Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5NZT

The structure of the COPI coat linkage I

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0003729	molecular_function	mRNA binding
A	0005198	molecular_function	structural molecule activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0005794	cellular_component	Golgi apparatus
A	0006886	biological_process	intracellular protein transport
A	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
A	0006890	biological_process	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
A	0006891	biological_process	intra-Golgi vesicle-mediated transport
A	0016192	biological_process	vesicle-mediated transport
A	0030117	cellular_component	membrane coat
A	0030126	cellular_component	COPI vesicle coat
A	0030137	cellular_component	COPI-coated vesicle
A	0030157	biological_process	pancreatic juice secretion
A	0030424	cellular_component	axon
A	0030426	cellular_component	growth cone
A	0030663	cellular_component	COPI-coated vesicle membrane
A	0044297	cellular_component	cell body
A	0099612	biological_process	protein localization to axon
A	1902463	biological_process	protein localization to cell leading edge
B	0000139	cellular_component	Golgi membrane
B	0005198	molecular_function	structural molecule activity
B	0005737	cellular_component	cytoplasm
B	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
B	0005794	cellular_component	Golgi apparatus
B	0005798	cellular_component	Golgi-associated vesicle
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006886	biological_process	intracellular protein transport
B	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
B	0006891	biological_process	intra-Golgi vesicle-mediated transport
B	0016192	biological_process	vesicle-mediated transport
B	0030117	cellular_component	membrane coat
B	0030126	cellular_component	COPI vesicle coat
B	0030137	cellular_component	COPI-coated vesicle
B	0030663	cellular_component	COPI-coated vesicle membrane
C	0000139	cellular_component	Golgi membrane
C	0005080	molecular_function	protein kinase C binding
C	0005198	molecular_function	structural molecule activity
C	0005794	cellular_component	Golgi apparatus
C	0005829	cellular_component	cytosol
C	0006886	biological_process	intracellular protein transport
C	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
C	0006890	biological_process	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
C	0006891	biological_process	intra-Golgi vesicle-mediated transport
C	0016192	biological_process	vesicle-mediated transport
C	0030117	cellular_component	membrane coat
C	0030126	cellular_component	COPI vesicle coat
C	0030663	cellular_component	COPI-coated vesicle membrane
D	0000139	cellular_component	Golgi membrane
D	0005737	cellular_component	cytoplasm
D	0005783	cellular_component	endoplasmic reticulum
D	0005794	cellular_component	Golgi apparatus
D	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
D	0006890	biological_process	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
D	0008344	biological_process	adult locomotory behavior
D	0021691	biological_process	cerebellar Purkinje cell layer maturation
D	0030126	cellular_component	COPI vesicle coat
D	0030137	cellular_component	COPI-coated vesicle
D	0030663	cellular_component	COPI-coated vesicle membrane
D	0031410	cellular_component	cytoplasmic vesicle
D	0043473	biological_process	pigmentation
D	0048193	biological_process	Golgi vesicle transport
D	0051645	biological_process	Golgi localization
E	0000139	cellular_component	Golgi membrane
E	0005198	molecular_function	structural molecule activity
E	0005515	molecular_function	protein binding
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005794	cellular_component	Golgi apparatus
E	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
E	0006890	biological_process	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
E	0006891	biological_process	intra-Golgi vesicle-mediated transport
E	0030126	cellular_component	COPI vesicle coat
E	0030137	cellular_component	COPI-coated vesicle
E	0030663	cellular_component	COPI-coated vesicle membrane
E	0031410	cellular_component	cytoplasmic vesicle
E	0099612	biological_process	protein localization to axon
F	0003924	molecular_function	GTPase activity
F	0003925	molecular_function	G protein activity
F	0005515	molecular_function	protein binding
F	0005525	molecular_function	GTP binding
F	0005794	cellular_component	Golgi apparatus
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006886	biological_process	intracellular protein transport
F	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
F	0006893	biological_process	Golgi to plasma membrane transport
F	0010636	biological_process	positive regulation of mitochondrial fusion
F	0016236	biological_process	macroautophagy
F	0019217	biological_process	regulation of fatty acid metabolic process
F	0044232	cellular_component	organelle membrane contact site
F	0048193	biological_process	Golgi vesicle transport
F	0090141	biological_process	positive regulation of mitochondrial fission
F	1903292	biological_process	protein localization to Golgi membrane
F	1903358	biological_process	regulation of Golgi organization
G	0000139	cellular_component	Golgi membrane
G	0005198	molecular_function	structural molecule activity
G	0005783	cellular_component	endoplasmic reticulum
G	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
G	0005794	cellular_component	Golgi apparatus
G	0005829	cellular_component	cytosol
G	0006886	biological_process	intracellular protein transport
G	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
G	0006891	biological_process	intra-Golgi vesicle-mediated transport
G	0009306	biological_process	protein secretion
G	0016192	biological_process	vesicle-mediated transport
G	0030117	cellular_component	membrane coat
G	0030126	cellular_component	COPI vesicle coat
G	0030663	cellular_component	COPI-coated vesicle membrane
G	0051683	biological_process	establishment of Golgi localization
G	0072384	biological_process	organelle transport along microtubule
H	0000139	cellular_component	Golgi membrane
H	0005080	molecular_function	protein kinase C binding
H	0005198	molecular_function	structural molecule activity
H	0005794	cellular_component	Golgi apparatus
H	0005829	cellular_component	cytosol
H	0006886	biological_process	intracellular protein transport
H	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
H	0006890	biological_process	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
H	0006891	biological_process	intra-Golgi vesicle-mediated transport
H	0016192	biological_process	vesicle-mediated transport
H	0030117	cellular_component	membrane coat
H	0030126	cellular_component	COPI vesicle coat
