Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5MT9

Human insulin in complex with serotonin and arginine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005179	molecular_function	hormone activity
A	0005576	cellular_component	extracellular region
B	0005179	molecular_function	hormone activity
B	0005576	cellular_component	extracellular region
C	0005179	molecular_function	hormone activity
C	0005576	cellular_component	extracellular region
D	0005179	molecular_function	hormone activity
D	0005576	cellular_component	extracellular region
E	0005179	molecular_function	hormone activity
E	0005576	cellular_component	extracellular region
F	0005179	molecular_function	hormone activity
F	0005576	cellular_component	extracellular region
G	0005179	molecular_function	hormone activity
G	0005576	cellular_component	extracellular region
H	0005179	molecular_function	hormone activity
H	0005576	cellular_component	extracellular region
I	0005179	molecular_function	hormone activity
I	0005576	cellular_component	extracellular region
J	0005179	molecular_function	hormone activity
J	0005576	cellular_component	extracellular region
K	0005179	molecular_function	hormone activity
K	0005576	cellular_component	extracellular region
L	0005179	molecular_function	hormone activity
L	0005576	cellular_component	extracellular region
M	0005179	molecular_function	hormone activity
M	0005576	cellular_component	extracellular region
N	0005179	molecular_function	hormone activity
N	0005576	cellular_component	extracellular region
O	0005179	molecular_function	hormone activity
O	0005576	cellular_component	extracellular region
P	0005179	molecular_function	hormone activity
P	0005576	cellular_component	extracellular region
Q	0005179	molecular_function	hormone activity
Q	0005576	cellular_component	extracellular region
R	0005179	molecular_function	hormone activity
R	0005576	cellular_component	extracellular region
S	0005179	molecular_function	hormone activity
S	0005576	cellular_component	extracellular region
T	0005179	molecular_function	hormone activity
T	0005576	cellular_component	extracellular region
U	0005179	molecular_function	hormone activity
U	0005576	cellular_component	extracellular region
V	0005179	molecular_function	hormone activity
V	0005576	cellular_component	extracellular region
W	0005179	molecular_function	hormone activity
W	0005576	cellular_component	extracellular region
X	0005179	molecular_function	hormone activity
X	0005576	cellular_component	extracellular region
Y	0005179	molecular_function	hormone activity
Y	0005576	cellular_component	extracellular region
Z	0005179	molecular_function	hormone activity
Z	0005576	cellular_component	extracellular region
a	0005179	molecular_function	hormone activity
a	0005576	cellular_component	extracellular region
b	0005179	molecular_function	hormone activity
b	0005576	cellular_component	extracellular region
c	0005179	molecular_function	hormone activity
c	0005576	cellular_component	extracellular region
d	0005179	molecular_function	hormone activity
d	0005576	cellular_component	extracellular region
e	0005179	molecular_function	hormone activity
e	0005576	cellular_component	extracellular region
f	0005179	molecular_function	hormone activity
f	0005576	cellular_component	extracellular region

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue ZN B 101

Chain	Residue
B	HIS10
B	HIS10
B	HIS10
B	CL102
B	CL102
B	CL102

site_id	AC2
Number of Residues	3
Details	binding site for residue CL B 102

Chain	Residue
B	ZN101
B	ZN101
B	ZN101

site_id	AC3
Number of Residues	7
Details	binding site for residue ARG B 103

Chain	Residue
B	HIS5
B	LEU6
B	CYS7
B	SER9
B	HIS10
B	GLU13
D	LEU17

site_id	AC4
Number of Residues	7
Details	binding site for residue SRO C 101

Chain	Residue
B	GLU21
C	CYS6
C	SER9
C	CYS11
C	HOH202
D	HIS5
D	LEU11

site_id	AC5
Number of Residues	6
Details	binding site for residue ZN D 101

Chain	Residue
D	HIS10
D	HIS10
D	HIS10
D	CL102
D	CL102
D	CL102

site_id	AC6
Number of Residues	6
Details	binding site for residue CL D 102

Chain	Residue
D	HIS10
D	HIS10
D	HIS10
D	ZN101
D	ZN101
D	ZN101

site_id	AC7
Number of Residues	6
Details	binding site for residue SRO E 101

Chain	Residue
E	TYR14
E	GLU17
O	LEU13
O	TYR14
O	GLU17
P	HOH205

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN F 101

Chain	Residue
F	HIS10
F	CL102
L	HIS10
N	HIS10

site_id	AC9
Number of Residues	4
Details	binding site for residue CL F 102

Chain	Residue
F	ZN101
F	ARG103
L	ARG101
N	ARG101

site_id	AD1
Number of Residues	7
Details	binding site for residue ARG F 103

Chain	Residue
F	HIS5
F	LEU6
F	HIS10
F	GLU13
F	CL102
N	SER9
P	LEU17

site_id	AD2
Number of Residues	8
Details	binding site for residue SRO G 101

Chain	Residue
G	CYS6
G	SER9
G	ILE10
G	CYS11
H	LEU11
J	HIS5
L	LEU17
L	GLU21

site_id	AD3
Number of Residues	4
Details	binding site for residue ZN H 101

Chain	Residue
H	HIS10
J	HIS10
P	HIS10
P	CL101

site_id	AD4
Number of Residues	9
Details	binding site for residue SRO I 101

Chain	Residue
I	CYS6
I	SER9
I	ILE10
I	CYS11
J	LEU11
N	LEU17
N	GLU21
N	HOH201
P	HIS5

