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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5N0X

Crystal structure of OphA-DeltaC6 in complex with SAM

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008168	molecular_function	methyltransferase activity
A	0032259	biological_process	methylation
B	0008168	molecular_function	methyltransferase activity
B	0032259	biological_process	methylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	25
Details	binding site for residue SAM A 501

Chain	Residue
A	ILE19
A	PHE171
A	GLN172
A	TYR211
A	ILE212
A	ALA213
A	GLY242
A	VAL243
A	SER244
A	THR245
A	HOH615
A	TYR98
A	HOH666
A	HOH720
B	SAR408
B	VAL409
B	ILE410
B	GLY411
A	GLY99
A	HIS100
A	VAL103
A	PHE104
A	VAL105
A	SER129
A	ALA130

site_id	AC2
Number of Residues	4
Details	binding site for residue EDO A 502

Chain	Residue
A	PHE40
A	LEU82
A	GLU86
A	HOH667

site_id	AC3
Number of Residues	5
Details	binding site for residue MG A 503

Chain	Residue
A	PHE135
A	ILE140
B	GLY102
B	HIS109
B	MET124

site_id	AC4
Number of Residues	25
Details	binding site for residue SAM B 501

Chain	Residue
A	SAR408
A	VAL409
A	ILE410
A	GLY411
B	ILE19
B	TYR98
B	GLY99
B	HIS100
B	VAL103
B	PHE104
B	VAL105
B	SER129
B	ALA130
B	PHE171
B	GLN172
B	TYR211
B	ILE212
B	ALA213
B	GLY242
B	VAL243
B	SER244
B	THR245
B	HOH609
B	HOH691
B	HOH737

site_id	AC5
Number of Residues	6
Details	binding site for residue MG B 502

Chain	Residue
A	GLY102
A	HIS109
A	MET124
B	PHE135
B	ALA136
B	ILE140

site_id	AC6
Number of Residues	5
Details	binding site for residues SAR A 405 and MVA A 406

Chain	Residue
A	VAL404
A	IML407
A	SAR408
B	PHE183
B	THR184

site_id	AC7
Number of Residues	8
Details	binding site for residues MVA A 406 and IML A 407

Chain	Residue
A	VAL404
A	SAR405
A	SAR408
B	TYR63
B	PHE181
B	ASN182
B	PHE183
B	PHE186

site_id	AC8
Number of Residues	13
Details	binding site for residues IML A 407 and SAR A 408

Chain	Residue
A	MVA406
A	VAL409
A	ILE410
B	ILE44
B	TYR63
B	TYR98
B	PHE181
B	ASN182
B	PHE183
B	PHE186
B	GLY242
B	VAL243
B	SAM501

site_id	AC9
Number of Residues	4
Details	binding site for residues MVA B 406 and IML B 407

Chain	Residue
A	TYR63
A	PHE183
A	THR184
B	SAR408

site_id	AD1
Number of Residues	11
Details	binding site for residues IML B 407 and SAR B 408

Chain	Residue
A	THR184
A	GLY242
A	VAL243
A	SAM501
B	MVA406
B	VAL409
B	ILE410
A	ILE44
A	TYR63
A	TYR98
A	PHE183

site_id	AD2
Number of Residues	13
Details	binding site for Di-peptide SAR B 408 and VAL B 409

Chain	Residue
A	ILE44
A	TYR66
A	ARG72
A	TYR76
A	TYR98
A	GLN172
A	GLY242
A	VAL243
A	SAM501
B	MVA406
B	IML407
B	ILE410
B	GLY411

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: ACT_SITE => ECO:0000269\|PubMed:30151425

Chain	Residue	Details
A	ARG72
A	TYR76
A	TYR98
B	ARG72
B	TYR76
B	TYR98

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:30151425, ECO:0007744\|PDB:5N0P, ECO:0007744\|PDB:5N0T, ECO:0007744\|PDB:5N0U

Chain	Residue	Details
A	TYR98
B	TYR98

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:30151425, ECO:0007744\|PDB:5N0O, ECO:0007744\|PDB:5N0P, ECO:0007744\|PDB:5N0Q, ECO:0007744\|PDB:5N0R, ECO:0007744\|PDB:5N0S, ECO:0007744\|PDB:5N0T, ECO:0007744\|PDB:5N0U, ECO:0007744\|PDB:5N0V, ECO:0007744\|PDB:5N0W, ECO:0007744\|PDB:5N0X, ECO:0007744\|PDB:5N4I, ECO:0007744\|PDB:6GEW, ECO:0007744\|PDB:6QZY, ECO:0007744\|PDB:6QZZ, ECO:0007744\|PDB:6R00, ECO:0007744\|PDB:6TSC

Chain	Residue	Details
A	HIS100
A	ALA130
A	ALA213
A	THR245
B	HIS100
B	ALA130
B	ALA213
B	THR245

site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:30151425, ECO:0007744\|PDB:5N0O, ECO:0007744\|PDB:5N0Q, ECO:0007744\|PDB:5N0R, ECO:0007744\|PDB:5N0S, ECO:0007744\|PDB:5N0T, ECO:0007744\|PDB:5N0W, ECO:0007744\|PDB:5N0X, ECO:0007744\|PDB:5N4I, ECO:0007744\|PDB:6QZY, ECO:0007744\|PDB:6QZZ

Chain	Residue	Details
A	VAL103
B	VAL103

site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:30151425, ECO:0007744\|PDB:5N0O, ECO:0007744\|PDB:5N0P, ECO:0007744\|PDB:5N0R, ECO:0007744\|PDB:5N0S, ECO:0007744\|PDB:5N0T, ECO:0007744\|PDB:5N0U, ECO:0007744\|PDB:5N0V, ECO:0007744\|PDB:5N0W, ECO:0007744\|PDB:5N0X, ECO:0007744\|PDB:5N4I, ECO:0007744\|PDB:6GEW, ECO:0007744\|PDB:6QZY, ECO:0007744\|PDB:6QZZ, ECO:0007744\|PDB:6R00, ECO:0007744\|PDB:6TSC

Chain	Residue	Details
A	GLN172
B	GLN172

site_id	SWS_FT_FI6
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:30151425, ECO:0007744\|PDB:5N0P, ECO:0007744\|PDB:5N0Q, ECO:0007744\|PDB:6GEW

Chain	Residue	Details
A	SER244
B	SER244

site_id	SWS_FT_FI7
Number of Residues	8
Details	MOD_RES: N-methylvaline => ECO:0000269\|PubMed:28715095, ECO:0000269\|PubMed:30151425, ECO:0000269\|PubMed:32491837, ECO:0000269\|PubMed:33574430

Chain	Residue	Details
A	VAL401
A	VAL403
A	VAL404
A	MVA406
B	VAL401
B	VAL403
B	VAL404
B	MVA406

site_id	SWS_FT_FI8
Number of Residues	6
Details	MOD_RES: N-methylglycine => ECO:0000269\|PubMed:28715095, ECO:0000269\|PubMed:30151425, ECO:0000269\|PubMed:32491837, ECO:0000269\|PubMed:33574430

Chain	Residue	Details
A	SAR405
A	SAR408
A	GLY411
B	SAR405
B	SAR408
B	GLY411

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: N-methylisoleucine => ECO:0000269\|PubMed:28715095, ECO:0000269\|PubMed:30151425, ECO:0000269\|PubMed:32491837, ECO:0000269\|PubMed:33574430

Chain	Residue	Details
A	IML407
A	ILE410
B	IML407
B	ILE410

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PDB entries from 2024-07-24

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