Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5NMI

Cytochrome bc1 bound to the inhibitor MJM170

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0016020	cellular_component	membrane
A	0046872	molecular_function	metal ion binding
A	0070469	cellular_component	respirasome
B	0004222	molecular_function	metalloendopeptidase activity
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0006508	biological_process	proteolysis
B	0016020	cellular_component	membrane
B	0046872	molecular_function	metal ion binding
B	0070469	cellular_component	respirasome
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0005750	cellular_component	mitochondrial respiratory chain complex III
C	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
C	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
C	0009055	molecular_function	electron transfer activity
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0020037	molecular_function	heme binding
C	0022904	biological_process	respiratory electron transport chain
C	0031966	cellular_component	mitochondrial membrane
C	0045275	cellular_component	respiratory chain complex III
C	0046872	molecular_function	metal ion binding
C	0048039	molecular_function	ubiquinone binding
C	0070469	cellular_component	respirasome
C	1902600	biological_process	proton transmembrane transport
D	0009055	molecular_function	electron transfer activity
D	0020037	molecular_function	heme binding
E	0005739	cellular_component	mitochondrion
E	0005743	cellular_component	mitochondrial inner membrane
E	0005750	cellular_component	mitochondrial respiratory chain complex III
E	0005886	cellular_component	plasma membrane
E	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
E	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
E	0016020	cellular_component	membrane
E	0016491	molecular_function	oxidoreductase activity
E	0046872	molecular_function	metal ion binding
E	0051536	molecular_function	iron-sulfur cluster binding
E	0051537	molecular_function	2 iron, 2 sulfur cluster binding
E	0070469	cellular_component	respirasome
E	1902600	biological_process	proton transmembrane transport
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0005750	cellular_component	mitochondrial respiratory chain complex III
F	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
F	0016020	cellular_component	membrane
F	0070469	cellular_component	respirasome
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0005750	cellular_component	mitochondrial respiratory chain complex III
G	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
G	0016020	cellular_component	membrane
G	0070469	cellular_component	respirasome
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0005750	cellular_component	mitochondrial respiratory chain complex III
H	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
H	0016020	cellular_component	membrane
H	0070469	cellular_component	respirasome
I	0005739	cellular_component	mitochondrion
I	0005743	cellular_component	mitochondrial inner membrane
I	0005750	cellular_component	mitochondrial respiratory chain complex III
I	0005886	cellular_component	plasma membrane
I	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
I	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
I	0016020	cellular_component	membrane
I	0016491	molecular_function	oxidoreductase activity
I	0046872	molecular_function	metal ion binding
I	0051536	molecular_function	iron-sulfur cluster binding
I	0051537	molecular_function	2 iron, 2 sulfur cluster binding
I	0070469	cellular_component	respirasome
I	1902600	biological_process	proton transmembrane transport
J	0005739	cellular_component	mitochondrion
J	0005743	cellular_component	mitochondrial inner membrane
J	0005750	cellular_component	mitochondrial respiratory chain complex III
J	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
J	0016020	cellular_component	membrane
J	0070469	cellular_component	respirasome
K	0005750	cellular_component	mitochondrial respiratory chain complex III
K	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
N	0005739	cellular_component	mitochondrion
N	0005743	cellular_component	mitochondrial inner membrane
N	0016020	cellular_component	membrane
