5NCZ
mPI3Kd IN COMPLEX WITH inh1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001782 | biological_process | B cell homeostasis |
| A | 0002250 | biological_process | adaptive immune response |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005942 | cellular_component | phosphatidylinositol 3-kinase complex |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006935 | biological_process | chemotaxis |
| A | 0006954 | biological_process | inflammatory response |
| A | 0007166 | biological_process | cell surface receptor signaling pathway |
| A | 0010628 | biological_process | positive regulation of gene expression |
| A | 0010629 | biological_process | negative regulation of gene expression |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016303 | molecular_function | 1-phosphatidylinositol-3-kinase activity |
| A | 0030154 | biological_process | cell differentiation |
| A | 0035005 | molecular_function | 1-phosphatidylinositol-4-phosphate 3-kinase activity |
| A | 0036092 | biological_process | phosphatidylinositol-3-phosphate biosynthetic process |
| A | 0042113 | biological_process | B cell activation |
| A | 0043491 | biological_process | phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| A | 0045087 | biological_process | innate immune response |
| A | 0045766 | biological_process | positive regulation of angiogenesis |
| A | 0046854 | biological_process | phosphatidylinositol phosphate biosynthetic process |
| A | 0046934 | molecular_function | 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity |
| A | 0048015 | biological_process | phosphatidylinositol-mediated signaling |
| A | 0048872 | biological_process | homeostasis of number of cells |
| A | 0050832 | biological_process | defense response to fungus |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 1101 |
| Chain | Residue |
| A | ASP787 |
| A | TYR813 |
| A | ASP911 |
| A | PHE912 |
| A | 8TN1105 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 1102 |
| Chain | Residue |
| A | LYS779 |
| A | ASP911 |
| A | 8TN1105 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 1103 |
| Chain | Residue |
| A | GLN170 |
| A | ASP605 |
| A | PHE609 |
| A | ASN640 |
| A | LYS642 |
| A | HOH1223 |
| A | PRO168 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 1104 |
| Chain | Residue |
| A | LEU120 |
| A | TRP649 |
| A | ARG652 |
| A | GLY686 |
| A | HOH1210 |
| A | HOH1251 |
| A | HOH1259 |
| site_id | AC5 |
| Number of Residues | 17 |
| Details | binding site for residue 8TN A 1105 |
| Chain | Residue |
| A | PHE751 |
| A | MET752 |
| A | PRO758 |
| A | TRP760 |
| A | ILE777 |
| A | TYR813 |
| A | ILE825 |
| A | GLU826 |
| A | VAL827 |
| A | VAL828 |
| A | SER831 |
| A | ASP832 |
| A | MET900 |
| A | ILE910 |
| A | EDO1101 |
| A | EDO1102 |
| A | HOH1391 |
Functional Information from PROSITE/UniProt
| site_id | PS00915 |
| Number of Residues | 15 |
| Details | PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. FKng.DDLRQDmltlQ |
| Chain | Residue | Details |
| A | PHE778-GLN792 |
| site_id | PS00916 |
| Number of Residues | 21 |
| Details | PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ScAgycVatYVLgIgDRHsdN |
| Chain | Residue | Details |
| A | SER878-ASN898 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:O00329 |
| Chain | Residue | Details |
| A | HIS526 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by autocatalysis => ECO:0000250|UniProtKB:O00329 |
| Chain | Residue | Details |
| A | ASP1041 |
