5MQF

Cryo-EM structure of a human spliceosome activated for step 2 of splicing (C* complex)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000244	biological_process	spliceosomal tri-snRNP complex assembly
A	0000375	biological_process	RNA splicing, via transesterification reactions
A	0000398	biological_process	mRNA splicing, via spliceosome
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005681	cellular_component	spliceosomal complex
A	0005682	cellular_component	U5 snRNP
A	0006397	biological_process	mRNA processing
A	0008233	molecular_function	peptidase activity
A	0008237	molecular_function	metallopeptidase activity
A	0008380	biological_process	RNA splicing
A	0016020	cellular_component	membrane
A	0016607	cellular_component	nuclear speck
A	0017070	molecular_function	U6 snRNA binding
A	0030532	cellular_component	small nuclear ribonucleoprotein complex
A	0030619	molecular_function	U1 snRNA binding
A	0030620	molecular_function	U2 snRNA binding
A	0030623	molecular_function	U5 snRNA binding
A	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
A	0070530	molecular_function	K63-linked polyubiquitin modification-dependent protein binding
A	0071005	cellular_component	U2-type precatalytic spliceosome
A	0071006	cellular_component	U2-type catalytic step 1 spliceosome
A	0071007	cellular_component	U2-type catalytic step 2 spliceosome
A	0071013	cellular_component	catalytic step 2 spliceosome
A	0071222	biological_process	cellular response to lipopolysaccharide
A	0071356	biological_process	cellular response to tumor necrosis factor
A	0097157	molecular_function	pre-mRNA intronic binding
A	0140492	molecular_function	metal-dependent deubiquitinase activity
B	0000398	biological_process	mRNA splicing, via spliceosome
B	0003723	molecular_function	RNA binding
B	0003924	molecular_function	GTPase activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005681	cellular_component	spliceosomal complex
B	0005829	cellular_component	cytosol
B	0006397	biological_process	mRNA processing
B	0008380	biological_process	RNA splicing
B	0015030	cellular_component	Cajal body
B	0016020	cellular_component	membrane
B	0016607	cellular_component	nuclear speck
B	0030623	molecular_function	U5 snRNA binding
B	0042220	biological_process	response to cocaine
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
B	0071005	cellular_component	U2-type precatalytic spliceosome
B	0071007	cellular_component	U2-type catalytic step 2 spliceosome
B	0071013	cellular_component	catalytic step 2 spliceosome
B	0071466	biological_process	cellular response to xenobiotic stimulus
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0000398	biological_process	mRNA splicing, via spliceosome
C	0003713	molecular_function	transcription coactivator activity
C	0003714	molecular_function	transcription corepressor activity
C	0003723	molecular_function	RNA binding
C	0005112	molecular_function	Notch binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005681	cellular_component	spliceosomal complex
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0006397	biological_process	mRNA processing
C	0008024	cellular_component	cyclin/CDK positive transcription elongation factor complex
C	0008380	biological_process	RNA splicing
C	0016363	cellular_component	nuclear matrix
C	0016604	cellular_component	nuclear body
C	0016607	cellular_component	nuclear speck
C	0016922	molecular_function	nuclear receptor binding
C	0019899	molecular_function	enzyme binding
C	0030511	biological_process	positive regulation of transforming growth factor beta receptor signaling pathway
C	0042771	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
C	0042809	molecular_function	nuclear vitamin D receptor binding
C	0042974	molecular_function	nuclear retinoic acid receptor binding
C	0043923	biological_process	positive regulation by host of viral transcription
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0046332	molecular_function	SMAD binding
C	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
C	0048384	biological_process	retinoic acid receptor signaling pathway
C	0048385	biological_process	regulation of retinoic acid receptor signaling pathway
C	0050681	molecular_function	nuclear androgen receptor binding
C	0050769	biological_process	positive regulation of neurogenesis
C	0070562	biological_process	regulation of vitamin D receptor signaling pathway
C	0070564	biological_process	positive regulation of vitamin D receptor signaling pathway
C	0071007	cellular_component	U2-type catalytic step 2 spliceosome
C	0071013	cellular_component	catalytic step 2 spliceosome
C	0071300	biological_process	cellular response to retinoic acid
D	0000398	biological_process	mRNA splicing, via spliceosome
D	0000974	cellular_component	Prp19 complex
D	0001650	cellular_component	fibrillar center
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005662	cellular_component	DNA replication factor A complex
D	0005681	cellular_component	spliceosomal complex
D	0006397	biological_process	mRNA processing
D	0008380	biological_process	RNA splicing
D	0016607	cellular_component	nuclear speck
D	0031965	cellular_component	nuclear membrane
D	0034504	biological_process	protein localization to nucleus
D	0071007	cellular_component	U2-type catalytic step 2 spliceosome
D	0071013	cellular_component	catalytic step 2 spliceosome
D	1900087	biological_process	positive regulation of G1/S transition of mitotic cell cycle
E	0000398	biological_process	mRNA splicing, via spliceosome
E	0003723	molecular_function	RNA binding
E	0003729	molecular_function	mRNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005681	cellular_component	spliceosomal complex
E	0006397	biological_process	mRNA processing
E	0008380	biological_process	RNA splicing
E	0016607	cellular_component	nuclear speck
E	0071007	cellular_component	U2-type catalytic step 2 spliceosome
E	0071013	cellular_component	catalytic step 2 spliceosome
E	1990403	biological_process	embryonic brain development
F	0000375	biological_process	RNA splicing, via transesterification reactions
F	0000398	biological_process	mRNA splicing, via spliceosome
F	0003723	molecular_function	RNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005681	cellular_component	spliceosomal complex
F	0005682	cellular_component	U5 snRNP
F	0005732	cellular_component	sno(s)RNA-containing ribonucleoprotein complex
F	0005829	cellular_component	cytosol
F	0006396	biological_process	RNA processing
F	0006397	biological_process	mRNA processing
F	0008380	biological_process	RNA splicing
F	0016607	cellular_component	nuclear speck
F	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
F	0071007	cellular_component	U2-type catalytic step 2 spliceosome
F	0071013	cellular_component	catalytic step 2 spliceosome
G	0000077	biological_process	DNA damage checkpoint signaling
G	0000209	biological_process	protein polyubiquitination
G	0000244	biological_process	spliceosomal tri-snRNP complex assembly
G	0000245	biological_process	spliceosomal complex assembly
G	0000398	biological_process	mRNA splicing, via spliceosome
G	0000974	cellular_component	Prp19 complex
G	0004842	molecular_function	ubiquitin-protein transferase activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005662	cellular_component	DNA replication factor A complex
G	0005681	cellular_component	spliceosomal complex
G	0005737	cellular_component	cytoplasm
G	0005811	cellular_component	lipid droplet
G	0005819	cellular_component	spindle
G	0005856	cellular_component	cytoskeleton
G	0006281	biological_process	DNA repair
G	0006303	biological_process	double-strand break repair via nonhomologous end joining
G	0006397	biological_process	mRNA processing
G	0008104	biological_process	protein localization
G	0008380	biological_process	RNA splicing
G	0008610	biological_process	lipid biosynthetic process
G	0010498	biological_process	proteasomal protein catabolic process
G	0016020	cellular_component	membrane
G	0016567	biological_process	protein ubiquitination
G	0016607	cellular_component	nuclear speck
G	0016740	molecular_function	transferase activity
G	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
G	0035861	cellular_component	site of double-strand break
G	0042802	molecular_function	identical protein binding
G	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
G	0061630	molecular_function	ubiquitin protein ligase activity
G	0070534	biological_process	protein K63-linked ubiquitination
G	0071006	cellular_component	U2-type catalytic step 1 spliceosome
G	0071007	cellular_component	U2-type catalytic step 2 spliceosome
G	0071013	cellular_component	catalytic step 2 spliceosome
H	0000077	biological_process	DNA damage checkpoint signaling
H	0000209	biological_process	protein polyubiquitination
H	0000244	biological_process	spliceosomal tri-snRNP complex assembly
H	0000245	biological_process	spliceosomal complex assembly
H	0000398	biological_process	mRNA splicing, via spliceosome
H	0000974	cellular_component	Prp19 complex
H	0004842	molecular_function	ubiquitin-protein transferase activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005662	cellular_component	DNA replication factor A complex