N	0046872	molecular_function	metal ion binding
N	0070469	cellular_component	respirasome
O	0004222	molecular_function	metalloendopeptidase activity
O	0005739	cellular_component	mitochondrion
O	0005743	cellular_component	mitochondrial inner membrane
O	0006508	biological_process	proteolysis
O	0016020	cellular_component	membrane
O	0046872	molecular_function	metal ion binding
O	0070469	cellular_component	respirasome
P	0005739	cellular_component	mitochondrion
P	0005743	cellular_component	mitochondrial inner membrane
P	0005750	cellular_component	mitochondrial respiratory chain complex III
P	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
P	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
P	0009055	molecular_function	electron transfer activity
P	0016020	cellular_component	membrane
P	0016491	molecular_function	oxidoreductase activity
P	0020037	molecular_function	heme binding
P	0022904	biological_process	respiratory electron transport chain
P	0031966	cellular_component	mitochondrial membrane
P	0045275	cellular_component	respiratory chain complex III
P	0046872	molecular_function	metal ion binding
P	0048039	molecular_function	ubiquinone binding
P	0070469	cellular_component	respirasome
P	1902600	biological_process	proton transmembrane transport
Q	0009055	molecular_function	electron transfer activity
Q	0020037	molecular_function	heme binding
R	0005739	cellular_component	mitochondrion
R	0005743	cellular_component	mitochondrial inner membrane
R	0005750	cellular_component	mitochondrial respiratory chain complex III
R	0005886	cellular_component	plasma membrane
R	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
R	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
R	0016020	cellular_component	membrane
R	0016491	molecular_function	oxidoreductase activity
R	0046872	molecular_function	metal ion binding
R	0051536	molecular_function	iron-sulfur cluster binding
R	0051537	molecular_function	2 iron, 2 sulfur cluster binding
R	0070469	cellular_component	respirasome
R	1902600	biological_process	proton transmembrane transport
S	0005739	cellular_component	mitochondrion
S	0005743	cellular_component	mitochondrial inner membrane
S	0005750	cellular_component	mitochondrial respiratory chain complex III
S	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
S	0016020	cellular_component	membrane
S	0070469	cellular_component	respirasome
T	0005739	cellular_component	mitochondrion
T	0005743	cellular_component	mitochondrial inner membrane
T	0005750	cellular_component	mitochondrial respiratory chain complex III
T	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
T	0016020	cellular_component	membrane
T	0070469	cellular_component	respirasome
U	0005739	cellular_component	mitochondrion
U	0005743	cellular_component	mitochondrial inner membrane
U	0005750	cellular_component	mitochondrial respiratory chain complex III
U	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
U	0016020	cellular_component	membrane
U	0070469	cellular_component	respirasome
V	0005739	cellular_component	mitochondrion
V	0005743	cellular_component	mitochondrial inner membrane
V	0005750	cellular_component	mitochondrial respiratory chain complex III
V	0005886	cellular_component	plasma membrane
V	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
V	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
V	0016020	cellular_component	membrane
V	0016491	molecular_function	oxidoreductase activity
V	0046872	molecular_function	metal ion binding
V	0051536	molecular_function	iron-sulfur cluster binding
V	0051537	molecular_function	2 iron, 2 sulfur cluster binding
V	0070469	cellular_component	respirasome
V	1902600	biological_process	proton transmembrane transport
W	0005739	cellular_component	mitochondrion
W	0005743	cellular_component	mitochondrial inner membrane
W	0005750	cellular_component	mitochondrial respiratory chain complex III
W	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
W	0016020	cellular_component	membrane
W	0070469	cellular_component	respirasome
X	0005750	cellular_component	mitochondrial respiratory chain complex III
X	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue HEM C 501

