5MS4
Kallikrein-related peptidase 8 leupeptin inhibitor complex
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004252 | molecular_function | serine-type endopeptidase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005576 | cellular_component | extracellular region |
A | 0005615 | cellular_component | extracellular space |
A | 0005737 | cellular_component | cytoplasm |
A | 0006508 | biological_process | proteolysis |
A | 0007613 | biological_process | memory |
A | 0008233 | molecular_function | peptidase activity |
A | 0008236 | molecular_function | serine-type peptidase activity |
A | 0009611 | biological_process | response to wounding |
A | 0030141 | cellular_component | secretory granule |
A | 0043616 | biological_process | keratinocyte proliferation |
A | 0048812 | biological_process | neuron projection morphogenesis |
A | 0050807 | biological_process | regulation of synapse organization |
A | 0050808 | biological_process | synapse organization |
A | 0097180 | cellular_component | serine protease inhibitor complex |
B | 0004252 | molecular_function | serine-type endopeptidase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005576 | cellular_component | extracellular region |
B | 0005615 | cellular_component | extracellular space |
B | 0005737 | cellular_component | cytoplasm |
B | 0006508 | biological_process | proteolysis |
B | 0007613 | biological_process | memory |
B | 0008233 | molecular_function | peptidase activity |
B | 0008236 | molecular_function | serine-type peptidase activity |
B | 0009611 | biological_process | response to wounding |
B | 0030141 | cellular_component | secretory granule |
B | 0043616 | biological_process | keratinocyte proliferation |
B | 0048812 | biological_process | neuron projection morphogenesis |
B | 0050807 | biological_process | regulation of synapse organization |
B | 0050808 | biological_process | synapse organization |
B | 0097180 | cellular_component | serine protease inhibitor complex |
C | 0004252 | molecular_function | serine-type endopeptidase activity |
C | 0005515 | molecular_function | protein binding |
C | 0005576 | cellular_component | extracellular region |
C | 0005615 | cellular_component | extracellular space |
C | 0005737 | cellular_component | cytoplasm |
C | 0006508 | biological_process | proteolysis |
C | 0007613 | biological_process | memory |
C | 0008233 | molecular_function | peptidase activity |
C | 0008236 | molecular_function | serine-type peptidase activity |
C | 0009611 | biological_process | response to wounding |
C | 0030141 | cellular_component | secretory granule |
C | 0043616 | biological_process | keratinocyte proliferation |
C | 0048812 | biological_process | neuron projection morphogenesis |
C | 0050807 | biological_process | regulation of synapse organization |
C | 0050808 | biological_process | synapse organization |
C | 0097180 | cellular_component | serine protease inhibitor complex |
D | 0004252 | molecular_function | serine-type endopeptidase activity |
D | 0005515 | molecular_function | protein binding |
D | 0005576 | cellular_component | extracellular region |
D | 0005615 | cellular_component | extracellular space |
D | 0005737 | cellular_component | cytoplasm |
D | 0006508 | biological_process | proteolysis |
D | 0007613 | biological_process | memory |
D | 0008233 | molecular_function | peptidase activity |
D | 0008236 | molecular_function | serine-type peptidase activity |
D | 0009611 | biological_process | response to wounding |
D | 0030141 | cellular_component | secretory granule |
D | 0043616 | biological_process | keratinocyte proliferation |
D | 0048812 | biological_process | neuron projection morphogenesis |
D | 0050807 | biological_process | regulation of synapse organization |
D | 0050808 | biological_process | synapse organization |
