5NUG
Motor domains from human cytoplasmic dynein-1 in the phi-particle conformation
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005813 | cellular_component | centrosome |
| A | 0005829 | cellular_component | cytosol |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0005858 | cellular_component | axonemal dynein complex |
| A | 0005868 | cellular_component | cytoplasmic dynein complex |
| A | 0005874 | cellular_component | microtubule |
| A | 0005881 | cellular_component | cytoplasmic microtubule |
| A | 0005938 | cellular_component | cell cortex |
| A | 0007018 | biological_process | microtubule-based movement |
| A | 0007049 | biological_process | cell cycle |
| A | 0007052 | biological_process | mitotic spindle organization |
| A | 0007097 | biological_process | nuclear migration |
| A | 0008090 | biological_process | retrograde axonal transport |
| A | 0008569 | molecular_function | minus-end-directed microtubule motor activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0030175 | cellular_component | filopodium |
| A | 0030286 | cellular_component | dynein complex |
| A | 0031122 | biological_process | cytoplasmic microtubule organization |
| A | 0032388 | biological_process | positive regulation of intracellular transport |
| A | 0033962 | biological_process | P-body assembly |
| A | 0034063 | biological_process | stress granule assembly |
| A | 0035578 | cellular_component | azurophil granule lumen |
| A | 0045505 | molecular_function | dynein intermediate chain binding |
| A | 0051293 | biological_process | establishment of spindle localization |
| A | 0051301 | biological_process | cell division |
| A | 0051959 | molecular_function | dynein light intermediate chain binding |
| A | 0060236 | biological_process | regulation of mitotic spindle organization |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0090235 | biological_process | regulation of metaphase plate congression |
| A | 0120162 | biological_process | positive regulation of cold-induced thermogenesis |
| A | 1904115 | cellular_component | axon cytoplasm |
| A | 1905832 | biological_process | positive regulation of spindle assembly |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003723 | molecular_function | RNA binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005813 | cellular_component | centrosome |
| B | 0005829 | cellular_component | cytosol |
| B | 0005856 | cellular_component | cytoskeleton |
| B | 0005858 | cellular_component | axonemal dynein complex |
| B | 0005868 | cellular_component | cytoplasmic dynein complex |
| B | 0005874 | cellular_component | microtubule |
| B | 0005881 | cellular_component | cytoplasmic microtubule |
| B | 0005938 | cellular_component | cell cortex |
| B | 0007018 | biological_process | microtubule-based movement |
| B | 0007049 | biological_process | cell cycle |
| B | 0007052 | biological_process | mitotic spindle organization |
| B | 0007097 | biological_process | nuclear migration |
| B | 0008090 | biological_process | retrograde axonal transport |
| B | 0008569 | molecular_function | minus-end-directed microtubule motor activity |
| B | 0016020 | cellular_component | membrane |
| B | 0016887 | molecular_function | ATP hydrolysis activity |
| B | 0030175 | cellular_component | filopodium |
| B | 0030286 | cellular_component | dynein complex |
| B | 0031122 | biological_process | cytoplasmic microtubule organization |
| B | 0032388 | biological_process | positive regulation of intracellular transport |
| B | 0033962 | biological_process | P-body assembly |
| B | 0034063 | biological_process | stress granule assembly |
| B | 0035578 | cellular_component | azurophil granule lumen |
| B | 0045505 | molecular_function | dynein intermediate chain binding |
| B | 0051293 | biological_process | establishment of spindle localization |
| B | 0051301 | biological_process | cell division |
| B | 0051959 | molecular_function | dynein light intermediate chain binding |
| B | 0060236 | biological_process | regulation of mitotic spindle organization |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0090235 | biological_process | regulation of metaphase plate congression |
| B | 0120162 | biological_process | positive regulation of cold-induced thermogenesis |
| B | 1904115 | cellular_component | axon cytoplasm |