H	0005681	cellular_component	spliceosomal complex
H	0005737	cellular_component	cytoplasm
H	0005811	cellular_component	lipid droplet
H	0005819	cellular_component	spindle
H	0005856	cellular_component	cytoskeleton
H	0006281	biological_process	DNA repair
H	0006303	biological_process	double-strand break repair via nonhomologous end joining
H	0006397	biological_process	mRNA processing
H	0008104	biological_process	protein localization
H	0008380	biological_process	RNA splicing
H	0008610	biological_process	lipid biosynthetic process
H	0010498	biological_process	proteasomal protein catabolic process
H	0016020	cellular_component	membrane
H	0016567	biological_process	protein ubiquitination
H	0016607	cellular_component	nuclear speck
H	0016740	molecular_function	transferase activity
H	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
H	0035861	cellular_component	site of double-strand break
H	0042802	molecular_function	identical protein binding
H	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
H	0061630	molecular_function	ubiquitin protein ligase activity
H	0070534	biological_process	protein K63-linked ubiquitination
H	0071006	cellular_component	U2-type catalytic step 1 spliceosome
H	0071007	cellular_component	U2-type catalytic step 2 spliceosome
H	0071013	cellular_component	catalytic step 2 spliceosome
I	0000077	biological_process	DNA damage checkpoint signaling
I	0000209	biological_process	protein polyubiquitination
I	0000244	biological_process	spliceosomal tri-snRNP complex assembly
I	0000245	biological_process	spliceosomal complex assembly
I	0000398	biological_process	mRNA splicing, via spliceosome
I	0000974	cellular_component	Prp19 complex
I	0004842	molecular_function	ubiquitin-protein transferase activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005662	cellular_component	DNA replication factor A complex
I	0005681	cellular_component	spliceosomal complex
I	0005737	cellular_component	cytoplasm
I	0005811	cellular_component	lipid droplet
I	0005819	cellular_component	spindle
I	0005856	cellular_component	cytoskeleton
I	0006281	biological_process	DNA repair
I	0006303	biological_process	double-strand break repair via nonhomologous end joining
I	0006397	biological_process	mRNA processing
I	0008104	biological_process	protein localization
I	0008380	biological_process	RNA splicing
I	0008610	biological_process	lipid biosynthetic process
I	0010498	biological_process	proteasomal protein catabolic process
I	0016020	cellular_component	membrane
I	0016567	biological_process	protein ubiquitination
I	0016607	cellular_component	nuclear speck
I	0016740	molecular_function	transferase activity
I	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
I	0035861	cellular_component	site of double-strand break
I	0042802	molecular_function	identical protein binding
I	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
I	0061630	molecular_function	ubiquitin protein ligase activity
I	0070534	biological_process	protein K63-linked ubiquitination
I	0071006	cellular_component	U2-type catalytic step 1 spliceosome
I	0071007	cellular_component	U2-type catalytic step 2 spliceosome
I	0071013	cellular_component	catalytic step 2 spliceosome
J	0000077	biological_process	DNA damage checkpoint signaling
J	0000209	biological_process	protein polyubiquitination
J	0000244	biological_process	spliceosomal tri-snRNP complex assembly
J	0000245	biological_process	spliceosomal complex assembly
J	0000398	biological_process	mRNA splicing, via spliceosome
J	0000974	cellular_component	Prp19 complex
J	0004842	molecular_function	ubiquitin-protein transferase activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005662	cellular_component	DNA replication factor A complex
J	0005681	cellular_component	spliceosomal complex
J	0005737	cellular_component	cytoplasm
J	0005811	cellular_component	lipid droplet
J	0005819	cellular_component	spindle
J	0005856	cellular_component	cytoskeleton
J	0006281	biological_process	DNA repair
J	0006303	biological_process	double-strand break repair via nonhomologous end joining
J	0006397	biological_process	mRNA processing
J	0008104	biological_process	protein localization
J	0008380	biological_process	RNA splicing
J	0008610	biological_process	lipid biosynthetic process
J	0010498	biological_process	proteasomal protein catabolic process
J	0016020	cellular_component	membrane
J	0016567	biological_process	protein ubiquitination
J	0016607	cellular_component	nuclear speck
J	0016740	molecular_function	transferase activity
J	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
J	0035861	cellular_component	site of double-strand break
J	0042802	molecular_function	identical protein binding
J	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
J	0061630	molecular_function	ubiquitin protein ligase activity
J	0070534	biological_process	protein K63-linked ubiquitination
J	0071006	cellular_component	U2-type catalytic step 1 spliceosome
J	0071007	cellular_component	U2-type catalytic step 2 spliceosome
J	0071013	cellular_component	catalytic step 2 spliceosome
K	0000375	biological_process	RNA splicing, via transesterification reactions
K	0000398	biological_process	mRNA splicing, via spliceosome
K	0000974	cellular_component	Prp19 complex
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005662	cellular_component	DNA replication factor A complex
K	0005681	cellular_component	spliceosomal complex
K	0005730	cellular_component	nucleolus
K	0005813	cellular_component	centrosome
K	0006397	biological_process	mRNA processing
K	0008380	biological_process	RNA splicing
K	0016607	cellular_component	nuclear speck
K	0071007	cellular_component	U2-type catalytic step 2 spliceosome
K	0071013	cellular_component	catalytic step 2 spliceosome
L	0000077	biological_process	DNA damage checkpoint signaling
L	0000398	biological_process	mRNA splicing, via spliceosome
L	0000974	cellular_component	Prp19 complex
L	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
L	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
L	0001228	molecular_function	DNA-binding transcription activator activity, RNA polymerase II-specific
L	0003677	molecular_function	DNA binding
L	0003723	molecular_function	RNA binding
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005662	cellular_component	DNA replication factor A complex
L	0005681	cellular_component	spliceosomal complex
L	0005737	cellular_component	cytoplasm
L	0006281	biological_process	DNA repair
L	0006357	biological_process	regulation of transcription by RNA polymerase II
L	0006397	biological_process	mRNA processing
L	0008380	biological_process	RNA splicing
L	0016020	cellular_component	membrane
L	0016607	cellular_component	nuclear speck
L	0042802	molecular_function	identical protein binding
L	0045944	biological_process	positive regulation of transcription by RNA polymerase II
L	0071007	cellular_component	U2-type catalytic step 2 spliceosome
L	0071013	cellular_component	catalytic step 2 spliceosome
L	0071987	molecular_function	WD40-repeat domain binding
M	0000349	biological_process	generation of catalytic spliceosome for first transesterification step
M	0000398	biological_process	mRNA splicing, via spliceosome
M	0000974	cellular_component	Prp19 complex
M	0001824	biological_process	blastocyst development
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005681	cellular_component	spliceosomal complex
M	0006281	biological_process	DNA repair
M	0006283	biological_process	transcription-coupled nucleotide-excision repair
M	0006351	biological_process	DNA-templated transcription
M	0006396	biological_process	RNA processing
M	0006397	biological_process	mRNA processing
M	0008380	biological_process	RNA splicing
M	0016020	cellular_component	membrane
M	0043231	cellular_component	intracellular membrane-bounded organelle
M	0071007	cellular_component	U2-type catalytic step 2 spliceosome
M	0071013	cellular_component	catalytic step 2 spliceosome
M	0071014	cellular_component	post-mRNA release spliceosomal complex
N	0000398	biological_process	mRNA splicing, via spliceosome
N	0000974	cellular_component	Prp19 complex
N	0001701	biological_process	in utero embryonic development
N	0003723	molecular_function	RNA binding
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005681	cellular_component	spliceosomal complex
N	0006397	biological_process	mRNA processing
N	0007095	biological_process	mitotic G2 DNA damage checkpoint signaling
N	0007369	biological_process	gastrulation
N	0008284	biological_process	positive regulation of cell population proliferation
N	0008380	biological_process	RNA splicing
N	0016607	cellular_component	nuclear speck
N	0048568	biological_process	embryonic organ development
N	0071007	cellular_component	U2-type catalytic step 2 spliceosome
N	0071013	cellular_component	catalytic step 2 spliceosome
N	0071014	cellular_component	post-mRNA release spliceosomal complex
O	0000245	biological_process	spliceosomal complex assembly
O	0000398	biological_process	mRNA splicing, via spliceosome
O	0000974	cellular_component	Prp19 complex
