5N4C

Prolyl oligopeptidase B from Galerina marginata bound to 35mer hydrolysis and macrocyclization substrate - S577A mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005829	cellular_component	cytosol
A	0006508	biological_process	proteolysis
A	0008236	molecular_function	serine-type peptidase activity
A	0070012	molecular_function	oligopeptidase activity
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005829	cellular_component	cytosol
B	0006508	biological_process	proteolysis
B	0008236	molecular_function	serine-type peptidase activity
B	0070012	molecular_function	oligopeptidase activity
C	0004252	molecular_function	serine-type endopeptidase activity
C	0005829	cellular_component	cytosol
C	0006508	biological_process	proteolysis
C	0008236	molecular_function	serine-type peptidase activity
C	0070012	molecular_function	oligopeptidase activity
D	0004252	molecular_function	serine-type endopeptidase activity
D	0005829	cellular_component	cytosol
D	0006508	biological_process	proteolysis
D	0008236	molecular_function	serine-type peptidase activity
D	0070012	molecular_function	oligopeptidase activity
E	0035821	biological_process	modulation of process of another organism
E	0090729	molecular_function	toxin activity
F	0035821	biological_process	modulation of process of another organism
F	0090729	molecular_function	toxin activity
G	0035821	biological_process	modulation of process of another organism
G	0090729	molecular_function	toxin activity
H	0035821	biological_process	modulation of process of another organism
H	0090729	molecular_function	toxin activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue GOL D 801

Chain	Residue
D	ALA7
D	PRO8
D	PRO684
D	PRO686

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: (3R,4S)-4-hydroxyisoleucine; in form gamma-amanitin => ECO:0000250|UniProtKB:P85421

Chain	Residue	Details
E	ILE11
D	ALA577
D	ASP661
D	HIS698
F	ILE11
G	ILE11
H	ILE11
B	ASP661
B	HIS698
C	ALA577
C	ASP661
C	HIS698

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site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: 4-hydroxyproline => ECO:0000250|UniProtKB:P85421

Chain	Residue	Details
E	PRO18
F	PRO18
G	PRO18
H	PRO18

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site_id	SWS_FT_FI3
Number of Residues	8
Details	CROSSLNK: Cyclopeptide (Ile-Pro) => ECO:0000250|UniProtKB:P85421

Chain	Residue	Details
E	ILE11
E	PRO18
F	ILE11
F	PRO18
G	ILE11
G	PRO18
H	ILE11
H	PRO18

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site_id	SWS_FT_FI4
Number of Residues	8
Details	CROSSLNK: 2'-cysteinyl-6'-hydroxytryptophan sulfoxide (Trp-Cys) => ECO:0000250|UniProtKB:P85421

Chain	Residue	Details
E	TRP12
E	CYS16
F	TRP12
F	CYS16
G	TRP12
G	CYS16
H	TRP12
H	CYS16

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