5NMF

868 TCR in complex with HLA A02 presenting SLYNTIATL

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000139	cellular_component	Golgi membrane
B	0001913	biological_process	T cell mediated cytotoxicity
B	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
B	0002237	biological_process	response to molecule of bacterial origin
B	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
B	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
B	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
B	0002726	biological_process	positive regulation of T cell cytokine production
B	0005198	molecular_function	structural molecule activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005765	cellular_component	lysosomal membrane
B	0005783	cellular_component	endoplasmic reticulum
B	0005788	cellular_component	endoplasmic reticulum lumen
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005925	cellular_component	focal adhesion
B	0006826	biological_process	iron ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0006955	biological_process	immune response
B	0007608	biological_process	sensory perception of smell
B	0007611	biological_process	learning or memory
B	0009897	cellular_component	external side of plasma membrane
B	0009986	cellular_component	cell surface
B	0010977	biological_process	negative regulation of neuron projection development
B	0012507	cellular_component	ER to Golgi transport vesicle membrane
B	0016020	cellular_component	membrane
B	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
B	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
B	0023026	molecular_function	MHC class II protein complex binding
B	0030670	cellular_component	phagocytic vesicle membrane
B	0031901	cellular_component	early endosome membrane
B	0031902	cellular_component	late endosome membrane
B	0031905	cellular_component	early endosome lumen
B	0032092	biological_process	positive regulation of protein binding
B	0033077	biological_process	T cell differentiation in thymus
B	0034756	biological_process	regulation of iron ion transport
B	0035580	cellular_component	specific granule lumen
B	0042026	biological_process	protein refolding
B	0042605	molecular_function	peptide antigen binding
B	0042612	cellular_component	MHC class I protein complex
B	0042613	cellular_component	MHC class II protein complex
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0042824	cellular_component	MHC class I peptide loading complex
B	0045646	biological_process	regulation of erythrocyte differentiation
B	0048260	biological_process	positive regulation of receptor-mediated endocytosis
B	0050680	biological_process	negative regulation of epithelial cell proliferation
B	0050768	biological_process	negative regulation of neurogenesis
B	0050778	biological_process	positive regulation of immune response
B	0050870	biological_process	positive regulation of T cell activation
B	0051289	biological_process	protein homotetramerization
B	0055038	cellular_component	recycling endosome membrane
B	0060586	biological_process	multicellular organismal-level iron ion homeostasis
B	0070062	cellular_component	extracellular exosome
B	0071281	biological_process	cellular response to iron ion
B	0071283	biological_process	cellular response to iron(III) ion
B	0071316	biological_process	cellular response to nicotine
B	1900121	biological_process	negative regulation of receptor binding
B	1900122	biological_process	positive regulation of receptor binding
B	1904434	biological_process	positive regulation of ferrous iron binding
B	1904437	biological_process	positive regulation of transferrin receptor binding
B	1904724	cellular_component	tertiary granule lumen
B	1990000	biological_process	amyloid fibril formation
B	1990712	cellular_component	HFE-transferrin receptor complex
B	2000774	biological_process	positive regulation of cellular senescence
B	2000978	biological_process	negative regulation of forebrain neuron differentiation
G	0000139	cellular_component	Golgi membrane
G	0001913	biological_process	T cell mediated cytotoxicity