O	0003723	molecular_function	RNA binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005681	cellular_component	spliceosomal complex
O	0006396	biological_process	RNA processing
O	0006397	biological_process	mRNA processing
O	0008380	biological_process	RNA splicing
O	0016607	cellular_component	nuclear speck
O	0071007	cellular_component	U2-type catalytic step 2 spliceosome
O	0071013	cellular_component	catalytic step 2 spliceosome
O	0071014	cellular_component	post-mRNA release spliceosomal complex
P	0000398	biological_process	mRNA splicing, via spliceosome
P	0000974	cellular_component	Prp19 complex
P	0003676	molecular_function	nucleic acid binding
P	0003723	molecular_function	RNA binding
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005681	cellular_component	spliceosomal complex
P	0005737	cellular_component	cytoplasm
P	0006397	biological_process	mRNA processing
P	0008380	biological_process	RNA splicing
P	0017070	molecular_function	U6 snRNA binding
P	0033120	biological_process	positive regulation of RNA splicing
P	0036002	molecular_function	pre-mRNA binding
P	0042307	biological_process	positive regulation of protein import into nucleus
P	0045292	biological_process	mRNA cis splicing, via spliceosome
P	0046827	biological_process	positive regulation of protein export from nucleus
P	0046872	molecular_function	metal ion binding
P	0048306	molecular_function	calcium-dependent protein binding
P	0071006	cellular_component	U2-type catalytic step 1 spliceosome
P	0071007	cellular_component	U2-type catalytic step 2 spliceosome
P	0071013	cellular_component	catalytic step 2 spliceosome
P	0071466	biological_process	cellular response to xenobiotic stimulus
Q	0000398	biological_process	mRNA splicing, via spliceosome
Q	0000785	cellular_component	chromatin
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005681	cellular_component	spliceosomal complex
Q	0006397	biological_process	mRNA processing
Q	0008380	biological_process	RNA splicing
Q	0016922	molecular_function	nuclear receptor binding
Q	0030374	molecular_function	nuclear receptor coactivator activity
Q	0045893	biological_process	positive regulation of DNA-templated transcription
Q	0071007	cellular_component	U2-type catalytic step 2 spliceosome
Q	2000825	biological_process	positive regulation of androgen receptor activity
R	0000398	biological_process	mRNA splicing, via spliceosome
R	0000974	cellular_component	Prp19 complex
R	0003723	molecular_function	RNA binding
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005681	cellular_component	spliceosomal complex
R	0005739	cellular_component	mitochondrion
R	0006397	biological_process	mRNA processing
R	0008380	biological_process	RNA splicing
R	0016607	cellular_component	nuclear speck
R	0045292	biological_process	mRNA cis splicing, via spliceosome
R	0071007	cellular_component	U2-type catalytic step 2 spliceosome
R	0071013	cellular_component	catalytic step 2 spliceosome
S	0000398	biological_process	mRNA splicing, via spliceosome
S	0003723	molecular_function	RNA binding
S	0003729	molecular_function	mRNA binding
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005681	cellular_component	spliceosomal complex
S	0006397	biological_process	mRNA processing
S	0008380	biological_process	RNA splicing
S	0015030	cellular_component	Cajal body
S	0016607	cellular_component	nuclear speck
S	0070742	molecular_function	C2H2 zinc finger domain binding
S	0071005	cellular_component	U2-type precatalytic spliceosome
S	0071007	cellular_component	U2-type catalytic step 2 spliceosome
S	0071013	cellular_component	catalytic step 2 spliceosome
T	0000398	biological_process	mRNA splicing, via spliceosome
T	0003723	molecular_function	RNA binding
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005681	cellular_component	spliceosomal complex
T	0005829	cellular_component	cytosol
T	0006397	biological_process	mRNA processing
T	0008380	biological_process	RNA splicing
T	0016607	cellular_component	nuclear speck
T	0048024	biological_process	regulation of mRNA splicing, via spliceosome
T	0071005	cellular_component	U2-type precatalytic spliceosome
T	0071006	cellular_component	U2-type catalytic step 1 spliceosome
T	0071007	cellular_component	U2-type catalytic step 2 spliceosome
T	0071013	cellular_component	catalytic step 2 spliceosome
U	0000398	biological_process	mRNA splicing, via spliceosome
U	0003723	molecular_function	RNA binding
U	0003724	molecular_function	RNA helicase activity
U	0003727	molecular_function	single-stranded RNA binding
U	0003729	molecular_function	mRNA binding
U	0004386	molecular_function	helicase activity
U	0005515	molecular_function	protein binding
U	0005524	molecular_function	ATP binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005681	cellular_component	spliceosomal complex
U	0006397	biological_process	mRNA processing
U	0008380	biological_process	RNA splicing
U	0016020	cellular_component	membrane
U	0016787	molecular_function	hydrolase activity
U	0016887	molecular_function	ATP hydrolysis activity
U	0034458	molecular_function	3'-5' RNA helicase activity
U	0071007	cellular_component	U2-type catalytic step 2 spliceosome
U	0071013	cellular_component	catalytic step 2 spliceosome
V	0000398	biological_process	mRNA splicing, via spliceosome
V	0000413	biological_process	protein peptidyl-prolyl isomerization
V	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005681	cellular_component	spliceosomal complex
V	0006397	biological_process	mRNA processing
V	0006457	biological_process	protein folding
V	0008380	biological_process	RNA splicing
V	0016018	molecular_function	cyclosporin A binding
V	0071007	cellular_component	U2-type catalytic step 2 spliceosome
V	0071013	cellular_component	catalytic step 2 spliceosome
V	0097718	molecular_function	disordered domain specific binding
V	1990403	biological_process	embryonic brain development
W	0000398	biological_process	mRNA splicing, via spliceosome
W	0003723	molecular_function	RNA binding
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005681	cellular_component	spliceosomal complex
W	0005684	cellular_component	U2-type spliceosomal complex
W	0005686	cellular_component	U2 snRNP
W	0006397	biological_process	mRNA processing
W	0007283	biological_process	spermatogenesis
W	0008380	biological_process	RNA splicing
W	0016604	cellular_component	nuclear body
W	0016607	cellular_component	nuclear speck
W	0030532	cellular_component	small nuclear ribonucleoprotein complex
W	0030620	molecular_function	U2 snRNA binding
W	0071005	cellular_component	U2-type precatalytic spliceosome
W	0071007	cellular_component	U2-type catalytic step 2 spliceosome
W	0071013	cellular_component	catalytic step 2 spliceosome
W	1903241	biological_process	U2-type prespliceosome assembly
X	0000398	biological_process	mRNA splicing, via spliceosome
X	0001650	cellular_component	fibrillar center
X	0003676	molecular_function	nucleic acid binding
X	0003723	molecular_function	RNA binding
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005681	cellular_component	spliceosomal complex
X	0005684	cellular_component	U2-type spliceosomal complex
X	0005685	cellular_component	U1 snRNP
X	0005686	cellular_component	U2 snRNP
X	0006397	biological_process	mRNA processing
X	0008380	biological_process	RNA splicing
X	0016607	cellular_component	nuclear speck
X	0030619	molecular_function	U1 snRNA binding
X	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
X	0071005	cellular_component	U2-type precatalytic spliceosome
X	0071007	cellular_component	U2-type catalytic step 2 spliceosome
X	0071013	cellular_component	catalytic step 2 spliceosome
X	1903241	biological_process	U2-type prespliceosome assembly
a	0000245	biological_process	spliceosomal complex assembly
a	0000387	biological_process	spliceosomal snRNP assembly
a	0000398	biological_process	mRNA splicing, via spliceosome
a	0003723	molecular_function	RNA binding
a	0005515	molecular_function	protein binding
a	0005634	cellular_component	nucleus
a	0005654	cellular_component	nucleoplasm
a	0005681	cellular_component	spliceosomal complex
a	0005682	cellular_component	U5 snRNP
a	0005684	cellular_component	U2-type spliceosomal complex
a	0005685	cellular_component	U1 snRNP
a	0005686	cellular_component	U2 snRNP
a	0005687	cellular_component	U4 snRNP
a	0005689	cellular_component	U12-type spliceosomal complex
a	0005737	cellular_component	cytoplasm
a	0005829	cellular_component	cytosol
a	0006397	biological_process	mRNA processing
a	0008380	biological_process	RNA splicing
a	0030532	cellular_component	small nuclear ribonucleoprotein complex
a	0034709	cellular_component	methylosome
a	0034715	cellular_component	pICln-Sm protein complex
a	0034719	cellular_component	SMN-Sm protein complex
a	0036261	biological_process	7-methylguanosine cap hypermethylation
a	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
a	0070062	cellular_component	extracellular exosome
a	0071005	cellular_component	U2-type precatalytic spliceosome
a	0071007	cellular_component	U2-type catalytic step 2 spliceosome
a	0071011	cellular_component	precatalytic spliceosome
a	0071013	cellular_component	catalytic step 2 spliceosome
a	1903241	biological_process	U2-type prespliceosome assembly
