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5NJV

Flavivirus NS5 domain

Functional Information from GO Data
ChainGOidnamespacecontents
A0004482molecular_functionmRNA 5'-cap (guanine-N7-)-methyltransferase activity
A0004483molecular_functionmRNA (nucleoside-2'-O-)-methyltransferase activity
A0008168molecular_functionmethyltransferase activity
A0032259biological_processmethylation
B0004482molecular_functionmRNA 5'-cap (guanine-N7-)-methyltransferase activity
B0004483molecular_functionmRNA (nucleoside-2'-O-)-methyltransferase activity
B0008168molecular_functionmethyltransferase activity
B0032259biological_processmethylation
C0004482molecular_functionmRNA 5'-cap (guanine-N7-)-methyltransferase activity
C0004483molecular_functionmRNA (nucleoside-2'-O-)-methyltransferase activity
C0008168molecular_functionmethyltransferase activity
C0032259biological_processmethylation
D0004482molecular_functionmRNA 5'-cap (guanine-N7-)-methyltransferase activity
D0004483molecular_functionmRNA (nucleoside-2'-O-)-methyltransferase activity
D0008168molecular_functionmethyltransferase activity
D0032259biological_processmethylation
Functional Information from PDB Data
site_idAC1
Number of Residues19
Detailsbinding site for residue SAM A 301
ChainResidue
ASER56
AHIS110
AGLU111
AVAL130
AASP131
AVAL132
APHE133
AASP146
AHOH448
AHOH468
AHOH485
AGLY58
AGLY81
ACYS82
AGLY83
AGLY86
ATRP87
ATHR104
ALYS105

site_idAC2
Number of Residues3
Detailsbinding site for residue CL A 302
ChainResidue
AGLY148
AGLU149
AHOH501

site_idAC3
Number of Residues2
Detailsbinding site for residue CL A 303
ChainResidue
AGLY148
AGLU149

site_idAC4
Number of Residues22
Detailsbinding site for residue SAM B 301
ChainResidue
BSER56
BGLY58
BGLY81
BCYS82
BGLY83
BGLY86
BTRP87
BTHR104
BLYS105
BHIS110
BGLU111
BVAL130
BASP131
BVAL132
BPHE133
BASP146
BCL303
BHOH426
BHOH442
BHOH466
BHOH532
BHOH543

site_idAC5
Number of Residues3
Detailsbinding site for residue CL B 302
ChainResidue
BTHR7
BLEU8
BHOH549

site_idAC6
Number of Residues2
Detailsbinding site for residue CL B 303
ChainResidue
BGLY148
BSAM301

site_idAC7
Number of Residues17
Detailsbinding site for residue SAM C 301
ChainResidue
CSER56
CGLY58
CGLY81
CCYS82
CGLY83
CGLY86
CTRP87
CTHR104
CLYS105
CHIS110
CGLU111
CVAL130
CASP131
CVAL132
CPHE133
CASP146
CHOH414

site_idAC8
Number of Residues19
Detailsbinding site for residue SAM D 301
ChainResidue
DSER56
DGLY58
DGLY81
DCYS82
DGLY83
DGLY86
DTRP87
DTHR104
DLYS105
DHIS110
DGLU111
DVAL130
DASP131
DVAL132
DPHE133
DASP146
DILE147
DHOH419
DHOH424

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues16
DetailsACT_SITE: For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4
ChainResidueDetails
ALYS61
CASP146
CLYS182
CGLU218
DLYS61
DASP146
DLYS182
DGLU218
AASP146
ALYS182
AGLU218
BLYS61
BASP146
BLYS182
BGLU218
CLYS61

site_idSWS_FT_FI2
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:27866982
ChainResidueDetails
ALYS13
DLYS13
DGLU149
DARG213
AGLU149
AARG213
BLYS13
BGLU149
BARG213
CLYS13
CGLU149
CARG213

site_idSWS_FT_FI3
Number of Residues8
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27866982
ChainResidueDetails
ASER56
ATHR104
BSER56
BTHR104
CSER56
CTHR104
DSER56
DTHR104

site_idSWS_FT_FI4
Number of Residues20
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359
ChainResidueDetails
AGLY86
BVAL132
CGLY86
CTRP87
CLYS105
CASP131
CVAL132
DGLY86
DTRP87
DLYS105
DASP131
ATRP87
DVAL132
ALYS105
AASP131
AVAL132
BGLY86
BTRP87
BLYS105
BASP131

site_idSWS_FT_FI5
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359
ChainResidueDetails
AHIS110
DHIS110
DGLU111
DASP146
AGLU111
AASP146
BHIS110
BGLU111
BASP146
CHIS110
CGLU111
CASP146

site_idSWS_FT_FI6
Number of Residues8
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00924
ChainResidueDetails
AILE147
ATYR220
BILE147
BTYR220
CILE147
CTYR220
DILE147
DTYR220

site_idSWS_FT_FI7
Number of Residues28
DetailsSITE: mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924
ChainResidueDetails
ALYS13
BPHE24
BLYS28
BSER150
BARG213
BSER215
CLYS13
CASN17
CPHE24
CLYS28
CSER150
AASN17
CARG213
CSER215
DLYS13
DASN17
DPHE24
DLYS28
DSER150
DARG213
DSER215
APHE24
ALYS28
ASER150
AARG213
ASER215
BLYS13
BASN17

site_idSWS_FT_FI8
Number of Residues8
DetailsSITE: mRNA cap binding; via carbonyl oxygen => ECO:0000255|PROSITE-ProRule:PRU00924
ChainResidueDetails
ALEU16
AMET19
BLEU16
BMET19
CLEU16
CMET19
DLEU16
DMET19

site_idSWS_FT_FI9
Number of Residues12
DetailsSITE: Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924
ChainResidueDetails
ALYS61
DLYS61
DLYS182
DGLU218
ALYS182
AGLU218
BLYS61
BLYS182
BGLU218
CLYS61
CLYS182
CGLU218

site_idSWS_FT_FI10
Number of Residues4
DetailsSITE: Essential for 2'-O-methyltransferase and N-7 methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924
ChainResidueDetails
AASP146
BASP146
CASP146
DASP146

site_idSWS_FT_FI11
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P03314
ChainResidueDetails
ASER56
BSER56
CSER56
DSER56

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PDB entries from 2024-03-27

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