5NIL

Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump-MacB section

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005515	molecular_function	protein binding
A	0009279	cellular_component	cell outer membrane
A	0009410	biological_process	response to xenobiotic stimulus
A	0009636	biological_process	response to toxic substance
A	0015125	molecular_function	bile acid transmembrane transporter activity
A	0015288	molecular_function	porin activity
A	0015562	molecular_function	efflux transmembrane transporter activity
A	0015721	biological_process	bile acid and bile salt transport
A	0016020	cellular_component	membrane
A	0019867	cellular_component	outer membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0042802	molecular_function	identical protein binding
A	0042930	biological_process	enterobactin transport
A	0042931	molecular_function	enterobactin transmembrane transporter activity
A	0046677	biological_process	response to antibiotic
A	0055085	biological_process	transmembrane transport
A	0098567	cellular_component	periplasmic side of plasma membrane
A	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
A	1990196	cellular_component	MacAB-TolC complex
A	1990281	cellular_component	efflux pump complex
A	1990961	biological_process	xenobiotic detoxification by transmembrane export across the plasma membrane
B	0005216	molecular_function	monoatomic ion channel activity
B	0005515	molecular_function	protein binding
B	0009279	cellular_component	cell outer membrane
B	0009410	biological_process	response to xenobiotic stimulus
B	0009636	biological_process	response to toxic substance
B	0015125	molecular_function	bile acid transmembrane transporter activity
B	0015288	molecular_function	porin activity
B	0015562	molecular_function	efflux transmembrane transporter activity
B	0015721	biological_process	bile acid and bile salt transport
B	0016020	cellular_component	membrane
B	0019867	cellular_component	outer membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0042802	molecular_function	identical protein binding
B	0042930	biological_process	enterobactin transport
B	0042931	molecular_function	enterobactin transmembrane transporter activity
B	0046677	biological_process	response to antibiotic
B	0055085	biological_process	transmembrane transport
B	0098567	cellular_component	periplasmic side of plasma membrane
B	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
B	1990196	cellular_component	MacAB-TolC complex
B	1990281	cellular_component	efflux pump complex
B	1990961	biological_process	xenobiotic detoxification by transmembrane export across the plasma membrane
C	0005216	molecular_function	monoatomic ion channel activity
C	0005515	molecular_function	protein binding
C	0009279	cellular_component	cell outer membrane
C	0009410	biological_process	response to xenobiotic stimulus
C	0009636	biological_process	response to toxic substance
C	0015125	molecular_function	bile acid transmembrane transporter activity
C	0015288	molecular_function	porin activity
C	0015562	molecular_function	efflux transmembrane transporter activity
C	0015721	biological_process	bile acid and bile salt transport
C	0016020	cellular_component	membrane
C	0019867	cellular_component	outer membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0042802	molecular_function	identical protein binding
C	0042930	biological_process	enterobactin transport
C	0042931	molecular_function	enterobactin transmembrane transporter activity
C	0046677	biological_process	response to antibiotic
C	0055085	biological_process	transmembrane transport
C	0098567	cellular_component	periplasmic side of plasma membrane
C	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
C	1990196	cellular_component	MacAB-TolC complex
C	1990281	cellular_component	efflux pump complex
C	1990961	biological_process	xenobiotic detoxification by transmembrane export across the plasma membrane
D	0005515	molecular_function	protein binding
D	0005886	cellular_component	plasma membrane
D	0015562	molecular_function	efflux transmembrane transporter activity
D	0016020	cellular_component	membrane
D	0019898	cellular_component	extrinsic component of membrane
D	0022857	molecular_function	transmembrane transporter activity
D	0042802	molecular_function	identical protein binding
D	0042893	biological_process	polymyxin transport
D	0042897	molecular_function	polymyxin transmembrane transporter activity
D	0046677	biological_process	response to antibiotic
D	0055085	biological_process	transmembrane transport
D	1990195	cellular_component	macrolide transmembrane transporter complex
D	1990196	cellular_component	MacAB-TolC complex
D	1990281	cellular_component	efflux pump complex
D	1990961	biological_process	xenobiotic detoxification by transmembrane export across the plasma membrane
E	0005515	molecular_function	protein binding
E	0005886	cellular_component	plasma membrane
E	0015562	molecular_function	efflux transmembrane transporter activity
E	0016020	cellular_component	membrane
E	0019898	cellular_component	extrinsic component of membrane
E	0022857	molecular_function	transmembrane transporter activity
E	0042802	molecular_function	identical protein binding
E	0042893	biological_process	polymyxin transport
E	0042897	molecular_function	polymyxin transmembrane transporter activity
E	0046677	biological_process	response to antibiotic
E	0055085	biological_process	transmembrane transport
E	1990195	cellular_component	macrolide transmembrane transporter complex
E	1990196	cellular_component	MacAB-TolC complex
E	1990281	cellular_component	efflux pump complex
E	1990961	biological_process	xenobiotic detoxification by transmembrane export across the plasma membrane
F	0005515	molecular_function	protein binding
F	0005886	cellular_component	plasma membrane
F	0015562	molecular_function	efflux transmembrane transporter activity
F	0016020	cellular_component	membrane
F	0019898	cellular_component	extrinsic component of membrane
F	0022857	molecular_function	transmembrane transporter activity
F	0042802	molecular_function	identical protein binding
F	0042893	biological_process	polymyxin transport
F	0042897	molecular_function	polymyxin transmembrane transporter activity
F	0046677	biological_process	response to antibiotic
F	0055085	biological_process	transmembrane transport