b	0000387	biological_process	spliceosomal snRNP assembly
b	0000398	biological_process	mRNA splicing, via spliceosome
b	0003723	molecular_function	RNA binding
b	0005515	molecular_function	protein binding
b	0005634	cellular_component	nucleus
b	0005654	cellular_component	nucleoplasm
b	0005681	cellular_component	spliceosomal complex
b	0005682	cellular_component	U5 snRNP
b	0005683	cellular_component	U7 snRNP
b	0005684	cellular_component	U2-type spliceosomal complex
b	0005685	cellular_component	U1 snRNP
b	0005686	cellular_component	U2 snRNP
b	0005687	cellular_component	U4 snRNP
b	0005689	cellular_component	U12-type spliceosomal complex
b	0005737	cellular_component	cytoplasm
b	0005829	cellular_component	cytosol
b	0006397	biological_process	mRNA processing
b	0008380	biological_process	RNA splicing
b	0030532	cellular_component	small nuclear ribonucleoprotein complex
b	0034709	cellular_component	methylosome
b	0034715	cellular_component	pICln-Sm protein complex
b	0034719	cellular_component	SMN-Sm protein complex
b	0036261	biological_process	7-methylguanosine cap hypermethylation
b	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
b	0071005	cellular_component	U2-type precatalytic spliceosome
b	0071007	cellular_component	U2-type catalytic step 2 spliceosome
b	0071013	cellular_component	catalytic step 2 spliceosome
b	0120114	cellular_component	Sm-like protein family complex
b	1903241	biological_process	U2-type prespliceosome assembly
c	0000245	biological_process	spliceosomal complex assembly
c	0000387	biological_process	spliceosomal snRNP assembly
c	0000398	biological_process	mRNA splicing, via spliceosome
c	0003723	molecular_function	RNA binding
c	0005515	molecular_function	protein binding
c	0005634	cellular_component	nucleus
c	0005654	cellular_component	nucleoplasm
c	0005681	cellular_component	spliceosomal complex
c	0005682	cellular_component	U5 snRNP
c	0005683	cellular_component	U7 snRNP
c	0005684	cellular_component	U2-type spliceosomal complex
c	0005685	cellular_component	U1 snRNP
c	0005686	cellular_component	U2 snRNP
c	0005687	cellular_component	U4 snRNP
c	0005689	cellular_component	U12-type spliceosomal complex
c	0005697	cellular_component	telomerase holoenzyme complex
c	0005737	cellular_component	cytoplasm
c	0005829	cellular_component	cytosol
c	0006397	biological_process	mRNA processing
c	0008380	biological_process	RNA splicing
c	0030532	cellular_component	small nuclear ribonucleoprotein complex
c	0034709	cellular_component	methylosome
c	0034715	cellular_component	pICln-Sm protein complex
c	0034719	cellular_component	SMN-Sm protein complex
c	0036261	biological_process	7-methylguanosine cap hypermethylation
c	0043229	cellular_component	intracellular organelle
c	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
c	0071005	cellular_component	U2-type precatalytic spliceosome
c	0071007	cellular_component	U2-type catalytic step 2 spliceosome
c	0071011	cellular_component	precatalytic spliceosome
c	0071013	cellular_component	catalytic step 2 spliceosome
c	1903241	biological_process	U2-type prespliceosome assembly
d	0000245	biological_process	spliceosomal complex assembly
d	0000387	biological_process	spliceosomal snRNP assembly
d	0000398	biological_process	mRNA splicing, via spliceosome
d	0003723	molecular_function	RNA binding
d	0005515	molecular_function	protein binding
d	0005634	cellular_component	nucleus
d	0005654	cellular_component	nucleoplasm
d	0005681	cellular_component	spliceosomal complex
d	0005682	cellular_component	U5 snRNP
d	0005683	cellular_component	U7 snRNP
d	0005684	cellular_component	U2-type spliceosomal complex
d	0005685	cellular_component	U1 snRNP
d	0005686	cellular_component	U2 snRNP
d	0005687	cellular_component	U4 snRNP
d	0005689	cellular_component	U12-type spliceosomal complex
d	0005737	cellular_component	cytoplasm
d	0005829	cellular_component	cytosol
d	0006397	biological_process	mRNA processing
d	0008380	biological_process	RNA splicing
d	0030532	cellular_component	small nuclear ribonucleoprotein complex
d	0034709	cellular_component	methylosome
d	0034719	cellular_component	SMN-Sm protein complex
d	0036261	biological_process	7-methylguanosine cap hypermethylation
d	0043186	cellular_component	P granule
d	0043229	cellular_component	intracellular organelle
d	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
d	0071004	cellular_component	U2-type prespliceosome
d	0071005	cellular_component	U2-type precatalytic spliceosome
d	0071007	cellular_component	U2-type catalytic step 2 spliceosome
d	0071011	cellular_component	precatalytic spliceosome
d	0071013	cellular_component	catalytic step 2 spliceosome
d	0097526	cellular_component	spliceosomal tri-snRNP complex
d	1903241	biological_process	U2-type prespliceosome assembly
e	0000243	cellular_component	commitment complex
e	0000387	biological_process	spliceosomal snRNP assembly
e	0000398	biological_process	mRNA splicing, via spliceosome
e	0003723	molecular_function	RNA binding
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005654	cellular_component	nucleoplasm
e	0005681	cellular_component	spliceosomal complex
e	0005682	cellular_component	U5 snRNP
e	0005683	cellular_component	U7 snRNP
e	0005684	cellular_component	U2-type spliceosomal complex
e	0005685	cellular_component	U1 snRNP
e	0005686	cellular_component	U2 snRNP
e	0005687	cellular_component	U4 snRNP
e	0005689	cellular_component	U12-type spliceosomal complex
e	0005697	cellular_component	telomerase holoenzyme complex
e	0005737	cellular_component	cytoplasm
e	0005829	cellular_component	cytosol
e	0006396	biological_process	RNA processing
e	0006397	biological_process	mRNA processing
e	0006479	biological_process	protein methylation
e	0008380	biological_process	RNA splicing
e	0016604	cellular_component	nuclear body
e	0019899	molecular_function	enzyme binding
e	0030532	cellular_component	small nuclear ribonucleoprotein complex
e	0034709	cellular_component	methylosome
e	0034715	cellular_component	pICln-Sm protein complex
e	0034719	cellular_component	SMN-Sm protein complex
e	0036261	biological_process	7-methylguanosine cap hypermethylation
e	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
e	0070034	molecular_function	telomerase RNA binding
e	0071005	cellular_component	U2-type precatalytic spliceosome
e	0071007	cellular_component	U2-type catalytic step 2 spliceosome
e	0071011	cellular_component	precatalytic spliceosome
e	0071013	cellular_component	catalytic step 2 spliceosome
e	0071208	molecular_function	histone pre-mRNA DCP binding
e	0071209	molecular_function	U7 snRNA binding
e	0097526	cellular_component	spliceosomal tri-snRNP complex
e	1903241	biological_process	U2-type prespliceosome assembly
e	1990446	molecular_function	U1 snRNP binding
f	0000387	biological_process	spliceosomal snRNP assembly
f	0000398	biological_process	mRNA splicing, via spliceosome
f	0003723	molecular_function	RNA binding
f	0005515	molecular_function	protein binding
f	0005634	cellular_component	nucleus
f	0005654	cellular_component	nucleoplasm
f	0005681	cellular_component	spliceosomal complex
f	0005682	cellular_component	U5 snRNP
f	0005683	cellular_component	U7 snRNP
f	0005684	cellular_component	U2-type spliceosomal complex
f	0005685	cellular_component	U1 snRNP
f	0005686	cellular_component	U2 snRNP
f	0005687	cellular_component	U4 snRNP
f	0005689	cellular_component	U12-type spliceosomal complex
f	0005697	cellular_component	telomerase holoenzyme complex
f	0005737	cellular_component	cytoplasm
f	0005829	cellular_component	cytosol
f	0006397	biological_process	mRNA processing
f	0006479	biological_process	protein methylation
f	0008380	biological_process	RNA splicing
f	0030532	cellular_component	small nuclear ribonucleoprotein complex
f	0034709	cellular_component	methylosome
f	0034719	cellular_component	SMN-Sm protein complex
f	0036261	biological_process	7-methylguanosine cap hypermethylation
f	0043229	cellular_component	intracellular organelle
f	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
f	0070034	molecular_function	telomerase RNA binding
f	0070990	molecular_function	snRNP binding
f	0071004	cellular_component	U2-type prespliceosome
f	0071005	cellular_component	U2-type precatalytic spliceosome
f	0071007	cellular_component	U2-type catalytic step 2 spliceosome
f	0071013	cellular_component	catalytic step 2 spliceosome
f	0071204	cellular_component	histone pre-mRNA 3'end processing complex
f	0071208	molecular_function	histone pre-mRNA DCP binding
f	1903241	biological_process	U2-type prespliceosome assembly
f	1990446	molecular_function	U1 snRNP binding
f	1990447	molecular_function	U2 snRNP binding
g	0000243	cellular_component	commitment complex
g	0000245	biological_process	spliceosomal complex assembly
g	0000387	biological_process	spliceosomal snRNP assembly
g	0000398	biological_process	mRNA splicing, via spliceosome
g	0003723	molecular_function	RNA binding
g	0005515	molecular_function	protein binding
g	0005634	cellular_component	nucleus
g	0005654	cellular_component	nucleoplasm
g	0005681	cellular_component	spliceosomal complex
g	0005682	cellular_component	U5 snRNP
g	0005684	cellular_component	U2-type spliceosomal complex
