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5MVS

Crystal structure of Dot1L in complex with adenosine and inhibitor CPD1 [N6-(2,6-dichlorophenyl)-N6-(pent-2-yn-1-yl)quinoline-4,6-diamine]

Functional Information from GO Data
ChainGOidnamespacecontents
A0031151molecular_functionhistone H3K79 methyltransferase activity
A0051726biological_processregulation of cell cycle
B0031151molecular_functionhistone H3K79 methyltransferase activity
B0051726biological_processregulation of cell cycle
Functional Information from PDB Data
site_idAC1
Number of Residues10
Detailsbinding site for residue ADN A 401
ChainResidue
AGLY163
AHOH619
AGLU186
ALYS187
AALA188
AGLY221
AASP222
APHE223
AASN241
AHOH553

site_idAC2
Number of Residues14
Detailsbinding site for residue 5JJ A 402
ChainResidue
APHE131
ASER140
ALEU143
AVAL144
APHE239
AVAL240
AASN241
AVAL267
ASER268
ASER269
AVAL310
ASER311
AHOH510
AHOH618

site_idAC3
Number of Residues6
Detailsbinding site for residue TLA A 403
ChainResidue
AGLY246
APRO247
AGLU248
AVAL249
ALYS330
AHOH570

site_idAC4
Number of Residues9
Detailsbinding site for residue ADN B 401
ChainResidue
BGLY163
BGLU186
BLYS187
BGLY221
BASP222
BPHE223
BASN241
BPHE245
BHOH593

site_idAC5
Number of Residues13
Detailsbinding site for residue 5JJ B 402
ChainResidue
BPHE131
BSER140
BLEU143
BVAL144
BPHE239
BVAL240
BASN241
BVAL267
BSER268
BSER269
BVAL310
BSER311
BHOH575

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues28
DetailsBinding site: {}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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