Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 501 |
| Chain | Residue |
| A | GLU263 |
| A | HIS267 |
| A | CYS454 |
| A | HOH749 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue MES A 502 |
| Chain | Residue |
| A | LYS107 |
| A | THR171 |
| A | HOH647 |
| A | HOH729 |
| A | ARG32 |
| A | LEU33 |
| A | ASP34 |
| A | GLY104 |
| A | ASP105 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue MES A 503 |
| Chain | Residue |
| A | THR98 |
| A | ILE99 |
| A | ARG101 |
| A | HOH854 |
| B | ASP135 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 504 |
| Chain | Residue |
| A | TYR35 |
| A | ARG340 |
| A | HOH672 |
| A | HOH824 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 505 |
| Chain | Residue |
| A | SER117 |
| A | HOH963 |
| A | HOH1015 |
| A | HOH1032 |
| A | HOH1078 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 506 |
| Chain | Residue |
| A | GLU74 |
| A | HOH717 |
| B | ARG51 |
| B | ARG75 |
| B | PRO105 |
| site_id | AC7 |
| Number of Residues | 11 |
| Details | binding site for residue MES B 701 |
| Chain | Residue |
| B | ASP34 |
| B | GLY53 |
| B | TYR71 |
| B | HIS72 |
| B | GLN73 |
| B | ASN74 |
| B | ALA109 |
| B | GLN146 |
| B | HOH808 |
| B | HOH856 |
| B | HOH936 |
| site_id | AC8 |
| Number of Residues | 11 |
| Details | binding site for residue EDO B 702 |
| Chain | Residue |
| B | MET213 |
| B | SER214 |
| B | LEU216 |
| B | THR218 |
| B | HOH879 |
| B | HOH884 |
| B | HOH997 |
| D | LEU239 |
| D | TRP396 |
| D | TYR404 |
| D | HOH804 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 703 |
| Chain | Residue |
| B | MET242 |
| B | LYS243 |
| B | LYS446 |
| B | HOH913 |
| D | GLU220 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 704 |
| Chain | Residue |
| B | GLN356 |
| B | VAL423 |
| B | THR424 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue NA B 705 |
| Chain | Residue |
| B | SER30 |
| B | SER33 |
| B | HOH1163 |
| B | HOH1172 |
| B | HOH1202 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN C 501 |
| Chain | Residue |
| C | GLU263 |
| C | HIS267 |
| C | CYS454 |
| C | HOH737 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue MES C 502 |
| Chain | Residue |
| C | ARG32 |
| C | LEU33 |
| C | ASP34 |
| C | GLY104 |
| C | ASP105 |
| C | LYS107 |
| C | HOH664 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue EDO C 503 |
| Chain | Residue |
| C | TYR35 |
| C | ARG340 |
| C | HOH865 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue NA C 504 |
| Chain | Residue |
| C | ASN14 |
| C | ILE84 |
| C | HOH819 |
| C | HOH942 |
| C | HOH948 |
| C | HOH953 |
| site_id | AD7 |
| Number of Residues | 13 |
| Details | binding site for residue MES D 701 |
| Chain | Residue |
| D | HOH924 |
| D | ASP34 |
| D | GLY53 |
| D | TYR71 |
| D | HIS72 |
| D | GLN73 |
| D | ASN74 |
| D | ALA109 |
| D | ALA142 |
| D | GLN146 |
| D | HOH806 |
| D | HOH831 |
| D | HOH913 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO D 702 |
| Chain | Residue |
| C | GLU74 |
| D | ARG51 |
| D | ARG75 |
| D | HOH847 |
| site_id | AD9 |
| Number of Residues | 7 |
| Details | binding site for residue EDO D 703 |
| Chain | Residue |
| B | MET242 |
| B | HOH803 |
| D | MET213 |
| D | SER214 |
| D | LEU216 |
| D | THR218 |
| D | HOH1004 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO D 704 |
| Chain | Residue |
| B | GLU220 |
| D | MET242 |
| D | LYS243 |
| D | LYS446 |
| D | HOH866 |
| site_id | AE2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO D 705 |
| Chain | Residue |
| D | TRP288 |
| D | GLN356 |
| D | VAL423 |
| D | THR424 |
| site_id | AE3 |
| Number of Residues | 5 |
| Details | binding site for residue NA D 706 |
| Chain | Residue |
| D | SER30 |
| D | SER33 |
| D | HOH1158 |
| D | HOH1205 |
| D | HOH1230 |