g	0005685	cellular_component	U1 snRNP
g	0005686	cellular_component	U2 snRNP
g	0005687	cellular_component	U4 snRNP
g	0005689	cellular_component	U12-type spliceosomal complex
g	0005737	cellular_component	cytoplasm
g	0005829	cellular_component	cytosol
g	0006396	biological_process	RNA processing
g	0006397	biological_process	mRNA processing
g	0008380	biological_process	RNA splicing
g	0030532	cellular_component	small nuclear ribonucleoprotein complex
g	0034709	cellular_component	methylosome
g	0034715	cellular_component	pICln-Sm protein complex
g	0034719	cellular_component	SMN-Sm protein complex
g	0036261	biological_process	7-methylguanosine cap hypermethylation
g	0043229	cellular_component	intracellular organelle
g	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
g	0071005	cellular_component	U2-type precatalytic spliceosome
g	0071007	cellular_component	U2-type catalytic step 2 spliceosome
g	0071011	cellular_component	precatalytic spliceosome
g	0071013	cellular_component	catalytic step 2 spliceosome
g	0097526	cellular_component	spliceosomal tri-snRNP complex
g	1903241	biological_process	U2-type prespliceosome assembly
h	0000245	biological_process	spliceosomal complex assembly
h	0000387	biological_process	spliceosomal snRNP assembly
h	0000398	biological_process	mRNA splicing, via spliceosome
h	0003723	molecular_function	RNA binding
h	0005515	molecular_function	protein binding
h	0005634	cellular_component	nucleus
h	0005654	cellular_component	nucleoplasm
h	0005681	cellular_component	spliceosomal complex
h	0005682	cellular_component	U5 snRNP
h	0005684	cellular_component	U2-type spliceosomal complex
h	0005685	cellular_component	U1 snRNP
h	0005686	cellular_component	U2 snRNP
h	0005687	cellular_component	U4 snRNP
h	0005689	cellular_component	U12-type spliceosomal complex
h	0005737	cellular_component	cytoplasm
h	0005829	cellular_component	cytosol
h	0006397	biological_process	mRNA processing
h	0008380	biological_process	RNA splicing
h	0030532	cellular_component	small nuclear ribonucleoprotein complex
h	0034709	cellular_component	methylosome
h	0034715	cellular_component	pICln-Sm protein complex
h	0034719	cellular_component	SMN-Sm protein complex
h	0036261	biological_process	7-methylguanosine cap hypermethylation
h	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
h	0070062	cellular_component	extracellular exosome
h	0071005	cellular_component	U2-type precatalytic spliceosome
h	0071007	cellular_component	U2-type catalytic step 2 spliceosome
h	0071011	cellular_component	precatalytic spliceosome
h	0071013	cellular_component	catalytic step 2 spliceosome
h	1903241	biological_process	U2-type prespliceosome assembly
i	0000387	biological_process	spliceosomal snRNP assembly
i	0000398	biological_process	mRNA splicing, via spliceosome
i	0003723	molecular_function	RNA binding
i	0005515	molecular_function	protein binding
i	0005634	cellular_component	nucleus
i	0005654	cellular_component	nucleoplasm
i	0005681	cellular_component	spliceosomal complex
i	0005682	cellular_component	U5 snRNP
i	0005683	cellular_component	U7 snRNP
i	0005684	cellular_component	U2-type spliceosomal complex
i	0005685	cellular_component	U1 snRNP
i	0005686	cellular_component	U2 snRNP
i	0005687	cellular_component	U4 snRNP
i	0005689	cellular_component	U12-type spliceosomal complex
i	0005737	cellular_component	cytoplasm
i	0005829	cellular_component	cytosol
i	0006397	biological_process	mRNA processing
i	0008380	biological_process	RNA splicing
i	0030532	cellular_component	small nuclear ribonucleoprotein complex
i	0034709	cellular_component	methylosome
i	0034715	cellular_component	pICln-Sm protein complex
i	0034719	cellular_component	SMN-Sm protein complex
i	0036261	biological_process	7-methylguanosine cap hypermethylation
i	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
i	0071005	cellular_component	U2-type precatalytic spliceosome
i	0071007	cellular_component	U2-type catalytic step 2 spliceosome
i	0071013	cellular_component	catalytic step 2 spliceosome
i	0120114	cellular_component	Sm-like protein family complex
i	1903241	biological_process	U2-type prespliceosome assembly
j	0000245	biological_process	spliceosomal complex assembly
j	0000387	biological_process	spliceosomal snRNP assembly
j	0000398	biological_process	mRNA splicing, via spliceosome
j	0003723	molecular_function	RNA binding
j	0005515	molecular_function	protein binding
j	0005634	cellular_component	nucleus
j	0005654	cellular_component	nucleoplasm
j	0005681	cellular_component	spliceosomal complex
j	0005682	cellular_component	U5 snRNP
j	0005683	cellular_component	U7 snRNP
j	0005684	cellular_component	U2-type spliceosomal complex
j	0005685	cellular_component	U1 snRNP
j	0005686	cellular_component	U2 snRNP
j	0005687	cellular_component	U4 snRNP
j	0005689	cellular_component	U12-type spliceosomal complex
j	0005697	cellular_component	telomerase holoenzyme complex
j	0005737	cellular_component	cytoplasm
j	0005829	cellular_component	cytosol
j	0006397	biological_process	mRNA processing
j	0008380	biological_process	RNA splicing
j	0030532	cellular_component	small nuclear ribonucleoprotein complex
j	0034709	cellular_component	methylosome
j	0034715	cellular_component	pICln-Sm protein complex
j	0034719	cellular_component	SMN-Sm protein complex
j	0036261	biological_process	7-methylguanosine cap hypermethylation
j	0043229	cellular_component	intracellular organelle
j	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
j	0071005	cellular_component	U2-type precatalytic spliceosome
j	0071007	cellular_component	U2-type catalytic step 2 spliceosome
j	0071011	cellular_component	precatalytic spliceosome
j	0071013	cellular_component	catalytic step 2 spliceosome
j	1903241	biological_process	U2-type prespliceosome assembly
k	0000245	biological_process	spliceosomal complex assembly
k	0000387	biological_process	spliceosomal snRNP assembly
k	0000398	biological_process	mRNA splicing, via spliceosome
k	0003723	molecular_function	RNA binding
k	0005515	molecular_function	protein binding
k	0005634	cellular_component	nucleus
k	0005654	cellular_component	nucleoplasm
k	0005681	cellular_component	spliceosomal complex
k	0005682	cellular_component	U5 snRNP
k	0005683	cellular_component	U7 snRNP
k	0005684	cellular_component	U2-type spliceosomal complex
k	0005685	cellular_component	U1 snRNP
k	0005686	cellular_component	U2 snRNP
k	0005687	cellular_component	U4 snRNP
k	0005689	cellular_component	U12-type spliceosomal complex
k	0005737	cellular_component	cytoplasm
k	0005829	cellular_component	cytosol
k	0006397	biological_process	mRNA processing
k	0008380	biological_process	RNA splicing
k	0030532	cellular_component	small nuclear ribonucleoprotein complex
k	0034709	cellular_component	methylosome
k	0034719	cellular_component	SMN-Sm protein complex
k	0036261	biological_process	7-methylguanosine cap hypermethylation
k	0043186	cellular_component	P granule
k	0043229	cellular_component	intracellular organelle
k	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
k	0071004	cellular_component	U2-type prespliceosome
k	0071005	cellular_component	U2-type precatalytic spliceosome
k	0071007	cellular_component	U2-type catalytic step 2 spliceosome
k	0071011	cellular_component	precatalytic spliceosome
k	0071013	cellular_component	catalytic step 2 spliceosome
k	0097526	cellular_component	spliceosomal tri-snRNP complex
k	1903241	biological_process	U2-type prespliceosome assembly
l	0000243	cellular_component	commitment complex
l	0000387	biological_process	spliceosomal snRNP assembly
l	0000398	biological_process	mRNA splicing, via spliceosome
l	0003723	molecular_function	RNA binding
l	0005515	molecular_function	protein binding
l	0005634	cellular_component	nucleus
l	0005654	cellular_component	nucleoplasm
l	0005681	cellular_component	spliceosomal complex
l	0005682	cellular_component	U5 snRNP
l	0005683	cellular_component	U7 snRNP
l	0005684	cellular_component	U2-type spliceosomal complex
l	0005685	cellular_component	U1 snRNP
l	0005686	cellular_component	U2 snRNP
l	0005687	cellular_component	U4 snRNP
l	0005689	cellular_component	U12-type spliceosomal complex
l	0005697	cellular_component	telomerase holoenzyme complex
l	0005737	cellular_component	cytoplasm
l	0005829	cellular_component	cytosol
l	0006396	biological_process	RNA processing
l	0006397	biological_process	mRNA processing
l	0006479	biological_process	protein methylation
l	0008380	biological_process	RNA splicing
l	0016604	cellular_component	nuclear body
l	0019899	molecular_function	enzyme binding
l	0030532	cellular_component	small nuclear ribonucleoprotein complex
l	0034709	cellular_component	methylosome
l	0034715	cellular_component	pICln-Sm protein complex
l	0034719	cellular_component	SMN-Sm protein complex
l	0036261	biological_process	7-methylguanosine cap hypermethylation
l	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
l	0070034	molecular_function	telomerase RNA binding
l	0071005	cellular_component	U2-type precatalytic spliceosome
l	0071007	cellular_component	U2-type catalytic step 2 spliceosome
l	0071011	cellular_component	precatalytic spliceosome
