5N5N

Cryo-EM structure of tsA201 cell alpha1B and betaI and betaIVb microtubules

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000278	biological_process	mitotic cell cycle
A	0003924	molecular_function	GTPase activity
A	0005198	molecular_function	structural molecule activity
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005641	cellular_component	nuclear envelope lumen
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0005929	cellular_component	cilium
A	0007017	biological_process	microtubule-based process
A	0015630	cellular_component	microtubule cytoskeleton
A	0019904	molecular_function	protein domain specific binding
A	0030705	biological_process	cytoskeleton-dependent intracellular transport
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0032794	molecular_function	GTPase activating protein binding
A	0032991	cellular_component	protein-containing complex
A	0035578	cellular_component	azurophil granule lumen
A	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
A	0042267	biological_process	natural killer cell mediated cytotoxicity
A	0042288	molecular_function	MHC class I protein binding
A	0044297	cellular_component	cell body
A	0044877	molecular_function	protein-containing complex binding
A	0045121	cellular_component	membrane raft
A	0045171	cellular_component	intercellular bridge
A	0046872	molecular_function	metal ion binding
A	0050807	biological_process	regulation of synapse organization
A	0051301	biological_process	cell division
A	0070062	cellular_component	extracellular exosome
A	0071895	biological_process	odontoblast differentiation
A	0072686	cellular_component	mitotic spindle
A	0097228	cellular_component	sperm principal piece
A	0097229	cellular_component	sperm end piece
A	0097542	cellular_component	ciliary tip
B	0000166	molecular_function	nucleotide binding
B	0000226	biological_process	microtubule cytoskeleton organization
B	0000278	biological_process	mitotic cell cycle
B	0003924	molecular_function	GTPase activity
B	0005198	molecular_function	structural molecule activity
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005641	cellular_component	nuclear envelope lumen
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0005929	cellular_component	cilium
B	0007017	biological_process	microtubule-based process
B	0015630	cellular_component	microtubule cytoskeleton
B	0019904	molecular_function	protein domain specific binding
B	0030705	biological_process	cytoskeleton-dependent intracellular transport
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0032794	molecular_function	GTPase activating protein binding
B	0032991	cellular_component	protein-containing complex
B	0035578	cellular_component	azurophil granule lumen
B	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
B	0042267	biological_process	natural killer cell mediated cytotoxicity
B	0042288	molecular_function	MHC class I protein binding
B	0044297	cellular_component	cell body
B	0044877	molecular_function	protein-containing complex binding
B	0045121	cellular_component	membrane raft
B	0045171	cellular_component	intercellular bridge
B	0046872	molecular_function	metal ion binding
B	0050807	biological_process	regulation of synapse organization
B	0051301	biological_process	cell division
B	0070062	cellular_component	extracellular exosome
B	0071895	biological_process	odontoblast differentiation
B	0072686	cellular_component	mitotic spindle
B	0097228	cellular_component	sperm principal piece
B	0097229	cellular_component	sperm end piece
B	0097542	cellular_component	ciliary tip
C	0000166	molecular_function	nucleotide binding
C	0000226	biological_process	microtubule cytoskeleton organization
C	0000278	biological_process	mitotic cell cycle
C	0003924	molecular_function	GTPase activity
C	0005198	molecular_function	structural molecule activity
C	0005200	molecular_function	structural constituent of cytoskeleton
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005641	cellular_component	nuclear envelope lumen
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005874	cellular_component	microtubule
C	0005929	cellular_component	cilium
C	0007017	biological_process	microtubule-based process
C	0015630	cellular_component	microtubule cytoskeleton
C	0019904	molecular_function	protein domain specific binding
C	0030705	biological_process	cytoskeleton-dependent intracellular transport
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0032794	molecular_function	GTPase activating protein binding
