Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

5MW4

Crystal structure of Dot1L in complex with inhibitor CPD7 [N-(3-(((R)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)(methyl)amino)propyl)-2-(3-(2-chloro-3-(2-methylpyridin-3-yl)benzo[b]thiophen-5-yl)ureido)acetamide]

Functional Information from GO Data
ChainGOidnamespacecontents
A0031151molecular_functionhistone H3K79 methyltransferase activity
A0051726biological_processregulation of cell cycle
B0031151molecular_functionhistone H3K79 methyltransferase activity
B0051726biological_processregulation of cell cycle
Functional Information from PDB Data
site_idAC1
Number of Residues21
Detailsbinding site for residue 5JU A 401
ChainResidue
ASER140
ALYS187
AGLY221
AASP222
APHE223
APHE239
AVAL240
AASN241
AVAL267
ASER268
ASER269
ALEU143
ASER311
AHOH511
AVAL144
AASP161
AGLY163
ASER164
AGLY165
AVAL169
AGLU186

site_idAC2
Number of Residues2
Detailsbinding site for residue SO4 A 402
ChainResidue
AASN79
AARG80

site_idAC3
Number of Residues3
Detailsbinding site for residue SO4 A 403
ChainResidue
ATHR100
AARG101
ALYS212

site_idAC4
Number of Residues21
Detailsbinding site for residue 5JU B 401
ChainResidue
BSER140
BLEU143
BVAL144
BASP161
BGLY163
BSER164
BGLY165
BVAL169
BGLU186
BLYS187
BGLY221
BASP222
BPHE223
BPHE239
BVAL240
BASN241
BVAL267
BSER268
BSER269
BSER311
BHOH506

site_idAC5
Number of Residues4
Detailsbinding site for residue SO4 B 402
ChainResidue
BARG8
BLYS10
BASN79
BARG80

site_idAC6
Number of Residues3
Detailsbinding site for residue SO4 B 403
ChainResidue
BTHR100
BARG101
BLYS212

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues22
DetailsBinding site: {}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

PDB statisticsPDBj update infoContact PDBjnumon