Chain	Residue
C	GLN44
C	PHE179
C	HIS182
C	PHE183
C	PRO186
C	GLY48
C	TYR55
C	ARG80
C	HIS83
C	THR126
C	GLY130
C	LEU133
C	PRO134

site_id	AC2
Number of Residues	17
Details	binding site for residue HEM C 502

Chain	Residue
C	TRP31
C	GLY34
C	LEU37
C	PHE90
C	LEU94
C	HIS97
C	VAL98
C	ARG100
C	SER106
C	TRP113
C	GLY116
C	VAL117
C	HIS196
C	LEU197
C	LEU200
C	ASN206
C	MJM503

site_id	AC3
Number of Residues	9
Details	binding site for residue MJM C 503

Chain	Residue
C	PHE18
C	TRP31
C	SER35
C	ILE39
C	LEU197
C	SER205
C	PHE220
C	ASP228
C	HEM502

site_id	AC4
Number of Residues	13
Details	binding site for residue PEE C 504

Chain	Residue
C	TRP30
C	TYR95
C	MET96
C	TYR103
C	TYR104
C	MET316
C	GLN322
C	PHE325
C	TRP326
C	CDL506
F	GLN72
G	CYS44
G	VAL48

site_id	AC5
Number of Residues	10
Details	binding site for residue CDL C 505

Chain	Residue
A	PHE336
A	ARG436
A	SER439
C	MET11
C	LYS12
C	ASN15
C	ASP20
C	HIS221
C	ILE229
E	PEE502

site_id	AC6
Number of Residues	7
Details	binding site for residue CDL C 506

Chain	Residue
C	SER28
C	SER29
C	TRP30
C	PEE504
F	GLN72
G	ARG40
G	CYS44

site_id	AC7
Number of Residues	15
Details	binding site for residue HEC D 501

Chain	Residue
D	VAL32
D	VAL36
D	CYS37
D	CYS40
D	HIS41
D	LEU109
D	PRO110
D	PRO111
D	ILE116
D	ARG120
D	TYR126
D	PHE153
D	GLY159
D	MET160
D	PRO163

site_id	AC8
Number of Residues	13
Details	binding site for residue PEE D 502

Chain	Residue
C	LEU43
C	ILE236
D	HIS200
D	MET204
D	LYS207
D	MET211
D	LEU215
E	TYR49
E	ALA50
E	ASN53
E	VAL54
E	GLN57
J	ASP36

site_id	AC9
Number of Residues	16
Details	binding site for residue CDL D 503

Chain	Residue
C	MET89
C	LYS227
C	LEU230
C	GLY231
D	TYR220
D	LYS223
D	ARG224
D	LYS231
F	MET70
G	PRO27
G	GLY33
G	ASN36
G	VAL37
G	ARG40
C	SER29
C	ASN32

site_id	AD1
Number of Residues	6
Details	binding site for residue FES E 501

Chain	Residue
E	CYS139
E	HIS141
E	LEU142
E	CYS158
E	HIS161
E	SER163

site_id	AD2
Number of Residues	8
Details	binding site for residue PEE E 502

Chain	Residue
A	PHE442
C	CDL505
E	TYR37
E	THR40
E	THR44
J	ARG15
J	THR17
J	PHE20

site_id	AD3
Number of Residues	9
Details	binding site for residue CDL P 401

Chain	Residue
P	SER29
P	ASN32
P	CDL407
Q	TYR220
Q	LYS223
Q	ARG224
T	GLY33
T	ASN36
T	ARG40

site_id	AD4
Number of Residues	15
Details	binding site for residue HEM P 402

Chain	Residue
P	GLN44
P	ILE45
P	GLY48
P	LEU49
P	ALA52
P	TYR55
P	ARG80
P	HIS83
P	ALA87
P	GLY130
P	LEU133
P	PRO134
P	HIS182
P	PHE183
P	PRO186

site_id	AD5
Number of Residues	17
Details	binding site for residue HEM P 403

Chain	Residue
P	TRP31
P	GLY34
P	LEU37
P	PHE90
P	LEU94
P	HIS97
P	VAL98
P	ARG100
P	SER106
P	GLY116
P	VAL117
P	HIS196
P	LEU197
P	LEU200
P	SER205
P	ASN206
P	MJM404

site_id	AD6
Number of Residues	7
Details	binding site for residue MJM P 404

Chain	Residue
P	PHE18
P	ILE27
P	HIS201
P	SER205
P	PHE220
P	ASP228
P	HEM403

site_id	AD7
Number of Residues	14
Details	binding site for residue PEE P 405

Chain	Residue
P	TRP30
P	TYR95
P	MET96
P	TYR103
P	TYR104
P	MET316
P	GLN322
P	TRP326
P	VAL329
P	CDL407
S	GLN72
T	CYS44
T	VAL48
T	PHE52

site_id	AD8
Number of Residues	8
Details	binding site for residue CDL P 406

Chain	Residue
N	ASP333
N	ARG436
N	SER439
P	ASN15
P	ILE19
P	HIS221
P	ILE229
R	PEE202

site_id	AD9
Number of Residues	9
Details	binding site for residue CDL P 407

Chain	Residue
P	SER28
P	SER29
P	TRP30
P	CDL401
P	PEE405
S	GLN72
T	ARG40
T	THR41
T	CYS44

site_id	AE1
Number of Residues	10
Details	binding site for residue PEE R 201

Chain	Residue
P	LEU43
P	MET240
Q	HIS200
Q	MET204
Q	LYS207
R	TYR49
R	ALA50
R	ASN53
R	VAL54
R	GLN57

site_id	AE2
Number of Residues	6
Details	binding site for residue PEE R 202

Chain	Residue
P	CDL406
Q	MET222
R	TYR37
R	THR40
W	THR17
W	PHE20

site_id	AE3
Number of Residues	15
Details	binding site for Di-peptide HEC Q 501 and CYS Q 37