C	0032991	cellular_component	protein-containing complex
C	0035578	cellular_component	azurophil granule lumen
C	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
C	0042267	biological_process	natural killer cell mediated cytotoxicity
C	0042288	molecular_function	MHC class I protein binding
C	0044297	cellular_component	cell body
C	0044877	molecular_function	protein-containing complex binding
C	0045121	cellular_component	membrane raft
C	0045171	cellular_component	intercellular bridge
C	0046872	molecular_function	metal ion binding
C	0050807	biological_process	regulation of synapse organization
C	0051301	biological_process	cell division
C	0070062	cellular_component	extracellular exosome
C	0071895	biological_process	odontoblast differentiation
C	0072686	cellular_component	mitotic spindle
C	0097228	cellular_component	sperm principal piece
C	0097229	cellular_component	sperm end piece
C	0097542	cellular_component	ciliary tip
D	0000166	molecular_function	nucleotide binding
D	0000226	biological_process	microtubule cytoskeleton organization
D	0000278	biological_process	mitotic cell cycle
D	0003924	molecular_function	GTPase activity
D	0005198	molecular_function	structural molecule activity
D	0005200	molecular_function	structural constituent of cytoskeleton
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005641	cellular_component	nuclear envelope lumen
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0005874	cellular_component	microtubule
D	0005929	cellular_component	cilium
D	0007017	biological_process	microtubule-based process
D	0015630	cellular_component	microtubule cytoskeleton
D	0019904	molecular_function	protein domain specific binding
D	0030705	biological_process	cytoskeleton-dependent intracellular transport
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0032794	molecular_function	GTPase activating protein binding
D	0032991	cellular_component	protein-containing complex
D	0035578	cellular_component	azurophil granule lumen
D	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
D	0042267	biological_process	natural killer cell mediated cytotoxicity
D	0042288	molecular_function	MHC class I protein binding
D	0044297	cellular_component	cell body
D	0044877	molecular_function	protein-containing complex binding
D	0045121	cellular_component	membrane raft
D	0045171	cellular_component	intercellular bridge
D	0046872	molecular_function	metal ion binding
D	0050807	biological_process	regulation of synapse organization
D	0051301	biological_process	cell division
D	0070062	cellular_component	extracellular exosome
D	0071895	biological_process	odontoblast differentiation
D	0072686	cellular_component	mitotic spindle
D	0097228	cellular_component	sperm principal piece
D	0097229	cellular_component	sperm end piece
D	0097542	cellular_component	ciliary tip
E	0000166	molecular_function	nucleotide binding
E	0000226	biological_process	microtubule cytoskeleton organization
E	0000278	biological_process	mitotic cell cycle
E	0003924	molecular_function	GTPase activity
E	0005198	molecular_function	structural molecule activity
E	0005200	molecular_function	structural constituent of cytoskeleton
E	0005515	molecular_function	protein binding
E	0005525	molecular_function	GTP binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005641	cellular_component	nuclear envelope lumen
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005874	cellular_component	microtubule
E	0005929	cellular_component	cilium
E	0007017	biological_process	microtubule-based process
E	0015630	cellular_component	microtubule cytoskeleton
E	0019904	molecular_function	protein domain specific binding
E	0030705	biological_process	cytoskeleton-dependent intracellular transport
E	0031625	molecular_function	ubiquitin protein ligase binding
E	0032794	molecular_function	GTPase activating protein binding
E	0032991	cellular_component	protein-containing complex
E	0035578	cellular_component	azurophil granule lumen
E	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
E	0042267	biological_process	natural killer cell mediated cytotoxicity
E	0042288	molecular_function	MHC class I protein binding
E	0044297	cellular_component	cell body
E	0044877	molecular_function	protein-containing complex binding
E	0045121	cellular_component	membrane raft
E	0045171	cellular_component	intercellular bridge
E	0046872	molecular_function	metal ion binding
E	0050807	biological_process	regulation of synapse organization
