E 504 |
Chain | Residue |
E | ARG274 |
F | VAL242 |
site_id | AE5 |
Number of Residues | 6 |
Details | binding site for residue SO4 E 505 |
Chain | Residue |
C | ALA270 |
C | ARG274 |
D | LYS246 |
E | SER241 |
E | VAL242 |
F | ARG274 |
site_id | AE6 |
Number of Residues | 19 |
Details | binding site for residue ONM F 501 |
Chain | Residue |
E | LYS296 |
E | VAL366 |
E | TRP367 |
E | GLY368 |
E | VAL371 |
E | ASN372 |
F | ASP256 |
F | ILE257 |
F | VAL258 |
F | GLY259 |
F | PHE260 |
F | THR261 |
F | PRO269 |
F | LEU272 |
F | GLY299 |
F | ASP300 |
F | ARG344 |
F | MN503 |
F | MN504 |
site_id | AE7 |
Number of Residues | 3 |
Details | binding site for residue SO4 F 502 |
Chain | Residue |
E | LEU227 |
E | GLU293 |
F | ARG361 |
site_id | AE8 |
Number of Residues | 5 |
Details | binding site for residue MN F 503 |
Chain | Residue |
F | ASP256 |
F | ILE257 |
F | ASP300 |
F | ONM501 |
F | MN504 |
site_id | AE9 |
Number of Residues | 3 |
Details | binding site for residue MN F 504 |
Chain | Residue |
F | ASP256 |
F | ONM501 |
F | MN503 |
site_id | AF1 |
Number of Residues | 5 |
Details | binding site for residue MN I 501 |
Chain | Residue |
I | ASP256 |
I | ILE257 |
I | ASP300 |
I | MN502 |
I | ONM504 |
site_id | AF2 |
Number of Residues | 4 |
Details | binding site for residue MN I 502 |
Chain | Residue |
I | ASP256 |
I | ASP300 |
I | MN501 |
I | ONM504 |
site_id | AF3 |
Number of Residues | 6 |
Details | binding site for residue SO4 I 503 |
Chain | Residue |
I | ALA224 |
I | LEU227 |
I | PRO228 |
I | GLY229 |
J | ARG360 |
J | ARG361 |
site_id | AF4 |
Number of Residues | 25 |
Details | binding site for residue ONM I 504 |
Chain | Residue |
I | ASP256 |
I | ILE257 |
I | VAL258 |
I | GLY259 |
I | PHE260 |
I | THR261 |
I | PRO269 |
I | LEU272 |
I | SER298 |
I | GLY299 |
I | ASP300 |
I | ARG344 |
I | MN501 |
I | MN502 |
J | PHE254 |
J | MET303 |
J | ASP365 |
J | VAL366 |
J | GLY368 |
J | ASP369 |
J | VAL371 |
J | ASN372 |
J | SER375 |
J | ARG376 |
J | LYS411 |
site_id | AF5 |
Number of Residues | 22 |
Details | binding site for residue ONM J 501 |
Chain | Residue |
I | PHE254 |
I | LYS296 |
I | MET303 |
I | VAL366 |
I | TRP367 |
I | GLY368 |
I | ASP369 |
I | VAL371 |
I | ASN372 |
I | SER375 |
J | ASP256 |
J | ILE257 |
J | VAL258 |
J | GLY259 |
J | PHE260 |
J | THR261 |
J | ALA264 |
J | GLY299 |
J | ASP300 |
J | ARG344 |
J | MN503 |
J | MN504 |
site_id | AF6 |
Number of Residues | 2 |
Details | binding site for residue SO4 J 502 |
Chain | Residue |
J | SER241 |
J | VAL242 |
site_id | AF7 |
Number of Residues | 7 |
Details | binding site for residue MN J 503 |
Chain | Residue |
J | ASP256 |
J | ILE257 |
J | VAL258 |
J | GLY259 |
J | ASP300 |
J | ARG344 |
J | ONM501 |
site_id | AF8 |
Number of Residues | 3 |
Details | binding site for residue MN J 504 |
Chain | Residue |
J | ASP256 |
J | ASP300 |
J | ONM501 |
site_id | AF9 |
Number of Residues | 5 |
Details | binding site for residue SO4 J 505 |
Chain | Residue |
G | ARG274 |
H | SER241 |
H | VAL242 |
J | ALA270 |
J | ARG274 |
site_id | AG1 |
Number of Residues | 4 |
Details | binding site for residue SO4 H 501 |
Chain | Residue |
G | ALA224 |
G | GLU293 |
H | ARG360 |
H | ARG361 |
site_id | AG2 |
Number of Residues | 4 |
Details | binding site for residue MN H 502 |
Chain | Residue |
H | ASP256 |
H | ILE257 |
H | ASP300 |
H | ONM504 |
site_id | AG3 |
Number of Residues | 2 |
Details | binding site for residue MN H 503 |
Chain | Residue |
H | ASP256 |
H | ONM504 |
site_id | AG4 |
Number of Residues | 20 |
Details | binding site for residue ONM H 504 |
Chain | Residue |
G | PHE254 |
G | LYS296 |
G | TRP367 |
G | GLY368 |
G | ASP369 |
G | VAL371 |
G | ASN372 |
G | SER375 |
H | ASP256 |
H | ILE257 |
H | VAL258 |
H | GLY259 |
H | PHE260 |
H | THR261 |
H | GLU262 |
H | PRO269 |
H | ASP300 |
H | ARG344 |
H | MN502 |
H | MN503 |
site_id | AG5 |
Number of Residues | 19 |
Details | binding site for residue ONM G 501 |
Chain | Residue |
G | ASP256 |
G | ILE257 |
G | PHE260 |
G | THR261 |
G | PRO269 |
G | LEU272 |
G | GLY299 |
G | ASP300 |
G | ARG344 |
G | MN502 |
G | MN503 |
H | PHE254 |
H | LYS296 |
H | MET303 |
H | ASP365 |
H | TRP367 |
H | ASN372 |
H | ARG376 |
H | LYS411 |
site_id | AG6 |
Number of Residues | 4 |
Details | binding site for residue MN G 502 |
Chain | Residue |
G | ASP256 |
G | ILE257 |
G | ASP300 |
G | ONM501 |
site_id | AG7 |
Number of Residues | 3 |
Details | binding site for residue MN G 503 |
Chain | Residue |
G | ASP256 |
G | ASP300 |
G | ONM501 |
site_id | AG8 |
Number of Residues | 14 |
Details | binding site for residue ONM K 501 |
Chain | Residue |
K | ASP256 |
K | ILE257 |
K | GLY259 |
K | PHE260 |
K | THR261 |
K | GLU262 |
K | PRO269 |
K | LEU272 |
K | SER298 |
K | GLY299 |
K | ASP300 |
K | ARG344 |
K | MN502 |
K | MN503 |
site_id | AG9 |
Number of Residues | 5 |
Details | binding site for residue MN K 502 |
Chain | Residue |
K | ASP256 |
K | ILE257 |
K | ASP300 |
K | ONM501 |
K | MN503 |
site_id | AH1 |
Number of Residues | 3 |
Details | binding site for residue MN K 503 |
Chain | Residue |
K | ASP256 |
K | ONM501 |
K | MN502 |
Functional Information from PROSITE/UniProt
site_id | PS00452 |
Number of Residues | 24 |
Details | GUANYLATE_CYCLASE_1 Guanylate cyclase signature. GVV.GsrrffYdVWGDAVNvasrmE |
Chain | Residue | Details |
A | GLY355-GLU378 |