Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5N78

Crystal structure of the cytosolic domain of the CorA Mg2+ channel from Escherichia coli in complex with magnesium and cobalt hexammine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006824	biological_process	cobalt ion transport
A	0015087	molecular_function	cobalt ion transmembrane transporter activity
A	0015095	molecular_function	magnesium ion transmembrane transporter activity
A	0015693	biological_process	magnesium ion transport
A	0016020	cellular_component	membrane
A	0030001	biological_process	metal ion transport
A	0046873	molecular_function	metal ion transmembrane transporter activity
A	0055085	biological_process	transmembrane transport
B	0006824	biological_process	cobalt ion transport
B	0015087	molecular_function	cobalt ion transmembrane transporter activity
B	0015095	molecular_function	magnesium ion transmembrane transporter activity
B	0015693	biological_process	magnesium ion transport
B	0016020	cellular_component	membrane
B	0030001	biological_process	metal ion transport
B	0046873	molecular_function	metal ion transmembrane transporter activity
B	0055085	biological_process	transmembrane transport
C	0006824	biological_process	cobalt ion transport
C	0015087	molecular_function	cobalt ion transmembrane transporter activity
C	0015095	molecular_function	magnesium ion transmembrane transporter activity
C	0015693	biological_process	magnesium ion transport
C	0016020	cellular_component	membrane
C	0030001	biological_process	metal ion transport
C	0046873	molecular_function	metal ion transmembrane transporter activity
C	0055085	biological_process	transmembrane transport
D	0006824	biological_process	cobalt ion transport
D	0015087	molecular_function	cobalt ion transmembrane transporter activity
D	0015095	molecular_function	magnesium ion transmembrane transporter activity
D	0015693	biological_process	magnesium ion transport
D	0016020	cellular_component	membrane
D	0030001	biological_process	metal ion transport
D	0046873	molecular_function	metal ion transmembrane transporter activity
D	0055085	biological_process	transmembrane transport
E	0006824	biological_process	cobalt ion transport
E	0015087	molecular_function	cobalt ion transmembrane transporter activity
E	0015095	molecular_function	magnesium ion transmembrane transporter activity
E	0015693	biological_process	magnesium ion transport
E	0016020	cellular_component	membrane
E	0030001	biological_process	metal ion transport
E	0046873	molecular_function	metal ion transmembrane transporter activity
E	0055085	biological_process	transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue MG A 301

Chain	Residue
A	ASP58
A	HOH403

site_id	AC2
Number of Residues	5
Details	binding site for residue NCO A 303

Chain	Residue
A	ASP146
A	GLU149
A	ASN150
C	GLU57
E	GLN21

site_id	AC3
Number of Residues	5
Details	binding site for residue NCO A 304

Chain	Residue
A	ASN150
A	ILE184
E	GLU19
A	GLU81
A	GLU147

site_id	AC4
Number of Residues	2
Details	binding site for residue NCO A 305

Chain	Residue
A	LEU50
A	GLU55

site_id	AC5
Number of Residues	4
Details	binding site for residue MG B 301

Chain	Residue
B	ASP58
B	HOH402
E	ASP146
E	HOH402

site_id	AC6
Number of Residues	5
Details	binding site for residue PG0 B 302

Chain	Residue
B	ARG189
B	MET193
B	HOH409
E	PRO228
E	HIS229

site_id	AC7
Number of Residues	11
Details	binding site for residue NCO B 303

Chain	Residue
A	ASN249
A	GLN252
B	ASN249
B	GLN252
B	HOH403
C	ASN249
C	GLN252
D	ASN249
D	GLN252
E	ASN249
E	GLN252

site_id	AC8
Number of Residues	3
Details	binding site for residue NCO B 304

Chain	Residue
B	SER49
B	GLU55
B	ASP70

site_id	AC9
Number of Residues	3
Details	binding site for residue NCO B 305

Chain	Residue
A	GLU57
B	GLU149
B	ASN150

site_id	AD1
Number of Residues	4
Details	binding site for residue MG C 301

Chain	Residue
A	ASP146
C	ASP58
C	HOH401
C	HOH407

site_id	AD2
Number of Residues	5
Details	binding site for residue PG0 C 302

Chain	Residue
A	PRO228
A	SER232
C	ARG189
C	MET193
C	HOH408

site_id	AD3
Number of Residues	3
Details	binding site for residue NCO C 303

Chain	Residue
C	LEU50
C	GLU55
C	ASP70

site_id	AD4
Number of Residues	2
Details	binding site for residue NCO C 304

Chain	Residue
C	GLU81
C	ASP85

site_id	AD5
Number of Residues	3
Details	binding site for residue MG D 301

Chain	Residue
D	ASP58
D	HOH403
D	HOH412

site_id	AD6
Number of Residues	4
Details	binding site for residue NCO D 302

Chain	Residue
D	GLU81
D	ASP85
D	GLU147
D	ASN150

site_id	AD7
Number of Residues	3
Details	binding site for residue NCO D 303

Chain	Residue
D	ASP146
D	GLU149
E	GLU57

site_id	AD8
Number of Residues	3
Details	binding site for residue NCO D 304

Chain	Residue
D	LEU50
D	GLU55
D	ASP70

site_id	AD9
Number of Residues	4
Details	binding site for residue MG E 301

Chain	Residue
D	HOH402
E	ASP58
E	GLU60
E	HOH404

site_id	AE1
Number of Residues	6
Details	binding site for residue PG0 E 302

Chain	Residue
D	PRO228
D	HIS229
D	SER232
E	ARG189
E	MET193
E	ARG197

site_id	AE2
Number of Residues	3
Details	binding site for residue NCO E 303

Chain	Residue
E	GLU81
E	GLU147
E	ASN150

site_id	AE3
Number of Residues	3
Details	binding site for residue NCO E 304

Chain	Residue
E	ASP146
E	GLU149
E	ASN150

site_id	AE4
Number of Residues	1
Details	binding site for residue NCO E 305

Chain	Residue
E	GLU55

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1265
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	MET1-ARG254
B	MET1-ARG254
C	MET1-ARG254
D	MET1-ARG254
E	MET1-ARG254

site_id	SWS_FT_FI2
Number of Residues	5
Details	SITE: Essential for ion permeation => ECO:0000250\|UniProtKB:Q9WZ31

Chain	Residue	Details
A	ASN253
B	ASN253
C	ASN253
D	ASN253
E	ASN253

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)