H	0030663	cellular_component	COPI-coated vesicle membrane
I	0000139	cellular_component	Golgi membrane
I	0005737	cellular_component	cytoplasm
I	0005783	cellular_component	endoplasmic reticulum
I	0005794	cellular_component	Golgi apparatus
I	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
I	0006890	biological_process	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
I	0008344	biological_process	adult locomotory behavior
I	0021691	biological_process	cerebellar Purkinje cell layer maturation
I	0030126	cellular_component	COPI vesicle coat
I	0030137	cellular_component	COPI-coated vesicle
I	0030663	cellular_component	COPI-coated vesicle membrane
I	0031410	cellular_component	cytoplasmic vesicle
I	0043473	biological_process	pigmentation
I	0048193	biological_process	Golgi vesicle transport
I	0051645	biological_process	Golgi localization
J	0003924	molecular_function	GTPase activity
J	0003925	molecular_function	G protein activity
J	0005515	molecular_function	protein binding
J	0005525	molecular_function	GTP binding
J	0005794	cellular_component	Golgi apparatus
J	0005829	cellular_component	cytosol
J	0005886	cellular_component	plasma membrane
J	0006886	biological_process	intracellular protein transport
J	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
J	0006893	biological_process	Golgi to plasma membrane transport
J	0010636	biological_process	positive regulation of mitochondrial fusion
J	0016236	biological_process	macroautophagy
J	0019217	biological_process	regulation of fatty acid metabolic process
J	0044232	cellular_component	organelle membrane contact site
J	0048193	biological_process	Golgi vesicle transport
J	0090141	biological_process	positive regulation of mitochondrial fission
J	1903292	biological_process	protein localization to Golgi membrane
J	1903358	biological_process	regulation of Golgi organization
K	0000139	cellular_component	Golgi membrane
K	0005198	molecular_function	structural molecule activity
K	0005783	cellular_component	endoplasmic reticulum
K	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
K	0005794	cellular_component	Golgi apparatus
K	0005829	cellular_component	cytosol
K	0006886	biological_process	intracellular protein transport
K	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
K	0006891	biological_process	intra-Golgi vesicle-mediated transport
K	0009306	biological_process	protein secretion
K	0016192	biological_process	vesicle-mediated transport
K	0030117	cellular_component	membrane coat
K	0030126	cellular_component	COPI vesicle coat
K	0030663	cellular_component	COPI-coated vesicle membrane
K	0051683	biological_process	establishment of Golgi localization
K	0072384	biological_process	organelle transport along microtubule
L	0000139	cellular_component	Golgi membrane
L	0003674	molecular_function	molecular_function
L	0005737	cellular_component	cytoplasm
L	0006886	biological_process	intracellular protein transport
L	0006890	biological_process	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
L	0006891	biological_process	intra-Golgi vesicle-mediated transport
L	0016192	biological_process	vesicle-mediated transport
L	0030117	cellular_component	membrane coat
L	0030126	cellular_component	COPI vesicle coat
L	0030663	cellular_component	COPI-coated vesicle membrane
M	0003924	molecular_function	GTPase activity
M	0003925	molecular_function	G protein activity
M	0005515	molecular_function	protein binding
M	0005525	molecular_function	GTP binding
M	0005794	cellular_component	Golgi apparatus
M	0005829	cellular_component	cytosol
M	0005886	cellular_component	plasma membrane
M	0006886	biological_process	intracellular protein transport
M	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
M	0006893	biological_process	Golgi to plasma membrane transport
M	0010636	biological_process	positive regulation of mitochondrial fusion
M	0016236	biological_process	macroautophagy
M	0019217	biological_process	regulation of fatty acid metabolic process
M	0044232	cellular_component	organelle membrane contact site
M	0048193	biological_process	Golgi vesicle transport
M	0090141	biological_process	positive regulation of mitochondrial fission
M	1903292	biological_process	protein localization to Golgi membrane
M	1903358	biological_process	regulation of Golgi organization
N	0000139	cellular_component	Golgi membrane
N	0005198	molecular_function	structural molecule activity
N	0005737	cellular_component	cytoplasm
N	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
N	0005794	cellular_component	Golgi apparatus
N	0005798	cellular_component	Golgi-associated vesicle
N	0005829	cellular_component	cytosol
N	0005886	cellular_component	plasma membrane
N	0006886	biological_process	intracellular protein transport
N	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
N	0006891	biological_process	intra-Golgi vesicle-mediated transport
N	0016192	biological_process	vesicle-mediated transport
N	0030117	cellular_component	membrane coat
N	0030126	cellular_component	COPI vesicle coat
N	0030137	cellular_component	COPI-coated vesicle
N	0030663	cellular_component	COPI-coated vesicle membrane
R	0003924	molecular_function	GTPase activity
R	0003925	molecular_function	G protein activity
R	0005515	molecular_function	protein binding
R	0005525	molecular_function	GTP binding
R	0005794	cellular_component	Golgi apparatus
R	0005829	cellular_component	cytosol
R	0005886	cellular_component	plasma membrane
R	0006886	biological_process	intracellular protein transport
R	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
R	0006893	biological_process	Golgi to plasma membrane transport
R	0010636	biological_process	positive regulation of mitochondrial fusion
R	0016236	biological_process	macroautophagy
R	0019217	biological_process	regulation of fatty acid metabolic process
R	0044232	cellular_component	organelle membrane contact site
R	0048193	biological_process	Golgi vesicle transport
R	0090141	biological_process	positive regulation of mitochondrial fission
R	1903292	biological_process	protein localization to Golgi membrane
R	1903358	biological_process	regulation of Golgi organization
Z	0000139	cellular_component	Golgi membrane
Z	0003674	molecular_function	molecular_function
Z	0005737	cellular_component	cytoplasm
Z	0006886	biological_process	intracellular protein transport
Z	0006890	biological_process	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
Z	0006891	biological_process	intra-Golgi vesicle-mediated transport
Z	0016192	biological_process	vesicle-mediated transport
Z	0030117	cellular_component	membrane coat
Z	0030126	cellular_component	COPI vesicle coat
Z	0030663	cellular_component	COPI-coated vesicle membrane