F	1990195	cellular_component	macrolide transmembrane transporter complex
F	1990196	cellular_component	MacAB-TolC complex
F	1990281	cellular_component	efflux pump complex
F	1990961	biological_process	xenobiotic detoxification by transmembrane export across the plasma membrane
G	0005515	molecular_function	protein binding
G	0005886	cellular_component	plasma membrane
G	0015562	molecular_function	efflux transmembrane transporter activity
G	0016020	cellular_component	membrane
G	0019898	cellular_component	extrinsic component of membrane
G	0022857	molecular_function	transmembrane transporter activity
G	0042802	molecular_function	identical protein binding
G	0042893	biological_process	polymyxin transport
G	0042897	molecular_function	polymyxin transmembrane transporter activity
G	0046677	biological_process	response to antibiotic
G	0055085	biological_process	transmembrane transport
G	1990195	cellular_component	macrolide transmembrane transporter complex
G	1990196	cellular_component	MacAB-TolC complex
G	1990281	cellular_component	efflux pump complex
G	1990961	biological_process	xenobiotic detoxification by transmembrane export across the plasma membrane
H	0005515	molecular_function	protein binding
H	0005886	cellular_component	plasma membrane
H	0015562	molecular_function	efflux transmembrane transporter activity
H	0016020	cellular_component	membrane
H	0019898	cellular_component	extrinsic component of membrane
H	0022857	molecular_function	transmembrane transporter activity
H	0042802	molecular_function	identical protein binding
H	0042893	biological_process	polymyxin transport
H	0042897	molecular_function	polymyxin transmembrane transporter activity
H	0046677	biological_process	response to antibiotic
H	0055085	biological_process	transmembrane transport
H	1990195	cellular_component	macrolide transmembrane transporter complex
H	1990196	cellular_component	MacAB-TolC complex
H	1990281	cellular_component	efflux pump complex
H	1990961	biological_process	xenobiotic detoxification by transmembrane export across the plasma membrane
I	0005515	molecular_function	protein binding
I	0005886	cellular_component	plasma membrane
I	0015562	molecular_function	efflux transmembrane transporter activity
I	0016020	cellular_component	membrane
I	0019898	cellular_component	extrinsic component of membrane
I	0022857	molecular_function	transmembrane transporter activity
I	0042802	molecular_function	identical protein binding
I	0042893	biological_process	polymyxin transport
I	0042897	molecular_function	polymyxin transmembrane transporter activity
I	0046677	biological_process	response to antibiotic
I	0055085	biological_process	transmembrane transport
I	1990195	cellular_component	macrolide transmembrane transporter complex
I	1990196	cellular_component	MacAB-TolC complex
I	1990281	cellular_component	efflux pump complex
I	1990961	biological_process	xenobiotic detoxification by transmembrane export across the plasma membrane
J	0000166	molecular_function	nucleotide binding
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005886	cellular_component	plasma membrane
J	0008559	molecular_function	ABC-type xenobiotic transporter activity
J	0016020	cellular_component	membrane
J	0016887	molecular_function	ATP hydrolysis activity
J	0022857	molecular_function	transmembrane transporter activity
J	0042802	molecular_function	identical protein binding
J	0042803	molecular_function	protein homodimerization activity
J	0042893	biological_process	polymyxin transport
J	0042897	molecular_function	polymyxin transmembrane transporter activity
J	0046677	biological_process	response to antibiotic
J	1902495	cellular_component	transmembrane transporter complex
J	1990196	cellular_component	MacAB-TolC complex
J	1990961	biological_process	xenobiotic detoxification by transmembrane export across the plasma membrane
K	0000166	molecular_function	nucleotide binding
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005886	cellular_component	plasma membrane
K	0008559	molecular_function	ABC-type xenobiotic transporter activity
K	0016020	cellular_component	membrane
K	0016887	molecular_function	ATP hydrolysis activity
K	0022857	molecular_function	transmembrane transporter activity
K	0042802	molecular_function	identical protein binding
K	0042803	molecular_function	protein homodimerization activity
K	0042893	biological_process	polymyxin transport
K	0042897	molecular_function	polymyxin transmembrane transporter activity
K	0046677	biological_process	response to antibiotic
K	1902495	cellular_component	transmembrane transporter complex
K	1990196	cellular_component	MacAB-TolC complex
K	1990961	biological_process	xenobiotic detoxification by transmembrane export across the plasma membrane

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQQQRVSIARAL

Chain	Residue	Details
J	LEU145-LEU159

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	630
Details	Topological domain: {"description":"Periplasmic"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	33
Details	Transmembrane: {"description":"Beta stranded; Name=S1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	81
Details	Topological domain: {"description":"Extracellular"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	39
Details	Transmembrane: {"description":"Beta stranded; Name=S2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	30
Details	Transmembrane: {"description":"Beta stranded; Name=S4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	30
Details	Transmembrane: {"description":"Beta stranded; Name=S5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	621
Details	Repeat: {"description":"1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	645
Details	Repeat: {"description":"2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	84
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	45
Details	Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2516
Details	Topological domain: {"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	270
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	160
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"HAMAP-Rule","id":"MF_01720","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	94
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01720","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---