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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5N2R

Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with PSB36 at 2.8A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001609	molecular_function	G protein-coupled adenosine receptor activity
A	0001973	biological_process	G protein-coupled adenosine receptor signaling pathway
A	0004930	molecular_function	G protein-coupled receptor activity
A	0005506	molecular_function	iron ion binding
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0009055	molecular_function	electron transfer activity
A	0016020	cellular_component	membrane
A	0020037	molecular_function	heme binding
A	0022900	biological_process	electron transport chain
A	0042597	cellular_component	periplasmic space
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue NA A 2400

Chain	Residue
A	ASP52
A	SER91
A	ASN280
A	HOH2514
A	HOH2534

site_id	AC2
Number of Residues	15
Details	binding site for residue 8JN A 2401

Chain	Residue
A	TRP246
A	LEU249
A	ASN253
A	THR256
A	HIS264
A	MET270
A	ILE274
A	HIS278
A	HOH2502
A	HOH2504
A	HOH2513
A	PHE168
A	GLU169
A	MET174
A	MET177

site_id	AC3
Number of Residues	6
Details	binding site for residue CLR A 2402

Chain	Residue
A	ALA72
A	ALA73
A	GLY76
A	ILE80
A	CLR2404
A	OLC2426

site_id	AC4
Number of Residues	5
Details	binding site for residue CLR A 2403

Chain	Residue
A	PRO248
A	CYS262
A	SER263
A	LEU269
A	OLA2424

site_id	AC5
Number of Residues	7
Details	binding site for residue CLR A 2404

Chain	Residue
A	CYS254
A	PHE255
A	PHE258
A	CYS259
A	CLR2402
A	OLA2407
A	OLC2428

site_id	AC6
Number of Residues	2
Details	binding site for residue OLA A 2405

Chain	Residue
A	THR65
A	OLC2428

site_id	AC7
Number of Residues	2
Details	binding site for residue OLA A 2406

Chain	Residue
A	PRO266
A	LEU272

site_id	AC8
Number of Residues	6
Details	binding site for residue OLA A 2407

Chain	Residue
A	LEU194
A	PHE201
A	ALA236
A	CLR2404
A	OLA2416
A	OLA2417

site_id	AC9
Number of Residues	3
Details	binding site for residue OLA A 2408

Chain	Residue
A	HIS75
A	GLY76
A	OLA2419

site_id	AD1
Number of Residues	2
Details	binding site for residue OLA A 2409

Chain	Residue
A	LEU19
A	THR279

site_id	AD2
Number of Residues	4
Details	binding site for residue OLA A 2410

Chain	Residue
A	GLY5
A	SER6
A	LEU267
A	TYR271

site_id	AD3
Number of Residues	4
Details	binding site for residue OLA A 2411

Chain	Residue
A	LEU96
A	ILE127
A	OLA2415
A	OLA2418

site_id	AD4
Number of Residues	3
Details	binding site for residue OLA A 2412

Chain	Residue
A	LEU19
A	PHE286
A	HOH2524

site_id	AD5
Number of Residues	3
Details	binding site for residue OLA A 2415

Chain	Residue
A	GLY123
A	OLA2411
A	OLA2418

site_id	AD6
Number of Residues	5
Details	binding site for residue OLA A 2416

Chain	Residue
A	TRP32
A	PHE201
A	LYS233
A	OLA2407
A	OLC2430

site_id	AD7
Number of Residues	3
Details	binding site for residue OLA A 2417

Chain	Residue
A	ALA236
A	GLY240
A	OLA2407

site_id	AD8
Number of Residues	12
Details	binding site for residue OLA A 2418

Chain	Residue
A	HIS75
A	LEU131
A	ALA134
A	MET140
A	LEU141
A	TYR179
A	PHE183
A	OLA2411
A	OLA2415
A	OLA2419
A	OLC2427
A	HOH2503