G	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
G	0002237	biological_process	response to molecule of bacterial origin
G	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
G	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
G	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
G	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
G	0002726	biological_process	positive regulation of T cell cytokine production
G	0005198	molecular_function	structural molecule activity
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005765	cellular_component	lysosomal membrane
G	0005783	cellular_component	endoplasmic reticulum
G	0005788	cellular_component	endoplasmic reticulum lumen
G	0005794	cellular_component	Golgi apparatus
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0005925	cellular_component	focal adhesion
G	0006826	biological_process	iron ion transport
G	0006879	biological_process	intracellular iron ion homeostasis
G	0006955	biological_process	immune response
G	0007608	biological_process	sensory perception of smell
G	0007611	biological_process	learning or memory
G	0009897	cellular_component	external side of plasma membrane
G	0009986	cellular_component	cell surface
G	0010977	biological_process	negative regulation of neuron projection development
G	0012507	cellular_component	ER to Golgi transport vesicle membrane
G	0016020	cellular_component	membrane
G	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
G	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
G	0023026	molecular_function	MHC class II protein complex binding
G	0030670	cellular_component	phagocytic vesicle membrane
G	0031901	cellular_component	early endosome membrane
G	0031902	cellular_component	late endosome membrane
G	0031905	cellular_component	early endosome lumen
G	0032092	biological_process	positive regulation of protein binding
G	0033077	biological_process	T cell differentiation in thymus
G	0034756	biological_process	regulation of iron ion transport
G	0035580	cellular_component	specific granule lumen
G	0042026	biological_process	protein refolding
G	0042605	molecular_function	peptide antigen binding
G	0042612	cellular_component	MHC class I protein complex
G	0042613	cellular_component	MHC class II protein complex
G	0042802	molecular_function	identical protein binding
G	0042803	molecular_function	protein homodimerization activity
G	0042824	cellular_component	MHC class I peptide loading complex
G	0045646	biological_process	regulation of erythrocyte differentiation
G	0048260	biological_process	positive regulation of receptor-mediated endocytosis
G	0050680	biological_process	negative regulation of epithelial cell proliferation
G	0050768	biological_process	negative regulation of neurogenesis
G	0050778	biological_process	positive regulation of immune response
G	0050870	biological_process	positive regulation of T cell activation
G	0051289	biological_process	protein homotetramerization
G	0055038	cellular_component	recycling endosome membrane
G	0060586	biological_process	multicellular organismal-level iron ion homeostasis
G	0070062	cellular_component	extracellular exosome
G	0071281	biological_process	cellular response to iron ion
G	0071283	biological_process	cellular response to iron(III) ion
G	0071316	biological_process	cellular response to nicotine
G	1900121	biological_process	negative regulation of receptor binding
G	1900122	biological_process	positive regulation of receptor binding
G	1904434	biological_process	positive regulation of ferrous iron binding
G	1904437	biological_process	positive regulation of transferrin receptor binding
G	1904724	cellular_component	tertiary granule lumen
G	1990000	biological_process	amyloid fibril formation
G	1990712	cellular_component	HFE-transferrin receptor complex
G	2000774	biological_process	positive regulation of cellular senescence
G	2000978	biological_process	negative regulation of forebrain neuron differentiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue EDO A 301

