5N6R

Solution structure of the Dbl-homology domain of Bcr-Abl

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005085	molecular_function	guanyl-nucleotide exchange factor activity
A	0005096	molecular_function	GTPase activator activity
A	0035556	biological_process	intracellular signal transduction
A	0043547	biological_process	positive regulation of GTPase activity

Functional Information from PROSITE/UniProt

site_id	PS00741
Number of Residues	26
Details	DH_1 Dbl homology (DH) domain signature. LetLLykPVdrVtRstLvLhDLlkhT

Chain	Residue	Details
A	LEU639-THR664

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	193
Details	Domain: {"description":"DH","evidences":[{"source":"PROSITE-ProRule","id":"PRU00062","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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