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5NIL

Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump-MacB section

Functional Information from GO Data
ChainGOidnamespacecontents
A0005216molecular_functionmonoatomic ion channel activity
A0005515molecular_functionprotein binding
A0009279cellular_componentcell outer membrane
A0009410biological_processresponse to xenobiotic stimulus
A0009636biological_processresponse to toxic substance
A0014070biological_processresponse to organic cyclic compound
A0015125molecular_functionbile acid transmembrane transporter activity
A0015288molecular_functionporin activity
A0015562molecular_functionefflux transmembrane transporter activity
A0015721biological_processbile acid and bile salt transport
A0016020cellular_componentmembrane
A0019867cellular_componentouter membrane
A0030288cellular_componentouter membrane-bounded periplasmic space
A0034220biological_processmonoatomic ion transmembrane transport
A0042802molecular_functionidentical protein binding
A0042930biological_processenterobactin transport
A0042931molecular_functionenterobactin transmembrane transporter activity
A0046677biological_processresponse to antibiotic
A0055085biological_processtransmembrane transport
A0098567cellular_componentperiplasmic side of plasma membrane
A0140330biological_processxenobiotic detoxification by transmembrane export across the cell outer membrane
A1990196cellular_componentMacAB-TolC complex
A1990281cellular_componentefflux pump complex
A1990961biological_processxenobiotic detoxification by transmembrane export across the plasma membrane
B0005216molecular_functionmonoatomic ion channel activity
B0005515molecular_functionprotein binding
B0009279cellular_componentcell outer membrane
B0009410biological_processresponse to xenobiotic stimulus
B0009636biological_processresponse to toxic substance
B0014070biological_processresponse to organic cyclic compound
B0015125molecular_functionbile acid transmembrane transporter activity
B0015288molecular_functionporin activity
B0015562molecular_functionefflux transmembrane transporter activity
B0015721biological_processbile acid and bile salt transport
B0016020cellular_componentmembrane
B0019867cellular_componentouter membrane
B0030288cellular_componentouter membrane-bounded periplasmic space
B0034220biological_processmonoatomic ion transmembrane transport
B0042802molecular_functionidentical protein binding
B0042930biological_processenterobactin transport
B0042931molecular_functionenterobactin transmembrane transporter activity
B0046677biological_processresponse to antibiotic
B0055085biological_processtransmembrane transport
B0098567cellular_componentperiplasmic side of plasma membrane
B0140330biological_processxenobiotic detoxification by transmembrane export across the cell outer membrane
B1990196cellular_componentMacAB-TolC complex
B1990281cellular_componentefflux pump complex
B1990961biological_processxenobiotic detoxification by transmembrane export across the plasma membrane
C0005216molecular_functionmonoatomic ion channel activity
C0005515molecular_functionprotein binding
C0009279cellular_componentcell outer membrane
C0009410biological_processresponse to xenobiotic stimulus
C0009636biological_processresponse to toxic substance
C0014070biological_processresponse to organic cyclic compound
C0015125molecular_functionbile acid transmembrane transporter activity
C0015288molecular_functionporin activity
C0015562molecular_functionefflux transmembrane transporter activity
C0015721biological_processbile acid and bile salt transport
C0016020cellular_componentmembrane
C0019867cellular_componentouter membrane
C0030288cellular_componentouter membrane-bounded periplasmic space
C0034220biological_processmonoatomic ion transmembrane transport
C0042802molecular_functionidentical protein binding
C0042930biological_processenterobactin transport
C0042931molecular_functionenterobactin transmembrane transporter activity
C0046677biological_processresponse to antibiotic
C0055085biological_processtransmembrane transport
C0098567cellular_componentperiplasmic side of plasma membrane
C0140330biological_processxenobiotic detoxification by transmembrane export across the cell outer membrane
C1990196cellular_componentMacAB-TolC complex
C1990281cellular_componentefflux pump complex
C1990961biological_processxenobiotic detoxification by transmembrane export across the plasma membrane
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0009636biological_processresponse to toxic substance
D0015562molecular_functionefflux transmembrane transporter activity
D0016020cellular_componentmembrane
D0019898cellular_componentextrinsic component of membrane
D0022857molecular_functiontransmembrane transporter activity
D0042802molecular_functionidentical protein binding
D0042893biological_processpolymyxin transport
D0042897molecular_functionpolymyxin transmembrane transporter activity
D0046677biological_processresponse to antibiotic
D0055085biological_processtransmembrane transport
D1990195cellular_componentmacrolide transmembrane transporter complex
D1990196cellular_componentMacAB-TolC complex
D1990281cellular_componentefflux pump complex
D1990961biological_processxenobiotic detoxification by transmembrane export across the plasma membrane
E0005515molecular_functionprotein binding
E0005886cellular_componentplasma membrane
E0009636biological_processresponse to toxic substance
E0015562molecular_functionefflux transmembrane transporter activity
E0016020cellular_componentmembrane
E0019898cellular_componentextrinsic component of membrane
E0022857molecular_functiontransmembrane transporter activity
E0042802molecular_functionidentical protein binding
E0042893biological_processpolymyxin transport
