5NJV
Flavivirus NS5 domain
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
A | 0004483 | molecular_function | mRNA (nucleoside-2'-O-)-methyltransferase activity |
A | 0008168 | molecular_function | methyltransferase activity |
A | 0032259 | biological_process | methylation |
B | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
B | 0004483 | molecular_function | mRNA (nucleoside-2'-O-)-methyltransferase activity |
B | 0008168 | molecular_function | methyltransferase activity |
B | 0032259 | biological_process | methylation |
C | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
C | 0004483 | molecular_function | mRNA (nucleoside-2'-O-)-methyltransferase activity |
C | 0008168 | molecular_function | methyltransferase activity |
C | 0032259 | biological_process | methylation |
D | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
D | 0004483 | molecular_function | mRNA (nucleoside-2'-O-)-methyltransferase activity |
D | 0008168 | molecular_function | methyltransferase activity |
D | 0032259 | biological_process | methylation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 19 |
Details | binding site for residue SAM A 301 |
Chain | Residue |
A | SER56 |
A | HIS110 |
A | GLU111 |
A | VAL130 |
A | ASP131 |
A | VAL132 |
A | PHE133 |
A | ASP146 |
A | HOH448 |
A | HOH468 |
A | HOH485 |
A | GLY58 |
A | GLY81 |
A | CYS82 |
A | GLY83 |
A | GLY86 |
A | TRP87 |
A | THR104 |
A | LYS105 |
site_id | AC2 |
Number of Residues | 3 |
Details | binding site for residue CL A 302 |
Chain | Residue |
A | GLY148 |
A | GLU149 |
A | HOH501 |
site_id | AC3 |
Number of Residues | 2 |
Details | binding site for residue CL A 303 |
Chain | Residue |
A | GLY148 |
A | GLU149 |
site_id | AC4 |
Number of Residues | 22 |
Details | binding site for residue SAM B 301 |
Chain | Residue |
B | SER56 |
B | GLY58 |
B | GLY81 |
B | CYS82 |
B | GLY83 |
B | GLY86 |
B | TRP87 |
B | THR104 |
B | LYS105 |
B | HIS110 |
B | GLU111 |
B | VAL130 |
B | ASP131 |
B | VAL132 |
B | PHE133 |
B | ASP146 |
B | CL303 |
B | HOH426 |
B | HOH442 |
B | HOH466 |
B | HOH532 |
B | HOH543 |
site_id | AC5 |
Number of Residues | 3 |
Details | binding site for residue CL B 302 |
Chain | Residue |
B | THR7 |
B | LEU8 |
B | HOH549 |
site_id | AC6 |
Number of Residues | 2 |
Details | binding site for residue CL B 303 |
Chain | Residue |
B | GLY148 |
B | SAM301 |
site_id | AC7 |
Number of Residues | 17 |
Details | binding site for residue SAM C 301 |
Chain | Residue |
C | SER56 |
C | GLY58 |
C | GLY81 |
C | CYS82 |
C | GLY83 |
C | GLY86 |
C | TRP87 |
C | THR104 |
C | LYS105 |
C | HIS110 |
C | GLU111 |
C | VAL130 |
C | ASP131 |
C | VAL132 |
C | PHE133 |
C | ASP146 |
C | HOH414 |
site_id | AC8 |
Number of Residues | 19 |
Details | binding site for residue SAM D 301 |
Chain | Residue |
D | SER56 |
D | GLY58 |
D | GLY81 |
D | CYS82 |
D | GLY83 |
D | GLY86 |
D | TRP87 |
D | THR104 |
D | LYS105 |
D | HIS110 |
D | GLU111 |
D | VAL130 |
D | ASP131 |
D | VAL132 |
D | PHE133 |
D | ASP146 |
D | ILE147 |
D | HOH419 |
D | HOH424 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 16 |
Details | ACT_SITE: For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4 |
Chain | Residue | Details |
A | LYS61 | |
C | ASP146 | |
