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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5NLJ

Crystal structure of Zn3-E16V human ubiquitin (hUb) mutant adduct, from a solution 70 mM zinc acetate/20% v/v TFE/1.3 mM E16V hUb

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue ACT A 101

Chain	Residue
A	LYS6
A	THR66
A	HIS68
A	ZN107
B	LYS6
B	HIS68

site_id	AC2
Number of Residues	6
Details	binding site for residue ACT A 102

Chain	Residue
A	LYS29
A	ZN105
B	GLU18
A	VAL16
A	GLU18
A	ASP21

site_id	AC3
Number of Residues	5
Details	binding site for residue ACT A 103

Chain	Residue
A	ASP39
A	ZN106
A	HOH245
C	HIS68
C	ACT101

site_id	AC4
Number of Residues	5
Details	binding site for residue ZN A 104

Chain	Residue
A	GLU18
A	ACT108
B	ZN105
C	ASP21
C	HOH222

site_id	AC5
Number of Residues	6
Details	binding site for residue ZN A 105

Chain	Residue
A	ASP21
A	ACT102
A	HOH213
B	GLU18
B	PEG102
B	ZN105

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN A 106

Chain	Residue
A	ASP39
A	ACT103
C	HIS68
C	ACT101

site_id	AC7
Number of Residues	4
Details	binding site for residue ZN A 107

Chain	Residue
A	HIS68
A	ACT101
B	LYS6
B	HIS68

site_id	AC8
Number of Residues	9
Details	binding site for residue ACT A 108

Chain	Residue
A	GLU18
A	ZN104
A	HOH205
A	HOH224
B	ZN105
C	VAL16
C	GLU18
C	ASP21
C	LYS29

site_id	AC9
Number of Residues	3
Details	binding site for residue ZN A 109

Chain	Residue
A	MET1
B	GLU51
C	ASP32

site_id	AD1
Number of Residues	9
Details	binding site for residue ACT B 101

Chain	Residue
A	HOH205
B	VAL16
B	GLU18
B	ASP21
B	LYS29
B	ZN104
B	HOH215
B	HOH216
C	GLU18

site_id	AD2
Number of Residues	13
Details	binding site for residue PEG B 102

Chain	Residue
A	SER20
A	ASP21
A	ASN25
A	ZN105
A	HOH213
B	SER20
B	ASN25
B	ZN105
B	HOH202
C	SER20
C	ASP21
C	ASN25
C	HOH222

site_id	AD3
Number of Residues	3
Details	binding site for residue ZN B 103

Chain	Residue
B	MET1
B	HOH228
B	HOH278

site_id	AD4
Number of Residues	5
Details	binding site for residue ZN B 104

Chain	Residue
B	ASP21
B	ACT101
B	ZN105
B	HOH216
C	GLU18

site_id	AD5
Number of Residues	12
Details	binding site for residue ZN B 105

Chain	Residue
A	GLU18
A	ZN104
A	ZN105
A	ACT108
A	HOH205
A	HOH213
B	GLU18
B	PEG102
B	ZN104
B	HOH216
C	GLU18
C	HOH222

site_id	AD6
Number of Residues	4
Details	binding site for residue ZN B 106

Chain	Residue
B	LYS11
B	GLU34
B	HOH258
B	HOH269

site_id	AD7
Number of Residues	5
Details	binding site for residue ETF B 107

Chain	Residue
B	LEU8
B	ILE36
B	GLN40
B	HOH250
C	HOH248

site_id	AD8
Number of Residues	6
Details	binding site for residue ACT C 101

Chain	Residue
A	ASP39
A	ACT103
A	ZN106
C	ALA46
C	HIS68
C	HOH230

site_id	AD9
Number of Residues	4
Details	binding site for residue EDO C 102

Chain	Residue
B	SER20
B	THR55
C	HOH206
C	HOH209

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
A	LYS27-ASP52

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	SITE: Interacts with activating enzyme

Chain	Residue	Details
A	ARG54
A	ARG72
B	ARG54
B	ARG72
C	ARG54
C	ARG72

site_id	SWS_FT_FI2
Number of Residues	3
Details	SITE: Essential for function

Chain	Residue	Details
A	HIS68
B	HIS68
C	HIS68

site_id	SWS_FT_FI3
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PINK1 => ECO:0000269\|PubMed:24660806, ECO:0000269\|PubMed:24751536, ECO:0000269\|PubMed:24784582, ECO:0000269\|PubMed:25527291

Chain	Residue	Details
A	SER65
B	SER65
C	SER65

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: (Microbial infection) ADP-ribosylthreonine => ECO:0000269\|PubMed:32330457

Chain	Residue	Details
A	THR66
B	THR66
C	THR66

site_id	SWS_FT_FI5
Number of Residues	3
Details	MOD_RES: ADP-ribosylglycine => ECO:0000269\|PubMed:28525742

Chain	Residue	Details
A	GLY76
B	GLY76
C	GLY76

site_id	SWS_FT_FI6
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:16443603

Chain	Residue	Details
A	LYS6
B	LYS6
C	LYS6

site_id	SWS_FT_FI7
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)

Chain	Residue	Details
A	GLY76
B	GLY76
C	GLY76

site_id	SWS_FT_FI8
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:16443603, ECO:0000269\|PubMed:16543144

Chain	Residue	Details
A	LYS11
A	LYS48
B	LYS11
B	LYS48
C	LYS11
C	LYS48

site_id	SWS_FT_FI9
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305\|PubMed:15466860

Chain	Residue	Details
A	LYS27
B	LYS27
C	LYS27

site_id	SWS_FT_FI10
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:16543144, ECO:0000269\|PubMed:25752573, ECO:0000269\|PubMed:25752577, ECO:0000269\|PubMed:34239127

Chain	Residue	Details
A	LYS29
B	LYS29
C	LYS29

site_id	SWS_FT_FI11
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:25752577

Chain	Residue	Details
A	LYS33
B	LYS33
C	LYS33

site_id	SWS_FT_FI12
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:16543144, ECO:0000269\|PubMed:18719106

Chain	Residue	Details
A	LYS63
B	LYS63
C	LYS63

227344

PDB entries from 2024-11-13

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