5N4C
Prolyl oligopeptidase B from Galerina marginata bound to 35mer hydrolysis and macrocyclization substrate - S577A mutant
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0070012 | molecular_function | oligopeptidase activity |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006508 | biological_process | proteolysis |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0008236 | molecular_function | serine-type peptidase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0070012 | molecular_function | oligopeptidase activity |
| C | 0004252 | molecular_function | serine-type endopeptidase activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0006508 | biological_process | proteolysis |
| C | 0008233 | molecular_function | peptidase activity |
| C | 0008236 | molecular_function | serine-type peptidase activity |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0070012 | molecular_function | oligopeptidase activity |
| D | 0004252 | molecular_function | serine-type endopeptidase activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0006508 | biological_process | proteolysis |
| D | 0008233 | molecular_function | peptidase activity |
| D | 0008236 | molecular_function | serine-type peptidase activity |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0070012 | molecular_function | oligopeptidase activity |
| E | 0035821 | biological_process | modulation of process of another organism |
| E | 0090729 | molecular_function | toxin activity |
| F | 0035821 | biological_process | modulation of process of another organism |
| F | 0090729 | molecular_function | toxin activity |
| G | 0035821 | biological_process | modulation of process of another organism |
| G | 0090729 | molecular_function | toxin activity |
| H | 0035821 | biological_process | modulation of process of another organism |
| H | 0090729 | molecular_function | toxin activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue GOL D 801 |
| Chain | Residue |
| D | ALA7 |
| D | PRO8 |
| D | PRO684 |
| D | PRO686 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"PROSITE-ProRule","id":"PRU10084","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"29051530","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 64 |
| Details | Propeptide: {"featureId":"PRO_0000443566","evidences":[{"source":"UniProtKB","id":"A8W7M4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"(3R,4S)-4-hydroxyisoleucine; in form gamma-amanitin","evidences":[{"source":"UniProtKB","id":"P85421","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"4-hydroxyproline","evidences":[{"source":"UniProtKB","id":"P85421","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 14 |
| Details | Peptide: {"description":"Alpha-amanitin","featureId":"PRO_0000443565","evidences":[{"source":"UniProtKB","id":"A8W7M4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Cyclopeptide (Ile-Pro)","evidences":[{"source":"UniProtKB","id":"P85421","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"2'-cysteinyl-6'-hydroxytryptophan sulfoxide (Trp-Cys)","evidences":[{"source":"UniProtKB","id":"P85421","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
