5MOZ

OXA-10 Avibactam complex with bound Iodide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0008658	molecular_function	penicillin binding
A	0008800	molecular_function	beta-lactamase activity
A	0016787	molecular_function	hydrolase activity
A	0017001	biological_process	antibiotic catabolic process
A	0042597	cellular_component	periplasmic space
A	0046677	biological_process	response to antibiotic
A	0071555	biological_process	cell wall organization
B	0005886	cellular_component	plasma membrane
B	0008658	molecular_function	penicillin binding
B	0008800	molecular_function	beta-lactamase activity
B	0016787	molecular_function	hydrolase activity
B	0017001	biological_process	antibiotic catabolic process
B	0042597	cellular_component	periplasmic space
B	0046677	biological_process	response to antibiotic
B	0071555	biological_process	cell wall organization

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue NXL A 701

Chain	Residue
A	ALA66
A	HOH848
A	HOH986
A	HOH995
A	HOH1000
A	HOH1038
A	SER67
A	SER115
A	VAL117
A	LYS205
A	THR206
A	GLY207
A	PHE208
A	ARG250

---

site_id	AC2
Number of Residues	9
Details	binding site for residue GOL A 702

Chain	Residue
A	ALA197
A	PRO198
A	GLU199
A	TYR200
A	GLU227
A	GLU229
A	HOH916
B	THR107
B	ARG109

---

site_id	AC3
Number of Residues	8
Details	binding site for residue GOL A 703

Chain	Residue
A	LYS138
A	PHE139
A	SER140
A	GLU168
A	SER172
A	LEU178
A	HOH808
A	HOH943

---

site_id	AC4
Number of Residues	6
Details	binding site for residue GOL A 704

Chain	Residue
A	GLU79
A	THR80
A	TYR135
A	GLU156
A	HOH886
A	HOH982

---

site_id	AC5
Number of Residues	8
Details	binding site for residue GOL A 705

Chain	Residue
A	GLN88
A	LYS91
A	GLU126
A	GLU214
A	HOH810
A	HOH905
A	HOH996
A	HOH1023

---

site_id	AC6
Number of Residues	7
Details	binding site for residue GOL A 706

Chain	Residue
A	TYR200
A	TRP222
A	ILE263
A	HOH804
A	HOH807
A	HOH821
A	HOH937

---

site_id	AC7
Number of Residues	4
Details	binding site for residue NA A 707

Chain	Residue
A	LEU64
A	HOH976
A	HOH1063
A	HOH1082

---

site_id	AC8
Number of Residues	5
Details	binding site for residue NA A 708

Chain	Residue
A	LYS45
A	LYS49
A	SER50
A	HOH813
A	HOH946

---

site_id	AC9
Number of Residues	1
Details	binding site for residue NA A 709

Chain	Residue
A	HOH1071

---

site_id	AD1
Number of Residues	1
Details	binding site for residue NA A 710

Chain	Residue
A	GLU199

---

site_id	AD2
Number of Residues	3
Details	binding site for residue NA A 711

Chain	Residue
A	GLU31
A	SER260
A	HOH924

---

site_id	AD3
Number of Residues	2
Details	binding site for residue IOD A 712

Chain	Residue
A	LYS70
A	TRP154

---

site_id	AD4
Number of Residues	1
Details	binding site for residue IOD A 713

Chain	Residue
A	ALA98

---

site_id	AD5
Number of Residues	1
Details	binding site for residue IOD A 714

Chain	Residue
A	ARG250

---

site_id	AD6
Number of Residues	2
Details	binding site for residue IOD A 715

Chain	Residue
A	HOH1038
A	HOH1088

---

site_id	AD7
Number of Residues	9
Details	binding site for residue GOL B 301

Chain	Residue
A	THR107
A	ARG109
B	ALA197
B	PRO198
B	GLU199
B	TYR200
B	GLU227
B	GLU229
B	HOH467

---

site_id	AD8
Number of Residues	5
Details	binding site for residue NA B 302

Chain	Residue
B	GLU168
B	SER172
B	HOH515
B	HOH572
B	HOH591

---

site_id	AD9
Number of Residues	3
Details	binding site for residue CL B 303

Chain	Residue
B	ARG131
B	LYS134
B	HOH530

---

site_id	AE1
Number of Residues	1
Details	binding site for residue IOD B 304

Chain	Residue
B	ARG250

---

site_id	AE2
Number of Residues	5
Details	binding site for residue IOD B 305

Chain	Residue
B	SER67
B	LYS70
B	TRP154
B	NXL308
B	HOH517

---

site_id	AE3
Number of Residues	1
Details	binding site for residue IOD B 306

Chain	Residue
B	ALA98

---

site_id	AE4
Number of Residues	1
Details	binding site for residue IOD B 307

Chain	Residue
B	HOH451

---

site_id	AE5
Number of Residues	14
Details	binding site for Di-peptide NXL B 308 and SER B 67

Chain	Residue
B	THR68
B	PHE69
B	LYS70
B	SER115
B	VAL117
B	LYS205
B	THR206
B	GLY207
B	PHE208
B	ARG250
B	IOD305
B	HOH538
B	PRO65
B	ALA66

---

Functional Information from PROSITE/UniProt

site_id	PS00337
Number of Residues	11
Details	BETA_LACTAMASE_D Beta-lactamase class-D active site. PaSTFKIPnAI

Chain	Residue	Details
A	PRO65-ILE75

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Acyl-ester intermediate","evidences":[{"source":"PubMed","id":"11724923","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19860471","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1K54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WGI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19860471","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2WGI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"N6-carboxylysine","evidences":[{"source":"PubMed","id":"11188693","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11724923","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19860471","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1E4D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K4E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K4F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K55","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K6S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2RL3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---