5N0Q

Crystal structure of OphA-DeltaC6 in complex with SAH

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008168	molecular_function	methyltransferase activity
A	0016740	molecular_function	transferase activity
A	0032259	biological_process	methylation
B	0008168	molecular_function	methyltransferase activity
B	0016740	molecular_function	transferase activity
B	0032259	biological_process	methylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	binding site for residue SAH A 501

Chain	Residue
A	ILE19
A	PHE171
A	GLN172
A	ILE212
A	ALA213
A	GLY242
A	VAL243
A	SER244
A	THR245
B	SAR408
A	TYR98
A	GLY99
A	HIS100
A	VAL103
A	PHE104
A	VAL105
A	SER129
A	ALA130

---

site_id	AC2
Number of Residues	16
Details	binding site for residue SAH B 501

Chain	Residue
A	SAR408
B	TYR98
B	HIS100
B	VAL103
B	PHE104
B	SER129
B	ALA130
B	PHE171
B	GLN172
B	TYR211
B	ILE212
B	ALA213
B	GLY242
B	VAL243
B	SER244
B	THR245

---

site_id	AC3
Number of Residues	3
Details	binding site for residues MVA A 403 and MVA A 404

Chain	Residue
A	GLN316
A	CYS373
A	SAR405

---

site_id	AC4
Number of Residues	4
Details	binding site for residues MVA A 404 and SAR A 405

Chain	Residue
A	GLN316
A	CYS373
A	MVA403
A	MVA406

---

site_id	AC5
Number of Residues	2
Details	binding site for residues SAR A 405 and MVA A 406

Chain	Residue
A	MVA404
A	IML407

---

site_id	AC6
Number of Residues	6
Details	binding site for residues MVA A 406 and IML A 407

Chain	Residue
A	SAR405
A	SAR408
B	TYR63
B	PHE181
B	ASN182
B	PHE183

---

site_id	AC7
Number of Residues	10
Details	binding site for residues IML A 407 and SAR A 408

Chain	Residue
A	MVA406
A	VAL409
A	ILE410
B	TYR63
B	TYR98
B	PHE181
B	ASN182
B	PHE183
B	GLY242
B	SAH501

---

site_id	AC8
Number of Residues	4
Details	binding site for residues MVA B 406 and IML B 407

Chain	Residue
A	TYR63
A	PHE181
B	ARG372
B	SAR408

---

site_id	AC9
Number of Residues	8
Details	binding site for residues IML B 407 and SAR B 408

Chain	Residue
A	TYR63
A	TYR98
A	PHE181
A	GLY242
A	SAH501
B	MVA406
B	VAL409
B	ILE410

---

site_id	AD1
Number of Residues	10
Details	binding site for Di-peptide SAR B 408 and VAL B 409

Chain	Residue
A	TYR66
A	ARG72
A	TYR76
A	TYR98
A	GLN172
A	GLY242
A	SAH501
B	IML407
B	ILE410
B	GLY411

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	126
Details	Region: {"description":"Clasp domain","evidences":[{"source":"PubMed","id":"28715095","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Active site: {"evidences":[{"source":"PubMed","id":"30151425","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30151425","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5N0P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5N0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5N0U","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30151425","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5N0O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5N0P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5N0Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5N0R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5N0S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5N0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5N0U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5N0V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5N0W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5N0X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5N4I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6GEW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6QZY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6QZZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6R00","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6TSC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30151425","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5N0O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5N0Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5N0R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5N0S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5N0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5N0W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5N0X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5N4I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6QZY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6QZZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30151425","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5N0O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5N0P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5N0R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5N0S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5N0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5N0U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5N0V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5N0W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5N0X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5N4I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6GEW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6QZY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6QZZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6R00","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6TSC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30151425","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5N0P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5N0Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6GEW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---