5NH5
Crystal structure of native xylose isomerase from Piromyces E2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0009045 | molecular_function | xylose isomerase activity |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0042732 | biological_process | D-xylose metabolic process |
| A | 0044577 | biological_process | xylose catabolic process to ethanol |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0009045 | molecular_function | xylose isomerase activity |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0042732 | biological_process | D-xylose metabolic process |
| B | 0044577 | biological_process | xylose catabolic process to ethanol |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0009045 | molecular_function | xylose isomerase activity |
| C | 0016853 | molecular_function | isomerase activity |
| C | 0042732 | biological_process | D-xylose metabolic process |
| C | 0044577 | biological_process | xylose catabolic process to ethanol |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005975 | biological_process | carbohydrate metabolic process |
| D | 0009045 | molecular_function | xylose isomerase activity |
| D | 0016853 | molecular_function | isomerase activity |
| D | 0042732 | biological_process | D-xylose metabolic process |
| D | 0044577 | biological_process | xylose catabolic process to ethanol |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 501 |
| Chain | Residue |
| A | GLU233 |
| A | GLU269 |
| A | ASP297 |
| A | ASP340 |
| A | GOL507 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue FE2 A 502 |
| Chain | Residue |
| A | GOL507 |
| A | GLU233 |
| A | GLU269 |
| A | ASP297 |
| A | ASP340 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 503 |
| Chain | Residue |
| A | GLU233 |
| A | GLU269 |
| A | ASP297 |
| A | ASP340 |
| A | GOL507 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | binding site for residue SO4 A 504 |
| Chain | Residue |
| A | SER112 |
| A | ILE113 |
| A | HOH679 |
| A | HOH680 |
| A | HOH721 |
| A | HOH787 |
| A | HOH806 |
| A | HOH860 |
| B | GLY417 |
| B | GLU418 |
| B | HOH778 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 505 |
| Chain | Residue |
| A | GLU249 |
| A | LYS256 |
| A | HOH614 |
| A | HOH646 |
| A | HOH730 |
| A | HOH870 |
| B | ALA257 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | binding site for residue GOL A 506 |
| Chain | Residue |
| A | HIS26 |
| A | TYR27 |
| A | ASP362 |
| A | ARG366 |
| A | HOH613 |
| A | HOH805 |
| A | HOH863 |
| D | ALA434 |
| D | MET435 |
| D | GLN437 |
| D | HOH1017 |
| site_id | AC7 |
| Number of Residues | 11 |
| Details | binding site for residue GOL A 507 |
| Chain | Residue |
| A | HIS102 |
| A | TRP140 |
| A | TRP189 |
| A | GLU233 |
| A | GLU269 |
| A | ASP297 |
| A | ASP340 |
| A | CA501 |
| A | FE2502 |
| A | MG503 |
| A | HOH735 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 508 |
| Chain | Residue |
| A | GLN10 |
| A | ASN21 |
| A | LEU23 |
| A | HOH940 |
| C | LYS13 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 509 |
| Chain | Residue |
| A | ASP202 |
| A | ARG205 |
| A | HOH616 |
| A | HOH690 |
| B | LYS385 |
| B | TYR388 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 510 |
| Chain | Residue |
| A | LEU23 |
| A | GLU351 |
| A | HOH702 |
| A | HOH733 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue CA B 501 |
| Chain | Residue |
| B | GLU233 |
| B | GLU269 |
| B | ASP297 |
| B | ASP340 |
| B | GOL506 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue FE2 B 502 |
| Chain | Residue |
| B | GLU233 |
| B | GLU269 |
| B | ASP297 |
| B | ASP340 |
| B | GOL506 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 503 |
| Chain | Residue |
| B | GLU233 |
| B | GLU269 |
| B | ASP297 |
| B | ASP340 |
| B | GOL506 |
| site_id | AD5 |
| Number of Residues | 12 |
| Details | binding site for residue SO4 B 504 |
| Chain | Residue |
| A | GLY417 |
| A | GLU418 |
| A | HOH657 |
| A | HOH774 |
| B | SER112 |
| B | ILE113 |
| B | HOH660 |
| B | HOH669 |
| B | HOH760 |
| B | HOH870 |
| B | HOH912 |
| B | HOH966 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 505 |
| Chain | Residue |
| B | LEU23 |
| B | HOH728 |
| D | LYS13 |
| B | GLN10 |
| B | ASN21 |
| site_id | AD7 |
| Number of Residues | 11 |
| Details | binding site for residue GOL B 506 |