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. VVSAslDqTVRVWDI

Chain	Residue	Details
A	VAL150-ILE164

site_id	PS00989
Number of Residues	11
Details	CLAT_ADAPTOR_S Clathrin adaptor complexes small chain signature. VVYKssidLYF

Chain	Residue	Details
Z	VAL67-PHE77

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	34
Details	Peptide: {"description":"Proxenin","featureId":"PRO_0000327497"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	24
Details	Peptide: {"description":"Xenin","featureId":"PRO_0000327498"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	108
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	108
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	108
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	110
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	112
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	108
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P53621","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	1
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"UniProtKB","id":"P53621","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P53621","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"O14579","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	144
Details	Repeat: {"description":"HEAT 1"}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	109
Details	Repeat: {"description":"HEAT 2"}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	105
Details	Repeat: {"description":"HEAT 3"}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	110
Details	Repeat: {"description":"HEAT 4"}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	74
Details	Repeat: {"description":"HEAT 5"}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	74
Details	Repeat: {"description":"HEAT 6"}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"23806337","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	76
Details	Repeat: {"description":"WD 7"}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	70
Details	Repeat: {"description":"WD 8"}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	37
Details	Repeat: {"description":"WD 9"}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P35606","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P48444","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P48444","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	52
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20601958","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI28
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI29
Number of Residues	530
Details	Region: {"description":"Interaction with ZNF289/ARFGAP2","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)