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5NU3

Crystal structure of the human bromodomain of CREBBP bound to the inhibitor XDM-CBP

Functional Information from GO Data
ChainGOidnamespacecontents
A0004402molecular_functionhistone acetyltransferase activity
A0006355biological_processregulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues13
Detailsbinding site for residue 99E A 1201
ChainResidue
ALEU1109
AHOH1317
AHOH1333
AHOH1351
AHOH1366
APRO1110
AVAL1115
ALEU1120
ATYR1125
ATYR1167
AASN1168
AARG1173
AVAL1174

site_idAC2
Number of Residues3
Detailsbinding site for residue BU3 A 1202
ChainResidue
AARG1173
AGLU1183
ABU31204

site_idAC3
Number of Residues5
Detailsbinding site for residue BU3 A 1203
ChainResidue
AARG1103
AGLN1104
AASP1105
ALYS1170
AHOH1315

site_idAC4
Number of Residues6
Detailsbinding site for residue BU3 A 1204
ChainResidue
ATRP1165
AARG1173
APHE1177
ASER1179
ABU31202
AHOH1464

site_idAC5
Number of Residues5
Detailsbinding site for residue BU3 A 1205
ChainResidue
ALYS1141
AGLN1146
AHOH1307
AHOH1320
AHOH1336

site_idAC6
Number of Residues5
Detailsbinding site for residue SO4 A 1206
ChainResidue
AARG1169
ALYS1170
AGLN1194
AHOH1369
AHOH1390

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. SlpFrqpvDpqllgipDYFdiVknpMdlstIkrkldtgq..Yqepwqyvddvwl.MfnNAwlY
ChainResidueDetails
ASER1108-TYR1167

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues107
DetailsDomain: {"description":"Bromo","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues46
DetailsRegion: {"description":"Interaction with histone","evidences":[{"source":"PubMed","id":"24361270","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues18
DetailsRegion: {"description":"Interaction with ASF1A","evidences":[{"source":"PubMed","id":"24616510","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

246031

PDB entries from 2025-12-10

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