l	0071013	cellular_component	catalytic step 2 spliceosome
l	0071208	molecular_function	histone pre-mRNA DCP binding
l	0071209	molecular_function	U7 snRNA binding
l	0097526	cellular_component	spliceosomal tri-snRNP complex
l	1903241	biological_process	U2-type prespliceosome assembly
l	1990446	molecular_function	U1 snRNP binding
m	0000387	biological_process	spliceosomal snRNP assembly
m	0000398	biological_process	mRNA splicing, via spliceosome
m	0003723	molecular_function	RNA binding
m	0005515	molecular_function	protein binding
m	0005634	cellular_component	nucleus
m	0005654	cellular_component	nucleoplasm
m	0005681	cellular_component	spliceosomal complex
m	0005682	cellular_component	U5 snRNP
m	0005683	cellular_component	U7 snRNP
m	0005684	cellular_component	U2-type spliceosomal complex
m	0005685	cellular_component	U1 snRNP
m	0005686	cellular_component	U2 snRNP
m	0005687	cellular_component	U4 snRNP
m	0005689	cellular_component	U12-type spliceosomal complex
m	0005697	cellular_component	telomerase holoenzyme complex
m	0005737	cellular_component	cytoplasm
m	0005829	cellular_component	cytosol
m	0006397	biological_process	mRNA processing
m	0006479	biological_process	protein methylation
m	0008380	biological_process	RNA splicing
m	0030532	cellular_component	small nuclear ribonucleoprotein complex
m	0034709	cellular_component	methylosome
m	0034719	cellular_component	SMN-Sm protein complex
m	0036261	biological_process	7-methylguanosine cap hypermethylation
m	0043229	cellular_component	intracellular organelle
m	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
m	0070034	molecular_function	telomerase RNA binding
m	0070990	molecular_function	snRNP binding
m	0071004	cellular_component	U2-type prespliceosome
m	0071005	cellular_component	U2-type precatalytic spliceosome
m	0071007	cellular_component	U2-type catalytic step 2 spliceosome
m	0071013	cellular_component	catalytic step 2 spliceosome
m	0071204	cellular_component	histone pre-mRNA 3'end processing complex
m	0071208	molecular_function	histone pre-mRNA DCP binding
m	1903241	biological_process	U2-type prespliceosome assembly
m	1990446	molecular_function	U1 snRNP binding
m	1990447	molecular_function	U2 snRNP binding
n	0000243	cellular_component	commitment complex
n	0000245	biological_process	spliceosomal complex assembly
n	0000387	biological_process	spliceosomal snRNP assembly
n	0000398	biological_process	mRNA splicing, via spliceosome
n	0003723	molecular_function	RNA binding
n	0005515	molecular_function	protein binding
n	0005634	cellular_component	nucleus
n	0005654	cellular_component	nucleoplasm
n	0005681	cellular_component	spliceosomal complex
n	0005682	cellular_component	U5 snRNP
n	0005684	cellular_component	U2-type spliceosomal complex
n	0005685	cellular_component	U1 snRNP
n	0005686	cellular_component	U2 snRNP
n	0005687	cellular_component	U4 snRNP
n	0005689	cellular_component	U12-type spliceosomal complex
n	0005737	cellular_component	cytoplasm
n	0005829	cellular_component	cytosol
n	0006396	biological_process	RNA processing
n	0006397	biological_process	mRNA processing
n	0008380	biological_process	RNA splicing
n	0030532	cellular_component	small nuclear ribonucleoprotein complex
n	0034709	cellular_component	methylosome
n	0034715	cellular_component	pICln-Sm protein complex
n	0034719	cellular_component	SMN-Sm protein complex
n	0036261	biological_process	7-methylguanosine cap hypermethylation
n	0043229	cellular_component	intracellular organelle
n	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
n	0071005	cellular_component	U2-type precatalytic spliceosome
n	0071007	cellular_component	U2-type catalytic step 2 spliceosome
n	0071011	cellular_component	precatalytic spliceosome
n	0071013	cellular_component	catalytic step 2 spliceosome
n	0097526	cellular_component	spliceosomal tri-snRNP complex
n	1903241	biological_process	U2-type prespliceosome assembly
o	0000398	biological_process	mRNA splicing, via spliceosome
o	0000413	biological_process	protein peptidyl-prolyl isomerization
o	0003676	molecular_function	nucleic acid binding
o	0003723	molecular_function	RNA binding
o	0003729	molecular_function	mRNA binding
o	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
o	0005515	molecular_function	protein binding
o	0005576	cellular_component	extracellular region
o	0005634	cellular_component	nucleus
o	0005654	cellular_component	nucleoplasm
o	0005681	cellular_component	spliceosomal complex
o	0005737	cellular_component	cytoplasm
o	0005829	cellular_component	cytosol
o	0006355	biological_process	regulation of DNA-templated transcription
o	0006397	biological_process	mRNA processing
o	0006457	biological_process	protein folding
o	0008143	molecular_function	poly(A) binding
o	0008380	biological_process	RNA splicing
o	0016018	molecular_function	cyclosporin A binding
o	0016607	cellular_component	nuclear speck
o	0034774	cellular_component	secretory granule lumen
o	0043231	cellular_component	intracellular membrane-bounded organelle
o	0045070	biological_process	positive regulation of viral genome replication
o	0071007	cellular_component	U2-type catalytic step 2 spliceosome
o	0071013	cellular_component	catalytic step 2 spliceosome
o	1904813	cellular_component	ficolin-1-rich granule lumen
p	0000184	biological_process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
p	0000398	biological_process	mRNA splicing, via spliceosome
p	0003676	molecular_function	nucleic acid binding
p	0003723	molecular_function	RNA binding
p	0003724	molecular_function	RNA helicase activity
p	0003729	molecular_function	mRNA binding
p	0004386	molecular_function	helicase activity
p	0005515	molecular_function	protein binding
p	0005524	molecular_function	ATP binding
p	0005634	cellular_component	nucleus
p	0005654	cellular_component	nucleoplasm
p	0005681	cellular_component	spliceosomal complex
p	0005730	cellular_component	nucleolus
p	0005737	cellular_component	cytoplasm
p	0005829	cellular_component	cytosol
p	0006364	biological_process	rRNA processing
p	0006397	biological_process	mRNA processing
p	0006406	biological_process	mRNA export from nucleus
p	0006417	biological_process	regulation of translation
p	0008143	molecular_function	poly(A) binding
p	0008306	biological_process	associative learning
p	0008380	biological_process	RNA splicing
p	0010629	biological_process	negative regulation of gene expression
p	0014070	biological_process	response to organic cyclic compound
p	0016020	cellular_component	membrane
p	0016607	cellular_component	nuclear speck
p	0016787	molecular_function	hydrolase activity
p	0016887	molecular_function	ATP hydrolysis activity
p	0017148	biological_process	negative regulation of translation
p	0030425	cellular_component	dendrite
p	0035145	cellular_component	exon-exon junction complex
p	0035368	molecular_function	selenocysteine insertion sequence binding
p	0035613	molecular_function	RNA stem-loop binding
p	0035640	biological_process	exploration behavior
p	0043021	molecular_function	ribonucleoprotein complex binding
p	0043025	cellular_component	neuronal cell body
p	0045727	biological_process	positive regulation of translation
p	0048701	biological_process	embryonic cranial skeleton morphogenesis
p	0051028	biological_process	mRNA transport
p	0071006	cellular_component	U2-type catalytic step 1 spliceosome
p	0071013	cellular_component	catalytic step 2 spliceosome
p	0072715	biological_process	cellular response to selenite ion
p	0090394	biological_process	negative regulation of excitatory postsynaptic potential
p	0098794	cellular_component	postsynapse
p	0098978	cellular_component	glutamatergic synapse
p	0099578	biological_process	regulation of translation at postsynapse, modulating synaptic transmission
p	1904570	biological_process	negative regulation of selenocysteine incorporation
p	1990416	biological_process	cellular response to brain-derived neurotrophic factor stimulus
p	1990904	cellular_component	ribonucleoprotein complex
p	2000622	biological_process	regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
q	0000390	biological_process	spliceosomal complex disassembly
q	0000398	biological_process	mRNA splicing, via spliceosome
q	0003676	molecular_function	nucleic acid binding
q	0003723	molecular_function	RNA binding
q	0003724	molecular_function	RNA helicase activity
q	0004386	molecular_function	helicase activity
q	0005515	molecular_function	protein binding
q	0005524	molecular_function	ATP binding
q	0005634	cellular_component	nucleus
q	0005654	cellular_component	nucleoplasm
q	0005681	cellular_component	spliceosomal complex
q	0005829	cellular_component	cytosol
q	0006396	biological_process	RNA processing
q	0006397	biological_process	mRNA processing
q	0008186	molecular_function	ATP-dependent activity, acting on RNA
q	0008380	biological_process	RNA splicing
q	0016604	cellular_component	nuclear body
q	0016787	molecular_function	hydrolase activity
q	0016887	molecular_function	ATP hydrolysis activity
q	0042802	molecular_function	identical protein binding
q	0071007	cellular_component	U2-type catalytic step 2 spliceosome
q	0071013	cellular_component	catalytic step 2 spliceosome