Chain	Residue
A	ARG21
B	HIS51

---

site_id	AC2
Number of Residues	1
Details	binding site for residue GOL A 302

Chain	Residue
A	SER105

---

site_id	AC3
Number of Residues	4
Details	binding site for residue SO4 A 303

Chain	Residue
A	THR271
A	ARG273
E	ALA235
E	GLU236

---

site_id	AC4
Number of Residues	3
Details	binding site for residue SO4 A 304

Chain	Residue
A	ALA193
A	HIS191
A	HIS192

---

site_id	AC5
Number of Residues	4
Details	binding site for residue SO4 A 305

Chain	Residue
A	HIS151
A	VAL152
A	ALA153
A	GLU154

---

site_id	AC6
Number of Residues	2
Details	binding site for residue SO4 A 306

Chain	Residue
A	TRP167
D	ARG28

---

site_id	AC7
Number of Residues	3
Details	binding site for residue EDO D 301

Chain	Residue
D	ARG60
D	LYS80
D	HOH403

---

site_id	AC8
Number of Residues	3
Details	binding site for residue GOL D 302

Chain	Residue
D	ASN7
D	SER8
D	LYS103

---

site_id	AC9
Number of Residues	2
Details	binding site for residue EDO E 301

Chain	Residue
E	PRO8
E	HIS10

---

site_id	AD1
Number of Residues	2
Details	binding site for residue EDO E 302

Chain	Residue
E	HIS165
E	SER166

---

site_id	AD2
Number of Residues	1
Details	binding site for residue EDO E 303

Chain	Residue
E	LYS227

---

site_id	AD3
Number of Residues	2
Details	binding site for residue SO4 E 304

Chain	Residue
E	ARG15
E	GLY84

---

site_id	AD4
Number of Residues	2
Details	binding site for residue SO4 E 305

Chain	Residue
E	GLN17
E	GLN18

---

site_id	AD5
Number of Residues	2
Details	binding site for residue SO4 E 306

Chain	Residue
E	PRO61
E	ARG63

---

site_id	AD6
Number of Residues	8
Details	binding site for residue SO4 E 307

Chain	Residue
E	ARG15
E	ARG15
E	LEU82
E	LEU82
E	LEU83
E	LEU83
E	GLY84
E	GLY84

---

site_id	AD7
Number of Residues	2
Details	binding site for residue EDO F 301

Chain	Residue
F	ARG21
G	HIS51

---

site_id	AD8
Number of Residues	1
Details	binding site for residue EDO F 302

Chain	Residue
F	ARG35

---

site_id	AD9
Number of Residues	1
Details	binding site for residue EDO F 303

Chain	Residue
F	ALA193

---

site_id	AE1
Number of Residues	2
Details	binding site for residue EDO F 304

Chain	Residue
F	GLU166
F	ARG170

---

site_id	AE2
Number of Residues	2
Details	binding site for residue EDO F 305

Chain	Residue
F	GLN87
F	SER88

---

site_id	AE3
Number of Residues	3
Details	binding site for residue EDO F 306

Chain	Residue
F	LYS127
F	ALA135
F	LYS144

---

site_id	AE4
Number of Residues	4
Details	binding site for residue SO4 F 307

Chain	Residue
F	ASN86
J	VAL164
J	HIS165
J	SER166

---

site_id	AE5
Number of Residues	5
Details	binding site for residue SO4 F 308

Chain	Residue
F	ARG131
F	HIS151
F	ALA153
F	GLU154
F	HOH402

---

site_id	AE6
Number of Residues	3
Details	binding site for residue EDO I 301

Chain	Residue
F	LYS127
F	GLU128
I	SER180

---

site_id	AE7
Number of Residues	3
Details	binding site for residue EDO I 302

Chain	Residue
I	LYS80
I	LEU81
I	SER82

---

site_id	AE8
Number of Residues	1
Details	binding site for residue GOL I 303

Chain	Residue
I	ARG60

---

site_id	AE9
Number of Residues	4
Details	binding site for residue EDO J 301

Chain	Residue
I	ARG164
I	HOH403
J	VAL168
J	HOH401

---

site_id	AF1
Number of Residues	5
Details	binding site for residue EDO J 303

Chain	Residue
G	THR4
J	LYS116
J	TRP221
J	THR222
J	GLN223

---

site_id	AF2
Number of Residues	1
Details	binding site for residue EDO J 304

Chain	Residue
J	GLN223

---

site_id	AF3
Number of Residues	3
Details	binding site for residue EDO J 305

Chain	Residue
F	ARG82
F	GLU89
J	HOH406

---

site_id	AF4
Number of Residues	4
Details	binding site for residue EDO J 306

Chain	Residue
F	ARG65
F	GLN72
J	TYR50
J	ARG55

---

site_id	AF5
Number of Residues	2
Details	binding site for residue SO4 J 307

Chain	Residue
J	GLY147
J	GLU177

---

site_id	AF6
Number of Residues	3
Details	binding site for residue SO4 J 308

Chain	Residue
J	GLY161
J	HIS205
J	ARG207

---

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCHVQH

Chain	Residue	Details
A	TYR257-HIS263
B	TYR78-HIS84

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280

Chain	Residue	Details
B	GLN2
F	THR143
F	LYS146
F	TYR171
G	GLN2
A	TYR84
A	THR143
A	LYS146
A	TYR171
F	TYR7
F	THR73
F	TYR84

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	CARBOHYD: N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269|PubMed:7918443

Chain	Residue	Details
B	ILE1
G	ILE1
F	TYR116
F	TYR159

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	CARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443

Chain	Residue	Details
B	LYS19
G	LYS58
G	LYS91
G	LYS94
B	LYS41
B	LYS48
B	LYS58
B	LYS91
B	LYS94
G	LYS19
G	LYS41
G	LYS48

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218

Chain	Residue	Details
A	ASN86
F	ASN86

---