5N0T
Crystal structure of OphA-DeltaC6 mutant Y76F in complex with SAM
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | binding site for residue SAM A 501 |
| Chain | Residue |
| A | TYR98 |
| A | GLN172 |
| A | TYR211 |
| A | ILE212 |
| A | ALA213 |
| A | GLY242 |
| A | VAL243 |
| A | SER244 |
| A | THR245 |
| B | VAL401 |
| B | ILE402 |
| A | GLY99 |
| B | VAL403 |
| A | HIS100 |
| A | VAL103 |
| A | PHE104 |
| A | VAL105 |
| A | SER129 |
| A | ALA130 |
| A | PHE171 |
| site_id | AC2 |
| Number of Residues | 22 |
| Details | binding site for residue SAM B 501 |
| Chain | Residue |
| A | VAL401 |
| A | ILE402 |
| A | VAL403 |
| B | TYR98 |
| B | GLY99 |
| B | HIS100 |
| B | VAL103 |
| B | PHE104 |
| B | VAL105 |
| B | SER129 |
| B | ALA130 |
| B | PHE171 |
| B | GLN172 |
| B | TYR211 |
| B | ILE212 |
| B | ALA213 |
| B | MET215 |
| B | GLY242 |
| B | VAL243 |
| B | SER244 |
| B | THR245 |
| B | HOH705 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for Di-peptide GLY B 174 and CSO B 175 |
| Chain | Residue |
| B | GLN172 |
| B | VAL173 |
| B | VAL176 |
| B | GLY177 |
| B | ILE178 |
| B | PHE186 |
| B | ASN188 |
| B | GLY241 |
| B | HOH654 |
| B | HOH696 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | binding site for Di-peptide CSO B 175 and VAL B 176 |
| Chain | Residue |
| B | SER153 |
| B | GLN172 |
| B | VAL173 |
| B | GLY174 |
| B | GLY177 |
| B | ILE178 |
| B | PHE186 |
| B | ASN188 |
| B | LYS190 |
| B | HOH631 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | ACT_SITE: ACT_SITE => ECO:0000269|PubMed:30151425 |
| Chain | Residue | Details |
| A | ARG72 | |
| A | PHE76 | |
| A | TYR98 | |
| B | ARG72 | |
| B | PHE76 | |
| B | TYR98 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:30151425, ECO:0007744|PDB:5N0P, ECO:0007744|PDB:5N0T, ECO:0007744|PDB:5N0U |
| Chain | Residue | Details |
| A | TYR98 | |
| B | TYR98 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:30151425, ECO:0007744|PDB:5N0O, ECO:0007744|PDB:5N0P, ECO:0007744|PDB:5N0Q, ECO:0007744|PDB:5N0R, ECO:0007744|PDB:5N0S, ECO:0007744|PDB:5N0T, ECO:0007744|PDB:5N0U, ECO:0007744|PDB:5N0V, ECO:0007744|PDB:5N0W, ECO:0007744|PDB:5N0X, ECO:0007744|PDB:5N4I, ECO:0007744|PDB:6GEW, ECO:0007744|PDB:6QZY, ECO:0007744|PDB:6QZZ, ECO:0007744|PDB:6R00, ECO:0007744|PDB:6TSC |
| Chain | Residue | Details |
| A | HIS100 | |
| A | ALA130 | |
| A | ALA213 | |
| A | THR245 | |
| B | HIS100 | |
| B | ALA130 | |
| B | ALA213 | |
| B | THR245 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:30151425, ECO:0007744|PDB:5N0O, ECO:0007744|PDB:5N0Q, ECO:0007744|PDB:5N0R, ECO:0007744|PDB:5N0S, ECO:0007744|PDB:5N0T, ECO:0007744|PDB:5N0W, ECO:0007744|PDB:5N0X, ECO:0007744|PDB:5N4I, ECO:0007744|PDB:6QZY, ECO:0007744|PDB:6QZZ |
| Chain | Residue | Details |
| A | VAL103 | |
| B | VAL103 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:30151425, ECO:0007744|PDB:5N0O, ECO:0007744|PDB:5N0P, ECO:0007744|PDB:5N0R, ECO:0007744|PDB:5N0S, ECO:0007744|PDB:5N0T, ECO:0007744|PDB:5N0U, ECO:0007744|PDB:5N0V, ECO:0007744|PDB:5N0W, ECO:0007744|PDB:5N0X, ECO:0007744|PDB:5N4I, ECO:0007744|PDB:6GEW, ECO:0007744|PDB:6QZY, ECO:0007744|PDB:6QZZ, ECO:0007744|PDB:6R00, ECO:0007744|PDB:6TSC |
| Chain | Residue | Details |
| A | GLN172 | |
| B | GLN172 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:30151425, ECO:0007744|PDB:5N0P, ECO:0007744|PDB:5N0Q, ECO:0007744|PDB:6GEW |
| Chain | Residue | Details |
| A | SER244 | |
| B | SER244 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | MOD_RES: N-methylvaline => ECO:0000269|PubMed:28715095, ECO:0000269|PubMed:30151425, ECO:0000269|PubMed:32491837, ECO:0000269|PubMed:33574430 |
| Chain | Residue | Details |
| A | VAL401 | |
| A | VAL403 | |
| A | VAL404 | |
| A | VAL406 | |
| B | VAL401 | |
| B | VAL403 | |
| B | VAL404 | |
| B | VAL406 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | MOD_RES: N-methylglycine => ECO:0000269|PubMed:28715095, ECO:0000269|PubMed:30151425, ECO:0000269|PubMed:32491837, ECO:0000269|PubMed:33574430 |
| Chain | Residue | Details |
| A | GLY405 | |
| A | GLY408 | |
| A | GLY411 | |
| B | GLY405 | |
| B | GLY408 | |
| B | GLY411 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | MOD_RES: N-methylisoleucine => ECO:0000269|PubMed:28715095, ECO:0000269|PubMed:30151425, ECO:0000269|PubMed:32491837, ECO:0000269|PubMed:33574430 |
| Chain | Residue | Details |
| A | ILE407 | |
| A | ILE410 | |
| B | ILE407 | |
| B | ILE410 |
