5NFY

SARS-CoV nsp10/nsp14 dynamic complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000175	molecular_function	3'-5'-RNA exonuclease activity
A	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
A	0004532	molecular_function	RNA exonuclease activity
A	0008168	molecular_function	methyltransferase activity
B	0000175	molecular_function	3'-5'-RNA exonuclease activity
B	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
B	0004532	molecular_function	RNA exonuclease activity
B	0008168	molecular_function	methyltransferase activity
C	0000175	molecular_function	3'-5'-RNA exonuclease activity
C	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
C	0004532	molecular_function	RNA exonuclease activity
C	0008168	molecular_function	methyltransferase activity
D	0000175	molecular_function	3'-5'-RNA exonuclease activity
D	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
D	0004532	molecular_function	RNA exonuclease activity
D	0008168	molecular_function	methyltransferase activity
M	0003723	molecular_function	RNA binding
M	0008270	molecular_function	zinc ion binding
M	0019079	biological_process	viral genome replication
N	0003723	molecular_function	RNA binding
N	0008270	molecular_function	zinc ion binding
N	0019079	biological_process	viral genome replication
O	0003723	molecular_function	RNA binding
O	0008270	molecular_function	zinc ion binding
O	0019079	biological_process	viral genome replication
P	0003723	molecular_function	RNA binding
P	0008270	molecular_function	zinc ion binding
P	0019079	biological_process	viral genome replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 601

Chain	Residue
A	CYS207
A	CYS210
A	CYS226
A	HIS229

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 602

Chain	Residue
A	HIS257
A	CYS261
A	HIS264
A	CYS279

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 603

Chain	Residue
A	CYS477
A	CYS484
A	HIS487
A	CYS452

---

site_id	AC4
Number of Residues	3
Details	binding site for residue PEG A 604

Chain	Residue
A	LEU209
C	SER221
C	HOH717

---

site_id	AC5
Number of Residues	5
Details	binding site for residue ZN B 601

Chain	Residue
B	CYS207
B	CYS210
B	CYS226
B	HIS229
B	HOH707

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN B 602

Chain	Residue
B	HIS257
B	CYS261
B	HIS264
B	CYS279

---

site_id	AC7
Number of Residues	4
Details	binding site for residue ZN B 603

Chain	Residue
B	CYS452
B	CYS477
B	CYS484
B	HIS487

---

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN C 601

Chain	Residue
C	CYS207
C	CYS210
C	CYS226
C	HIS229

---

site_id	AC9
Number of Residues	4
Details	binding site for residue ZN C 602

Chain	Residue
C	HIS257
C	CYS261
C	HIS264
C	CYS279

---

site_id	AD1
Number of Residues	5
Details	binding site for residue ZN C 603

Chain	Residue
C	CYS452
C	THR475
C	CYS477
C	CYS484
C	HIS487

---

site_id	AD2
Number of Residues	1
Details	binding site for residue PEG C 604

Chain	Residue
C	LEU209

---

site_id	AD3
Number of Residues	5
Details	binding site for residue ZN D 601

Chain	Residue
D	CYS207
D	LEU209
D	CYS210
D	CYS226
D	HIS229

---

site_id	AD4
Number of Residues	4
Details	binding site for residue ZN D 602

Chain	Residue
D	HIS257
D	CYS261
D	HIS264
D	CYS279

---

site_id	AD5
Number of Residues	4
Details	binding site for residue ZN D 603

Chain	Residue
D	CYS452
D	CYS477
D	CYS484
D	HIS487

---

site_id	AD6
Number of Residues	4
Details	binding site for residue ZN M 201

Chain	Residue
M	CYS74
M	CYS77
M	HIS83
M	CYS90

---

site_id	AD7
Number of Residues	4
Details	binding site for residue ZN M 202

Chain	Residue
M	CYS117
M	CYS120
M	CYS128
M	CYS130

---

site_id	AD8
Number of Residues	4
Details	binding site for residue ZN N 201

Chain	Residue
N	CYS74
N	CYS77
N	HIS83
N	CYS90

---

site_id	AD9
Number of Residues	4
Details	binding site for residue ZN N 202

Chain	Residue
N	CYS117
N	VAL119
N	CYS120
N	CYS130

---

site_id	AE1
Number of Residues	4
Details	binding site for residue ZN O 201

Chain	Residue
O	CYS74
O	CYS77
O	HIS83
O	CYS90

---

site_id	AE2
Number of Residues	4
Details	binding site for residue ZN O 202

Chain	Residue
O	CYS117
O	CYS120
O	CYS128
O	CYS130

---

site_id	AE3
Number of Residues	4
Details	binding site for residue ZN P 201

Chain	Residue
P	CYS74
P	CYS77
P	HIS83
P	CYS90

---

site_id	AE4
Number of Residues	4
Details	binding site for residue ZN P 202

Chain	Residue
P	CYS117
P	CYS120
P	CYS128
P	CYS130

---

site_id	AE5
Number of Residues	10
Details	binding site for Di-peptide VAL O 116 and TRP O 123

Chain	Residue
O	ALA54
O	GLN98
O	PHE110
O	THR115
O	CYS117
O	THR118
O	MET122
O	LYS124
O	GLY125
O	TYR126

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI6
Number of Residues	116
Details	Zinc finger: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01297","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"22022266","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues
Details	M-CSA 830

Chain

Residue

Details

---

site_id	MCSA2
Number of Residues
Details	M-CSA 830

Chain

Residue

Details

---

site_id	MCSA3
Number of Residues
Details	M-CSA 830

Chain

Residue

Details

---

site_id	MCSA4
Number of Residues
Details	M-CSA 830

Chain

Residue

Details

---