Functional Information from PROSITE/UniProt

site_id	PS00039
Number of Residues	9
Details	DEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. VLDEADEmL

Chain	Residue	Details
p	VAL185-LEU193

---

site_id	PS00170
Number of Residues	18
Details	CSA_PPIASE_1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. YngTkFHRIIkdFMiQGG

Chain	Residue	Details
V	TYR48-GLY65
o	PHE184-GLY201

---

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. VSKGQRVKVKVLSFT

Chain	Residue	Details
q	VAL315-THR329

---

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSCsmDcKIKLWEV

Chain	Residue	Details
E	LEU304-VAL318
D	LEU303-VAL317
D	ILE345-LEU359
F	LEU81-VAL95
F	LEU124-SER138
F	VAL167-ILE181
F	ILE208-LEU222
F	ILE300-THR314
G	LEU407-LEU421

---

site_id	PS00690
Number of Residues	10
Details	DEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. AiIMLDEAHE

Chain	Residue	Details
q	ALA682-GLU691

---

site_id	PS00997
Number of Residues	23
Details	G10_1 G10 protein signature 1. LCClRCiqtrDtNfgtnCiCRVP

Chain	Residue	Details
Q	LEU100-PRO122

---

site_id	PS00998
Number of Residues	10
Details	G10_2 G10 protein signature 2. CtHCGCRGCS

Chain	Residue	Details
Q	CYS134-SER143

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00541

Chain	Residue	Details
q	GLY590
p	GLN65
p	GLY85
p	ASP342
p	ARG367
V	LYS125

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
q	SER397
m	ARG147
N	LYS234
H	LYS261
I	LYS122
I	LYS261
J	LYS122
J	LYS261

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231

Chain	Residue	Details
q	SER462
m	ARG172
H	LYS179
H	LYS244
I	LYS179
I	LYS244
J	LYS179
J	LYS244

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
q	LYS142
W	SER255
q	LYS401
h	LYS6
h	LYS8

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
p	SER12
S	SER1460
S	SER1462
S	SER1482
S	SER1483
S	SER1501
S	SER1621
S	SER1893
S	SER2343
S	SER2394
S	SER2453
S	SER222
S	SER454
S	SER484
S	SER486
S	SER875
S	SER1336
S	SER1368
S	SER1421

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P60842

Chain	Residue	Details
p	LYS124
C	LYS416
C	LYS441
C	LYS452
W	LYS221
P	LYS290
C	LYS141
C	LYS158
C	LYS258
C	LYS286
C	LYS339
C	LYS344

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
p	THR163
S	SER994
S	SER1014

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P60843

Chain	Residue	Details
p	LYS198
S	SER1179
S	SER2581

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
p	LYS296
p	LYS321
S	SER1152

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733

Chain	Residue	Details
p	LYS19
S	SER857
S	SER952
S	SER1318
S	SER1401
S	SER2100

---

site_id	SWS_FT_FI11
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
S	SER323
p	LYS314
p	LYS382

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0000250|UniProtKB:P60842

Chain	Residue	Details
p	LYS152
p	LYS374

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332

Chain	Residue	Details
S	SER357
S	SER358
S	SER846
S	SER1214

---

site_id	SWS_FT_FI14
Number of Residues	3
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332

Chain	Residue	Details
S	THR359
S	THR1106
S	THR2381

---

site_id	SWS_FT_FI15
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
S	THR367
L	LYS487

---

site_id	SWS_FT_FI16
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:17525332, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
S	SER377

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
S	THR383
S	THR384

---

site_id	SWS_FT_FI18
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
S	SER387

---

site_id	SWS_FT_FI19
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
S	SER395
S	SER935
S	SER1311