| B | 1905832 | biological_process | positive regulation of spindle assembly |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue ADP A 4801 |
| Chain | Residue |
| A | LEU1879 |
| A | ILE2049 |
| A | LEU2090 |
| A | ARG2091 |
| A | LYS2094 |
| A | ASP2320 |
| A | ASP2321 |
| A | ARG2358 |
| A | VAL1880 |
| A | THR1885 |
| A | GLY1909 |
| A | GLY1911 |
| A | LYS1912 |
| A | THR1913 |
| A | GLU1914 |
| A | ASP1958 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | binding site for residue ATP A 4802 |
| Chain | Residue |
| A | LEU2191 |
| A | THR2192 |
| A | TRP2203 |
| A | SER2226 |
| A | GLY2227 |
| A | SER2228 |
| A | GLY2229 |
| A | LYS2230 |
| A | SER2231 |
| A | MET2232 |
| A | GLU2344 |
| A | LEU2369 |
| A | MET2373 |
| A | ASN2377 |
| A | ARG2684 |
| A | ARG2726 |
| A | ARG2729 |
| A | MG4803 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 4803 |
| Chain | Residue |
| A | LYS2230 |
| A | SER2231 |
| A | GLU2344 |
| A | GLU2688 |
| A | ATP4802 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | binding site for residue ADP A 4804 |
| Chain | Residue |
| A | THR2571 |
| A | THR2574 |
| A | PRO2597 |
| A | GLY2598 |
| A | SER2599 |
| A | GLY2600 |
| A | LYS2601 |
| A | THR2602 |
| A | MET2603 |
| A | PRO2739 |
| A | ILE2747 |
| A | PRO2796 |
| A | ARG2797 |
| A | THR2800 |
| site_id | AC5 |
| Number of Residues | 13 |
| Details | binding site for residue ADP A 4805 |
| Chain | Residue |
| A | VAL2907 |
| A | LEU2909 |
| A | VAL2910 |
| A | SER2939 |
| A | GLY2940 |
| A | ALA2941 |
| A | GLY2942 |
| A | LYS2943 |
| A | THR2944 |
| A | THR2945 |
| A | TRP3097 |
| A | ARG3174 |
| A | LEU3177 |
| site_id | AC6 |
| Number of Residues | 16 |
| Details | binding site for residue ADP B 4801 |
| Chain | Residue |
| B | LEU1879 |
| B | VAL1880 |
| B | THR1885 |
| B | GLY1909 |
| B | GLY1911 |
| B | LYS1912 |
| B | THR1913 |
| B | GLU1914 |
| B | ASP1958 |
| B | ILE2049 |
| B | LEU2090 |
| B | ARG2091 |
| B | LYS2094 |
| B | ASP2320 |
| B | ASP2321 |
| B | ARG2358 |
| site_id | AC7 |
| Number of Residues | 18 |
| Details | binding site for residue ATP B 4802 |
| Chain | Residue |
| B | MG4803 |
| B | LEU2191 |
| B | THR2192 |
| B | TRP2203 |
| B | SER2226 |
| B | GLY2227 |
| B | SER2228 |
| B | GLY2229 |
| B | LYS2230 |
| B | SER2231 |
| B | MET2232 |
| B | GLU2344 |
| B | LEU2369 |
| B | MET2373 |
| B | ASN2377 |
| B | ARG2684 |
| B | ARG2726 |
| B | ARG2729 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 4803 |
| Chain | Residue |
| B | LYS2230 |
| B | SER2231 |
| B | GLU2344 |
| B | GLU2688 |
| B | ATP4802 |
| site_id | AC9 |
| Number of Residues | 14 |
| Details | binding site for residue ADP B 4804 |
| Chain | Residue |
| B | THR2571 |
| B | THR2574 |
| B | PRO2597 |
| B | GLY2598 |
| B | SER2599 |
| B | GLY2600 |
| B | LYS2601 |
| B | THR2602 |
| B | MET2603 |
| B | PRO2739 |
| B | ILE2747 |
| B | PRO2796 |
| B | ARG2797 |
| B | THR2800 |
| site_id | AD1 |
| Number of Residues | 13 |
| Details | binding site for residue ADP B 4805 |
| Chain | Residue |
| B | VAL2907 |
| B | LEU2909 |
| B | VAL2910 |
| B | SER2939 |
| B | GLY2940 |
| B | ALA2941 |
| B | GLY2942 |
| B | LYS2943 |
| B | THR2944 |
| B | THR2945 |
| B | TRP3097 |
| B | ARG3174 |
| B | LEU3177 |
Functional Information from PROSITE/UniProt
| site_id | PS00639 |
| Number of Residues | 11 |
| Details | THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. INHGLMMVGPS |
| Chain | Residue | Details |
| A | ILE2216-SER2226 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255 |
| Chain | Residue | Details |
| A | GLY1906 | |
| A | GLY2224 | |
| A | GLY2595 | |
| A | GLY2937 | |
| B | GLY1906 | |
| B | GLY2224 | |
| B | GLY2595 | |
| B | GLY2937 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylserine => ECO:0007744|PubMed:22223895 |
| Chain | Residue | Details |
| A | SER2 | |
| B | SER2 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER70 | |
| A | SER4162 | |
| B | SER70 | |
| B | SER4162 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS1125 | |
| A | LYS3480 | |
| A | LYS4283 | |
| B | LYS1125 | |
| B | LYS3480 | |
| B | LYS4283 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9JHU4 |
| Chain | Residue | Details |
| A | SER1230 | |
| B | SER1230 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | THR4366 | |
| B | THR4366 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER4368 | |
| B | SER4368 |