E	0051301	biological_process	cell division
E	0070062	cellular_component	extracellular exosome
E	0071895	biological_process	odontoblast differentiation
E	0072686	cellular_component	mitotic spindle
E	0097228	cellular_component	sperm principal piece
E	0097229	cellular_component	sperm end piece
E	0097542	cellular_component	ciliary tip
F	0000166	molecular_function	nucleotide binding
F	0000226	biological_process	microtubule cytoskeleton organization
F	0000278	biological_process	mitotic cell cycle
F	0003924	molecular_function	GTPase activity
F	0005198	molecular_function	structural molecule activity
F	0005200	molecular_function	structural constituent of cytoskeleton
F	0005515	molecular_function	protein binding
F	0005525	molecular_function	GTP binding
F	0005576	cellular_component	extracellular region
F	0005634	cellular_component	nucleus
F	0005641	cellular_component	nuclear envelope lumen
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0005874	cellular_component	microtubule
F	0005929	cellular_component	cilium
F	0007017	biological_process	microtubule-based process
F	0015630	cellular_component	microtubule cytoskeleton
F	0019904	molecular_function	protein domain specific binding
F	0030705	biological_process	cytoskeleton-dependent intracellular transport
F	0031625	molecular_function	ubiquitin protein ligase binding
F	0032794	molecular_function	GTPase activating protein binding
F	0032991	cellular_component	protein-containing complex
F	0035578	cellular_component	azurophil granule lumen
F	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
F	0042267	biological_process	natural killer cell mediated cytotoxicity
F	0042288	molecular_function	MHC class I protein binding
F	0044297	cellular_component	cell body
F	0044877	molecular_function	protein-containing complex binding
F	0045121	cellular_component	membrane raft
F	0045171	cellular_component	intercellular bridge
F	0046872	molecular_function	metal ion binding
F	0050807	biological_process	regulation of synapse organization
F	0051301	biological_process	cell division
F	0070062	cellular_component	extracellular exosome
F	0071895	biological_process	odontoblast differentiation
F	0072686	cellular_component	mitotic spindle
F	0097228	cellular_component	sperm principal piece
F	0097229	cellular_component	sperm end piece
F	0097542	cellular_component	ciliary tip
G	0000166	molecular_function	nucleotide binding
G	0000226	biological_process	microtubule cytoskeleton organization
G	0000278	biological_process	mitotic cell cycle
G	0003725	molecular_function	double-stranded RNA binding
G	0003924	molecular_function	GTPase activity
G	0005198	molecular_function	structural molecule activity
G	0005200	molecular_function	structural constituent of cytoskeleton
G	0005515	molecular_function	protein binding
G	0005525	molecular_function	GTP binding
G	0005737	cellular_component	cytoplasm
G	0005856	cellular_component	cytoskeleton
G	0005874	cellular_component	microtubule
G	0005881	cellular_component	cytoplasmic microtubule
G	0005929	cellular_component	cilium
G	0007017	biological_process	microtubule-based process
G	0015630	cellular_component	microtubule cytoskeleton
G	0016787	molecular_function	hydrolase activity
G	0030182	biological_process	neuron differentiation
G	0030705	biological_process	cytoskeleton-dependent intracellular transport
G	0031625	molecular_function	ubiquitin protein ligase binding
G	0051301	biological_process	cell division
H	0000166	molecular_function	nucleotide binding
H	0000226	biological_process	microtubule cytoskeleton organization
H	0000278	biological_process	mitotic cell cycle
H	0003725	molecular_function	double-stranded RNA binding
H	0003924	molecular_function	GTPase activity
H	0005198	molecular_function	structural molecule activity
H	0005200	molecular_function	structural constituent of cytoskeleton
H	0005515	molecular_function	protein binding
H	0005525	molecular_function	GTP binding
H	0005737	cellular_component	cytoplasm
H	0005856	cellular_component	cytoskeleton
H	0005874	cellular_component	microtubule
H	0005881	cellular_component	cytoplasmic microtubule
H	0005929	cellular_component	cilium
H	0007017	biological_process	microtubule-based process
H	0015630	cellular_component	microtubule cytoskeleton
H	0016787	molecular_function	hydrolase activity
H	0030182	biological_process	neuron differentiation
H	0030705	biological_process	cytoskeleton-dependent intracellular transport
