5NMB

Structure-activity relationship study of vitamin D analogs with oxolane group in their side chain

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A2	0003677	molecular_function	DNA binding
A2	0004879	molecular_function	nuclear receptor activity
A2	0005634	cellular_component	nucleus
A2	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue 9CZ A2 4000

Chain	Residue
A2	TYR175
A2	VAL328
A2	HIS333
A2	HIS423
A2	PHE448
A2	LEU258
A2	SER265
A2	ILE299
A2	ARG302
A2	SER303
A2	SER306
A2	TRP314
A2	CYS316

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	Region: {"description":"Interaction with coactivator LXXLL motif","evidences":[{"source":"UniProtKB","id":"P13053","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Motif: {"description":"9aaTAD","evidences":[{"source":"UniProtKB","id":"P11473","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17218092","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2HC4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Motif: {"description":"LXXLL motif 4"}

Chain

Residue

Details

---