5O1V

Crystal structure of WNK3 kinase domain in a monophosphorylated apo state (A-loop swapped)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue EDO A 501

Chain	Residue
A	THR227
A	GLU228
A	MET230
A	EDO504
A	HOH630
A	HOH697

---

site_id	AC2
Number of Residues	7
Details	binding site for residue EDO A 502

Chain	Residue
A	ASP294
A	LEU295
A	HOH697
A	HOH734
A	VAL207
A	PHE209
A	GLY293

---

site_id	AC3
Number of Residues	5
Details	binding site for residue EDO A 503

Chain	Residue
A	GLU194
A	ILE272
A	HIS273
A	LEU295
A	GLY296

---

site_id	AC4
Number of Residues	5
Details	binding site for residue EDO A 504

Chain	Residue
A	LYS159
A	VAL161
A	ASP294
A	LEU297
A	EDO501

---

site_id	AC5
Number of Residues	4
Details	binding site for residue EDO A 505

Chain	Residue
A	ALA342
A	EDO509
A	HOH682
A	HOH689

---

site_id	AC6
Number of Residues	4
Details	binding site for residue EDO A 506

Chain	Residue
A	GLY364
A	LYS366
A	ILE386
A	HOH698

---

site_id	AC7
Number of Residues	4
Details	binding site for residue EDO A 507

Chain	Residue
A	GLN256
A	THR287
A	SER289
A	HOH648

---

site_id	AC8
Number of Residues	4
Details	binding site for residue EDO A 508

Chain	Residue
A	ARG387
A	GLU392
A	LEU394
A	HOH601

---

site_id	AC9
Number of Residues	4
Details	binding site for residue EDO A 509

Chain	Residue
A	ALA342
A	LYS372
A	EDO505
A	HOH602

---

site_id	AD1
Number of Residues	2
Details	binding site for residue EDO A 510

Chain	Residue
A	THR374
A	ASP375

---

site_id	AD2
Number of Residues	7
Details	binding site for residue EDO B 501

Chain	Residue
B	ALA137
B	ALA139
B	THR140
B	HOH613
B	HOH654
B	HOH699
B	HOH702

---

site_id	AD3
Number of Residues	7
Details	binding site for residue EDO B 502

Chain	Residue
B	VAL207
B	THR227
B	GLU228
B	LEU229
B	MET230
B	EDO505
B	HOH771

---

site_id	AD4
Number of Residues	3
Details	binding site for residue EDO B 503

Chain	Residue
B	ARG251
B	ALA403
B	PHE404

---

site_id	AD5
Number of Residues	4
Details	binding site for residue EDO B 504

Chain	Residue
B	GLU323
B	HIS324
B	TYR325
B	HOH752

---

site_id	AD6
Number of Residues	6
Details	binding site for residue EDO B 505

Chain	Residue
B	LYS159
B	GLY293
B	ASP294
B	EDO502
B	HOH623
B	HOH739

---

site_id	AD7
Number of Residues	3
Details	binding site for residue EDO B 506

Chain	Residue
A	PRO286
B	GLU172
B	HOH602

---

Functional Information from PROSITE/UniProt

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKcdNIFI

Chain	Residue	Details
A	ILE271-ILE283

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"Q9JIH7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9H4A3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by autocatalysis","evidences":[{"source":"UniProtKB","id":"Q9JIH7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by autocatalysis","evidences":[{"source":"PubMed","id":"33439774","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---