5O0A
Crystal structure of Phosphopantetheine adenylyltransferase from Mycobacterium abcessus in complex with 5-methyl-1-phenyl-pyrazole-4-carboxylic acid (Fragment 1)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004595 | molecular_function | pantetheine-phosphate adenylyltransferase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0015937 | biological_process | coenzyme A biosynthetic process |
| A | 0016779 | molecular_function | nucleotidyltransferase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004595 | molecular_function | pantetheine-phosphate adenylyltransferase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0015937 | biological_process | coenzyme A biosynthetic process |
| B | 0016779 | molecular_function | nucleotidyltransferase activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004595 | molecular_function | pantetheine-phosphate adenylyltransferase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0009058 | biological_process | biosynthetic process |
| C | 0015937 | biological_process | coenzyme A biosynthetic process |
| C | 0016779 | molecular_function | nucleotidyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue 9FH A 201 |
| Chain | Residue |
| A | THR14 |
| A | HOH304 |
| A | HOH306 |
| A | GLY16 |
| A | HIS17 |
| A | ARG90 |
| A | THR118 |
| A | TYR122 |
| A | VAL125 |
| A | SER126 |
| A | SER127 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue 9FH B 201 |
| Chain | Residue |
| B | THR14 |
| B | GLY16 |
| B | HIS17 |
| B | ARG90 |
| B | THR118 |
| B | TYR122 |
| B | VAL125 |
| B | SER126 |
| B | SER127 |
| B | HOH337 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue 9FH C 201 |
| Chain | Residue |
| C | THR14 |
| C | GLY16 |
| C | HIS17 |
| C | ARG90 |
| C | THR118 |
| C | TYR122 |
| C | VAL125 |
| C | SER126 |
| C | SER127 |
| C | HOH303 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00151 |
| Chain | Residue | Details |
| A | SER9 | |
| B | HIS17 | |
| B | LYS41 | |
| B | LEU73 | |
| B | LYS87 | |
| B | GLY88 | |
| B | GLU98 | |
| B | TYR122 | |
| C | SER9 | |
| C | HIS17 | |
| C | LYS41 | |
| A | HIS17 | |
| C | LEU73 | |
| C | LYS87 | |
| C | GLY88 | |
| C | GLU98 | |
| C | TYR122 | |
| A | LYS41 | |
| A | LEU73 | |
| A | LYS87 | |
| A | GLY88 | |
| A | GLU98 | |
| A | TYR122 | |
| B | SER9 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | SITE: Transition state stabilizer => ECO:0000255|HAMAP-Rule:MF_00151 |
| Chain | Residue | Details |
| A | HIS17 | |
| B | HIS17 | |
| C | HIS17 |
