Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5MS4

Kallikrein-related peptidase 8 leupeptin inhibitor complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0006508	biological_process	proteolysis
A	0007613	biological_process	memory
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0009611	biological_process	response to wounding
A	0016787	molecular_function	hydrolase activity
A	0030141	cellular_component	secretory granule
A	0038130	biological_process	ERBB4 signaling pathway
A	0043616	biological_process	keratinocyte proliferation
A	0048812	biological_process	neuron projection morphogenesis
A	0050807	biological_process	regulation of synapse organization
A	0050808	biological_process	synapse organization
A	0051604	biological_process	protein maturation
A	0097180	cellular_component	serine protease inhibitor complex
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005737	cellular_component	cytoplasm
B	0006508	biological_process	proteolysis
B	0007613	biological_process	memory
B	0008233	molecular_function	peptidase activity
B	0008236	molecular_function	serine-type peptidase activity
B	0009611	biological_process	response to wounding
B	0016787	molecular_function	hydrolase activity
B	0030141	cellular_component	secretory granule
B	0038130	biological_process	ERBB4 signaling pathway
B	0043616	biological_process	keratinocyte proliferation
B	0048812	biological_process	neuron projection morphogenesis
B	0050807	biological_process	regulation of synapse organization
B	0050808	biological_process	synapse organization
B	0051604	biological_process	protein maturation
B	0097180	cellular_component	serine protease inhibitor complex
C	0004252	molecular_function	serine-type endopeptidase activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005737	cellular_component	cytoplasm
C	0006508	biological_process	proteolysis
C	0007613	biological_process	memory
C	0008233	molecular_function	peptidase activity
C	0008236	molecular_function	serine-type peptidase activity
C	0009611	biological_process	response to wounding
C	0016787	molecular_function	hydrolase activity
C	0030141	cellular_component	secretory granule
C	0038130	biological_process	ERBB4 signaling pathway
C	0043616	biological_process	keratinocyte proliferation
C	0048812	biological_process	neuron projection morphogenesis
C	0050807	biological_process	regulation of synapse organization
C	0050808	biological_process	synapse organization
C	0051604	biological_process	protein maturation
C	0097180	cellular_component	serine protease inhibitor complex
D	0004252	molecular_function	serine-type endopeptidase activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005737	cellular_component	cytoplasm
D	0006508	biological_process	proteolysis
D	0007613	biological_process	memory
D	0008233	molecular_function	peptidase activity
D	0008236	molecular_function	serine-type peptidase activity
D	0009611	biological_process	response to wounding
D	0016787	molecular_function	hydrolase activity
D	0030141	cellular_component	secretory granule
D	0038130	biological_process	ERBB4 signaling pathway
D	0043616	biological_process	keratinocyte proliferation
D	0048812	biological_process	neuron projection morphogenesis
D	0050807	biological_process	regulation of synapse organization
D	0050808	biological_process	synapse organization
D	0051604	biological_process	protein maturation
D	0097180	cellular_component	serine protease inhibitor complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue TBU A 301

Chain	Residue
A	PRO79
A	HOH570
A	SER113
A	LEU114
A	GLY115
A	SER116
A	LYS117
A	VAL118
A	GLY174
A	HOH415

site_id	AC2
Number of Residues	5
Details	binding site for residue TBU A 302

Chain	Residue
A	HIS91
A	TYR234
A	ASP236
A	TRP237
A	HOH563

site_id	AC3
Number of Residues	4
Details	binding site for residue TBU A 303

Chain	Residue
A	PRO152
A	ASP153
A	THR154
D	LYS62

site_id	AC4
Number of Residues	7
Details	binding site for residue CA A 304

Chain	Residue
A	ARG66
A	ASP70
A	SER72
A	ASN75
A	ASP77
A	GLU80
A	HOH407

site_id	AC5
Number of Residues	6
Details	binding site for residue CA B 301

Chain	Residue
B	ASP70
B	SER72
B	ASN75
B	ASP77
B	GLU80
B	HOH504

site_id	AC6
Number of Residues	5
Details	binding site for residue CA C 301

Chain	Residue
C	ASP70
C	SER72
C	ASN75
C	ASP77
C	GLU80

site_id	AC7
Number of Residues	7
Details	binding site for residue CA D 301

Chain	Residue
D	ARG66
D	ASP70
D	SER72
D	ASN75
D	ASP77
D	GLU80
D	HOH489

site_id	AC8
Number of Residues	19
Details	binding site for Di-peptide AR7 G 4 and SER C 195

Chain	Residue
C	CYS42
C	GLY43
C	HIS57
C	ASP189
C	THR190
C	CYS191
C	GLY193
C	ASP194
C	GLY196
C	GLY197
C	THR213
C	SER214
C	GLY216
C	SER217
C	CYS220
C	GLY226
C	HOH416
G	LEU3
G	HOH101

site_id	AC9
Number of Residues	20
Details	binding site for Di-peptide AR7 H 4 and SER D 195

Chain	Residue
D	CYS42
D	GLY43
D	ASP189
D	THR190
D	CYS191
D	GLN192
D	GLY193
D	ASP194
D	GLY196
D	GLY197
D	THR213
D	SER214
D	TRP215
D	GLY216
D	SER217
D	CYS220
D	GLY226
H	LEU2
H	LEU3
H	HOH101

site_id	AD1
Number of Residues	14
Details	binding site for LEUPEPTIN chain E

Chain	Residue
A	HIS57
A	ASP189
A	THR190
A	GLN192
A	GLY193
A	SER195
A	SER214
A	TRP215
A	GLY216
A	SER217
A	ASP218
A	CYS220
E	HOH101
E	HOH102

site_id	AD2
Number of Residues	19
Details	binding site for LEUPEPTIN chain F

Chain	Residue
B	THR190
B	CYS191
B	GLN192
B	GLY193
B	SER195
B	SER214
B	TRP215
B	GLY216
B	SER217
B	ASP218
B	CYS220
B	GLY226
B	HOH403
B	HOH418
B	HOH430
B	HOH501
F	HOH101
B	HIS99
B	ASP189

site_id	AD3
Number of Residues	16
Details	binding site for LEUPEPTIN chain G

Chain	Residue
C	HIS57
C	HIS99
C	ASP189
C	THR190
C	CYS191
C	SER195
C	SER214
C	TRP215
C	GLY216
C	SER217
C	ASP218
C	CYS220
C	GLY226
C	HOH416
G	HOH101
G	HOH102

site_id	AD4
Number of Residues	14
Details	binding site for LEUPEPTIN chain H

Chain	Residue
D	HIS57
D	ASP189
D	THR190
D	CYS191
D	GLN192
D	GLY193
D	SER195
D	SER214
D	TRP215
D	GLY216
D	SER217
D	CYS220
D	GLY226
H	HOH101

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
A	LEU53-CYS58

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DTcqGDSGGPLV

Chain	Residue	Details
A	ASP189-VAL200

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	896
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	12
Details	Active site: {"description":"Charge relay system","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)