site_id	AD5
Number of Residues	6
Details	binding site for residue SRO K 101

Chain	Residue
G	LEU13
G	TYR14
G	GLU17
K	LEU13
K	TYR14
K	GLU17

site_id	AD6
Number of Residues	10
Details	binding site for residue ARG L 101

Chain	Residue
F	SER9
F	CL102
H	TYR16
H	LEU17
L	HIS5
L	LEU6
L	CYS7
L	HIS10
L	GLU13
L	HOH206

site_id	AD7
Number of Residues	5
Details	binding site for residue SRO M 101

Chain	Residue
I	LEU13
I	GLU17
M	LEU13
M	TYR14
M	GLU17

site_id	AD8
Number of Residues	8
Details	binding site for residue ARG N 101

Chain	Residue
J	LEU17
L	SER9
N	HIS5
N	LEU6
N	CYS7
N	HIS10
N	GLU13
F	CL102

site_id	AD9
Number of Residues	9
Details	binding site for residue SRO O 101

Chain	Residue
F	LEU17
F	GLU21
H	HIS5
O	CYS6
O	SER9
O	ILE10
O	CYS11
O	HOH202
P	LEU11

site_id	AE1
Number of Residues	4
Details	binding site for residue CL P 101

Chain	Residue
H	HIS10
H	ZN101
J	HIS10
P	HIS10

site_id	AE2
Number of Residues	6
Details	binding site for residue SRO Q 101

Chain	Residue
Q	TYR14
Q	GLU17
Q	HOH201
a	LEU13
a	TYR14
a	GLU17

site_id	AE3
Number of Residues	4
Details	binding site for residue ZN R 101

Chain	Residue
R	HIS10
V	HIS10
Z	HIS10
Z	CL101

site_id	AE4
Number of Residues	4
Details	binding site for residue SRO R 102

Chain	Residue
E	ASN18
F	ARG22
Q	GLY1
R	PRO28

site_id	AE5
Number of Residues	7
Details	binding site for residue SRO S 101

Chain	Residue
S	CYS6
S	SER9
S	ILE10
S	CYS11
T	LEU11
V	LEU17
X	HIS5

site_id	AE6
Number of Residues	6
Details	binding site for residue SRO S 102

Chain	Residue
S	LEU13
S	TYR14
S	GLU17
U	LEU13
U	TYR14
U	GLU17

site_id	AE7
Number of Residues	4
Details	binding site for residue ZN T 101

Chain	Residue
T	HIS10
T	CL102
X	HIS10
b	HIS10

site_id	AE8
Number of Residues	4
Details	binding site for residue CL T 102

Chain	Residue
T	HIS10
T	ZN101
X	HIS10
b	HIS10

site_id	AE9
Number of Residues	7
Details	binding site for residue SRO W 101

Chain	Residue
W	CYS6
W	SER9
W	ILE10
W	CYS11
X	LEU11
Z	GLU21
b	HIS5

site_id	AF1
Number of Residues	7
Details	binding site for residue SRO Y 101

Chain	Residue
W	LEU13
W	TYR14
W	GLU17
W	HOH203
Y	LEU13
Y	TYR14
Y	GLU17

site_id	AF2
Number of Residues	3
Details	binding site for residue CL Z 101

Chain	Residue
R	HIS10
R	ZN101
Z	HIS10

site_id	AF3
Number of Residues	8
Details	binding site for residue SRO a 101

Chain	Residue
R	GLU21
R	HOH202
T	HIS5
a	CYS6
a	SER9
a	ILE10
a	CYS11
b	LEU11

site_id	AF4
Number of Residues	6
Details	binding site for residue SRO c 101

Chain	Residue
c	TYR14
c	GLU17
e	LEU13
e	TYR14
e	GLU17
f	HOH206

site_id	AF5
Number of Residues	6
Details	binding site for residue ZN d 101

Chain	Residue
d	HIS10
d	HIS10
d	HIS10
d	CL102
d	CL102
d	CL102

site_id	AF6
Number of Residues	6
Details	binding site for residue CL d 102

Chain	Residue
d	HIS10
d	HIS10
d	HIS10
d	ZN101
d	ZN101
d	ZN101

site_id	AF7
Number of Residues	8
Details	binding site for residue SRO e 101

Chain	Residue
d	GLU21
d	HOH205
e	CYS6
e	SER9
e	ILE10
e	CYS11
f	HIS5
f	LEU11

site_id	AF8
Number of Residues	6
Details	binding site for residue ZN f 101

Chain	Residue
f	HIS10
f	HIS10
f	HIS10
f	CL102
f	CL102
f	CL102

site_id	AF9
Number of Residues	6
Details	binding site for residue CL f 102

Chain	Residue
f	HIS10
f	HIS10
f	HIS10
f	ZN101
f	ZN101
f	ZN101

Functional Information from PROSITE/UniProt

site_id	PS00262
Number of Residues	15
Details	INSULIN Insulin family signature. CCTSiCSlyqLenyC

Chain	Residue	Details
A	CYS6-CYS20

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	200
Details	Peptide: {"description":"Insulin A chain","featureId":"PRO_0000015821"}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)