C | LYS182 | |
C | GLU218 | |
D | LYS61 | |
D | ASP146 | |
D | LYS182 | |
D | GLU218 | |
A | ASP146 | |
A | LYS182 | |
A | GLU218 | |
B | LYS61 | |
B | ASP146 | |
B | LYS182 | |
B | GLU218 | |
C | LYS61 |
site_id | SWS_FT_FI2 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:27866982 |
Chain | Residue | Details |
A | LYS13 | |
D | LYS13 | |
D | GLU149 | |
D | ARG213 | |
A | GLU149 | |
A | ARG213 | |
B | LYS13 | |
B | GLU149 | |
B | ARG213 | |
C | LYS13 | |
C | GLU149 | |
C | ARG213 |
site_id | SWS_FT_FI3 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27866982 |
Chain | Residue | Details |
A | SER56 | |
A | THR104 | |
B | SER56 | |
B | THR104 | |
C | SER56 | |
C | THR104 | |
D | SER56 | |
D | THR104 |
site_id | SWS_FT_FI4 |
Number of Residues | 20 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 |
Chain | Residue | Details |
A | GLY86 | |
B | VAL132 | |
C | GLY86 | |
C | TRP87 | |
C | LYS105 | |
C | ASP131 | |
C | VAL132 | |
D | GLY86 | |
D | TRP87 | |
D | LYS105 | |
D | ASP131 | |
A | TRP87 | |
D | VAL132 | |
A | LYS105 | |
A | ASP131 | |
A | VAL132 | |
B | GLY86 | |
B | TRP87 | |
B | LYS105 | |
B | ASP131 |
site_id | SWS_FT_FI5 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 |
Chain | Residue | Details |
A | HIS110 | |
D | HIS110 | |
D | GLU111 | |
D | ASP146 | |
A | GLU111 | |
A | ASP146 | |
B | HIS110 | |
B | GLU111 | |
B | ASP146 | |
C | HIS110 | |
C | GLU111 | |
C | ASP146 |
site_id | SWS_FT_FI6 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 |
Chain | Residue | Details |
A | ILE147 | |
A | TYR220 | |
B | ILE147 | |
B | TYR220 | |
C | ILE147 | |
C | TYR220 | |
D | ILE147 | |
D | TYR220 |
site_id | SWS_FT_FI7 |
Number of Residues | 28 |
Details | SITE: mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 |
Chain | Residue | Details |
A | LYS13 | |
B | PHE24 | |
B | LYS28 | |
B | SER150 | |
B | ARG213 | |
B | SER215 | |
C | LYS13 | |
C | ASN17 | |
C | PHE24 | |
C | LYS28 | |
C | SER150 | |
A | ASN17 | |
C | ARG213 | |
C | SER215 | |
D | LYS13 | |
D | ASN17 | |
D | PHE24 | |
D | LYS28 | |
D | SER150 | |
D | ARG213 | |
D | SER215 | |
A | PHE24 | |
A | LYS28 | |
A | SER150 | |
A | ARG213 | |
A | SER215 | |
B | LYS13 | |
B | ASN17 |
site_id | SWS_FT_FI8 |
Number of Residues | 8 |
Details | SITE: mRNA cap binding; via carbonyl oxygen => ECO:0000255|PROSITE-ProRule:PRU00924 |
Chain | Residue | Details |
A | LEU16 | |
A | MET19 | |
B | LEU16 | |
B | MET19 | |
C | LEU16 | |
C | MET19 | |
D | LEU16 | |
D | MET19 |
site_id | SWS_FT_FI9 |
Number of Residues | 12 |
Details | SITE: Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 |
Chain | Residue | Details |
A | LYS61 | |
D | LYS61 | |
D | LYS182 | |
D | GLU218 | |
A | LYS182 | |
A | GLU218 | |
B | LYS61 | |
B | LYS182 | |
B | GLU218 | |
C | LYS61 | |
C | LYS182 | |
C | GLU218 |
site_id | SWS_FT_FI10 |
Number of Residues | 4 |
Details | SITE: Essential for 2'-O-methyltransferase and N-7 methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 |
Chain | Residue | Details |
A | ASP146 | |
B | ASP146 | |
C | ASP146 | |
D | ASP146 |
site_id | SWS_FT_FI11 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P03314 |
Chain | Residue | Details |
A | SER56 | |
B | SER56 | |
C | SER56 | |
D | SER56 |