---

site_id	SWS_FT_FI20
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:24275569

Chain	Residue	Details
S	SER398

---

site_id	SWS_FT_FI21
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:24275569

Chain	Residue	Details
S	SER404
S	SER408

---

site_id	SWS_FT_FI22
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
S	SER424
S	SER1124
S	SER2702

---

site_id	SWS_FT_FI23
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163

Chain	Residue	Details
S	SER435
S	SER2121
S	SER2675
S	SER2677
S	SER780
S	SER864
S	SER1064
S	SER1112
S	SER1537
S	SER1539
S	SER1541
S	SER1876

---

site_id	SWS_FT_FI24
Number of Residues	24
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
S	SER436
S	SER704
S	SER706
S	SER992
S	SER1198
S	SER1227
S	SER1254
S	SER1257
S	SER1258
S	SER2018
S	SER2030
S	SER437
S	SER2042
S	SER2310
S	SER2368
S	SER2376
S	SER2740
S	SER506
S	SER508
S	SER510
S	SER534
S	SER536
S	SER543
S	SER702

---

site_id	SWS_FT_FI25
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
S	SER440
S	SER1188

---

site_id	SWS_FT_FI26
Number of Residues	5
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
S	SER778
S	SER2123
S	SER2398
S	SER2407
S	SER2692

---

site_id	SWS_FT_FI27
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:21406692

Chain	Residue	Details
S	SER783
S	SER1522
S	SER1970

---

site_id	SWS_FT_FI28
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8BTI8

Chain	Residue	Details
S	SER854
S	SER1423
S	SER1616
S	SER1620
S	SER1024
S	SER1042
S	SER1266
S	SER1270
S	SER1271
S	SER1348
S	SER1383
S	SER1384

---

site_id	SWS_FT_FI29
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q8BTI8

Chain	Residue	Details
S	THR856

---

site_id	SWS_FT_FI30
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
S	THR866

---

site_id	SWS_FT_FI31
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:20068231

Chain	Residue	Details
S	SER871

---

site_id	SWS_FT_FI32
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
S	SER876

---

site_id	SWS_FT_FI33
Number of Residues	24
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692

Chain	Residue	Details
S	SER908
S	SER1582
S	SER1598
S	SER1600
S	SER1601
S	SER1658
S	SER1727
S	SER1729
S	SER1731
S	SER1732
S	SER1818
S	SER1129
S	SER1822
S	SER1884
S	SER2090
S	SER2415
S	SER2429
S	SER1424
S	SER1517
S	SER1519
S	SER1521
S	SER1577
S	SER1579
S	SER1581

---

site_id	SWS_FT_FI34
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
S	SER950

---

site_id	SWS_FT_FI35
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
S	SER954

---

site_id	SWS_FT_FI36
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
S	SER957
S	SER1946
S	SER1958
S	SER2118
S	SER968
S	SER970
S	SER972
S	SER1032
S	SER1451
S	SER1691
S	SER1693
S	SER1923

---

site_id	SWS_FT_FI37
Number of Residues	18
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692

Chain	Residue	Details
S	SER973
S	SER1975
S	SER1984
S	SER1987
S	SER1996
S	SER1999
S	SER2008
S	SER2011
S	SER2664
S	SER2706
S	SER1497
S	SER1502
S	SER1762
S	SER1764
S	SER1890
S	SER1916
S	SER1919
S	SER1972

---

site_id	SWS_FT_FI38
Number of Residues	5
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692

Chain	Residue	Details
S	SER974
S	SER1415
S	SER1925
S	SER1948
S	SER1960

---

site_id	SWS_FT_FI39
Number of Residues	7
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:21406692

Chain	Residue	Details
S	THR977
S	THR1043
S	THR1931
S	THR1954
S	THR1966
S	THR1978
S	THR2092

---

site_id	SWS_FT_FI40
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
S	THR983

---

site_id	SWS_FT_FI41
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
S	TYR996
S	TYR1049

---

site_id	SWS_FT_FI42
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
S	THR1003

---

site_id	SWS_FT_FI43
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
S	SER1010

---

site_id	SWS_FT_FI44
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231

Chain	Residue	Details
S	SER1028
S	SER2690

---

site_id	SWS_FT_FI45
Number of Residues	7
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
S	SER1069
S	SER1444
S	SER1542
S	SER1552
S	SER1694
S	SER1878
S	SER2412

---

site_id	SWS_FT_FI46
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648

Chain	Residue	Details
S	SER1072
S	SER1073

---

site_id	SWS_FT_FI47
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692

Chain	Residue	Details
S	SER1099
S	SER1101

---

site_id	SWS_FT_FI48
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332

Chain	Residue	Details
S	SER1102

---

site_id	SWS_FT_FI49
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
S	SER1103
S	SER1404
S	SER2132

---

site_id	SWS_FT_FI50
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
S	SER1122
S	SER1857
S	SER2335

---

site_id	SWS_FT_FI51
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
S	SER1132

---

site_id	SWS_FT_FI52
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163

Chain	Residue	Details
S	THR1208
S	THR1880

---

site_id	SWS_FT_FI53
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:24275569

Chain	Residue	Details
S	SER1219

---

site_id	SWS_FT_FI54
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
S	SER1320
S	SER1387

---

site_id	SWS_FT_FI55
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
S	SER1326

---

site_id	SWS_FT_FI56
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
S	SER1329

---

site_id	SWS_FT_FI57
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
S	SER1382

---

site_id	SWS_FT_FI58
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
S	SER1403

---

site_id	SWS_FT_FI59
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
S	THR1413

---

site_id	SWS_FT_FI60
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
S	THR1434

---

site_id	SWS_FT_FI61
Number of Residues	5
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
S	THR1453
S	THR1472
S	THR1511
S	THR1698
S	THR2144

---

site_id	SWS_FT_FI62
Number of Residues	5
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
S	SER1458
S	SER1648
S	SER2020
S	SER2032
S	SER2067

---

site_id	SWS_FT_FI63
Number of Residues	9
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
S	SER1463
S	SER1499
S	SER1854
S	SER2044
S	SER2046
S	SER2071
S	SER2426
S	SER2684
S	SER2688

---

site_id	SWS_FT_FI64
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
S	THR1492

---

site_id	SWS_FT_FI65
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17924679, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163

Chain	Residue	Details
S	THR1531

---

site_id	SWS_FT_FI66
Number of Residues	3
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692

Chain	Residue	Details
S	THR1927
S	THR1950
S	THR1962

---

site_id	SWS_FT_FI67
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
S	THR2022
S	THR2034

---

site_id	SWS_FT_FI68
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
S	THR2069

---

site_id	SWS_FT_FI69
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
S	SER2102

---

site_id	SWS_FT_FI70
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
S	THR2104

---

site_id	SWS_FT_FI71
Number of Residues	7
Details	MOD_RES: Omega-N-methylarginine => ECO:0007744|PubMed:24129315

Chain	Residue	Details
S	ARG2194
S	ARG2207
S	ARG2231
S	ARG2246
S	ARG2274
S	ARG2288
S	ARG2342

---

site_id	SWS_FT_FI72
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
S	SER2272

---

site_id	SWS_FT_FI73
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
S	THR2289

---

site_id	SWS_FT_FI74
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:16964243

Chain	Residue	Details
S	THR2291

---

site_id	SWS_FT_FI75
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231

Chain	Residue	Details
S	THR2302

---

site_id	SWS_FT_FI76
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
S	THR2316

---

site_id	SWS_FT_FI77
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
S	THR2329
S	THR2409

---

site_id	SWS_FT_FI78
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:24275569

Chain	Residue	Details
S	SER2382

---

site_id	SWS_FT_FI79
Number of Residues	1
Details	MOD_RES: Omega-N-methylarginine; alternate => ECO:0007744|PubMed:24129315

Chain	Residue	Details
S	ARG2384

---

site_id	SWS_FT_FI80
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17525332, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
S	SER2449

---

site_id	SWS_FT_FI81
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:24275569

Chain	Residue	Details
S	THR2583

---

site_id	SWS_FT_FI82
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
S	THR2599
S	THR2738

---

site_id	SWS_FT_FI83
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
S	SER2694

---

site_id	SWS_FT_FI84
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
S	LYS108
S	LYS130
S	LYS2587

---