D | 0097180 | cellular_component | serine protease inhibitor complex |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 10 |
Details | binding site for residue TBU A 301 |
Chain | Residue |
A | PRO79 |
A | HOH570 |
A | SER113 |
A | LEU114 |
A | GLY115 |
A | SER116 |
A | LYS117 |
A | VAL118 |
A | GLY174 |
A | HOH415 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue TBU A 302 |
Chain | Residue |
A | HIS91 |
A | TYR234 |
A | ASP236 |
A | TRP237 |
A | HOH563 |
site_id | AC3 |
Number of Residues | 4 |
Details | binding site for residue TBU A 303 |
Chain | Residue |
A | PRO152 |
A | ASP153 |
A | THR154 |
D | LYS62 |
site_id | AC4 |
Number of Residues | 7 |
Details | binding site for residue CA A 304 |
Chain | Residue |
A | ARG66 |
A | ASP70 |
A | SER72 |
A | ASN75 |
A | ASP77 |
A | GLU80 |
A | HOH407 |
site_id | AC5 |
Number of Residues | 6 |
Details | binding site for residue CA B 301 |
Chain | Residue |
B | ASP70 |
B | SER72 |
B | ASN75 |
B | ASP77 |
B | GLU80 |
B | HOH504 |
site_id | AC6 |
Number of Residues | 5 |
Details | binding site for residue CA C 301 |
Chain | Residue |
C | ASP70 |
C | SER72 |
C | ASN75 |
C | ASP77 |
C | GLU80 |
site_id | AC7 |
Number of Residues | 7 |
Details | binding site for residue CA D 301 |
Chain | Residue |
D | ARG66 |
D | ASP70 |
D | SER72 |
D | ASN75 |
D | ASP77 |
D | GLU80 |
D | HOH489 |
site_id | AC8 |
Number of Residues | 19 |
Details | binding site for Di-peptide AR7 G 4 and SER C 195 |
Chain | Residue |
C | CYS42 |
C | GLY43 |
C | HIS57 |
C | ASP189 |
C | THR190 |
C | CYS191 |
C | GLY193 |
C | ASP194 |
C | GLY196 |
C | GLY197 |
C | THR213 |
C | SER214 |
C | GLY216 |
C | SER217 |
C | CYS220 |
C | GLY226 |
C | HOH416 |
G | LEU3 |
G | HOH101 |
site_id | AC9 |
Number of Residues | 20 |
Details | binding site for Di-peptide AR7 H 4 and SER D 195 |
Chain | Residue |
D | CYS42 |
D | GLY43 |
D | ASP189 |
D | THR190 |
D | CYS191 |
D | GLN192 |
D | GLY193 |
D | ASP194 |
D | GLY196 |
D | GLY197 |
D | THR213 |
D | SER214 |
D | TRP215 |
D | GLY216 |
D | SER217 |
D | CYS220 |
D | GLY226 |
H | LEU2 |
H | LEU3 |
H | HOH101 |
site_id | AD1 |
Number of Residues | 14 |
Details | binding site for LEUPEPTIN chain E |
Chain | Residue |
A | HIS57 |
A | ASP189 |
A | THR190 |
A | GLN192 |
A | GLY193 |
A | SER195 |
A | SER214 |
A | TRP215 |
A | GLY216 |
A | SER217 |
A | ASP218 |
A | CYS220 |
E | HOH101 |
E | HOH102 |
site_id | AD2 |
Number of Residues | 19 |
Details | binding site for LEUPEPTIN chain F |
Chain | Residue |
B | THR190 |
B | CYS191 |
B | GLN192 |
B | GLY193 |
B | SER195 |
B | SER214 |
B | TRP215 |
B | GLY216 |
B | SER217 |
B | ASP218 |
B | CYS220 |
B | GLY226 |
B | HOH403 |
B | HOH418 |
B | HOH430 |
B | HOH501 |
F | HOH101 |
B | HIS99 |
B | ASP189 |
site_id | AD3 |
Number of Residues | 16 |
Details | binding site for LEUPEPTIN chain G |
Chain | Residue |
C | HIS57 |
C | HIS99 |
C | ASP189 |
C | THR190 |
C | CYS191 |
C | SER195 |
C | SER214 |
C | TRP215 |
C | GLY216 |
C | SER217 |
C | ASP218 |
C | CYS220 |
C | GLY226 |
C | HOH416 |
G | HOH101 |
G | HOH102 |
site_id | AD4 |
Number of Residues | 14 |
Details | binding site for LEUPEPTIN chain H |
Chain | Residue |
D | HIS57 |
D | ASP189 |
D | THR190 |
D | CYS191 |
D | GLN192 |
D | GLY193 |
D | SER195 |
D | SER214 |
D | TRP215 |
D | GLY216 |
D | SER217 |
D | CYS220 |
D | GLY226 |
H | HOH101 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 12 |
Details | ACT_SITE: Charge relay system => ECO:0000250 |
Chain | Residue | Details |
A | HIS57 | |
A | ASP102 | |
A | SER195 | |
B | HIS57 | |
B | ASP102 | |
B | SER195 | |
C | HIS57 | |
C | ASP102 | |
C | SER195 | |
D | HIS57 | |
D | ASP102 | |
D | SER195 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
A | ASN95 | |
B | ASN95 | |
C | ASN95 | |
D | ASN95 |