5MVF
Active structure of EHD4 complexed with ADP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0002042 | biological_process | cell migration involved in sprouting angiogenesis |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005769 | cellular_component | early endosome |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005912 | cellular_component | adherens junction |
| A | 0006897 | biological_process | endocytosis |
| A | 0006907 | biological_process | pinocytosis |
| A | 0030100 | biological_process | regulation of endocytosis |
| A | 0030139 | cellular_component | endocytic vesicle |
| A | 0030674 | molecular_function | protein-macromolecule adaptor activity |
| A | 0031901 | cellular_component | early endosome membrane |
| A | 0032456 | biological_process | endocytic recycling |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0050731 | biological_process | positive regulation of peptidyl-tyrosine phosphorylation |
| A | 0051260 | biological_process | protein homooligomerization |
| A | 0055038 | cellular_component | recycling endosome membrane |
| A | 0060271 | biological_process | cilium assembly |
| A | 0071363 | biological_process | cellular response to growth factor stimulus |
| A | 0072659 | biological_process | protein localization to plasma membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue ADP A 601 |
| Chain | Residue |
| A | TYR70 |
| A | LYS223 |
| A | GLN226 |
| A | SER259 |
| A | TRP261 |
| A | MG602 |
| A | SER71 |
| A | THR72 |
| A | GLY73 |
| A | LYS74 |
| A | THR75 |
| A | THR76 |
| A | ILE91 |
| A | ASN222 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue MG A 602 |
| Chain | Residue |
| A | THR75 |
| A | ASP156 |
| A | ADP601 |
Functional Information from PROSITE/UniProt
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DCDCDGMLDeeEF |
| Chain | Residue | Details |
| A | ASP492-PHE504 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 7 |
| Details | Region: {"description":"G1 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01055","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Region: {"description":"G3 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01055","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Region: {"description":"G4 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01055","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Region: {"description":"G5 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01055","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8BH64","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9H223","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
