5N12
Crystal structure of TCE treated rPPEP-1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0006508 | biological_process | proteolysis |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0008237 | molecular_function | metallopeptidase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 301 |
| Chain | Residue |
| A | HIS142 |
| A | HIS146 |
| A | GLU185 |
| A | TRS303 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue 8FH A 302 |
| Chain | Residue |
| A | HOH469 |
| A | LYS35 |
| A | PHE44 |
| A | ASN55 |
| A | VAL58 |
| A | HOH436 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue TRS A 303 |
| Chain | Residue |
| A | HIS142 |
| A | GLU143 |
| A | HIS146 |
| A | TYR178 |
| A | GLU185 |
| A | ZN301 |
| A | HOH486 |
| A | HOH501 |
| A | HOH504 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 301 |
| Chain | Residue |
| B | HIS142 |
| B | HIS146 |
| B | GLU185 |
| B | TRS304 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue 8FH B 302 |
| Chain | Residue |
| B | LYS35 |
| B | PHE44 |
| B | ASN55 |
| B | VAL58 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue 8FH B 303 |
| Chain | Residue |
| B | SER39 |
| B | GLN40 |
| B | VAL42 |
| B | HOH455 |
| B | HOH543 |
| site_id | AC7 |
| Number of Residues | 11 |
| Details | binding site for residue TRS B 304 |
| Chain | Residue |
| A | HIS25 |
| B | HIS142 |
| B | GLU143 |
| B | HIS146 |
| B | TYR178 |
| B | GLU185 |
| B | ZN301 |
| B | HOH424 |
| B | HOH458 |
| B | HOH534 |
| B | HOH551 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 370 |
| Details | Domain: {"description":"ATLF-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU01339","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Region: {"description":"Interacts with substrate peptide","evidences":[{"source":"PubMed","id":"26211609","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01339","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24303041","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"26211609","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01339","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26211609","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01339","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Site: {"description":"Interacts with substrate peptide","evidences":[{"source":"PubMed","id":"26211609","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Site: {"description":"Transition state stabilizer","evidences":[{"source":"PubMed","id":"26211609","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
