5NMG

868 TCR in complex with HLA A02 presenting SLYFNTIAVL

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000139	cellular_component	Golgi membrane
B	0002376	biological_process	immune system process
B	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
B	0002477	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class Ib
B	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
B	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
B	0002715	biological_process	regulation of natural killer cell mediated immunity
B	0002726	biological_process	positive regulation of T cell cytokine production
B	0005198	molecular_function	structural molecule activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005765	cellular_component	lysosomal membrane
B	0005783	cellular_component	endoplasmic reticulum
B	0005788	cellular_component	endoplasmic reticulum lumen
B	0005794	cellular_component	Golgi apparatus
B	0005886	cellular_component	plasma membrane
B	0005925	cellular_component	focal adhesion
B	0006879	biological_process	intracellular iron ion homeostasis
B	0006955	biological_process	immune response
B	0007608	biological_process	sensory perception of smell
B	0007611	biological_process	learning or memory
B	0009897	cellular_component	external side of plasma membrane
B	0009986	cellular_component	cell surface
B	0010038	biological_process	response to metal ion
B	0012507	cellular_component	ER to Golgi transport vesicle membrane
B	0016020	cellular_component	membrane
B	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
B	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
B	0023026	molecular_function	MHC class II protein complex binding
B	0030670	cellular_component	phagocytic vesicle membrane
B	0031901	cellular_component	early endosome membrane
B	0031902	cellular_component	late endosome membrane
B	0031905	cellular_component	early endosome lumen
B	0033572	biological_process	transferrin transport
B	0034756	biological_process	regulation of iron ion transport
B	0034757	biological_process	negative regulation of iron ion transport
B	0035580	cellular_component	specific granule lumen
B	0042605	molecular_function	peptide antigen binding
B	0042612	cellular_component	MHC class I protein complex
B	0042613	cellular_component	MHC class II protein complex
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0042824	cellular_component	MHC class I peptide loading complex
B	0048260	biological_process	positive regulation of receptor-mediated endocytosis
B	0048261	biological_process	negative regulation of receptor-mediated endocytosis
B	0050680	biological_process	negative regulation of epithelial cell proliferation
B	0050768	biological_process	negative regulation of neurogenesis
B	0050778	biological_process	positive regulation of immune response
B	0050870	biological_process	positive regulation of T cell activation
B	0051289	biological_process	protein homotetramerization
B	0055038	cellular_component	recycling endosome membrane
B	0070062	cellular_component	extracellular exosome
B	0071281	biological_process	cellular response to iron ion
B	0071316	biological_process	cellular response to nicotine
B	1904724	cellular_component	tertiary granule lumen
B	1990000	biological_process	amyloid fibril formation
B	1990712	cellular_component	HFE-transferrin receptor complex
B	2000774	biological_process	positive regulation of cellular senescence
B	2000978	biological_process	negative regulation of forebrain neuron differentiation
G	0000139	cellular_component	Golgi membrane
G	0002376	biological_process	immune system process
G	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
G	0002477	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class Ib
G	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
G	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
G	0002715	biological_process	regulation of natural killer cell mediated immunity
G	0002726	biological_process	positive regulation of T cell cytokine production
G	0005198	molecular_function	structural molecule activity
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005765	cellular_component	lysosomal membrane
G	0005783	cellular_component	endoplasmic reticulum
G	0005788	cellular_component	endoplasmic reticulum lumen
G	0005794	cellular_component	Golgi apparatus
G	0005886	cellular_component	plasma membrane
G	0005925	cellular_component	focal adhesion
G	0006879	biological_process	intracellular iron ion homeostasis
G	0006955	biological_process	immune response
G	0007608	biological_process	sensory perception of smell
G	0007611	biological_process	learning or memory
G	0009897	cellular_component	external side of plasma membrane
G	0009986	cellular_component	cell surface
G	0010038	biological_process	response to metal ion
G	0012507	cellular_component	ER to Golgi transport vesicle membrane
G	0016020	cellular_component	membrane
G	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
G	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
G	0023026	molecular_function	MHC class II protein complex binding
G	0030670	cellular_component	phagocytic vesicle membrane
G	0031901	cellular_component	early endosome membrane
G	0031902	cellular_component	late endosome membrane
G	0031905	cellular_component	early endosome lumen
G	0033572	biological_process	transferrin transport
G	0034756	biological_process	regulation of iron ion transport
G	0034757	biological_process	negative regulation of iron ion transport
G	0035580	cellular_component	specific granule lumen
G	0042605	molecular_function	peptide antigen binding
G	0042612	cellular_component	MHC class I protein complex
G	0042613	cellular_component	MHC class II protein complex
G	0042802	molecular_function	identical protein binding
G	0042803	molecular_function	protein homodimerization activity
G	0042824	cellular_component	MHC class I peptide loading complex
G	0048260	biological_process	positive regulation of receptor-mediated endocytosis
G	0048261	biological_process	negative regulation of receptor-mediated endocytosis
G	0050680	biological_process	negative regulation of epithelial cell proliferation
G	0050768	biological_process	negative regulation of neurogenesis
G	0050778	biological_process	positive regulation of immune response
G	0050870	biological_process	positive regulation of T cell activation
G	0051289	biological_process	protein homotetramerization
G	0055038	cellular_component	recycling endosome membrane
G	0070062	cellular_component	extracellular exosome
G	0071281	biological_process	cellular response to iron ion
G	0071316	biological_process	cellular response to nicotine
G	1904724	cellular_component	tertiary granule lumen
G	1990000	biological_process	amyloid fibril formation
G	1990712	cellular_component	HFE-transferrin receptor complex
G	2000774	biological_process	positive regulation of cellular senescence
G	2000978	biological_process	negative regulation of forebrain neuron differentiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue EDO A 301