E0042897molecular_functionpolymyxin transmembrane transporter activity
E0046677biological_processresponse to antibiotic
E0055085biological_processtransmembrane transport
E1990195cellular_componentmacrolide transmembrane transporter complex
E1990196cellular_componentMacAB-TolC complex
E1990281cellular_componentefflux pump complex
E1990961biological_processxenobiotic detoxification by transmembrane export across the plasma membrane
F0005515molecular_functionprotein binding
F0005886cellular_componentplasma membrane
F0009636biological_processresponse to toxic substance
F0015562molecular_functionefflux transmembrane transporter activity
F0016020cellular_componentmembrane
F0019898cellular_componentextrinsic component of membrane
F0022857molecular_functiontransmembrane transporter activity
F0042802molecular_functionidentical protein binding
F0042893biological_processpolymyxin transport
F0042897molecular_functionpolymyxin transmembrane transporter activity
F0046677biological_processresponse to antibiotic
F0055085biological_processtransmembrane transport
F1990195cellular_componentmacrolide transmembrane transporter complex
F1990196cellular_componentMacAB-TolC complex
F1990281cellular_componentefflux pump complex
F1990961biological_processxenobiotic detoxification by transmembrane export across the plasma membrane
G0005515molecular_functionprotein binding
G0005886cellular_componentplasma membrane
G0009636biological_processresponse to toxic substance
G0015562molecular_functionefflux transmembrane transporter activity
G0016020cellular_componentmembrane
G0019898cellular_componentextrinsic component of membrane
G0022857molecular_functiontransmembrane transporter activity
G0042802molecular_functionidentical protein binding
G0042893biological_processpolymyxin transport
G0042897molecular_functionpolymyxin transmembrane transporter activity
G0046677biological_processresponse to antibiotic
G0055085biological_processtransmembrane transport
G1990195cellular_componentmacrolide transmembrane transporter complex
G1990196cellular_componentMacAB-TolC complex
G1990281cellular_componentefflux pump complex
G1990961biological_processxenobiotic detoxification by transmembrane export across the plasma membrane
H0005515molecular_functionprotein binding
H0005886cellular_componentplasma membrane
H0009636biological_processresponse to toxic substance
H0015562molecular_functionefflux transmembrane transporter activity
H0016020cellular_componentmembrane
H0019898cellular_componentextrinsic component of membrane
H0022857molecular_functiontransmembrane transporter activity
H0042802molecular_functionidentical protein binding
H0042893biological_processpolymyxin transport
H0042897molecular_functionpolymyxin transmembrane transporter activity
H0046677biological_processresponse to antibiotic
H0055085biological_processtransmembrane transport
H1990195cellular_componentmacrolide transmembrane transporter complex
H1990196cellular_componentMacAB-TolC complex
H1990281cellular_componentefflux pump complex
H1990961biological_processxenobiotic detoxification by transmembrane export across the plasma membrane
I0005515molecular_functionprotein binding
I0005886cellular_componentplasma membrane
I0009636biological_processresponse to toxic substance
I0015562molecular_functionefflux transmembrane transporter activity
I0016020cellular_componentmembrane
I0019898cellular_componentextrinsic component of membrane
I0022857molecular_functiontransmembrane transporter activity
I0042802molecular_functionidentical protein binding
I0042893biological_processpolymyxin transport
I0042897molecular_functionpolymyxin transmembrane transporter activity
I0046677biological_processresponse to antibiotic
I0055085biological_processtransmembrane transport
I1990195cellular_componentmacrolide transmembrane transporter complex
I1990196cellular_componentMacAB-TolC complex
I1990281cellular_componentefflux pump complex
I1990961biological_processxenobiotic detoxification by transmembrane export across the plasma membrane
J0005515molecular_functionprotein binding
J0005524molecular_functionATP binding
J0005886cellular_componentplasma membrane
J0008559molecular_functionABC-type xenobiotic transporter activity
J0016020cellular_componentmembrane
J0016887molecular_functionATP hydrolysis activity
J0022857molecular_functiontransmembrane transporter activity
J0042802molecular_functionidentical protein binding
J0042803molecular_functionprotein homodimerization activity
J0042893biological_processpolymyxin transport
J0042897molecular_functionpolymyxin transmembrane transporter activity
J0046677biological_processresponse to antibiotic
J1990196cellular_componentMacAB-TolC complex
J1990961biological_processxenobiotic detoxification by transmembrane export across the plasma membrane
K0005515molecular_functionprotein binding
K0005524molecular_functionATP binding
K0005886cellular_componentplasma membrane
K0008559molecular_functionABC-type xenobiotic transporter activity
K0016020cellular_componentmembrane
K0016887molecular_functionATP hydrolysis activity
K0022857molecular_functiontransmembrane transporter activity
K0042802molecular_functionidentical protein binding
K0042803molecular_functionprotein homodimerization activity
K0042893biological_processpolymyxin transport
K0042897molecular_functionpolymyxin transmembrane transporter activity
K0046677biological_processresponse to antibiotic
K1990196cellular_componentMacAB-TolC complex
K1990961biological_processxenobiotic detoxification by transmembrane export across the plasma membrane
Functional Information from PROSITE/UniProt
site_idPS00211
Number of Residues15
DetailsABC_TRANSPORTER_1 ABC transporters family signature. LSGGQQQRVSIARAL
ChainResidueDetails
JLEU145-LEU159