H	0031625	molecular_function	ubiquitin protein ligase binding
H	0051301	biological_process	cell division
I	0000166	molecular_function	nucleotide binding
I	0000226	biological_process	microtubule cytoskeleton organization
I	0000278	biological_process	mitotic cell cycle
I	0003725	molecular_function	double-stranded RNA binding
I	0003924	molecular_function	GTPase activity
I	0005198	molecular_function	structural molecule activity
I	0005200	molecular_function	structural constituent of cytoskeleton
I	0005515	molecular_function	protein binding
I	0005525	molecular_function	GTP binding
I	0005737	cellular_component	cytoplasm
I	0005856	cellular_component	cytoskeleton
I	0005874	cellular_component	microtubule
I	0005881	cellular_component	cytoplasmic microtubule
I	0005929	cellular_component	cilium
I	0007017	biological_process	microtubule-based process
I	0015630	cellular_component	microtubule cytoskeleton
I	0016787	molecular_function	hydrolase activity
I	0030182	biological_process	neuron differentiation
I	0030705	biological_process	cytoskeleton-dependent intracellular transport
I	0031625	molecular_function	ubiquitin protein ligase binding
I	0051301	biological_process	cell division
J	0000166	molecular_function	nucleotide binding
J	0000226	biological_process	microtubule cytoskeleton organization
J	0000278	biological_process	mitotic cell cycle
J	0003725	molecular_function	double-stranded RNA binding
J	0003924	molecular_function	GTPase activity
J	0005198	molecular_function	structural molecule activity
J	0005200	molecular_function	structural constituent of cytoskeleton
J	0005515	molecular_function	protein binding
J	0005525	molecular_function	GTP binding
J	0005737	cellular_component	cytoplasm
J	0005856	cellular_component	cytoskeleton
J	0005874	cellular_component	microtubule
J	0005881	cellular_component	cytoplasmic microtubule
J	0005929	cellular_component	cilium
J	0007017	biological_process	microtubule-based process
J	0015630	cellular_component	microtubule cytoskeleton
J	0016787	molecular_function	hydrolase activity
J	0030182	biological_process	neuron differentiation
J	0030705	biological_process	cytoskeleton-dependent intracellular transport
J	0031625	molecular_function	ubiquitin protein ligase binding
J	0051301	biological_process	cell division
K	0000166	molecular_function	nucleotide binding
K	0000226	biological_process	microtubule cytoskeleton organization
K	0000278	biological_process	mitotic cell cycle
K	0003725	molecular_function	double-stranded RNA binding
K	0003924	molecular_function	GTPase activity
K	0005198	molecular_function	structural molecule activity
K	0005200	molecular_function	structural constituent of cytoskeleton
K	0005515	molecular_function	protein binding
K	0005525	molecular_function	GTP binding
K	0005737	cellular_component	cytoplasm
K	0005856	cellular_component	cytoskeleton
K	0005874	cellular_component	microtubule
K	0005881	cellular_component	cytoplasmic microtubule
K	0005929	cellular_component	cilium
K	0007017	biological_process	microtubule-based process
K	0015630	cellular_component	microtubule cytoskeleton
K	0016787	molecular_function	hydrolase activity
K	0030182	biological_process	neuron differentiation
K	0030705	biological_process	cytoskeleton-dependent intracellular transport
K	0031625	molecular_function	ubiquitin protein ligase binding
K	0051301	biological_process	cell division
L	0000166	molecular_function	nucleotide binding
L	0000226	biological_process	microtubule cytoskeleton organization
L	0000278	biological_process	mitotic cell cycle
L	0003725	molecular_function	double-stranded RNA binding
L	0003924	molecular_function	GTPase activity
L	0005198	molecular_function	structural molecule activity
L	0005200	molecular_function	structural constituent of cytoskeleton
L	0005515	molecular_function	protein binding
L	0005525	molecular_function	GTP binding
L	0005737	cellular_component	cytoplasm
L	0005856	cellular_component	cytoskeleton
L	0005874	cellular_component	microtubule
L	0005881	cellular_component	cytoplasmic microtubule
L	0005929	cellular_component	cilium
L	0007017	biological_process	microtubule-based process
L	0015630	cellular_component	microtubule cytoskeleton
L	0016787	molecular_function	hydrolase activity
L	0030182	biological_process	neuron differentiation
L	0030705	biological_process	cytoskeleton-dependent intracellular transport
L	0031625	molecular_function	ubiquitin protein ligase binding
L	0051301	biological_process	cell division