Chain	Residue
A	GLY62
A	GLU63
A	LYS66
A	TRP167
C	SER1
D	SER95

---

site_id	AC2
Number of Residues	7
Details	binding site for residue EDO A 302

Chain	Residue
A	VAL152
A	ALA153
A	GLU154
A	HOH402
A	TRP133
A	TRP147
A	HIS151

---

site_id	AC3
Number of Residues	4
Details	binding site for residue EDO A 303

Chain	Residue
A	ARG21
A	HOH409
B	HIS51
B	EDO102

---

site_id	AC4
Number of Residues	4
Details	binding site for residue EDO A 304

Chain	Residue
A	HIS188
A	TRP204
B	ASP98
B	EDO103

---

site_id	AC5
Number of Residues	6
Details	binding site for residue GOL A 305

Chain	Residue
A	GLN87
A	SER88
A	GLY91
A	HIS93
A	HOH416
B	MET0

---

site_id	AC6
Number of Residues	4
Details	binding site for residue SO4 A 306

Chain	Residue
A	GLU166
A	TRP167
A	ARG170
D	ARG28

---

site_id	AC7
Number of Residues	4
Details	binding site for residue EDO B 101

Chain	Residue
A	ARG234
B	GLN8
B	VAL9
B	MET99

---

site_id	AC8
Number of Residues	5
Details	binding site for residue EDO B 102

Chain	Residue
A	ARG21
A	EDO303
A	HOH409
B	SER33
B	ASP34

---

site_id	AC9
Number of Residues	8
Details	binding site for residue EDO B 103

Chain	Residue
A	ARG234
A	EDO304
B	TYR10
B	SER11
B	TRP95
B	ARG97
B	MET99
B	HOH207

---

site_id	AD1
Number of Residues	1
Details	binding site for residue EDO B 104

Chain	Residue
B	ASP34

---

site_id	AD2
Number of Residues	4
Details	binding site for residue EDO B 105

Chain	Residue
B	LYS41
B	GLU44
B	ARG45
J	HIS135

---

site_id	AD3
Number of Residues	7
Details	binding site for residue EDO C 301

Chain	Residue
A	ARG97
A	HIS114
A	TRP147
A	VAL152
C	THR5
C	ILE6
C	ALA7

---

site_id	AD4
Number of Residues	6
Details	binding site for residue EDO D 301

Chain	Residue
D	TYR36
D	PRO44
D	GLU45
D	LEU46
E	TYR102
E	PHE103

---

site_id	AD5
Number of Residues	3
Details	binding site for residue GOL D 302

Chain	Residue
D	GLY59
D	ARG60
D	LYS80

---

site_id	AD6
Number of Residues	4
Details	binding site for residue EDO E 301

Chain	Residue
E	THR5
E	SER7
E	CYS23
E	SER24

---

site_id	AD7
Number of Residues	3
Details	binding site for residue EDO E 302

Chain	Residue
B	ILE1
E	GLN223
E	ARG225

---

site_id	AD8
Number of Residues	4
Details	binding site for residue GOL E 303

Chain	Residue
E	TRP158
E	GLY161
E	HIS205
E	ARG207

---

site_id	AD9
Number of Residues	4
Details	binding site for residue SO4 E 304

Chain	Residue
A	ASN86
E	VAL164
E	HIS165
E	SER166

---

site_id	AE1
Number of Residues	2
Details	binding site for residue EDO G 101

Chain	Residue
G	GLU47
G	LYS48

---

site_id	AE2
Number of Residues	5
Details	binding site for residue EDO I 301

Chain	Residue
D	ASP140
D	GLN142
I	GLU5
I	THR24
I	SER26

---

site_id	AE3
Number of Residues	3
Details	binding site for residue EDO J 301

Chain	Residue
J	LYS162
J	HIS165
J	SER166

---

site_id	AE4
Number of Residues	8
Details	binding site for residue SO4 J 302

Chain	Residue
J	LEU83
J	GLY84
J	GLY84
J	ARG15
J	ARG15
J	LEU82
J	LEU82
J	LEU83

---

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCHVQH

Chain	Residue	Details
A	TYR257-HIS263
B	TYR78-HIS84

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	172
Details	Domain: {"description":"Ig-like C1-type","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	178
Details	Region: {"description":"Alpha-1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	182
Details	Region: {"description":"Alpha-2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	182
Details	Region: {"description":"Alpha-3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21943705","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21543847","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Sulfotyrosine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	176
Details	Domain: {"description":"Ig-like C1-type"}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"Pyrrolidone carboxylic acid; in form pI 5.3","evidences":[{"source":"PubMed","id":"7554280","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	12
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) lysine; in vitro","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---