Chain	Residue
Q	VAL32
Q	TYR33
Q	VAL36
Q	SER38
Q	SER39
Q	CYS40
Q	HIS41
Q	LEU109
Q	PRO111
Q	ILE116
Q	ARG120
Q	TYR126
Q	GLY159
Q	MET160
Q	PRO163

site_id	AE4
Number of Residues	14
Details	binding site for Di-peptide HEC Q 501 and CYS Q 40

Chain	Residue
Q	VAL36
Q	CYS37
Q	SER38
Q	SER39
Q	HIS41
Q	PRO94
Q	LEU109
Q	PRO111
Q	ILE116
Q	ARG120
Q	TYR126
Q	GLY159
Q	MET160
Q	PRO163

site_id	AE5
Number of Residues	14
Details	binding site for Di-peptide HEC Q 501 and CYS Q 40

Chain	Residue
Q	VAL36
Q	CYS37
Q	SER38
Q	SER39
Q	HIS41
Q	PRO94
Q	LEU109
Q	PRO111
Q	ILE116
Q	ARG120
Q	TYR126
Q	GLY159
Q	MET160
Q	PRO163

site_id	AE6
Number of Residues	15
Details	binding site for Di-peptide HEC Q 501 and CYS Q 37

Chain	Residue
Q	VAL32
Q	TYR33
Q	VAL36
Q	SER38
Q	SER39
Q	CYS40
Q	HIS41
Q	LEU109
Q	PRO111
Q	ILE116
Q	ARG120
Q	TYR126
Q	GLY159
Q	MET160
Q	PRO163

Functional Information from PROSITE/UniProt

site_id	PS00143
Number of Residues	24
Details	INSULINASE Insulinase family, zinc-binding region signature. GsryensnnlGtSHLLRLAsSlTT

Chain	Residue	Details
B	GLY54-THR77

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	38
Details	TOPO_DOM: Mitochondrial matrix => ECO:0000269\|PubMed:9651245

Chain	Residue	Details
J	VAL1-PHE20
P	TRP77-VAL98
P	TRP113-LEU133
P	PHE178-LEU198
P	ILE226-ALA246
P	LEU288-HIS308
P	LEU320-GLY340
P	TYR347-PRO367
W	VAL1-PHE20
U	LYS29
U	LYS72
C	ILE226-ALA246
C	LEU288-HIS308
C	LEU320-GLY340
C	TYR347-PRO367
P	PHE33-MET53

site_id	SWS_FT_FI2
Number of Residues	50
Details	TRANSMEM: Helical => ECO:0000269\|PubMed:9651245

Chain	Residue	Details
J	ALA21-ILE46
W	ALA21-ILE46
F	LYS95
S	LYS18
S	LYS82
S	LYS95

site_id	SWS_FT_FI3
Number of Residues	32
Details	TOPO_DOM: Mitochondrial intermembrane => ECO:0000269\|PubMed:9651245

Chain	Residue	Details
J	ASN47-GLU63
W	ASN47-GLU63
S	LYS77
S	LYS87

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:Q9CQ69

Chain	Residue	Details
G	LYS32
I	SER241
R	CYS139
R	HIS141
R	CYS158
R	HIS161
R	SER163
V	CYS217
V	HIS219
V	CYS236
V	HIS239
T	LYS32
V	SER241
E	CYS158
E	HIS161
E	SER163
I	CYS217
I	HIS219
I	CYS236
I	HIS239

site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING: axial binding residue => ECO:0000269\|PubMed:9651245, ECO:0007744\|PDB:1BE3

Chain	Residue	Details
D	MET160
Q	MET160

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)