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue G2P B 501

Chain	Residue
B	GLN11
B	TYR224
B	ASN228
B	MG502
G	GLU254
B	CYS12
B	GLN15
B	ASN101
B	SER140
B	THR145
B	GLY146
B	ASP179
B	ASN206

---

site_id	AC2
Number of Residues	1
Details	binding site for residue MG B 502

Chain	Residue
B	G2P501

---

site_id	AC3
Number of Residues	17
Details	binding site for residue GTP K 501

Chain	Residue
B	LYS254
K	GLN11
K	ALA12
K	GLN15
K	ALA100
K	ASN101
K	SER140
K	GLY143
K	GLY144
K	THR145
K	GLY146
K	THR179
K	GLU183
K	ASN206
K	TYR224
K	ASN228
K	MG502

---

site_id	AC4
Number of Residues	2
Details	binding site for residue MG K 502

Chain	Residue
K	GLN11
K	GTP501

---

site_id	AC5
Number of Residues	17
Details	binding site for residue GTP G 501

Chain	Residue
A	LYS254
G	GLN11
G	ALA12
G	GLN15
G	ALA100
G	ASN101
G	SER140
G	GLY143
G	GLY144
G	THR145
G	GLY146
G	THR179
G	GLU183
G	ASN206
G	TYR224
G	ASN228
G	MG502

---

site_id	AC6
Number of Residues	3
Details	binding site for residue MG G 502

Chain	Residue
G	GLN11
G	GLU71
G	GTP501

---

site_id	AC7
Number of Residues	17
Details	binding site for residue GTP H 501

Chain	Residue
C	LYS254
H	GLN11
H	ALA12
H	GLN15
H	ALA100
H	ASN101
H	SER140
H	GLY143
H	GLY144
H	THR145
H	GLY146
H	THR179
H	GLU183
H	ASN206
H	TYR224
H	ASN228
H	MG502

---

site_id	AC8
Number of Residues	2
Details	binding site for residue MG H 502

Chain	Residue
H	GLN11
H	GTP501

---

site_id	AC9
Number of Residues	17
Details	binding site for residue GTP I 501

Chain	Residue
D	LYS254
I	GLN11
I	ALA12
I	GLN15
I	ALA100
I	ASN101
I	SER140
I	GLY143
I	GLY144
I	THR145
I	GLY146
I	THR179
I	GLU183
I	ASN206
I	TYR224
I	ASN228
I	MG502

---

site_id	AD1
Number of Residues	2
Details	binding site for residue MG I 502

Chain	Residue
I	GLN11
I	GTP501

---

site_id	AD2
Number of Residues	18
Details	binding site for residue GTP J 501

Chain	Residue
J	GLY143
J	GLY144
J	THR145
J	GLY146
J	THR179
J	GLU183
J	ASN206
J	TYR224
J	ASN228
J	MG502
E	LYS254
J	GLN11
J	ALA12
J	GLN15
J	ALA99
J	ALA100
J	ASN101
J	SER140