site_id	AD9
Number of Residues	5
Details	binding site for residue OLA A 2419

Chain	Residue
A	PHE133
A	MET140
A	OLA2408
A	OLA2418
A	OLA2420

site_id	AE1
Number of Residues	4
Details	binding site for residue OLA A 2420

Chain	Residue
A	ALA122
A	OLA2419
A	OLA2422
A	OLC2429

site_id	AE2
Number of Residues	3
Details	binding site for residue OLA A 2421

Chain	Residue
A	ALA97
A	ILE100
A	VAL116

site_id	AE3
Number of Residues	3
Details	binding site for residue OLA A 2422

Chain	Residue
A	ALA122
A	GLY123
A	OLA2420

site_id	AE4
Number of Residues	3
Details	binding site for residue OLA A 2424

Chain	Residue
A	PHE255
A	SER263
A	CLR2403

site_id	AE5
Number of Residues	2
Details	binding site for residue OLA A 2425

Chain	Residue
A	ILE287
A	TYR290

site_id	AE6
Number of Residues	3
Details	binding site for residue OLC A 2426

Chain	Residue
A	PHE258
A	CLR2402
A	OLC2427

site_id	AE7
Number of Residues	4
Details	binding site for residue OLC A 2427

Chain	Residue
A	TYR179
A	PHE257
A	OLA2418
A	OLC2426

site_id	AE8
Number of Residues	9
Details	binding site for residue OLC A 2428

Chain	Residue
A	LEU58
A	PHE62
A	THR65
A	PHE70
A	CYS71
A	GLN163
A	ASP261
A	CLR2404
A	OLA2405

site_id	AE9
Number of Residues	6
Details	binding site for residue OLC A 2429

Chain	Residue
A	GLY118
A	ILE125
A	TRP129
A	PHE133
A	OLA2420
A	OLC2430

site_id	AF1
Number of Residues	8
Details	binding site for residue OLC A 2430

Chain	Residue
A	CYS28
A	TRP32
A	TYR43
A	VAL46
A	ALA50
A	ARG205
A	OLA2416
A	OLC2429

site_id	AF2
Number of Residues	12
Details	binding site for residue TAR A 2431

Chain	Residue
A	GLY142
A	GLY142
A	TRP143
A	TRP143
A	ASN144
A	ASN144
A	ASN145
A	ASN145
A	PRO173
A	PRO173
A	ASN175
A	ASN175

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SSIfSLLAIAIDRYIaI

Chain	Residue	Details
A	SER90-ILE106

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	TRANSMEM: Helical; Name=1

Chain	Residue	Details
A	VAL8-TRP32

site_id	SWS_FT_FI2
Number of Residues	28
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:18832607

Chain	Residue	Details
A	LEU33-ASN42
A	ASP101-ARG120

site_id	SWS_FT_FI3
Number of Residues	23
Details	TRANSMEM: Helical; Name=2

Chain	Residue	Details
A	TYR43-ILE66

site_id	SWS_FT_FI4
Number of Residues	46
Details	TOPO_DOM: Extracellular => ECO:0000269\|PubMed:18832607

Chain	Residue	Details
A	SER67-CYS77
A	ASN144-PRO173
A	CYS259-PRO266

site_id	SWS_FT_FI5
Number of Residues	22
Details	TRANSMEM: Helical; Name=3

Chain	Residue	Details
A	LEU78-ILE100

site_id	SWS_FT_FI6
Number of Residues	22
Details	TRANSMEM: Helical; Name=4

Chain	Residue	Details
A	ALA121-TRP143

site_id	SWS_FT_FI7
Number of Residues	24
Details	TRANSMEM: Helical; Name=5

Chain	Residue	Details
A	MET174-LEU198

site_id	SWS_FT_FI8
Number of Residues	23
Details	TRANSMEM: Helical; Name=6

Chain	Residue	Details
A	ALA235-PHE258

site_id	SWS_FT_FI9
Number of Residues	23
Details	TRANSMEM: Helical; Name=7

Chain	Residue	Details
A	LEU267-TYR290

site_id	SWS_FT_FI10
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:21593763, ECO:0007744\|PDB:2YDO

Chain	Residue	Details
A	GLU169
A	ASN253
A	ALA277
A	HIS278

site_id	SWS_FT_FI11
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ALA154

site_id	SWS_FT_FI12
Number of Residues	2
Details	BINDING: axial binding residue

Chain	Residue	Details
A	TRP1007
A	ILE1102

218853

PDB entries from 2024-04-24

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