5MVS
Crystal structure of Dot1L in complex with adenosine and inhibitor CPD1 [N6-(2,6-dichlorophenyl)-N6-(pent-2-yn-1-yl)quinoline-4,6-diamine]
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue ADN A 401 |
| Chain | Residue |
| A | GLY163 |
| A | HOH619 |
| A | GLU186 |
| A | LYS187 |
| A | ALA188 |
| A | GLY221 |
| A | ASP222 |
| A | PHE223 |
| A | ASN241 |
| A | HOH553 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | binding site for residue 5JJ A 402 |
| Chain | Residue |
| A | PHE131 |
| A | SER140 |
| A | LEU143 |
| A | VAL144 |
| A | PHE239 |
| A | VAL240 |
| A | ASN241 |
| A | VAL267 |
| A | SER268 |
| A | SER269 |
| A | VAL310 |
| A | SER311 |
| A | HOH510 |
| A | HOH618 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue TLA A 403 |
| Chain | Residue |
| A | GLY246 |
| A | PRO247 |
| A | GLU248 |
| A | VAL249 |
| A | LYS330 |
| A | HOH570 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue ADN B 401 |
| Chain | Residue |
| B | GLY163 |
| B | GLU186 |
| B | LYS187 |
| B | GLY221 |
| B | ASP222 |
| B | PHE223 |
| B | ASN241 |
| B | PHE245 |
| B | HOH593 |
| site_id | AC5 |
| Number of Residues | 13 |
| Details | binding site for residue 5JJ B 402 |
| Chain | Residue |
| B | PHE131 |
| B | SER140 |
| B | LEU143 |
| B | VAL144 |
| B | PHE239 |
| B | VAL240 |
| B | ASN241 |
| B | VAL267 |
| B | SER268 |
| B | SER269 |
| B | VAL310 |
| B | SER311 |
| B | HOH575 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12628190","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1NW3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00902","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12628190","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1NW3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