---

site_id	AD3
Number of Residues	2
Details	binding site for residue MG J 502

Chain	Residue
J	GLN11
J	GTP501

---

site_id	AD4
Number of Residues	18
Details	binding site for residue GTP L 501

Chain	Residue
F	LYS254
L	GLN11
L	ALA12
L	GLN15
L	ALA99
L	ALA100
L	ASN101
L	SER140
L	GLY143
L	GLY144
L	THR145
L	GLY146
L	THR179
L	GLU183
L	ASN206
L	TYR224
L	ASN228
L	MG502

---

site_id	AD5
Number of Residues	2
Details	binding site for residue MG L 502

Chain	Residue
L	GLN11
L	GTP501

---

site_id	AD6
Number of Residues	12
Details	binding site for residue G2P A 501

Chain	Residue
A	GLN11
A	CYS12
A	GLN15
A	ASN101
A	SER140
A	THR145
A	GLY146
A	ASP179
A	ASN206
A	TYR224
A	ASN228
A	MG502

---

site_id	AD7
Number of Residues	1
Details	binding site for residue MG A 502

Chain	Residue
A	G2P501

---

site_id	AD8
Number of Residues	12
Details	binding site for residue G2P C 501

Chain	Residue
C	GLN11
C	CYS12
C	GLN15
C	ASN101
C	SER140
C	THR145
C	GLY146
C	ASP179
C	ASN206
C	TYR224
C	ASN228
C	MG502

---

site_id	AD9
Number of Residues	1
Details	binding site for residue MG C 502

Chain	Residue
C	G2P501

---

site_id	AE1
Number of Residues	13
Details	binding site for residue G2P D 501

Chain	Residue
D	GLN11
D	CYS12
D	GLN15
D	ASN101
D	SER140
D	THR145
D	GLY146
D	ASP179
D	ASN206
D	TYR224
D	ASN228
D	MG502
H	GLU254

---

site_id	AE2
Number of Residues	1
Details	binding site for residue MG D 502

Chain	Residue
D	G2P501

---

site_id	AE3
Number of Residues	13
Details	binding site for residue G2P E 501

Chain	Residue
E	GLN11
E	CYS12
E	GLN15
E	ASN101
E	SER140
E	THR145
E	GLY146
E	ASP179
E	ASN206
E	TYR224
E	ASN228
E	MG502
L	GLU254

---

site_id	AE4
Number of Residues	1
Details	binding site for residue MG E 502

Chain	Residue
E	G2P501

---

site_id	AE5
Number of Residues	14
Details	binding site for residue G2P F 501

Chain	Residue
F	GLY10
F	GLN11
F	CYS12
F	GLN15
F	ASN101
F	SER140
F	GLY143
F	THR145
F	GLY146
F	ASP179
F	ASN206
F	TYR224
F	ASN228
F	MG502

---

site_id	AE6
Number of Residues	2
Details	binding site for residue MG F 502

Chain	Residue
F	ASP69
F	G2P501

---

Functional Information from PROSITE/UniProt

site_id	PS00227
Number of Residues	7
Details	TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG

Chain	Residue	Details
B	GLY142-GLY148
K	GLY142-GLY148

---

site_id	PS00228
Number of Residues	4
Details	TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI

Chain	Residue	Details
B	MET1-ILE4

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	Motif: {"description":"MREI motif","evidences":[{"source":"PubMed","id":"31727855","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	42
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q13509","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P99024","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	18
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P99024","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine; by CDK1","evidences":[{"source":"PubMed","id":"16371510","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	6
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Campbell A.","Ozanne B.W.","Lourenco F.","Olson M.F."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	6
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate"}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	30
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)"}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	18
Details	Motif: {"description":"MREC motif","evidences":[{"source":"PubMed","id":"31727855","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	6
Details	Active site: {"evidences":[{"source":"PubMed","id":"34996871","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	54
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38609661","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VT7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34996871","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35482892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38609661","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7SJ7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Z6S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VT7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	12
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Waridel P.","Quadroni M."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	6
Details	Modified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"UniProtKB","id":"P68373","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	6
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Waridel P.","Quadroni M."]}}]}

Chain

Residue

Details

---