Functional Information from GO Data
| Chain | GOid | namespace | contents |
| b | 0003677 | molecular_function | DNA binding |
| b | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| b | 0005524 | molecular_function | ATP binding |
| b | 0006259 | biological_process | DNA metabolic process |
| b | 0006265 | biological_process | DNA topological change |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006259 | biological_process | DNA metabolic process |
| B | 0006265 | biological_process | DNA topological change |
| d | 0003677 | molecular_function | DNA binding |
| d | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| d | 0005524 | molecular_function | ATP binding |
| d | 0006259 | biological_process | DNA metabolic process |
| d | 0006265 | biological_process | DNA topological change |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0006259 | biological_process | DNA metabolic process |
| D | 0006265 | biological_process | DNA topological change |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue MN B 1501 |
| Chain | Residue |
| B | ASP508 |
| B | ASP510 |
| B | HOH1724 |
| B | HOH1840 |
| B | HOH1990 |
| E | HOH132 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | binding site for residue 94H B 1502 |
| Chain | Residue |
| B | MET1027 |
| B | MET1179 |
| B | ARG1342 |
| B | PRO1343 |
| B | HOH1683 |
| B | HOH1926 |
| B | HOH1952 |
| B | HOH1970 |
| B | HOH2016 |
| D | HOH1611 |
| B | ARG630 |
| B | GLU634 |
| B | ALA637 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 1503 |
| Chain | Residue |
| B | ARG458 |
| B | HOH1602 |
| B | HOH1870 |
| E | DG-1 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 1504 |
| Chain | Residue |
| B | GLY446 |
| B | ARG447 |
| B | TRP592 |
| B | HOH1613 |
| B | HOH1978 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 1505 |
| Chain | Residue |
| B | MET1113 |
| B | GLY1115 |
| B | GLN1267 |
| B | VAL1268 |
| E | DC-5 |
| E | HOH143 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | binding site for residue 94H B 1506 |
| Chain | Residue |
| B | ILE1386 |
| B | ASP1389 |
| B | HIS1390 |
| B | GLU1393 |
| B | ARG1414 |
| b | ARG468 |
| e | DA-8 |
| e | 9JN101 |
| f | DT12 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue MN D 1501 |
| Chain | Residue |
| D | ASP508 |
| D | ASP510 |
| D | HOH1632 |
| D | HOH1961 |
| D | HOH1968 |
| F | HOH106 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue GOL D 1502 |
| Chain | Residue |
| D | SER445 |
| D | GLY446 |
| D | ASP589 |
| D | TRP592 |
| D | HOH1636 |
| D | HOH2005 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | binding site for residue 94H D 1503 |
| Chain | Residue |
| D | ARG630 |
| D | GLU634 |
| D | ALA637 |
| D | MET1027 |
| D | MET1179 |
| D | ARG1342 |
| D | PRO1343 |
| D | HOH1656 |
| site_id | AD1 |
| Number of Residues | 9 |
| Details | binding site for residue GOL D 1504 |
| Chain | Residue |
| B | LYS1066 |
| B | ARG1122 |
| B | HOH1781 |
| D | PRO1080 |
| D | HIS1081 |
| D | GLY1082 |
| D | HOH1658 |
| D | HOH1680 |
| D | HOH1916 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue GOL D 1505 |
| Chain | Residue |
| D | PRO1044 |
| D | ARG1047 |
| D | PRO1157 |
| D | HOH1775 |
| D | HOH1783 |
| D | HOH1867 |
| D | HOH1937 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL D 1506 |
| Chain | Residue |
| D | TYR1051 |
| D | GLU1055 |
| D | TYR1078 |
| D | GLU1154 |
| D | ARG1155 |
| D | HOH1606 |
| D | HOH1794 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue CL D 1507 |
| Chain | Residue |
| D | HIS1390 |
| D | HOH2114 |
| f | DA-8 |
| f | HOH110 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue MN b 1501 |
| Chain | Residue |
| b | ASP508 |
| b | ASP510 |
| b | HOH1641 |
| b | HOH1935 |
| b | HOH1962 |
| e | HOH224 |
| site_id | AD6 |
| Number of Residues | 14 |
| Details | binding site for residue 94H b 1502 |
| Chain | Residue |
| b | MET1027 |
| b | MET1179 |
| b | ARG1342 |
| b | PRO1343 |
| b | HOH1802 |
| b | HOH1845 |
| b | HOH1903 |
| b | HOH1986 |
| b | HOH2017 |
| d | GLU1235 |
| d | HOH1609 |
| b | ARG630 |
| b | GLU634 |
| b | ALA637 |
| site_id | AD7 |
| Number of Residues | 9 |
| Details | binding site for residue GOL b 1503 |
| Chain | Residue |
| b | MET1075 |
| b | PRO1080 |
| b | HIS1081 |
| b | HOH1653 |
| b | HOH1697 |
| b | HOH1772 |
| b | HOH1841 |
| d | ARG1122 |
| d | PHE1123 |
| site_id | AD8 |