| Chain | Residue |
| B | HIS102 |
| B | TRP140 |
| B | TRP189 |
| B | GLU233 |
| B | GLU269 |
| B | ASP297 |
| B | ASP340 |
| B | CA501 |
| B | FE2502 |
| B | MG503 |
| B | HOH802 |
| site_id | AD8 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 507 |
| Chain | Residue |
| A | ALA257 |
| B | GLU249 |
| B | LYS256 |
| B | HOH628 |
| B | HOH650 |
| B | HOH737 |
| B | HOH844 |
| site_id | AD9 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 508 |
| Chain | Residue |
| B | PRO22 |
| B | GLU351 |
| B | HOH731 |
| site_id | AE1 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 509 |
| Chain | Residue |
| B | GLU56 |
| B | GLY64 |
| B | LYS66 |
| B | SER67 |
| B | HOH643 |
| D | LYS149 |
| D | HOH884 |
| site_id | AE2 |
| Number of Residues | 10 |
| Details | binding site for residue GOL B 510 |
| Chain | Residue |
| B | HIS26 |
| B | TYR27 |
| B | ASP362 |
| B | ARG366 |
| B | HOH612 |
| B | HOH773 |
| C | ALA434 |
| C | MET435 |
| C | GLN437 |
| C | HOH1024 |
| site_id | AE3 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 511 |
| Chain | Residue |
| B | LEU120 |
| B | ASN173 |
| B | ASP176 |
| B | ALA177 |
| B | HOH604 |
| B | HOH622 |
| B | HOH625 |
| B | HOH933 |
| site_id | AE4 |
| Number of Residues | 5 |
| Details | binding site for residue CA C 501 |
| Chain | Residue |
| C | GLU233 |
| C | GLU269 |
| C | ASP297 |
| C | ASP340 |
| C | GOL505 |
| site_id | AE5 |
| Number of Residues | 5 |
| Details | binding site for residue FE2 C 502 |
| Chain | Residue |
| C | GLU233 |
| C | GLU269 |
| C | ASP297 |
| C | ASP340 |
| C | GOL505 |
| site_id | AE6 |
| Number of Residues | 5 |
| Details | binding site for residue MG C 503 |
| Chain | Residue |
| C | GLU233 |
| C | GLU269 |
| C | ASP297 |
| C | ASP340 |
| C | GOL505 |
| site_id | AE7 |
| Number of Residues | 4 |
| Details | binding site for residue GOL C 504 |
| Chain | Residue |
| C | GLN10 |
| C | ASN21 |
| C | LEU23 |
| C | HOH779 |
| site_id | AE8 |
| Number of Residues | 12 |
| Details | binding site for residue GOL C 505 |
| Chain | Residue |
| C | HIS102 |
| C | TRP140 |
| C | TRP189 |
| C | GLU233 |
| C | GLU269 |
| C | ASP297 |
| C | ASP340 |
| C | CA501 |
| C | FE2502 |
| C | MG503 |
| C | HOH642 |
| C | HOH683 |
| site_id | AE9 |
| Number of Residues | 7 |
| Details | binding site for residue GOL C 506 |
| Chain | Residue |
| C | GLU249 |
| C | LYS256 |
| C | HOH608 |
| C | HOH609 |
| C | HOH706 |
| C | HOH717 |
| D | ALA257 |
| site_id | AF1 |
| Number of Residues | 11 |
| Details | binding site for residue GOL C 507 |
| Chain | Residue |
| B | ALA434 |
| B | MET435 |
| C | HIS26 |
| C | TYR27 |
| C | ASP362 |
| C | ARG366 |
| C | HOH601 |
| C | HOH602 |
| C | HOH654 |
| C | HOH949 |
| C | HOH952 |
| site_id | AF2 |
| Number of Residues | 5 |
| Details | binding site for residue CA D 501 |
| Chain | Residue |
| D | GLU233 |
| D | GLU269 |
| D | ASP297 |
| D | ASP340 |
| D | GOL505 |
| site_id | AF3 |
| Number of Residues | 5 |
| Details | binding site for residue FE2 D 502 |
| Chain | Residue |
| D | GLU233 |
| D | GLU269 |
| D | ASP297 |
| D | ASP340 |
| D | GOL505 |
| site_id | AF4 |
| Number of Residues | 5 |
| Details | binding site for residue MG D 503 |
| Chain | Residue |
| D | GLU233 |
| D | GLU269 |
| D | ASP297 |
| D | ASP340 |
| D | GOL505 |
| site_id | AF5 |
| Number of Residues | 12 |
| Details | binding site for residue SO4 D 504 |
| Chain | Residue |
| A | ALA2 |
| C | GLY417 |
| C | GLU418 |
| C | HOH785 |
| D | SER112 |
| D | ILE113 |
| D | HOH643 |
| D | HOH710 |
| D | HOH781 |
| D | HOH838 |
| D | HOH889 |
| D | HOH941 |
| site_id | AF6 |
| Number of Residues | 12 |
| Details | binding site for residue GOL D 505 |
| Chain | Residue |
| D | HIS102 |
| D | TRP140 |
| D | TRP189 |
| D | GLU233 |
| D | GLU269 |
| D | ASP297 |
| D | ASP340 |
| D | CA501 |
| D | FE2502 |
| D | MG503 |
| D | HOH801 |
| D | HOH808 |
| site_id | AF7 |
| Number of Residues | 4 |
| Details | binding site for residue GOL D 506 |
| Chain | Residue |
| D | GLN10 |
| D | ASN21 |
| D | LEU23 |
| D | HOH763 |
| site_id | AF8 |
| Number of Residues | 7 |
| Details | binding site for residue GOL D 507 |
| Chain | Residue |
| C | ALA257 |
| D | GLU249 |
| D | LYS256 |
| D | HOH603 |
| D | HOH614 |
| D | HOH678 |
| D | HOH833 |
