5MRP

Arabidopsis thaliana IspD Glu258Ala mutant in complex with Azolopyrimidine (2)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0008299	biological_process	isoprenoid biosynthetic process
A	0050518	molecular_function	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A	0070567	molecular_function	cytidylyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue 6BC A 401

Chain	Residue
A	ARG157
A	SER264
A	ILE265
A	VAL266
A	GLN158
A	ILE177
A	ALA203
A	GLN238
A	VAL239
A	ASP261
A	ASP262
A	VAL263

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site_id	AC2
Number of Residues	1
Details	binding site for residue K A 402

Chain	Residue
A	ASP290

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site_id	AC3
Number of Residues	2
Details	binding site for residue K A 403

Chain	Residue
A	PRO120
A	CD405

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site_id	AC4
Number of Residues	4
Details	binding site for residue CD A 404

Chain	Residue
A	LYS123
A	GLU138
A	GLU141
A	ASP169

---

site_id	AC5
Number of Residues	4
Details	binding site for residue CD A 405

Chain	Residue
A	GLU121
A	GLU191
A	HIS271
A	K403

---

site_id	AC6
Number of Residues	2
Details	binding site for residue CD A 406

Chain	Residue
A	GLU167
A	GLU167

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Functional Information from PROSITE/UniProt

site_id	PS01295
Number of Residues	8
Details	ISPD 4-diphosphocytidyl-2C-methyl-D-erythritol synthase signature. VCIHDSAR

Chain	Residue	Details
A	VAL175-ARG182

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Site: {"description":"Transition state stabilizer","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Site: {"description":"Positions MEP for the nucleophilic attack","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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