5NA5

Pseudomonas fluorescens kynurenine 3-monooxygenase (KMO) apo structure

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004497	molecular_function	monooxygenase activity
A	0004502	molecular_function	kynurenine 3-monooxygenase activity
A	0006569	biological_process	L-tryptophan catabolic process
A	0009435	biological_process	NAD+ biosynthetic process
A	0016174	molecular_function	NAD(P)H oxidase H2O2-forming activity
A	0016491	molecular_function	oxidoreductase activity
A	0019363	biological_process	pyridine nucleotide biosynthetic process
A	0019674	biological_process	NAD+ metabolic process
A	0019805	biological_process	quinolinate biosynthetic process
A	0043420	biological_process	anthranilate metabolic process
A	0050660	molecular_function	flavin adenine dinucleotide binding
A	0070189	biological_process	kynurenine metabolic process
A	0071949	molecular_function	FAD binding
B	0003824	molecular_function	catalytic activity
B	0004497	molecular_function	monooxygenase activity
B	0004502	molecular_function	kynurenine 3-monooxygenase activity
B	0006569	biological_process	L-tryptophan catabolic process
B	0009435	biological_process	NAD+ biosynthetic process
B	0016174	molecular_function	NAD(P)H oxidase H2O2-forming activity
B	0016491	molecular_function	oxidoreductase activity
B	0019363	biological_process	pyridine nucleotide biosynthetic process
B	0019674	biological_process	NAD+ metabolic process
B	0019805	biological_process	quinolinate biosynthetic process
B	0043420	biological_process	anthranilate metabolic process
B	0050660	molecular_function	flavin adenine dinucleotide binding
B	0070189	biological_process	kynurenine metabolic process
B	0071949	molecular_function	FAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	36
Details	binding site for residue FAD A 501

Chain	Residue
A	ILE13
A	ALA56
A	ARG111
A	GLY134
A	LEU135
A	ALA165
A	ASP166
A	GLY167
A	ALA171
A	GLY310
A	ASP311
A	GLY14
A	GLY321
A	GLN322
A	GLY323
A	MET324
A	ASN325
A	CL502
A	GOL503
A	HOH637
A	HOH650
A	HOH668
A	GLY16
A	HOH674
A	HOH677
A	HOH686
A	HOH701
A	HOH720
A	HOH750
A	HOH797
A	LEU17
A	ALA18
A	GLU37
A	ARG38
A	ARG39
A	LEU55

---

site_id	AC2
Number of Residues	4
Details	binding site for residue CL A 502

Chain	Residue
A	PRO318
A	GLN322
A	GLY323
A	FAD501

---

site_id	AC3
Number of Residues	7
Details	binding site for residue GOL A 503

Chain	Residue
A	LEU292
A	ALA293
A	PRO315
A	MET316
A	FAD501
A	HOH603
A	HOH656

---

site_id	AC4
Number of Residues	35
Details	binding site for residue FAD B 501

Chain	Residue
B	ILE13
B	GLY14
B	GLY16
B	LEU17
B	ALA18
B	GLU37
B	ARG38
B	ARG39
B	LEU55
B	ALA56
B	ARG111
B	GLY134
B	LEU135
B	ALA165
B	ASP166
B	GLY167
B	ALA171
B	GLY310
B	ASP311
B	GLY321
B	GLN322
B	GLY323
B	MET324
B	ASN325
B	CL502
B	GOL503
B	HOH609
B	HOH612
B	HOH642
B	HOH648
B	HOH671
B	HOH685
B	HOH696
B	HOH717
B	HOH737

---

site_id	AC5
Number of Residues	5
Details	binding site for residue CL B 502

Chain	Residue
B	PRO318
B	GLN322
B	GLY323
B	FAD501
B	HOH769

---

site_id	AC6
Number of Residues	6
Details	binding site for residue GOL B 503

Chain	Residue
B	LEU292
B	ALA293
B	PRO315
B	MET316
B	FAD501
B	HOH607

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28336141","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28398044","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28604669","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29208702","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29429898","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5FN0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5MZC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5MZI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5MZK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5N7T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5NA5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5NAB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5NAE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5NAG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5NAH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5NAK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5X6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5X6Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5Y66","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5Y77","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5Y7A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29208702","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5Y66","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5Y77","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29208702","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5Y77","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29208702","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5Y66","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5Y77","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5Y7A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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