5N8X

Trigonal structure of mutant V173I of 3D polymerase from Foot-and-Mouth Disease Virus

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003968	molecular_function	RNA-directed RNA polymerase activity
A	0006351	biological_process	DNA-templated transcription
A	0039694	biological_process	viral RNA genome replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue MN A 501

Chain	Residue
A	ASP238
A	ASP240
A	ASP339
A	THR384

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site_id	AC2
Number of Residues	3
Details	binding site for residue GOL A 502

Chain	Residue
A	ILE167
A	THR407
A	ILE411

---

site_id	AC3
Number of Residues	3
Details	binding site for residue GOL A 503

Chain	Residue
A	HOH619
A	ARG262
A	GLU272

---

site_id	AC4
Number of Residues	6
Details	binding site for residue GOL A 504

Chain	Residue
A	TYR81
A	ARG84
A	PRO209
A	GLN210
A	ASN312
A	LEU328

---

site_id	AC5
Number of Residues	8
Details	binding site for residue GOL A 505

Chain	Residue
A	VAL236
A	TRP237
A	ASP238
A	PRO366
A	ALA367
A	ASP368
A	VAL375
A	HIS378

---

site_id	AC6
Number of Residues	3
Details	binding site for residue GOL A 506

Chain	Residue
A	ARG262
A	GLU264
A	TYR455

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	118
Details	Domain: {"description":"RdRp catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00539","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"source":"PubMed","id":"25903341","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"For RdRp activity","evidences":[{"source":"UniProtKB","id":"P12296","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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