| Number of Residues | 7 |
| Details | binding site for residue GOL b 1504 |
| Chain | Residue |
| b | PRO1044 |
| b | ARG1047 |
| b | HOH1634 |
| b | HOH1656 |
| b | HOH1666 |
| b | HOH1758 |
| b | HOH1820 |
| site_id | AD9 |
| Number of Residues | 8 |
| Details | binding site for residue GOL b 1505 |
| Chain | Residue |
| b | ARG1122 |
| b | PHE1123 |
| b | HOH1655 |
| b | HOH1660 |
| b | HOH1706 |
| d | MET1075 |
| d | PRO1080 |
| d | HIS1081 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 b 1506 |
| Chain | Residue |
| b | ARG1429 |
| b | HOH1627 |
| b | HOH1973 |
| d | ARG1429 |
| d | ARG1432 |
| site_id | AE2 |
| Number of Residues | 6 |
| Details | binding site for residue NA b 1507 |
| Chain | Residue |
| b | TYR1322 |
| b | LYS1323 |
| b | THR1325 |
| b | GLN1328 |
| b | HOH1991 |
| b | HOH2074 |
| site_id | AE3 |
| Number of Residues | 12 |
| Details | binding site for residue 9JN b 1508 |
| Chain | Residue |
| B | ARG468 |
| B | HOH2073 |
| E | DA-8 |
| F | DT12 |
| b | ARG1385 |
| b | ILE1386 |
| b | ASP1389 |
| b | HIS1390 |
| b | GLU1393 |
| b | ARG1414 |
| b | LYS1416 |
| b | 94H1509 |
| site_id | AE4 |
| Number of Residues | 13 |
| Details | binding site for residue 94H b 1509 |
| Chain | Residue |
| B | ARG468 |
| B | HOH2073 |
| E | DA-8 |
| F | DT12 |
| b | ILE1386 |
| b | ASP1389 |
| b | HIS1390 |
| b | GLU1393 |
| b | ARG1414 |
| b | PHE1415 |
| b | LYS1416 |
| b | 9JN1508 |
| b | HOH1718 |
| site_id | AE5 |
| Number of Residues | 6 |
| Details | binding site for residue MN d 1501 |
| Chain | Residue |
| d | ASP508 |
| d | ASP510 |
| d | HOH1649 |
| d | HOH1843 |
| d | HOH1879 |
| f | HOH131 |
| site_id | AE6 |
| Number of Residues | 9 |
| Details | binding site for residue 94H d 1502 |
| Chain | Residue |
| d | ARG630 |
| d | ILE633 |
| d | GLU634 |
| d | ALA637 |
| d | MET1027 |
| d | MET1179 |
| d | ARG1342 |
| d | PRO1343 |
| d | HOH1840 |
| site_id | AE7 |
| Number of Residues | 4 |
| Details | binding site for residue GOL d 1503 |
| Chain | Residue |
| d | GLY446 |
| d | ARG447 |
| d | ASP589 |
| d | HOH1607 |
| site_id | AE8 |
| Number of Residues | 7 |
| Details | binding site for residue GOL d 1504 |
| Chain | Residue |
| d | PRO1044 |
| d | ARG1047 |
| d | ARG1048 |
| d | GLU1156 |
| d | HOH1601 |
| d | HOH1653 |
| d | HOH1676 |
| site_id | AE9 |
| Number of Residues | 2 |
| Details | binding site for residue MN d 1505 |
| Chain | Residue |
| F | DA-8 |
| d | HIS1390 |
| site_id | AF1 |
| Number of Residues | 11 |
| Details | binding site for residue 9JN e 101 |
| Chain | Residue |
| B | ARG1385 |
| B | ILE1386 |
| B | ASP1389 |
| B | HIS1390 |
| B | GLU1393 |
| B | ARG1414 |
| B | 94H1506 |
| B | HOH1852 |
| b | ARG468 |
| e | DA-8 |
| f | DT12 |
| site_id | AF2 |
| Number of Residues | 9 |
| Details | binding site for residue GOL e 102 |
| Chain | Residue |
| b | ARG458 |
| b | GLY459 |
| e | DG-1 |
| e | DG1 |
| e | DT2 |
| e | HOH203 |
| e | HOH222 |
| f | DA3 |
| f | DC4 |
| site_id | AF3 |
| Number of Residues | 12 |
| Details | binding site for Di-peptide GLN b 1413 and ARG b 1414 |
| Chain | Residue |
| b | GLU1393 |
| b | THR1397 |
| b | GLU1409 |
| b | SER1410 |
| b | LEU1411 |
| b | GLN1412 |
| b | PHE1415 |
| b | LYS1416 |
| b | 9JN1508 |
| b | 94H1509 |
| b | HOH1741 |
| b | HOH2094 |
| site_id | AF4 |
| Number of Residues | 12 |
| Details | binding site for Di-peptide GLN b 1413 and ARG b 1414 |
| Chain | Residue |
| b | GLU1393 |
| b | THR1397 |
| b | GLU1409 |
| b | SER1410 |
| b | LEU1411 |
| b | GLN1412 |
| b | PHE1415 |
| b | LYS1416 |
| b | 9JN1508 |
| b | 94H1509 |
| b | HOH1741 |
| b | HOH2094 |
Functional Information from PROSITE/UniProt
| site_id | PS00177 |
| Number of Residues | 9 |
| Details | TOPOISOMERASE_II DNA topoisomerase II signature. LVEGDSAGG |
| Chain | Residue | Details |
| B | LEU433-GLY441 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| B | GLU435 | |
| d | GLU435 | |
| d | ASP508 | |
| d | ASP510 | |
| B | ASP508 | |
| B | ASP510 | |
| D | GLU435 | |
| D | ASP508 | |
| D | ASP510 | |
| b | GLU435 | |
| b | ASP508 | |
| b | ASP510 | |
| Chain | Residue | Details |
| B | LYS460 | |
| B | ASN463 | |
| D | LYS460 | |
| D | ASN463 | |
| b | LYS460 | |
| b | ASN463 | |
| d | LYS460 | |
| d | ASN463 | |
| Chain | Residue | Details |
| B | PHE1123 | |
| D | PHE1123 | |
| b | PHE1123 | |
| d | PHE1123 | |