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues636
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
JMET1-THR272
JMET544-GLU575
JPRO632-GLU648
KMET1-THR272
KMET544-GLU575
KPRO632-GLU648
CGLU1-PRO40
CILE75-PRO246
CLEU290-ASN471

site_idSWS_FT_FI2
Number of Residues160
DetailsTRANSMEM: Helical => ECO:0000255|HAMAP-Rule:MF_01720
ChainResidueDetails
JLEU273-GLY293
JLEU523-ILE543
JALA576-PHE596
JPRO611-LEU631
KLEU273-GLY293
KLEU523-ILE543
KALA576-PHE596
KPRO611-LEU631

site_idSWS_FT_FI3
Number of Residues482
DetailsTOPO_DOM: Periplasmic => ECO:0000255
ChainResidueDetails
JASP294-GLN522
JTHR597-SER610
KASP294-GLN522
KTHR597-SER610
HPRO32-GLN371
IPRO32-GLN371

site_idSWS_FT_FI4
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01720
ChainResidueDetails
JGLY41
KGLY41
CASN61-SER74

site_idSWS_FT_FI5
Number of Residues30
DetailsTRANSMEM: Beta stranded; Name=S4
ChainResidueDetails
ATHR247-SER257
BTHR247-SER257
CTHR247-SER257

site_idSWS_FT_FI6
Number of Residues30
DetailsTRANSMEM: Beta stranded; Name=S5
ChainResidueDetails
AMET279-SER289
BMET279-SER289
CMET279-SER289

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PDB entries from 2024-10-30

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